Oleanolic Acid Delivery Using Biodegradable Nanoparticles For Cancer Therapy

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OLEANOLIC ACID DELIVERY USING

Author : Kwun-Wai Dede Man
Publisher : Open Dissertation Press
ISBN 13 : 9781361024140
Total Pages : 136 pages
Book Rating : 4.0/5 (241 download)

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Book Synopsis OLEANOLIC ACID DELIVERY USING by : Kwun-Wai Dede Man

Download or read book OLEANOLIC ACID DELIVERY USING written by Kwun-Wai Dede Man and published by Open Dissertation Press. This book was released on 2017-01-26 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Oleanolic Acid Delivery Using Biodegradable Nanoparticles for Cancer Therapy" by Kwun-wai, Dede, Man, 文冠慧, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Utilization of nanocarriers is having a significant impact on the diagnosis and treatment of cancer. It allows targeted administration to specific sites and sustained drug delivery. Therefore, this regimen greatly increases the therapeutic index and drug concentration in tumor tissues. Among all types, biomaterials-based nanocarriers, owing to their biocompatible nature, offers a potentially safer strategy to improve the survival of cancer patients. This thesis investigated the therapeutic activity of copolymeric nanoparticulate systems encapsulated with oleanolic acid (OA). Four types of biodegradable copolymers, namely, mPEG-P(D, L)LA, mPEG-P(L)LA, mPEG-P(D, L)LGA and mPEG-P(L)LGA, were employed to fabricate OA-loaded nanoparticles (OA-NPs) by nanoprecipitation. Physicochemical characterizations were performed using dynamic light scattering (DLS), transmission electron microscope(TEM)and high performance liquid chromatography (HPLC). Cytotoxicity of the formulations was evaluated on A549 (human alveolar carcinoma), HepG2 (human liver carcinoma) and BEAS-2B (normal bronchial epithelial) cells via 3-(4, 5-dimethylthiazolyl-2)-2, 5- diphenyltetrazolium bromide (MTT) assay. The induced cell death pathway was confirmed by fluorescence-activated cellsorting (FACS) flow cytometry. The synthesized NPs were spherical, with size dimensions of 40-70nm. The particle size increased to 230-260nm after the incorporation of OA. Polydispersity indices of less than 0.3 indicated the narrow size distribution of the negatively charged NPs. OA-NPs in suspension form were stable over 7 days of storage atboth in 4Cand 25C. Significant inhibitory effect was demonstrated by the OA-NPs on A549 and HepG2 cell lines through apoptosis (p mPEG-P(L)LGA > mPEG-P(D, L)LA > mPEG-P(L)LA NPs in decreasing order. The cytotoxic effect of OA-NPs on BEAS-2B cells was less than that on the two other cancer cell lines, while blank NPs (without OA incorporated) exhibited insignificant toxicity on all cell lines. This reflectedthe cytotoxic effect was ascribed to the encapsulated OA rather than the copolymeric NPs. Overall, our studies clearly revealed the specific anti-tumor capability of the developed OA-loaded nanoparticulate systems. DOI: 10.5353/th_b5388008 Subjects: Nanoparticles Drug carriers (Pharmacy) Cancer - Treatment

Oleanolic Acid Delivery Using Biodegradable Nanoparticles for Cancer Therapy

Author : 文冠慧
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (91 download)

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Book Synopsis Oleanolic Acid Delivery Using Biodegradable Nanoparticles for Cancer Therapy by : 文冠慧

Download or read book Oleanolic Acid Delivery Using Biodegradable Nanoparticles for Cancer Therapy written by 文冠慧 and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nanopharmaceuticals: Principles and Applications Vol. 3

Author : Vinod Kumar Yata
Publisher : Springer Nature
ISBN 13 : 3030471209
Total Pages : 340 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Nanopharmaceuticals: Principles and Applications Vol. 3 by : Vinod Kumar Yata

Download or read book Nanopharmaceuticals: Principles and Applications Vol. 3 written by Vinod Kumar Yata and published by Springer Nature. This book was released on 2020-08-19 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.

