Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442e In Vitro Skin Sensitisation In Vitro Skin Sensitisation Assays Addressing The Key Event On Activation Of Dendritic Cells On The Adverse Outcome Pathway For Skin Sensitisation
Download Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442e In Vitro Skin Sensitisation In Vitro Skin Sensitisation Assays Addressing The Key Event On Activation Of Dendritic Cells On The Adverse Outcome Pathway For Skin Sensitisation full books in PDF, epub, and Kindle. Read online Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442e In Vitro Skin Sensitisation In Vitro Skin Sensitisation Assays Addressing The Key Event On Activation Of Dendritic Cells On The Adverse Outcome Pathway For Skin Sensitisation ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442E: In Vitro Skin Sensitisation In Vitro Skin Sensitisation assays addressing the Key Event on activation of dendritic cells on the Adverse Outcome Pathway for Skin Sensitisation by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442E: In Vitro Skin Sensitisation In Vitro Skin Sensitisation assays addressing the Key Event on activation of dendritic cells on the Adverse Outcome Pathway for Skin Sensitisation written by OECD and published by OECD Publishing. This book was released on 2024-06-25 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present Key Event based Test Guideline (TG) addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with the tested chemical, as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS). This TG is proposed to address the activation of dendritic cells, which is one Key Event on the Adverse Outcome Pathway (AOP) for Skin Sensitisation. It provides four in vitro test methods addressing the same Key Event on the AOP: (i) the human cell Line Activation Test or h-CLAT method, (ii) the U937 Cell Line Activation Test or U-SENS, (iii) the Interleukin-8 Reporter Gene Assay or IL-8 Luc assay and (iv) the Genomic Allergen Rapid Detection for assessment of skin sensitisers (GARDTMskin). All of them are used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS. The test methods described in this TG either quantify the change in the expression of cell surface marker(s) CD54 and CD86, the cytokine IL-8, or a series of genes (genomic biomarker signature) that are associated with the process of activation of monocytes and DC following exposure to sensitisers.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442D: In Vitro Skin Sensitisation Assays addressing the Adverse Outcome Pathway Key Event on Keratinocyte activation by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442D: In Vitro Skin Sensitisation Assays addressing the Adverse Outcome Pathway Key Event on Keratinocyte activation written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline (TG) provides an in vitro procedure (the ARE-Nrf2 luciferase test method) used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442C: In Chemico Skin Sensitisation Assays addressing the Adverse Outcome Pathway key event on covalent binding to proteins by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442C: In Chemico Skin Sensitisation Assays addressing the Adverse Outcome Pathway key event on covalent binding to proteins written by OECD and published by OECD Publishing. This book was released on 2015-02-05 with total page 63 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. It provides an in chemico procedure (Direct Peptide Reactivity Assay – DPRA) used for supporting the discrimination between skin sensitisers and non-sensitisers.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Guideline No. 497: Defined Approaches on Skin Sensitisation by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Guideline No. 497: Defined Approaches on Skin Sensitisation written by OECD and published by OECD Publishing. This book was released on 2023-07-04 with total page 53 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Defined Approach (DA) consists of a selection of information sources (e.g in silico predictions, in chemico, in vitro data) used in a specific combination, and resulting data are interpreted using a fixed data interpretation procedure (DIP) (e.g. a mathematical, rule-based model). DAs use methods in combination and are intended to overcome some limitations of the individual, stand-alone methods.
Book Synopsis OECD Series on Testing and Assessment The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins by : OECD
Download or read book OECD Series on Testing and Assessment The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins written by OECD and published by OECD Publishing. This book was released on 2014-09-03 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: This document describes the state of knowledge of the adverse outcome pathway (AOP) for skin sensitisation initiated by covalent binding to proteins, assesses the weight-of-evidence supporting the AOP, identifies the key events, and identifies databases containing test results related to key events.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method written by OECD and published by OECD Publishing. This book was released on 2021-06-17 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2.
Book Synopsis Skin Allergy, An Issue of Immunology and Allergy Clinics of North America, E-Book by : Susan Nedorost
Download or read book Skin Allergy, An Issue of Immunology and Allergy Clinics of North America, E-Book written by Susan Nedorost and published by Elsevier Health Sciences. This book was released on 2021-07-08 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Skin Allergy, An Issue of Immunology and Allergy Clinics of North America, E-Book
Book Synopsis Chemical Testing Using New Approach Methodologies (NAMs) by : Amy J. Clippinger
Download or read book Chemical Testing Using New Approach Methodologies (NAMs) written by Amy J. Clippinger and published by Frontiers Media SA. This book was released on 2022-12-16 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Organotypic Models in Drug Development by : Monika Schäfer-Korting
Download or read book Organotypic Models in Drug Development written by Monika Schäfer-Korting and published by Springer Nature. This book was released on 2021-03-25 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.
