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Nucleic Acids In Innate Immunity
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Book Synopsis Nucleic Acids in Innate Immunity by : Ken J. Ishii
Download or read book Nucleic Acids in Innate Immunity written by Ken J. Ishii and published by CRC Press. This book was released on 2008-05-22 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Until recently, innate immunity was regarded as a relatively nonspecific system designed to engulf and destroy pathogens. However, new studies show that the innate immune system is highly developed in its ability to discriminate between self and foreign entities. Understanding this mechanism can lead to therapeutic strategies based on manipulation
Book Synopsis Nucleic Acid Sensors and Antiviral Immunity by : Dr. Prakash Sambhara
Download or read book Nucleic Acid Sensors and Antiviral Immunity written by Dr. Prakash Sambhara and published by CRC Press. This book was released on 2012-11-26 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of Toll-like receptors (TLRs) in the late 1990s ushered in a new age of discovery for innate immunity. The importance of TLRs for immunology and biomedical research was recognized with the Nobel Prize for Medicine or Physiology in 2011. The prize was shared by three scientists: Ralph Steinman (for the discovery of dendritic cells, whi
Book Synopsis Nucleic Acid Sensing and Immunity, Part A by :
Download or read book Nucleic Acid Sensing and Immunity, Part A written by and published by Academic Press. This book was released on 2019-02-22 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nucleic Acid Sensing and Immunity - PART A, Volume 344, provides a comprehensive overview of the nucleic acid machinery, from plants to mammalians, as well as their regulation. Specific chapters in this updated release include Molecular bases of discrimination between self from non-self nucleic acids, Intracellular RNA sensing in mammalian cells, Nuclear DNA damage and nucleic acid sensing, Negative regulation of nucleic acid sensing, Dendritic cell responses to exogenous nucleic acids, Activating the nucleic acid-sensing machinery for anticancer immunity, and Nucleic acid sensing and inflammasomes, amongst other topics. Provides an accurate, state-of-the-art resource on RNA sensing Includes the work of a well-known tumor immunologist Links intestinal host defense and viral nucleic acid sensing Presents a chapter on the negative regulation of DNA sensing, a timely topic
Book Synopsis Nucleic Acid Sensors and Antiviral Immunity by : Dr. Prakash Sambhara
Download or read book Nucleic Acid Sensors and Antiviral Immunity written by Dr. Prakash Sambhara and published by CRC Press. This book was released on 2012-11-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of Toll-like receptors (TLRs) in the late 1990s ushered in a new age of discovery for innate immunity. The importance of TLRs for immunology and biomedical research was recognized with the Nobel Prize for Medicine or Physiology in 2011. The prize was shared by three scientists: Ralph Steinman (for the discovery of dendritic cells, which express TLRs and whose activation by them provides a link between innate and adaptive immunity), Jules Hoffman (who made the pioneering observation of Toll in fruit fly anti-fungal immunity) and Bruce Beutler (who uncovered the role of TLR4 in the response to LPS). Work on TLRs inspired many researchers, and led to a search for other receptors in innate immunity. There are now several additional families of such receptors known, notably RIG-I-like receptors (RLRs), C-type lectin receptors (CLRs) and AIM2-like receptors (ALRs). A notable feature is the detection of nucleic acids from pathogens, but also from host cells in certain contexts, particularly in autoimmune diseases. Nucleic Acid Sensors and Antiviral Immunity presents a timely and extensive account of the detection of nucleic acids in infection and inflammation. We have chapters by Beutler, Hoffman and Shizuo Akira, who is the most cited immunologist of the past ten years, for his work on innate immunity, which gives us an indication of the importance of the field. Several other pioneers in the field present comprehensive and highly lucid up-to-date accounts of their particular interests, revealing the large amount of activity in the past few years, as the literature continues to grow and become ever more complex. The fly yet again provides new insights, and anti-viral mechanisms in this key model organism are described. Other topics include the ability of viruses such as poxviruses, hepatitis C virus and HIV to interfere with detection and signalling; new insights into signalling including subcellular localization of signalling proteins, complex regulation of TLRs and RLRs by ubiquination and negative regulation by miRNAs; and the role of autophagy in antiviral defence. The importance of the RLRs in viral detection is widely reviewed. DNA sensing by ALRs and other receptors is extensively described, and the prospect of additional as yet unknown receptors for DNA debated, revealing a field that is still burgeoning. The prospect of therapeutic utility is covered in the context of using nucleic acids or other compounds as agents to promote anti-viral immunity. This book therefore represents an unprecedented account of this important aspect of immunology, by a stellar cast of authors who have defined the field. We have a key resource which should act as a primary source of information. The chapters will inspire researchers to continue on their quest to provide mechanistic insights into anti-viral innate immunity. The discoveries provide us with new strategies in the never ending war between humanity and viral infection, and will help in the ultimate goal to provide treatments to use against viruses which continue to present a major threat to human health.