Nanomedicine and Tissue Engineering

Author : Nandakumar Kalarikkal
Publisher : CRC Press
ISBN 13 : 1498726429
Total Pages : 548 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Nanomedicine and Tissue Engineering by : Nandakumar Kalarikkal

Download or read book Nanomedicine and Tissue Engineering written by Nandakumar Kalarikkal and published by CRC Press. This book was released on 2016-03-30 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the recent advances in nanomedicine and tissue engineering. It outlines the basic tools and novel approaches that are becoming available in nanomedicine and tissue engineering and considers the full range of nanomedical applications which employ molecular nanotechnology inside the human body, from the perspective of a future pr

Integration of Biomaterials for Gene Therapy

Author : Rishabha Malviya
Publisher : John Wiley & Sons
ISBN 13 : 1394175612
Total Pages : 344 pages
Book Rating : 4.3/5 (941 download)

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Book Synopsis Integration of Biomaterials for Gene Therapy by : Rishabha Malviya

Download or read book Integration of Biomaterials for Gene Therapy written by Rishabha Malviya and published by John Wiley & Sons. This book was released on 2023-10-10 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: INTEGRATION OF BIOMATERIALS FOR GENE THERAPY Brings industrial practitioners and researchers together to discuss how the deeper integration of biomaterial platforms could play a significant role in enabling breakthroughs in the application of gene editing for the treatment of human disease. This book comprises research and review articles from leading researchers with multidisciplinary experience. It discusses many broad topics, including nanoparticle-enabled gene therapy, inorganic nanocarrier-based gene delivery, non-viral delivery of nucleic acid, biocompatible hydrogels, silk, and polysaccharides-based gene delivery. Other gene delivery topics discussed include the use of smart and engineered biomaterials, combined therapy with growth factors and cell transportation, and the prospects and challenges in the treatment of different diseases, including cancer. This book bridges the knowledge of pharmaceutics, engineering, basic science, and clinical research fields in a way that will help the research community expedite the clinical application of these therapies for various diseases and conditions. Audience A broad range of researchers, scientists, and engineers in diverse fields such as materials science, biomedicine, biomedical engineering, biology, chemistry, physics, biotechnology, pharmacology, toxicology, and formulation scientists.

Nanotechnology in Nutraceuticals

Author : Shampa Sen
Publisher : CRC Press
ISBN 13 : 1315353717
Total Pages : 335 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Nanotechnology in Nutraceuticals by : Shampa Sen

Download or read book Nanotechnology in Nutraceuticals written by Shampa Sen and published by CRC Press. This book was released on 2016-10-14 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: While nutraceuticals were verified to be expedient, they often lack stability, bioavailability, and permeability, and nano-nutraceuticals are being developed to afford a solution to the problem. Nanotechnology in Nutraceuticals: Production to Consumption delves into the promises and prospects of the application of nanotechnology to nutraceuticals, addressing concepts, techniques, and production methods. Nutraceuticals retain less stability, efficacy, and bioavailability when entering the human body. To overcome such problems, nanotechnology shows promise when applied as a tool to improve the quality and stability of nutraceuticals. This book discusses metallic nanoparticles and their applications in the food industry with specific application to nutraceuticals. It includes detailed discussion on potential functional properties of nutraceuticals with regard to antimicrobial activity, anti-inflammatory activity, and anti-cancer activity. Since nanoparticles can be toxic past a certain limit, implementing nanotechnology under thoughtful regulations is considered critical. The book addresses these issues with chapters covering the principles for the oversight of nanotechnologies and nanomaterials in nutraceuticals, the implications of regulatory requirements, the ethics and economics of nano-nutraceuticals, and consumer acceptance of nanotechnology based foods.

Smart Nanocontainers

Author : Phuong Nguyen Tri
Publisher : Elsevier
ISBN 13 : 0128168919
Total Pages : 558 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Smart Nanocontainers by : Phuong Nguyen Tri

Download or read book Smart Nanocontainers written by Phuong Nguyen Tri and published by Elsevier. This book was released on 2019-11-08 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: Smart Nanocontainers explores the fundamental concepts and emerging applications of nanocontainers in biomedicine, pharmaceuticals and smart materials. In pharmaceuticals, nanocontainers have advantages over their micro-counterparts, including more efficient drug detoxification, higher intracellular uptake, better stability, less side effects and higher biocompatibility with tissue and cells. In materials science, such as coating technology, they help by making coatings smarter, stronger and more durable. This important reference will help anyone who wants to learn more on how nanocontainers are used to provide the controlled release of active agents, including their applications in smart coatings, corrosion, drug delivery, diagnosis, agri-food and gas storage. Discusses how the molecular design of nanocarriers can be optimized to increase performance Explores how nanocarriers are being used to produce a new generation of active coatings Explains how nanocarriers are being used to deliver more effective nanoscale drug delivery

Multifunctional Nanocarriers for Contemporary Healthcare Applications

Author : Barkat, Md. Abul
Publisher : IGI Global
ISBN 13 : 1522547827
Total Pages : 624 pages
Book Rating : 4.5/5 (225 download)

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Book Synopsis Multifunctional Nanocarriers for Contemporary Healthcare Applications by : Barkat, Md. Abul

Download or read book Multifunctional Nanocarriers for Contemporary Healthcare Applications written by Barkat, Md. Abul and published by IGI Global. This book was released on 2018-01-12 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in technology permeates every aspect of life, including the healthcare system. Nanotechnology based systems have gained popularity based upon their promise, size, and other characteristics. Multifunctional Nanocarriers for Contemporary Healthcare Applications is a critical academic publication that explores advancements in nanostructured systems, applications of these systems in healthcare, and biomedical applications of these systems. Featuring coverage on a wide range of topics, such as hydrogels, controlled drug delivery systems, and nanomedicine, this book is geared toward researchers, students, and academicians seeking current research on advancements and applications of nanostructured systems in the healthcare industry.

Green Nanoparticles

Author : Jayanta Kumar Patra
Publisher : Springer Nature
ISBN 13 : 3030392465
Total Pages : 395 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Green Nanoparticles by : Jayanta Kumar Patra

Download or read book Green Nanoparticles written by Jayanta Kumar Patra and published by Springer Nature. This book was released on 2020-04-06 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology is the application of science to control matter at the molecular level. It has become one of the most promising applied technologies in all areas of science. Nanoparticles have multi-functional properties and have created very interesting applications in various fields such as medicine, nutrition, bioenergy, agriculture and the environment. But the biogenic syntheses of monodispersed nanoparticles with specific sizes and shapes have been a challenge in biomaterial science. Nanoparticles are of great interest due to their extremely small size and large surface-to-volume ratio, which lead to both chemical and physical differences in their properties (e.g., mechanical properties, biological and sterical properties, catalytic activity, thermal and electrical conductivity, optical absorption and melting point) compared to bulk of the same chemical composition. Recently, however, synthesizing metal nanoparticles using green technology via microorganisms, plants, viruses, and so on, has been extensively studied and has become recognized as a green and efficient way for further exploiting biological systems as convenient nanofactories. Thus the biological synthesis of nanoparticles is increasingly regarded as a rapid, ecofriendly, and easily scaled-up technology. Today researchers are developing new techniques and materials using nanotechnology that may be suitable for plants to boost their native functions. Recently, biological nanoparticles were found to be more pharmacologically active than physico-chemically synthesized nanoparticles. Various applications of biosynthesized nanoparticles have been discovered, especially in the field of biomedical research, such as applications to specific delivery of drugs, use for tumor detection, angiogenesis, genetic disease and genetic disorder diagnosis, photoimaging, and photothermal therapy. Further, iron oxide nanoparticles have been applied to cancer therapy, hyperthermia, drug delivery, tissue repair, cell labeling, targeting and immunoassays, detoxification of biological fluids, magnetic resonance imaging, and magnetically responsive drug delivery therapy. Nanoparticle synthesis for plant byproducts for biomedical applications has vast potential. This book offers researchers in plant science and biomedicine the latest research and opportunity to develop new tools for the synthesis of environmentally friendly and cost-effective nanoparticles for applications in biomedicine as well as other various fields.

Materials for Biomedical Engineering: Hydrogels and Polymer-based Scaffolds

Author : Alina-Maria Holban
Publisher : Elsevier
ISBN 13 : 0128169028
Total Pages : 562 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Materials for Biomedical Engineering: Hydrogels and Polymer-based Scaffolds by : Alina-Maria Holban

Download or read book Materials for Biomedical Engineering: Hydrogels and Polymer-based Scaffolds written by Alina-Maria Holban and published by Elsevier. This book was released on 2019-03-20 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: Materials for Biomedical Engineering: Hydrogels and Polymer-Based Scaffolds discusses the use of a wide variety of hydrogels as bioactive scaffolds in regenerative medicine, including updates on innovative materials and their properties. Various types of currently investigated scaffolding materials and hydrogels are discussed, as is their future roles and applications, the main techniques for scaffold fabrication, and their characterization procedures. Readers will be able to use this book as a guide for the selection of the best materials for a specific application. Provides a valuable resource of recent scientific progress, highlighting the most well-known applications of hydrogels as bioactive scaffolds in regenerative medicine Includes novel opportunities and ideas for developing or improving technologies in biomaterials, and in related biomedical industries Features at least 50% of references from the last 2-3 years

