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Novel Inhibitors Of The Hepatitis C Virus
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Book Synopsis Novel Inhibitors of the Hepatitis C Virus by : Daniel Cameron Talley
Download or read book Novel Inhibitors of the Hepatitis C Virus written by Daniel Cameron Talley and published by . This book was released on 2016 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several analogs of the natural product UK-1 have been identified as potent inhibitors of hepatitis C virus (HCV) replication in a replicon assay. One set of inhibitors has been shown to inhibit the HCV non-structural protein 3 helicase (NS3h), while another acts via an unknown cellular target. Efforts have been focused on (1) identifying the inhibitor binding pocket within the NS3 helicase and (2) exploring the possible role zinc binding may play in the inhibitory mode of action of the latter.
Book Synopsis Novel Inhibitors of the Hepatitis C Virus NS3 Helicase and Mechanism of Action by : Craig A. Belon
Download or read book Novel Inhibitors of the Hepatitis C Virus NS3 Helicase and Mechanism of Action written by Craig A. Belon and published by . This book was released on 2010 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterization of the Hepatitis C Virus NS5b RNA-Dependent RNA Polymerase by : Megan Heather Powdrill
Download or read book Characterization of the Hepatitis C Virus NS5b RNA-Dependent RNA Polymerase written by Megan Heather Powdrill and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Novel and Combination Therapies for Hepatitis C Virus, An Issue of Clinics in Liver Disease by : Paul J. Pockros
Download or read book Novel and Combination Therapies for Hepatitis C Virus, An Issue of Clinics in Liver Disease written by Paul J. Pockros and published by Elsevier Health Sciences. This book was released on 2013-02-28 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Pockros has created a clinically focused issue based on the CONO 2012 meeting, whereby he was able to have those presenters write articles for his issue. Therefore, the content for HCV in this issue reflects the most current knowledge. The issue is focused on basic/current information, current therapy and special populations, triple and quad combination therapies in development, and an article on second generation protease inhibitors. The reader can expect that this issue will provide thorough clinical reviews on the most current therapeutic options for HCV.
Book Synopsis Mechanisms of Action and Resistance to Novel Inhibitors of the Hepatitis C Virus RNA -dependent RNA Polymerase by : Anupriya Kulkarni
Download or read book Mechanisms of Action and Resistance to Novel Inhibitors of the Hepatitis C Virus RNA -dependent RNA Polymerase written by Anupriya Kulkarni and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "The hepatitis C virus (HCV) is a positive-sense RNA virus that encodes a non-structural protein, NS5B, which is an RNA-dependent RNA polymerase. NS5B is required for replication of the viral genome, making it an attractive target for antiviral drug development efforts. NS5B inhibitors are classified into two major categories: nucleoside inhibitors (NIs) and non-nucleoside inhibitors (NNIs). NIs bind to the enzyme active site and compete with the natural NTP for incorporation. In contrast, NNIs bind away from the active site and inhibit the polymerase activity allosterically, specifically during initiation of RNA synthesis by introducing conformational changes in the polymerase.The NS5B polymerase lacks proofreading ability, which results in a high rate of mutations during replication. This error prone nature of the HCV polymerase has given rise to a number of variants of the virus which are classified into different genotypes and subgenotypes. Different HCV genotypes show variations in drug susceptibility, particularly to NNIs, which limits their clinical utility. At least four distinct binding sites for NNIs have been identified on the NS5B protein and these binding sites are not necessarily conserved across the genotypes. This provides a possible explanation for the observed variations in drug susceptibility. As part of the first study described in this thesis, we tested the inhibitory activity of acyl pyrrolidine and 1,5-benzodiazepine against purified NS5B enzymes that represent the major HCV genotypes. We identified natural amino acid substitutions that contribute to resistance to the NNIs. In