Oligonucleotide Conjugates In Dna Nanotechnology

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Oligonucleotide Conjugates in DNA Nanotechnology

Author : Alexander Prinzen
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (131 download)

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Book Synopsis Oligonucleotide Conjugates in DNA Nanotechnology by : Alexander Prinzen

Download or read book Oligonucleotide Conjugates in DNA Nanotechnology written by Alexander Prinzen and published by . This book was released on 2022 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Oligonucleotides, in the form of DNA and RNA are primarily known as the information and messenger molecules of the cell. Roles beyond this informational molecule have seen oligonucleotides used as structural materials, therapeutics, and molecular recognition components. Combining many of these different roles, the field of DNA nanotechnology has emerged, to generate an unprecedented number of different devices, for applications in sensing, diagnostics, gene silencing and drug delivery. Especially in the case of gene silencing and drug delivery, the biocompatibility, and recognition abilities of DNA place these nanostructures as advantageous carriers for the transport and selective release of these agents. However, by its nature, DNA is chemically inert and to gain more function, chemical modifications are generally needed. This thesis presents new oligonucleotide conjugates used in combination with DNA nanotechnology for the selective delivery/release of both small molecule drugs and antisense oligonucleotides. At first, the evolution of a DNA device that was engineered to selectively amplify the release of small molecule therapeutics, in response to a molecular recognition event is described. A detailed investigation into the design, conjugation chemistry, and kinetics of release are presented. Furthermore, integrating structural DNA nanotechnology and the drug release platform together allows for the generation of well-defined nanostructures which can act as standalone devices without multiple components. Secondly, a new antisense oligonucleotide conjugated with hydrophobic disulfide modifications is generated for their ability to self-assemble into spherical nucleic acids and produce stimuli responsive gene silencing under reducing conditions. The stability of these structures in cellular media and uptake into cells of these structures is thoroughly investigated. Finally, different strategies to improve the drug release device from Chapter 2 for transitioning it into real biological drug delivery applications is developed. Factors such as off-target degradation/activation, delivery to the site of action, rate of metabolism and overall drug specificity are addressed"--

Nucleic Acids Chemistry

Author : Ramon Eritja
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110636484
Total Pages : 516 pages
Book Rating : 4.1/5 (16 download)

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Book Synopsis Nucleic Acids Chemistry by : Ramon Eritja

Download or read book Nucleic Acids Chemistry written by Ramon Eritja and published by Walter de Gruyter GmbH & Co KG. This book was released on 2021-01-18 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed as well.

DNA in Supramolecular Chemistry and Nanotechnology

Author : Eugen Stulz
Publisher : John Wiley & Sons
ISBN 13 : 111869693X
Total Pages : 538 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis DNA in Supramolecular Chemistry and Nanotechnology by : Eugen Stulz

Download or read book DNA in Supramolecular Chemistry and Nanotechnology written by Eugen Stulz and published by John Wiley & Sons. This book was released on 2015-07-14 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the emerging topic of DNA nanotechnology and DNA supramolecular chemistry in its broader sense. By taking DNA out of its biological role, this biomolecule has become a very versatile building block in materials chemistry, supramolecular chemistry and bio-nanotechnology. Many novel structures have been realized in the past decade, which are now being used to create molecular machines, drug delivery systems, diagnosis platforms or potential electronic devices. The book combines many aspects of DNA nanotechnology, including formation of functional structures based on covalent and non-covalent systems, DNA origami, DNA based switches, DNA machines, and alternative structures and templates. This broad coverage is very appealing since it combines both the synthesis of modified DNA as well as designer concepts to successfully plan and make DNA nanostructures. Contributing authors have provided first a general introduction for the non-specialist reader, followed by a more in-depth analysis and presentation of their topic. In this way the book is attractive and useful for both the non-specialist who would like to have an overview of the topic, as well as the specialist reader who requires more information and inspiration to foster their own research.