Book Synopsis Nucleic Acid-Associated Inflammation by : Nadine Laguette
Download or read book Nucleic Acid-Associated Inflammation written by Nadine Laguette and published by Frontiers Media SA. This book was released on 2021-12-30 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Nucleic acid associated mechanisms in immunity and disease by :
Download or read book Nucleic acid associated mechanisms in immunity and disease written by and published by Elsevier. This book was released on 2024-05-20 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Immunity volume 161 highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Presents current developments and comprehensive reviews in immunology Provides the latest in a longstanding and respected serial on the subject matter Focuses on recent advances in immunology
Book Synopsis Delivering Nucleic Acids to Immune and Non-Immune Cells by : Francesca Re
Download or read book Delivering Nucleic Acids to Immune and Non-Immune Cells written by Francesca Re and published by Frontiers Media SA. This book was released on 2024-02-16 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Nucleic Acids in Immunology by : O. J. Plescia
Download or read book Nucleic Acids in Immunology written by O. J. Plescia and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt: Two fields have played a leading role in biomedical research in recent years, the biochemistry of nucleic acids and immunology. Yet, with the exception of those aspects which have been concerned with antibody synthesis as an example of protein synthesis, there was until recently a lack of direct association between the two fields. Until quite recently the antigenicity of nucleic acids was still in doubt and indeed represented a controversial subject. Also, the exact role of the various nucleic acids in various stages of antibody synthesis was uncertain. These skepticisms and uncertainties disappeared rapidly in the last few years. New experi mental approaches brought the realization that nucleic acids, under appropriate conditions, are indeed immunogenic, and that the resulting antibodies can furnish new tools for the exploration of the mplecular structure of the all-important family of nucleic acid molecules. ' At the same time, the recognition of the antigenicity of nucleic acids brought a new level of understanding to certain auto-immune diseases and pro vided new material for the exploration of the role of a carrier in immune responses. Side by side with this development was the almost explosive development of new experimental approaches and new ideas pertaining to the problem of antibody formation. Nucleic acids in their various forms were recognized as playing an expected major role in the activation of antibody-forming cells. Perhaps less to be expected was the role they can playas non-specific stimulators of antibody formation.
Book Synopsis Innate Immunity of Plants, Animals and Humans by : Holger Heine
Download or read book Innate Immunity of Plants, Animals and Humans written by Holger Heine and published by Springer Science & Business Media. This book was released on 2007-12-07 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has been cunningly designed to provide an overview of our current knowledge about the innate immune systems of these three types of organisms. It not only covers the innate immune mechanisms and responses of such diverse organisms as plants, Cnidaria, Drosophila, urochordates and zebrafish, but also the major receptor systems in mammalians and humans. It delves too into the central defense mechanisms, antimicrobial peptides and the complement system.
Book Synopsis Nucleic Acid Sensing and Immunity - by :
Download or read book Nucleic Acid Sensing and Immunity - written by and published by Academic Press. This book was released on 2019-03-21 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nucleic Acid Sensing and Immunity - PART B, Volume 345 gives a comprehensive overview of the nucleic acid machinery, from plants to mammalians, along with their regulation. Chapters in this updated volume include Nucleic acids sensing in allergic disorders, Nucleic acids sensing in autoimmune disorders, Nucleic acid sensing in inflammatory disorders, Viral nucleic acid sensing inflammasomes in intestinal host defense, Genome damage sensing leads to tissue homeostasis in Drosophila, Nucleic acids sensing in plants, Nucleic Acid sensing in invertebrates, amongst other topics. Provides an accurate, state-of-the-art resource on RNA sensing Includes the work of a well-known tumor immunologist Links intestinal host defense and viral nucleic acid sensing Presents a chapter on the negative regulation of DNA sensing, a timely topic
Book Synopsis Sensing of Endogenous Nucleic Acids by the Innate Immune System During Viral Infection by :
Download or read book Sensing of Endogenous Nucleic Acids by the Innate Immune System During Viral Infection written by and published by . This book was released on 2015 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Nucleic Acid Sensors and Antiviral Immunity by : . Prakash Sambhara