Book Synopsis Biopolymer Membranes and Films by : Mariana Agostini De Moraes
Download or read book Biopolymer Membranes and Films written by Mariana Agostini De Moraes and published by Elsevier. This book was released on 2020-06-19 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biopolymer Membranes and Films: Health, Food, Environment, and Energy Applications presents the latest techniques for the design and preparation of biopolymer-based membranes and films, leading to a range of cutting-edge applications. The first part of the book introduces the fundamentals of biopolymers, two-dimensional systems, and the characterization of biopolymer membranes and films, considering physicochemical, mechanical and barrier properties. Subsequent sections are organized by application area, with each chapter explaining how biopolymer-based membranes or films can be developed for specific innovative uses across the health, food, environmental and energy sectors. This book is a valuable resource for researchers, scientists and advanced students involved in biopolymer science, polymer membranes and films, polymer chemistry and materials science, as well as for those in industry and academia who are looking to develop materials for advanced applications in the health, food science, environment or energy industries. Presents detailed coverage of a range of novel applications in key strategic areas across health, food, environment and energy Considers the difficulties associated with two-dimensional materials Assists the reader in selecting the best materials and properties for specific applications Helps researchers, scientists and engineers combine the enhanced properties of membranes and films with the sustainable characteristics of biopolymer-based materials
Book Synopsis Handbook of Cosmetic Science and Technology by : Frank Dreher
Download or read book Handbook of Cosmetic Science and Technology written by Frank Dreher and published by CRC Press. This book was released on 2022-08-11 with total page 997 pages. Available in PDF, EPUB and Kindle. Book excerpt: With chapters from experienced and internationally renowned contributors holding positions in research, industry, and clinical practice, this is the fifth edition of what has become the standard reference for cosmetic scientists and dermatologists seeking the latest innovations and technology for the formulation, design, testing, use, and production of cosmetic products for the skin. *Offers in-depth analysis of specific topics in cosmetic science and research *Presents the latest in international research and its translation to practice *Gives an indispensable guide to a hotly competitive area for research and practice
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 406: Skin Sensitisation by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 406: Skin Sensitisation written by OECD and published by OECD Publishing. This book was released on 1992-07-17 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from exposure to test substance via intradermical injection and/or epidermical application. In this Test Guideline, the methods preferred over other are: the Guinea Pig Maximisation ...
Book Synopsis OECD Series on Testing and Assessment Guidance Document on Good In Vitro Method Practices (GIVIMP) by : OECD
Download or read book OECD Series on Testing and Assessment Guidance Document on Good In Vitro Method Practices (GIVIMP) written by OECD and published by OECD Publishing. This book was released on 2018-12-10 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past several decades, there has been a substantial increase in the availability of in vitro test methods for evaluating chemical safety in an international regulatory context. To foster confidence in in vitro alternatives to animal testing, the test methods and conditions under which ...
Book Synopsis Practical Handbook on the 3Rs in the Context of the Directive 2010/63/EU by : Gianni Dal Negro
Download or read book Practical Handbook on the 3Rs in the Context of the Directive 2010/63/EU written by Gianni Dal Negro and published by Academic Press. This book was released on 2021-11-18 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical Handbook on the 3Rs in the Context of the Directive 2010/63/EU provides updated information on the EU Directive 2010/63/EU, which is the European Union legislation that protects animals being used in research. EU Directive 2010/63/EU is the European Union (EU) legislation 'on the protection of animals used for scientific purposes' and is one of the most stringent ethical and welfare standards worldwide. Closes a gap in scientific literature by addressing the need for clear guidance in walking through the multifaced universe of 3Rs Offers a useful starting point for readers and scientist who approach the 3Rs for the first-time Gives insights into the harmonization of the animal research legislation across countries
Book Synopsis Big Data in Predictive Toxicology by : Daniel Neagu
Download or read book Big Data in Predictive Toxicology written by Daniel Neagu and published by Royal Society of Chemistry. This book was released on 2019-12-04 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rate at which toxicological data is generated is continually becoming more rapid and the volume of data generated is growing dramatically. This is due in part to advances in software solutions and cheminformatics approaches which increase the availability of open data from chemical, biological and toxicological and high throughput screening resources. However, the amplified pace and capacity of data generation achieved by these novel techniques presents challenges for organising and analysing data output. Big Data in Predictive Toxicology discusses these challenges as well as the opportunities of new techniques encountered in data science. It addresses the nature of toxicological big data, their storage, analysis and interpretation. It also details how these data can be applied in toxicity prediction, modelling and risk assessment. This title is of particular relevance to researchers and postgraduates working and studying in the fields of computational methods, applied and physical chemistry, cheminformatics, biological sciences, predictive toxicology and safety and hazard assessment.
Book Synopsis Hayes' Principles and Methods of Toxicology by : A. Wallace Hayes
Download or read book Hayes' Principles and Methods of Toxicology written by A. Wallace Hayes and published by CRC Press. This book was released on 2023-07-03 with total page 2143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hayes’ Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field. Key Features: The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals. Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered. All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary. The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. "Principles of Toxicology"), major classes of established chemical hazards (Section II. "Agents"), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. "Methods"), as well as toxicology of specific target systems and organs (Section IV. "Organ- and System-Specific Toxicology"). This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442B: Skin Sensitization Local Lymph Node Assay: BrdU-ELISA or –FCM by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442B: Skin Sensitization Local Lymph Node Assay: BrdU-ELISA or –FCM written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Local Lymph Node Assay: BrdU-ELISA (LLNA:BrdU-ELISA) is a non-radioactive modification to the LLNA method for identifying potential skin sensitizing test substances and measuring the proliferation of lymphocytes they induce in the auricular ...