the second study described herein, we turned our attention to the mechanisms of action and resistance to NIs, with focus on sofosbuvir, which is part of the current standard of care in anti-HCV therapy. Previous crystallographic data of HCV NS5B in complex with an RNA primer-template has provided important information on the protein-nucleic acid interface during the elongation process. The structure points to specific interactions between residues of the nucleic acid binding channel and the 2'-hydroxyl group of the bound RNA substrate. Using templates with strategically engineered DNA-like residues, we examined the role of the 2'-hydroxyl group of the template strand in nucleotide incorporation. Our biochemical findings suggest that this 2'-hydroxyl group plays an essential role in establishing resistance to NIs, and this process may be mediated by the signature S282T mutation, which is been known to cause resistance to sofosbuvir. In the third study, we further evaluated the efficacy of novel NIs against known NI resistance-conferring mutations in NS5B. The compounds 2'F-2'-C-Me-UTP (sofosbuvir), 2'-C-Me-2'-NH2-UTP, 2'-C-Me-UTP and 2'-C-Me-(1-Thio)UTP, which were modified derivatives of sofosbuvir, were tested against mutations S282T, L159F, C316N and L320F. It was observed that S282T showed resistance to all the modified compounds. Mutations L159F, C316N and L320F showed sensitivity towards 2'-C-Me-UTP. WT NS5B, L159F, C316N and L320F showed increased IC50 values towards 2'-C-Me-2'-NH2-UTP and 2'-C-Me-(1-Thio) UTP suggesting that addition of NH2 and Thio groups do not increase the efficacy of the compounds.Overall, these studies provide a more detailed understanding of mechanisms of action and resistance to Nucleoside and Non-nucleoside inhibitors of the HCV polymerase. Our findings offer new avenues in current efforts to develop new viral polymerase inhibitors. " --
Book Synopsis Progress Towards the Synthesis of a Series of Novel Hepatitis C Virus Inhibitors by : Nayna A. Lodhia
Download or read book Progress Towards the Synthesis of a Series of Novel Hepatitis C Virus Inhibitors written by Nayna A. Lodhia and published by . This book was released on 2009 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Novel Therapies in Hepatitis C Virus, an Issue of Clinics in Liver Disease by : Paul J. Pockros
Download or read book Novel Therapies in Hepatitis C Virus, an Issue of Clinics in Liver Disease written by Paul J. Pockros and published by Saunders. This book was released on 2009-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Guest Editor presents state-of-the-art articles devoted to therapies for treatment of HCV. The novel therapies addressed in this issue include interferons, viral kinetics and anti-viral resistence, anti-fibrotics, immunotherapeutics, hepatoprotectants and caspace inhibitors, and cyclosporine analogues, to name a few.
Book Synopsis Proprotein Convertases and Serine Protease Inhibitors by : Andrea Denisse Olmstead
Download or read book Proprotein Convertases and Serine Protease Inhibitors written by Andrea Denisse Olmstead and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hepatitis C written by Imran Shahid and published by BoD – Books on Demand. This book was released on 2018-10-10 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The propagation of hepatitis C from acute to chronic infection and afterward to end-stage liver diseases (hepatic fibrosis, cirrhosis, and hepatocellular carcinoma) involves a highly orchestrated series of molecular and cellular events, including a plethora of genes and cell signaling cascades. The treatment paradigms was revolutionized after the development and approval of all oral interferon-free direct-acting antivirals achieving higher sustained virologic response rates in treated individuals. This book pragmatically overviews the intricate interplay between viral and host factors during hepatitis C virus infection progression, as well as other hepatitis C-associated clinical implications. Hepatitis C - From Infection to Cure also provides up-to-date information about hepatitis C cures for clinicians, physicians, and healthcare providers with an ample understanding of the current treatment horizon, as well as other investigational and emerging treatment strategies. The authors with their valuable scientific contributions belong to many eminent institutes around the world and are much experienced in hepatitis C virology, pathology, and therapeutics.