DNA Conjugates and Sensors

Author : Keith R Fox
Publisher : Royal Society of Chemistry
ISBN 13 : 1849734933
Total Pages : 317 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis DNA Conjugates and Sensors by : Keith R Fox

Download or read book DNA Conjugates and Sensors written by Keith R Fox and published by Royal Society of Chemistry. This book was released on 2012-11-30 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applications of nucleic acids have developed recently to provide solutions for biosensors, diagnostic tools and as platforms for the assembly of complex structures. These developments have been possible as their base sequence can be used to assemble precise structures following simple and predictable rules. Self-assembled DNA can then be amplified using polymerase chain reaction (PCR) and this ultimately enables the preparation of synthetic nucleic acids. Their use as molecular tools or DNA-conjugates has recently been enhanced by the addition of other groups including enzymes, fluorophores and small molecules. Written by leaders in the field, this volume describes the preparation and application of these DNA-conjugates. Several have been used as sensors (aptamers, riboswitches and nanostructures) based on the ability of nucleic acids to adopt specific structures in the presence of ligands, whilst others link reporter groups such as proteins or fluorophores to RNA or DNA for detection, single molecule studies, and increasing the sensitivity of PCR. The book is relevant to researchers in areas related to analytical chemistry, chemical biology, medicinal chemistry, molecular pharmacology, and structural and molecular biology.

Therapeutic Oligonucleotides

Author : Jens Kurreck
Publisher : Royal Society of Chemistry
ISBN 13 : 0854041168
Total Pages : 362 pages
Book Rating : 4.8/5 (54 download)

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Book Synopsis Therapeutic Oligonucleotides by : Jens Kurreck

Download or read book Therapeutic Oligonucleotides written by Jens Kurreck and published by Royal Society of Chemistry. This book was released on 2008 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a compelling overall update on current status of RNA interference

DNA Nanotechnology

Author : Chunhai Fan
Publisher : Springer Nature
ISBN 13 : 3030548066
Total Pages : 406 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis DNA Nanotechnology by : Chunhai Fan

Download or read book DNA Nanotechnology written by Chunhai Fan and published by Springer Nature. This book was released on 2020-09-07 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. The chapter "DNA-Programmed Chemical Synthesis of Polymers and Inorganic Nanomaterials" is available open access under a CC BY 4.0 License via link.springer.com.

Structural DNA Nanotechnology

Author : Nadrian C. Seeman
Publisher : Cambridge University Press
ISBN 13 : 0521764483
Total Pages : 269 pages
Book Rating : 4.5/5 (217 download)

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Book Synopsis Structural DNA Nanotechnology by : Nadrian C. Seeman

Download or read book Structural DNA Nanotechnology written by Nadrian C. Seeman and published by Cambridge University Press. This book was released on 2015 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the founder of the field, this is a comprehensive and accessible introduction to structural DNA nanotechnology.

Templated DNA Nanotechnology

Author : Thimmaiah Govindaraju
Publisher : CRC Press
ISBN 13 : 0429767676
Total Pages : 426 pages
Book Rating : 4.4/5 (297 download)

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Book Synopsis Templated DNA Nanotechnology by : Thimmaiah Govindaraju

Download or read book Templated DNA Nanotechnology written by Thimmaiah Govindaraju and published by CRC Press. This book was released on 2019-01-30 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nucleic acids have structurally evolved over billions of years to effectively store and transfer genetic information. In the 1980s, Nadrian Seeman’s idea of constructing a 3D lattice from DNA led to utilizing DNA as nanomolecular building blocks to create emergent molecular systems and nanomaterial objects. This bottom-up approach to construct nanoscale architectures with DNA marked the beginning of a new field, DNA nanotechnology, contributing significantly to the broad area of nanoscience and nanotechnology. The molecular architectonics of small "designer" molecules and short DNA sequences through complementary binding interaction engenders well-defined functional nanoarchitectures with realistic applications in areas ranging from biology to materials science and is termed "DNA nanoarchitectonics." This book discusses novel approaches adapted by leading researchers from all over the world to create functional nucleic acid molecular systems and nanoarchitectures. Individual chapters contributed by active practitioners provide fundamental and advanced knowledge emanated from their own and others’ work. Each chapter includes numerous illustrations, historical perspectives, case studies and practical examples, critical discussions, and future prospects. This book can serve as a practical handbook or as a textbook for advanced undergraduate- and graduate-level students of nanotechnology and DNA nanotechnology, supramolecular chemistry, and nanoarchitectonics and researchers working on macromolecular science, nanotechnology, chemistry, biology, and medicine, especially those with an interest in sensors, biosensors, nanoswitches and nanodevices, diagnostics, drug delivery, and therapeutics.