Principles of Biomaterials Encapsulation: Volume Two

Author : Farshid Sefat
Publisher : Elsevier
ISBN 13 : 0323853307
Total Pages : 806 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Principles of Biomaterials Encapsulation: Volume Two by : Farshid Sefat

Download or read book Principles of Biomaterials Encapsulation: Volume Two written by Farshid Sefat and published by Elsevier. This book was released on 2023-04-10 with total page 806 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Biomaterials Encapsulation: Volume Two provides an expansive and in-depth resource covering the key principles, biomaterials, techniques and applications of encapsulation in translational medicine. The book details the various biomaterials available for encapsulation, including polymers, natural and synthetic biomaterials, porous materials, and more. The advantages and disadvantages of conventional and contemporary biomaterials for encapsulations are reviewed, along with advice on the most effective materials for both shell and core. The final part of the book describes a broad range of applications in regenerative medicine, uniquely bringing encapsulation into the worlds of translational medicine and tissue engineering. This book enables readers to learn about the pros and cons of different biomaterials for encapsulation, as well as how they can be utilized in many bodily systems and tissues, such as the respiratory, digestive, endocrine and cardiovascular systems. Written and edited by well-versed materials scientists with extensive clinical, biomedical and regenerative medicine experience, this book offers a deeply interdisciplinary look at encapsulation in translational medicine. Details the various biomaterials available for encapsulation, as well as the advantages and disadvantages of conventional and contemporary biomaterials for encapsulations Describes a broad range of applications in regenerative medicine, uniquely bringing encapsulation into the worlds of translational medicine and tissue engineering Written and edited by well-versed materials scientists with extensive clinical, biomedical and regenerative medicine experience, offering an interdisciplinary approach

Nanotechnology in Medicine

Author : Mahendra Rai
Publisher : John Wiley & Sons
ISBN 13 : 1119769884
Total Pages : 448 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis Nanotechnology in Medicine by : Mahendra Rai

Download or read book Nanotechnology in Medicine written by Mahendra Rai and published by John Wiley & Sons. This book was released on 2021-10-19 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: NANOTECHNOLOGY IN MEDICINE Discover thorough insights into the toxicology of nanomaterials used in medicine In Nanotechnology in Medicine: Toxicity and Safety, an expert team of nanotechnologists delivers a robust and up-to-date review of current and future applications of nanotechnology in medicine with a special focus on neurodegenerative diseases, cancer, diagnostics, nano-nutraceuticals, dermatology, and gene therapy. The editors offer resources that address nanomaterial safety, which tends to be the greatest hurdle to obtaining the benefits of nanomedicine in healthcare. The book is a one-stop resource for recent and comprehensive information on the toxico logical and safety aspects of nanotechnology used in human health and medicine. It provides readers with cutting-edge techniques for delivering therapeutic agents into targeted cellular compartments, cells, tissues, and organs by using nanoparticulate carriers. The book also offers methodological considerations for toxicity, safety, and risk assessment. Nanotechnology in Medicine: Toxicity and Safety also provides readers with: A thorough introduction to the nanotoxicological aspects of nanomedicine, including translational nanomedicine and nanomedicine personalization Comprehensive introductions to nanoparticle toxicity and safety, including selenium nanoparticles and metallic nanoparticles Practical discussions of nanotoxicology and drug delivery, including gene delivery using nanocarriers and the use of nanomaterials for ocular delivery applications In-depth examinations of nanotechnology ethics and the regulatory framework of nanotechnology and medicine Perfect for researchers, post-doctoral candidates, and specialists in the fields of nanotechnology, nanomaterials, and nanocarriers, Nanotechnology in Medicine: Toxicity and Safety will also prove to be an indispensable part of the libraries of nanoengineering, nanomedicine, and biopharmaceutical professionals and nanobiotechnologists.

Biopolymer-Based Nanomaterials in Drug Delivery and Biomedical Applications

Author : Hriday Bera
Publisher : Academic Press
ISBN 13 : 0128208759
Total Pages : 630 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Biopolymer-Based Nanomaterials in Drug Delivery and Biomedical Applications by : Hriday Bera