Book Synopsis Dengue and Zika: Control and Antiviral Treatment Strategies by : Rolf Hilgenfeld
Download or read book Dengue and Zika: Control and Antiviral Treatment Strategies written by Rolf Hilgenfeld and published by Springer. This book was released on 2018-05-29 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume contains 25 chapters from leading international scientists working on dengue and Zika viruses, who came together in Praia do Tofo in Mozambique to discuss the latest developments in the fields of epidemiology, pathogenesis, structural virology, immunology, antiviral drug discovery and development, vaccine efficacy, and mosquito control programs. The meeting venue offered an opportunity to discuss current research on these flaviviruses in an idyllic setting, and also to develop first-hand appreciation of the issues in infectious diseases facing developing countries and of the research gaps in Africa. For readers, who should include basic and clinical researchers in the field and public health professionals, the chapters are organized to provide a comprehensive overview of the various topics in current dengue and Zika virus research. A unique feature of the proceedings of this meeting is the inclusion of the discussions that took place following presentations. These have been transcribed and appended to the end of the relevant chapters, and they form the “salt in the soup” of this book.
Book Synopsis Chronic Hepatitis C Virus by : Mitchell L. Shiffman
Download or read book Chronic Hepatitis C Virus written by Mitchell L. Shiffman and published by Springer Science & Business Media. This book was released on 2011-11-17 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this virus can affect other organs in addition to the liver, and whether treating chronic HCV alters the natural history of this disease. Section 2 reviews the advances that have been made in the treatment of chronic HCV during the past decade with interferon based therapy. Separate chapters on response guided therapy and how to manage the adverse events associated with these medications provide the physician with the concepts required to more effectively treat chronic HCV now and in the future. As the genetics of virologic response have recently been elucidated, a chapter is devoted to helping the clinician understand how genes that modulate disease processes and their treatment are identified and utilized in clinical care. Section 3 deals with the future of HCV treatment and specific inhibitors of HCV. Specific chapters explain how targets for drugs are identified and how drugs are then developed and tested; how mutations of HCV develop and how anti-viral agents will affect this process; the most up to date data regarding the treatment of chronic HCV with peginterferon, ribavirin and anti-viral agents; and the potential to treat chronic HCV with just oral anti-viral agents and without peginterferon and ribavirin in the future. The final section of this book covers issues related to liver transplantation in patients with chronic HCV. Separate chapters review the natural history of chronic HCV in liver transplant recipients and the impact of utilizing HCV positive donors. The volume concludes with chapters that cover the treatment of chronic HCV both prior to and after liver transplantation with potent anti-viral agents. Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future is a valuable resource for all physicians caring for patients with chronic HCV.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309438020 Total Pages :187 pages Book Rating :4.3/5 (94 download)
Book Synopsis Eliminating the Public Health Problem of Hepatitis B and C in the United States by : National Academies of Sciences, Engineering, and Medicine
Download or read book Eliminating the Public Health Problem of Hepatitis B and C in the United States written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-06-01 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatitis B and C cause most cases of hepatitis in the United States and the world. The two diseases account for about a million deaths a year and 78 percent of world's hepatocellular carcinoma and more than half of all fatal cirrhosis. In 2013 viral hepatitis, of which hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most common types, surpassed HIV and AIDS to become the seventh leading cause of death worldwide. The world now has the tools to prevent hepatitis B and cure hepatitis C. Perfect vaccination could eradicate HBV, but it would take two generations at least. In the meantime, there is no cure for the millions of people already infected. Conversely, there is no vaccine for HCV, but new direct-acting antivirals can cure 95 percent of chronic infections, though these drugs are unlikely to reach all chronically-infected people anytime soon. This report, the first of two, examines the feasibility of hepatitis B and C elimination in the United States and identifies critical success factors. The phase two report will outline a strategy for meeting the elimination goals discussed in this report.