Oligonucleotide Synthesis

Author : Piet Herdewijn
Publisher : Springer Science & Business Media
ISBN 13 : 1592598234
Total Pages : 436 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Oligonucleotide Synthesis by : Piet Herdewijn

Download or read book Oligonucleotide Synthesis written by Piet Herdewijn and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of powerful new techniques for oligonucleotide synthesis and for the use of modified oligonucleotides in biotechnology. Among the protocol highlights are a novel two-step process that yields a high purity, less costly, DNA, the synthesis of phosphorothioates using new sulfur transfer agents, the synthesis of LNA, peptide conjugation methods to improve cellular delivery and cell-specific targeting, and triple helix formation. The applications include using molecular beacons to monitor the PCR amplification process, nuclease footprinting to study the sequence-selective binding of small molecules of DNA, nucleic acid libraries, and the use of small interference RNA (siRNA) as an inhibitor of gene expression.

Templated DNA Nanotechnology

Author : Thimmaiah Govindaraju
Publisher : CRC Press
ISBN 13 : 0429767668
Total Pages : 293 pages
Book Rating : 4.4/5 (297 download)

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Book Synopsis Templated DNA Nanotechnology by : Thimmaiah Govindaraju

Download or read book Templated DNA Nanotechnology written by Thimmaiah Govindaraju and published by CRC Press. This book was released on 2019-01-30 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nucleic acids have structurally evolved over billions of years to effectively store and transfer genetic information. In the 1980s, Nadrian Seeman’s idea of constructing a 3D lattice from DNA led to utilizing DNA as nanomolecular building blocks to create emergent molecular systems and nanomaterial objects. This bottom-up approach to construct nanoscale architectures with DNA marked the beginning of a new field, DNA nanotechnology, contributing significantly to the broad area of nanoscience and nanotechnology. The molecular architectonics of small "designer" molecules and short DNA sequences through complementary binding interaction engenders well-defined functional nanoarchitectures with realistic applications in areas ranging from biology to materials science and is termed "DNA nanoarchitectonics." This book discusses novel approaches adapted by leading researchers from all over the world to create functional nucleic acid molecular systems and nanoarchitectures. Individual chapters contributed by active practitioners provide fundamental and advanced knowledge emanated from their own and others’ work. Each chapter includes numerous illustrations, historical perspectives, case studies and practical examples, critical discussions, and future prospects. This book can serve as a practical handbook or as a textbook for advanced undergraduate- and graduate-level students of nanotechnology and DNA nanotechnology, supramolecular chemistry, and nanoarchitectonics and researchers working on macromolecular science, nanotechnology, chemistry, biology, and medicine, especially those with an interest in sensors, biosensors, nanoswitches and nanodevices, diagnostics, drug delivery, and therapeutics.

Dna Nanotechnology For Bioanalysis: From Hybrid Dna Nanostructures To Functional Devices

Author : Giuseppe Domenico Arrabito
Publisher : World Scientific
ISBN 13 : 1786343819
Total Pages : 216 pages
Book Rating : 4.7/5 (863 download)

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Book Synopsis Dna Nanotechnology For Bioanalysis: From Hybrid Dna Nanostructures To Functional Devices by : Giuseppe Domenico Arrabito