Download or read book Biopolymer-Based Nanomaterials in Drug Delivery and Biomedical Applications written by Hriday Bera and published by Academic Press. This book was released on 2021-01-05 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past few decades, there has been unprecedented progress in the design of versatile biopolymer-based nanoplatforms for pharmaceutical and biomedical applications, particularly due to their attractive traits, including excellent biocompatibility, outstanding biodegradability, low immunogenicity, and facile chemical modifiability. Biopolymer-Based Nanomaterials in Drug Delivery and Biomedical Applications serves as a clear and detailed body of information on the synthesis and characterization of biopolymer-based materials in nanomedicine. This book describes various nanomaterials consisting of biopolymers including polysaccharides (i.e., derived from plants, animals, bacteria, algae, and fungi) and polypeptides in terms of their structures, synthetic protocols, and characterization and uses as therapeutic drugs and gene delivery carriers and in other biomedical fields. The chapters of this book, which are contributed by internationally renowned scholars working in the arena of biopolymer-based nanomaterials, would offer a wide vision on the potential future applications of these nanomaterials in the delivery and targeting of bioactive molecules of pharmaceutical interests and in tissue engineering, biosensing, bioimaging, and diagnostic purposes. The state-of-the-art information presented in the book would also encourage young investigators and researchers to further bring cutting-edge developments in the field of nanomedicine in the near future. Provides a scholarly insight into the recent development of biopolymer-based nanomaterials Focuses on the diverse cutting-edge techniques for the fabrication of native and modified biopolymer-based nanoplatforms and their applications in drug delivery and biomedical fields Assesses the opportunities and challenges of biopolymer-based nanocarriers in pharmaceutical and biomedical research

The Application of Nanoengineering in Advanced Drug Delivery and Translational Research

Author : Gan Liu
Publisher : Frontiers Media SA
ISBN 13 : 2889749304
Total Pages : 136 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis The Application of Nanoengineering in Advanced Drug Delivery and Translational Research by : Gan Liu

Download or read book The Application of Nanoengineering in Advanced Drug Delivery and Translational Research written by Gan Liu and published by Frontiers Media SA. This book was released on 2022-04-20 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Application of Nanotechnology in Drug Delivery

Author : Ali Demir Sezer
Publisher : BoD – Books on Demand
ISBN 13 : 9535116282
Total Pages : 556 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Application of Nanotechnology in Drug Delivery by : Ali Demir Sezer

Download or read book Application of Nanotechnology in Drug Delivery written by Ali Demir Sezer and published by BoD – Books on Demand. This book was released on 2014-07-25 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book collects reviews and original articles from eminent experts working in the interdisciplinary arena of nanotechnology use in drug delivery. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of nanotechnology application of drug delivery. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Novel Approaches for Drug Delivery

Author : Keservani, Raj K.
Publisher : IGI Global
ISBN 13 : 1522507523
Total Pages : 540 pages
Book Rating : 4.5/5 (225 download)

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Book Synopsis Novel Approaches for Drug Delivery by : Keservani, Raj K.

Download or read book Novel Approaches for Drug Delivery written by Keservani, Raj K. and published by IGI Global. This book was released on 2016-07-15 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing optimal care to patients is a primary concern in the healthcare field. By utilizing the latest resources and research in biomedical applications, the needs and expectations of patients can be successfully exceeded. Novel Approaches for Drug Delivery is an authoritative reference source for the latest scholarly research on emerging developments within the pharmaceutical industry, examining the current state and future directions of drug delivery systems. Highlighting therapeutic applications, predictive toxicology, and risk assessment perspectives, this book is ideally designed for medical practitioners, pharmacists, graduate-level students, scientists, and researchers.

Frontiers in Anti-Cancer Drug Discovery Volume 10

Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 9811401918
Total Pages : 252 pages
Book Rating : 4.8/5 (114 download)

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Book Synopsis Frontiers in Anti-Cancer Drug Discovery Volume 10 by : Atta-ur-Rahman

Download or read book Frontiers in Anti-Cancer Drug Discovery Volume 10 written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2019-05-31 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Anti-Cancer Drug Discovery is a book series devoted to publishing the latest advances in anti-cancer drug design and discovery. In each volume, eminent scientists contribute reviews relevant to all areas of rational drug design and drug discovery including medicinal chemistry,in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series should prove to be of interest to all pharmaceutical scientists involved in research in anti-cancer drug design and discovery. The book series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field. The tenth volume of the series features chapters covering the following topics: - Challenges in the Management of Hepatoblastoma - The Emerging Role of Monocarboxylate Transporter-1 in Cancer - In-vitro Anti-Proliferative Assays and Techniques Used in Pre-Clinical Anti-Cancer Drug Discovery - Recent Advances in the Development of Mesoporous Anti-Cancer Drug Nanocarriers - Polyphenols and Cancer - Glioblastoma Multiforme - Cutting Edge Targeting Strategies Utilizing Nanotechnology in Breast Cancer Therapy.