Download or read book Nucleic Acid Sensors and Antiviral Immunity written by . Prakash Sambhara and published by CRC Press. This book was released on 2019-12-02 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of Toll-like receptors (TLRs) in the late 1990s ushered in a new age of discovery for innate immunity. The importance of TLRs for immunology and biomedical research was recognized with the Nobel Prize for Medicine or Physiology in 2011. The prize was shared by three scientists: Ralph Steinman (for the discovery of dendritic cells, which express TLRs and whose activation by them provides a link between innate and adaptive immunity), Jules Hoffman (who made the pioneering observation of Toll in fruit fly anti-fungal immunity) and Bruce Beutler (who uncovered the role of TLR4 in the response to LPS). Work on TLRs inspired many researchers, and led to a search for other receptors in innate immunity. There are now several additional families of such receptors known, notably RIG-I-like receptors (RLRs), C-type lectin receptors (CLRs) and AIM2-like receptors (ALRs). A notable feature is the detection of nucleic acids from pathogens, but also from host cells in certain contexts, particularly in autoimmune diseases. Nucleic Acid Sensors and Antiviral Immunity presents a timely and extensive account of the detection of nucleic acids in infection and inflammation. We have chapters by Beutler, Hoffman and Shizuo Akira, who is the most cited immunologist of the past ten years, for his work on innate immunity, which gives us an indication of the importance of the field. Several other pioneers in the field present comprehensive and highly lucid up-to-date accounts of their particular interests, revealing the large amount of activity in the past few years, as the literature continues to grow and become ever more complex. The fly yet again provides new insights, and anti-viral mechanisms in this key model organism are described. Other topics include the ability of viruses such as poxviruses, hepatitis C virus and HIV to interfere with detection and signalling; new insights into signalling including subcellular localization of signalling proteins, complex regulation o
Book Synopsis Toll-Like Receptors (TLRs) and Innate Immunity by : Stefan Bauer
Download or read book Toll-Like Receptors (TLRs) and Innate Immunity written by Stefan Bauer and published by Springer Science & Business Media. This book was released on 2007-12-11 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.
Book Synopsis Structure-function Relationships in Innate Immunity Nucleic Acid Sensing by 2'-5'-oligoadenylate Synthetase 1 by : Jan Lohöfener
Download or read book Structure-function Relationships in Innate Immunity Nucleic Acid Sensing by 2'-5'-oligoadenylate Synthetase 1 written by Jan Lohöfener and published by . This book was released on 2015 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book RNA Nanotechnology written by Bin Wang and published by CRC Press. This book was released on 2014-04-02 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past few decades there has been incredible growth in "bionano"-related research, which has been accompanied by numerous publications in this field. Although various compilations address topics related to deoxyribonucleic acid (DNA) and protein, there are few books that focus on determining the structure of ribonucleic acid (RNA) and using RNA as building blocks to construct nanoarchitectures for biomedical and healthcare applications. RNA Nanotechnology is a comprehensive volume that details both the traditional approaches and the latest developments in the field of RNA-related technology. This book targets a wide audience: a broad introduction provides a solid academic background for students, researchers, and scientists who are unfamiliar with the subject, while the in-depth descriptions and discussions are useful for advanced professionals. The book opens with reviews on the basic aspects of RNA biology, computational approaches for predicting RNA structures, and traditional and emerging experimental approaches for probing RNA structures. This section is followed by explorations of the latest research and discoveries in RNA nanotechnology, including the design and construction of RNA-based nanostructures. The final segment of the book includes descriptions and discussions of the potential biological and therapeutic applications of small RNA molecules, such as small/short interfering RNAs (siRNAs), microRNAs (miRNAs), RNA aptamers, and ribozymes.
Book Synopsis The Innate Immune Response to Viruses by : Delphine Goubau
Download or read book The Innate Immune Response to Viruses written by Delphine Goubau and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Extracellular Nucleic Acids by : Yo Kikuchi
Download or read book Extracellular Nucleic Acids written by Yo Kikuchi and published by Springer Science & Business Media. This book was released on 2010-07-23 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular nucleic acids have recently emerged as important players in the fields of biology and the medical sciences. In the last several years, extracellular nucleic acids have been shown to be involved in not only microbial evolution as genetic elements but also to have structural roles in bacterial communities, such as biofilms. Circulating DNA and RNA have been found in human blood and expected to be useful as non-invasive markers for the diagnosis of several diseases. In addition, extracellular nucleic acids have attracted attention as active modulators of the immune system of higher organisms, including humans. This book covers nearly all of the newly developing fields related to extracellular nucleic acids, including those of basic biology, ecology and the medical sciences, and provides readers with the latest knowledge on them.