Download or read book Dna Nanotechnology For Bioanalysis: From Hybrid Dna Nanostructures To Functional Devices written by Giuseppe Domenico Arrabito and published by World Scientific. This book was released on 2017-09-25 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is intended for non-specialists and students, presenting a unique introduction to the field of DNA nanotechnology. The primary focus is on the extraordinary advantages of specificity and sensitivity obtained by integrating DNA nanostructures in bioanalytical devices.DNA Nanotechnology for Bioanalysis provides a concise and rigorous description for the fabrication of various types of functional nanostructures by optimized software-aided high-yield synthesis. Following this is the explanation of methods to decorate these nanostructures with molecules such as proteins, metal nanoparticles or bioorganic moieties covalently bonded onto DNA via self-assemblage processes. Also provided is a concise review on non-canonical DNA structures (such as G-quadruplexes) and their targeting by small molecules for applications in pharmacology. Finally, it describes the exciting applications of DNA nanostructures in life sciences and nanomedicine, including ultraspecific molecular delivery, control of cell behavior, analysis of cell lysate and DNA-based nano-tools for super-resolution sub-cellular imaging.

Protocols for Oligonucleotides and Analogs

Author : Sudhir Agrawal
Publisher : Springer Science & Business Media
ISBN 13 : 0896032817
Total Pages : 503 pages
Book Rating : 4.8/5 (96 download)

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Book Synopsis Protocols for Oligonucleotides and Analogs by : Sudhir Agrawal

Download or read book Protocols for Oligonucleotides and Analogs written by Sudhir Agrawal and published by Springer Science & Business Media. This book was released on 1993-08-31 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: When first conceived, not only was the aim of Protocols for Oligo nucleotides and Analogs to provide wide coverage of the ohgonuc- otide chemistry field for readers who are well versed within the field, but also to give investigators just entering into the field a new perspective. The very first book on this topic was edited and published by Michael Gait in 1984, in whose laboratory I encountered the newer aspects of oligonucleotide chemistry. Since then, oligonucleotide research has developed to such an extent that its uses extend far beyond basic studies, and now find wide application throughout clinical science as well. Until recently, the major application of oligonucleotides has been in the area of DNA-based diagnostic and "antisense oligonucleotid- based therapeutic approaches. However, oligonucleotides are now also being used as therapeutic agents and are thus frequently found in clinical trials in humans. Synthesis of unmodified oligonucleotides using automated synthe sizers has become a common practice in numerous laboratories. How ever, improvements on the existing techniques and the introduction of ever newer methods for oligonucleotide synthesis is constantly driving ahead in the leading research laboratories. And several new oligonucle otide analogs have been synthesized and studied for their individual prop erties in recent years. The present volume strives to bring the readers the most up-to-date information on the newest aspects of synthesis of oligo nucleotides and their analogs. A separate volume covers synthesis of oligonucleotide conjugates, along with most of the analytical techniques presently used for analysis of oligonucleotides.

Protocols for Oligonucleotide Conjugates

Author : Sudhir Agrawal
Publisher : Humana Press
ISBN 13 : 9780896032521
Total Pages : 377 pages
Book Rating : 4.0/5 (325 download)

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Book Synopsis Protocols for Oligonucleotide Conjugates by : Sudhir Agrawal

Download or read book Protocols for Oligonucleotide Conjugates written by Sudhir Agrawal and published by Humana Press. This book was released on 1993-11-30 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt:

DNA and RNA Origami

Author : Julián Valero
Publisher : Springer Nature
ISBN 13 : 1071630288
Total Pages : 351 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis DNA and RNA Origami by : Julián Valero

Download or read book DNA and RNA Origami written by Julián Valero and published by Springer Nature. This book was released on 2023-05-11 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume detials diverse methodological approaches on the assembly and applications of DNA origami assemblies. Chapters guide readers through different synthetic and computational methods, isolation and structural characterization of 2D and 3D DNA origami nanoarchitectures, nanophotonics, drug delivery, biophysics, and synthetic biology.Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, DNA and RNA Origami: Methods and Protocols aims to serve as a guideline describing the current state-of-the-art assembly methodologies and applications of DNA origami nanostructures.

DNA in Supramolecular Chemistry and Nanotechnology

Author : Eugen Stulz
Publisher : John Wiley & Sons
ISBN 13 : 1118696948
Total Pages : 528 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis DNA in Supramolecular Chemistry and Nanotechnology by : Eugen Stulz

Download or read book DNA in Supramolecular Chemistry and Nanotechnology written by Eugen Stulz and published by John Wiley & Sons. This book was released on 2015-07-14 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the emerging topic of DNA nanotechnology and DNA supramolecular chemistry in its broader sense. By taking DNA out of its biological role, this biomolecule has become a very versatile building block in materials chemistry, supramolecular chemistry and bio-nanotechnology. Many novel structures have been realized in the past decade, which are now being used to create molecular machines, drug delivery systems, diagnosis platforms or potential electronic devices. The book combines many aspects of DNA nanotechnology, including formation of functional structures based on covalent and non-covalent systems, DNA origami, DNA based switches, DNA machines, and alternative structures and templates. This broad coverage is very appealing since it combines both the synthesis of modified DNA as well as designer concepts to successfully plan and make DNA nanostructures. Contributing authors have provided first a general introduction for the non-specialist reader, followed by a more in-depth analysis and presentation of their topic. In this way the book is attractive and useful for both the non-specialist who would like to have an overview of the topic, as well as the specialist reader who requires more information and inspiration to foster their own research.

Protein Self-Assembly

Author : Jennifer J. McManus
Publisher : Humana
ISBN 13 : 9781493996803
Total Pages : 266 pages
Book Rating : 4.9/5 (968 download)

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Book Synopsis Protein Self-Assembly by : Jennifer J. McManus

Download or read book Protein Self-Assembly written by Jennifer J. McManus and published by Humana. This book was released on 2020-08-08 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores experimental and computational approaches to measuring the most widely studied protein assemblies, including condensed liquid phases, aggregates, and crystals. The chapters in this book are organized into three parts: Part One looks at the techniques used to measure protein-protein interactions and equilibrium protein phases in dilute and concentrated protein solutions; Part Two describes methods to measure kinetics of aggregation and to characterize the assembled state; and Part Three details several different computational approaches that are currently used to help researchers understand protein self-assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Protein Self-Assembly: Methods and Protocols is a valuable resource for researchers who are interested in learning more about this developing field.

Spherical Nucleic Acids

Author : Chad A. Mirkin
Publisher : CRC Press
ISBN 13 : 0429578067
Total Pages : 1806 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis Spherical Nucleic Acids by : Chad A. Mirkin

Download or read book Spherical Nucleic Acids written by Chad A. Mirkin and published by CRC Press. This book was released on 2020-09-01 with total page 1806 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spherical nucleic acids (SNAs) comprise a nanoparticle core and a densely packed and highly oriented nucleic acid shell, typically DNA or RNA. They have novel architecture-dependent properties that distinguish them from all other forms of nucleic acids and make them useful in materials synthesis, catalysis, diagnostics, therapeutics, and optics/plasmonics. This book covers over two decades of Dr. Mirkin’s research on SNAs and their anisotropic analogues, including synthesis and fundamental properties, and applications in colloidal crystallization, adaptive matter, and nanomedicine, spanning extra- and intracellular diagnostics, gene regulation, and immunomodulation. It is a reprint volume that compiles 101 key papers from high-impact journals in this research area published by the Mirkin Group at Northwestern University, Illinois, USA, within the International Institute for Nanotechnology, and collaborators. Volume 1 provides an overview and a historical framework of engineering matter from DNA-modified constructs and discusses the enabling features of nucleic acid–functionalized nanomaterials. Volume 2 covers design rules for colloidal crystallization, building blocks for crystal engineering, and DNA and RNA as programmable bonds. Volume 3 discusses colloidal crystallization processes and routes to hierarchical assembly, dynamic nanoparticle superlattices, surface-based and template-confined colloidal crystallization, optics and plasmonics with nanoparticle superlattices, and postsynthetic modification and catalysis with nanoparticle superlattices. Volume 4 covers diagnostic modalities, and intracellular therapeutic and diagnostic schemes based upon nucleic acid–functionalized nanomaterials.