Book Synopsis Studies on Hepatitis Viruses by : Satya Prakash Gupta
Download or read book Studies on Hepatitis Viruses written by Satya Prakash Gupta and published by Academic Press. This book was released on 2018-06-20 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies on Hepatitis Viruses: Life Cycle, Structure, Functions, and Inhibition presents the latest on this systemic infection that predominantly affects the liver with inflammation that can be acute or chronic. Hepatitis viruses have been the subject of intense study in the last twenty years, with a wealth of information related to their lifecycle, structure, functions and inhibition being presented. This book compiles the most important developments and research, giving users a very useful guide on this evolving area of virology and medicinal chemistry. Provides comprehensive, state-of-the-art coverage of hepatitis virus infections, the virus' lifecycle, and mechanisms of protease inhibition Analyzes structure-activity relationships of inhibitors of viral hepatitis Presents an in-depth view of the structure and function of viral hepatitis Discusses classification, epidemiology, pathogenesis, natural history, clinical manifestations, diagnosis, complications, associated disorders and animal models
Book Synopsis Handbook of Hepatitis C by : Nicolas Goossens
Download or read book Handbook of Hepatitis C written by Nicolas Goossens and published by Springer. This book was released on 2016-05-25 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a concise and up-to-date review of the clinical features, pathophysiology, diagnosis, and treatment of patients with hepatitis C. Busy health care professionals who want a quick review of hepatitis C and new developments in treatment for hepatitis C will benefit from this succinct guide. Hepatitis C virus primarily infects liver cells and can lead to chronic damage to the liver. Patients with hepatitis C infection often develop liver sequelae such as fibrosis, cirrhosis, and hepatocellular carcinoma if left untreated. It is estimated that 150 million people worldwide are infected with hepatitis C virus, and if eradication is to be achieved it is imperative to diagnose and treat such individuals.
Book Synopsis Advanced Therapy for Hepatitis C by : Geoffrey W. McCaughan
Download or read book Advanced Therapy for Hepatitis C written by Geoffrey W. McCaughan and published by John Wiley & Sons. This book was released on 2011-10-05 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatologists, both researchers and front-line clinicians, now have a comprehensive guide to the treatment of patients with the HCV virus. This book focuses mainly on the efficacy and clinical use of antiviral therapies, including the use of antivirals post liver transplantation and in the presence of the HIV virus. It also explores the foundations for understanding antiviral therapies in HCV, such as the complex pharmacology and mechanisms of antiviral drugs. A 'late-breaking information' chapter contains the most recent trial results on the latest antiviral drugs.
Book Synopsis HCV: The Journey from Discovery to a Cure by : Michael J. Sofia
Download or read book HCV: The Journey from Discovery to a Cure written by Michael J. Sofia and published by Springer Nature. This book was released on 2019-11-23 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatitis C is a liver disease caused by the hepatitis C virus (HCV) and infects approximately 75 million individuals worldwide. It is also one of the major causes of liver cancer and liver transplants. The elucidation of the HCV genome, and the development of a whole cell system to study the virus spurred the search for novel direct acting antiviral drugs to cure this disease. This global effort culminated in the development of direct acting antiviral drugs that led to cure rates approaching 100% in all patient populations after only 8-12 weeks of therapy. These efforts resulted in one of the greatest achievements in public health and provides the potential for eliminating HCV as a major disease worldwide. This volume is aimed at a broad audience of academic and industrial scientists interested in the discovery and development of drugs to treat viral diseases and those interested in reading about one of the most unique accomplishments in biomedical research. The volume will provide a one of a kind reference work that highlights the many efforts, from the discovery of the HCV virus, to the invention of breakthrough medicines and their use in the real world to cure patients. It is the companion book to the volume "HCV: The Journey from Discovery to a Cure - Volume II".
Book Synopsis Characterization of Hepatitis C Virus Entry and Potential Small Molecule Inhibitors by : Katharina Betty Rothwangl
Download or read book Characterization of Hepatitis C Virus Entry and Potential Small Molecule Inhibitors written by Katharina Betty Rothwangl and published by . This book was released on 2010 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:
