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Organic Cation Transporter 1 (OCT1): Not Vital for Life, but of Substantial Biomedical Relevance

Author : Jurgen Brockmoller
Publisher : Frontiers Media SA
ISBN 13 : 2889740293
Total Pages : 145 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Organic Cation Transporter 1 (OCT1): Not Vital for Life, but of Substantial Biomedical Relevance by : Jurgen Brockmoller

Download or read book Organic Cation Transporter 1 (OCT1): Not Vital for Life, but of Substantial Biomedical Relevance written by Jurgen Brockmoller and published by Frontiers Media SA. This book was released on 2022-01-12 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Around one third of all biologically relevant small molecules are organic cations. These include endogenous substances like catecholamines and other neurotransmitters, toxins and drugs designed to affect signaling processes. The organic cation transporter 1 (OCT1) is among the strongest expressed membrane transporters at the sinusoidal (blood-facing) side of liver cells and contributes substantially to the clearance of the blood from numerous organic cations. A most striking feature of OCT1 is its pronounced genetic diversity. Between 1 and 10% of all human populations have little to no OCT1 activity. With several of the OCT1 substrates up to 10% of Europeans are functionally OCT1 deficient. Apparently, the lack of OCT1 do not lead to apparent substantial pathological changes in these individuals. It thus appears that this transporter is not essential to human life, but does it means that OCT1 is irrelevant? In the last 25 years since the first cloning of this transporter, data on its pharmacological and physiological relevance is steadily accumulating. Numerous clinically relevant drugs (e.g. metformin, morphine, fenoterol, sumatriptan, tramadol and tropisetron) have been shown to be substrates of OCT1, and OCT1 deficiency has been shown to affect the pharmacokinetics, efficacy, or toxicity of these drugs. Also vitamin B1 has been shown to be a substrate of OCT1, and in genetically modified mice OCT1 substantially modulated hepatic lipid metabolism, total body fat and systemic glucose and lipid concentrations. Still, numerous important questions remain unsolved: For which drugs, toxins, or other endogenous or exogenous substances is OCT1 relevant? How can we predict the relevance of OCT1 from in vitro studies? What determines the substrate selectivity of OCT1 in comparison to other transporters or transport processes for organic cations? What regulates the expression of OCT1 in the liver and possibly in other tissues? What is the impact of OCT1 variation in different areas of medicine, including the therapies for cancer as well as for pulmonary, cardiovascular, or neurological diseases? How can evolutionary biology contribute to a better understanding of the roles of OCT1? And, importantly, what types of research are likely to significantly further the knowledge on OCT1 in the next decades?

Engadin Art Talks

Author : Cristina Bechtler
Publisher : Jrp Ringier
ISBN 13 : 9783037643501
Total Pages : 0 pages
Book Rating : 4.6/5 (435 download)

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Book Synopsis Engadin Art Talks by : Cristina Bechtler

Download or read book Engadin Art Talks written by Cristina Bechtler and published by Jrp Ringier. This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume compiles ideas and projects from well-known artists, architects, designers, filmmakers and researchers on mountainous regions not only in Switzerland, but worldwide. It includes writings by Vito Acconci, Doug Aitken, Ron Arad, Nairy Baghramian and Jan von Brevern, as well as a discussion on architect Bruno Taut's "Crystal Chain Letters."

Muntognas

Author : Alma Zevi
Publisher :
ISBN 13 : 9780993084348
Total Pages : 0 pages
Book Rating : 4.0/5 (843 download)

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Book Synopsis Muntognas by : Alma Zevi

Download or read book Muntognas written by Alma Zevi and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Muntognas, meaning 'Mountains' in the Swiss language of Romansch, the native tongue of the artist, presents eight marble, 'Dali stone' sculptures made by Vital in 2013. Mined in the Yunnan province of China, the marble has been sliced open to reveal the hidden landscapes within, inextricably linking these striking sculptures to Vital's birthplace of Sent, a tiny village in the Engadin valley of the Swiss Alps.

Theatre of the Unimpressed

Author : Jordan Tannahill
Publisher : Coach House Books
ISBN 13 : 177056411X
Total Pages : 161 pages
Book Rating : 4.7/5 (75 download)

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Book Synopsis Theatre of the Unimpressed by : Jordan Tannahill

Download or read book Theatre of the Unimpressed written by Jordan Tannahill and published by Coach House Books. This book was released on 2015-05-11 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: How dull plays are killing theatre and what we can do about it. Had I become disenchanted with the form I had once fallen so madly in love with as a pubescent, pimple-faced suburban homo with braces? Maybe theatre was like an all-consuming high school infatuation that now, ten years later, I saw as the closeted balding guy with a beer gut he’d become. There were of course those rare moments of transcendencethat kept me coming back. But why did they come so few and far between? A lot of plays are dull. And one dull play, it seems, can turn us off theatre for good. Playwright and theatre director Jordan Tannahill takes in the spectrum of English-language drama – from the flashiest of Broadway spectacles to productions mounted in scrappy storefront theatres – to consider where lifeless plays come from and why they persist. Having travelled the globe talking to theatre artists, critics, passionate patrons and the theatrically disillusioned, Tannahill addresses what he considers the culture of ‘risk aversion’ paralyzing the form. Theatre of the Unimpressed is Tannahill’s wry and revelatory personal reckoning with the discipline he’s dedicated his life to, and a roadmap for a vital twenty-first-century theatre – one that apprehends the value of ‘liveness’ in our mediated age and the necessity for artistic risk and its attendant failures. In considering dramaturgy, programming and alternative models for producing, Tannahill aims to turn theatre from an obligation to a destination. ‘[Tannahill is] the poster child of a new generation of (theatre? film? dance?) artists for whom "interdisciplinary" is not a buzzword, but a way of life.’ —J. Kelly Nestruck, Globe and Mail ‘Jordan is one of the most talented and exciting playwrights in the country, and he will be a force to be reckoned with for years to come.’ —Nicolas Billon, Governor General's Award–winning playwright (Fault Lines)

Healthside

Author :
Publisher :
ISBN 13 :
Total Pages : 444 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Healthside by :

Download or read book Healthside written by and published by . This book was released on 1846 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Vital Question

Author : Nick Lane
Publisher :
ISBN 13 : 9781781250372
Total Pages : 0 pages
Book Rating : 4.2/5 (53 download)

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Book Synopsis The Vital Question by : Nick Lane

Download or read book The Vital Question written by Nick Lane and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A game-changing book on the origins of life, called the most important scientific discovery 'since the Copernican revolution' in The Observer.

Vital Forces, Teleology and Organization

Author : Andrea Gambarotto
Publisher : Springer
ISBN 13 : 3319654152
Total Pages : 137 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Vital Forces, Teleology and Organization by : Andrea Gambarotto

Download or read book Vital Forces, Teleology and Organization written by Andrea Gambarotto and published by Springer. This book was released on 2017-10-03 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive account of vitalism and the Romantic philosophy of nature. The author explores the rise of biology as a unified science in Germany by reconstructing the history of the notion of “vital force,” starting from the mid-eighteenth through the early nineteenth century. Further, he argues that Romantic Naturphilosophie played a crucial role in the rise of biology in Germany, especially thanks to its treatment of teleology. In fact, both post-Kantian philosophers and naturalists were guided by teleological principles in defining the object of biological research. The book begins by considering the problem of generation, focusing on the debate over the notion of “formative force.” Readers are invited to engage with the epistemological status of this formative force, i.e. the question of the principle behind organization. The second chapter provides a reconstruction of the physiology of vital forces as it was elaborated in the mid- to late-eighteenth century by the group of physicians and naturalists known as the “Göttingen School.” Readers are shown how these authors developed an understanding of the animal kingdom as a graded series of organisms with increasing functional complexity. Chapter three tracks the development of such framework in Romantic Naturphilosophie. The author introduces the reader to the problem of classification, showing how Romantic philosophers of nature regarded classification as articulated by a unified plan that connects all living forms with one another, relying on the idea of living nature as a universal organism. In the closing chapter, this analysis shows how the three instances of pre-biological discourse on living beings – theory of generation, physiology and natural history – converged to form the consolidated disciplinary matrix of a general biology. The book offers an insightful read for all scholars interested in classical German philosophy, especially those researching the philosophy of nature, as well as the history and philosophy of biology.

Dictionary of Practical Surgery, etc

Author : Samuel COOPER (Senior Surgeon to University College Hospital.)
Publisher :
ISBN 13 :
Total Pages : 772 pages
Book Rating : 4.0/5 (18 download)

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Book Synopsis Dictionary of Practical Surgery, etc by : Samuel COOPER (Senior Surgeon to University College Hospital.)

Download or read book Dictionary of Practical Surgery, etc written by Samuel COOPER (Senior Surgeon to University College Hospital.) and published by . This book was released on 1809 with total page 772 pages. Available in PDF, EPUB and Kindle. Book excerpt:

In Vital Harmony

Author : Karen Glass
Publisher :
ISBN 13 : 9781700769800
Total Pages : 186 pages
Book Rating : 4.7/5 (698 download)

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Book Synopsis In Vital Harmony by : Karen Glass

Download or read book In Vital Harmony written by Karen Glass and published by . This book was released on 2019-11-11 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Charlotte Mason looked at the world and saw that it was governed by universal laws, such as the law of gravity. Then she wondered. What if there were similar laws that governed the way people learn? If we knew what those laws were, we'd be able to pursue education along the most promising lines . She devoted her life to finding the key principles of education and then developing methods to make the most of them. The result is a comprehensive picture of living and learning that breathes life into education at every level--from babyhood to the adult years. It's not a rote system, but a flexible set of ideas that keep education in focus. These principles are for everyone concerned with teaching and learning. They are no more difficult to implement than the principle of gravity which allows you to walk, run, and even--when you know what you are doing--to soar.

Parliamentary Debates

Author : New Zealand. Parliament
Publisher :
ISBN 13 :
Total Pages : 1066 pages
Book Rating : 4.:/5 (321 download)

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Book Synopsis Parliamentary Debates by : New Zealand. Parliament

Download or read book Parliamentary Debates written by New Zealand. Parliament and published by . This book was released on 1951 with total page 1066 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Collected Works of Witness Lee, 1993, volume 2

Author : Witness Lee
Publisher : Living Stream Ministry
ISBN 13 : 1536006963
Total Pages : 395 pages
Book Rating : 4.5/5 (36 download)

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Book Synopsis The Collected Works of Witness Lee, 1993, volume 2 by : Witness Lee

Download or read book The Collected Works of Witness Lee, 1993, volume 2 written by Witness Lee and published by Living Stream Ministry. This book was released on 2021-05-28 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Collected Works of Witness Lee, 1993, volume 2, contains messages given by Brother Witness Lee from May 28 through December 17, 1993. During the first eight months of 1993 Brother Lee was in Anaheim, California. At the beginning of September he visited Seattle, Washington, for one week, after which he returned to Anaheim and remained there until the end of the year. The contents of this volume are divided into nine sections, as follows: 1. Seven messages given in Anaheim, California, on May 28 through 30. These messages were previously published, along with the speaking of forty-six brothers from throughout Southern California, in a book entitled 1993 Blending Conference Messages concerning the Lord's Recovery and Our Present Need and are included in this volume under the same title. Only the outlines of the conference and the portions spoken by Brother Lee are included in The Collected Works of Witness Lee. 2. A message given in Anaheim, California, on May 28. This message is included in this volume as chapter 1 of the previous section entitled 1993 Blending Conference Messages concerning the Lord's Recovery and Our Present Need. Portions of this message were combined with other various writings by Brother Lee concerning the Triune God, and the compilation was previously published in a book entitled The Crucial Points of the Major Items of the Lord's Recovery Today. The contents of this book are included in this volume under the same title. 3. A message given in Anaheim, California, on July 3. This message was divided into two chapters and is included in this volume under the title Remaining in Life and Keeping the One Accord. 4. Four messages given in Anaheim, California, on August 13 through 15. These messages were previously published in a book entitled The Problems Causing the Turmoils in the Church Life and are included in this volume under the same title. 5. Fifteen messages given in Anaheim, California, on August 28 through December 17. These messages were previously published in a fourteen-chapter book entitled The Spirit with Our Spirit and are included in this volume under the same title. 6. Fourteen messages given in Anaheim, California, on September 1 through December 15. These messages were previously published in a thirteen-chapter book entitled The Training and the Practice of the Vital Groups and are included in this volume under the same title. 7. Six messages given in Seattle, Washington, on September 3 through 6. These messages were previously published in a book entitled The Organic Union in God's Relationship with Man and are included in this volume under the same title. 8. A message given in Seattle, Washington, on September 6. This message is included in this volume under the title Knowing and Experiencing the Organic Union in God's Relationship with Man. 9. Six messages given in Anaheim, California, on November 25 through 28. These messages were previously published in a seven-chapter book entitled The Issue of the Dispensing of the Processed Trinity and the Transmitting of the Transcending Christ and are included in this volume under the same title.

The Vital Center

Author : Arthur M. Schlesinger, Jr.
Publisher : Transaction Large Print
ISBN 13 : 9781412855631
Total Pages : 0 pages
Book Rating : 4.8/5 (556 download)

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Book Synopsis The Vital Center by : Arthur M. Schlesinger, Jr.

Download or read book The Vital Center written by Arthur M. Schlesinger, Jr. and published by Transaction Large Print. This book was released on 2014-09-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Vital Center is an eloquent and incisive defense of liberal democracy against its rivals to the left and to the right, communism and fascism. Originally published in 1949, it shows how the failures of free society led to the disenchantment of the masses with democracy, and sharpened the appeal of totalitarian solutions. The book calls for a radical reconstruction of the democratic polity based on a realistic understanding of human limitations and frailties.

Putting Defense Back into U.S. Defense Policy

Author : Ivan Eland
Publisher : Bloomsbury Publishing USA
ISBN 13 : 0313007012
Total Pages : 254 pages
Book Rating : 4.3/5 (13 download)

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Book Synopsis Putting Defense Back into U.S. Defense Policy by : Ivan Eland

Download or read book Putting Defense Back into U.S. Defense Policy written by Ivan Eland and published by Bloomsbury Publishing USA. This book was released on 2001-09-30 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the implications of counterinsurgency wars for U.S. defense policy and makes the compelling argument that the United States' default position on counterinsurgency wars should be to avoid them. In this compelling study, Eland questions the core assumptions of the American foreign policy and defense establishments that call for military interventions around the world and high and increasing defense budgets at home. He outlines a security policy more appropriate to the sober realities of the post-Cold War era. This is an approach that calls for military restraint overseas, taking advantage of the already secure U.S. geostrategic position, while safeguarding vital national interests. Eland details the military force structure needed for this new role and calculates the reduced defense budget required to pay for these forces. This book is a timely wake-up call to those who make American foreign and defense policies. It demands a badly needed re-thinking of America's national interests. In the author's view, America's natural geostrategic position places it at a natural advantage, rendering unnecessary a forward defense posture. A non-interventionist foreign policy would save money by requiring lower defense budgets. An America less willing to get involved in complex overseas disputes unrelated to U.S vital interests would also be less likely to make enemies around the world.

The Home Guard, Hearings ..., on S. 4175 ..., August 13, 15, Sept 5, 20, 25, 1940

Author : United States. Congress. Senate. Committee on Military Affairs
Publisher :
ISBN 13 :
Total Pages : 100 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis The Home Guard, Hearings ..., on S. 4175 ..., August 13, 15, Sept 5, 20, 25, 1940 by : United States. Congress. Senate. Committee on Military Affairs

Download or read book The Home Guard, Hearings ..., on S. 4175 ..., August 13, 15, Sept 5, 20, 25, 1940 written by United States. Congress. Senate. Committee on Military Affairs and published by . This book was released on 1940 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The National Preacher and the Prayer-meeting

Author :
Publisher :
ISBN 13 :
Total Pages : 668 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis The National Preacher and the Prayer-meeting by :

Download or read book The National Preacher and the Prayer-meeting written by and published by . This book was released on 1865 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Essential Guide to User Interface Design

Author : Wilbert O. Galitz
Publisher : John Wiley & Sons
ISBN 13 : 0470146222
Total Pages : 888 pages
Book Rating : 4.4/5 (71 download)

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Book Synopsis The Essential Guide to User Interface Design by : Wilbert O. Galitz

Download or read book The Essential Guide to User Interface Design written by Wilbert O. Galitz and published by John Wiley & Sons. This book was released on 2007-04-10 with total page 888 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bringing together the results of more than 300 new design studies, an understanding of people, knowledge of hardware and software capabilities, and the author’s practical experience gained from 45 years of work with display-based systems, this book addresses interface and screen design from the user’s perspective. You will learn how to create an effective design methodology, design and organize screens and Web pages that encourage efficient comprehension and execution, and create screen icons and graphics that make displays easier and more comfortable to use.

Evangelism

Author : Ellen G. White
Publisher : DigiCat
ISBN 13 :
Total Pages : 413 pages
Book Rating : 4.8/5 (596 download)

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Book Synopsis Evangelism by : Ellen G. White

Download or read book Evangelism written by Ellen G. White and published by DigiCat. This book was released on 2023-11-18 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ellen White was one of the founders of the Seventh Day Adventist Church and claimed to have had over 2000 visions. Excerpt: Everywhere the light of truth is to shine forth, that hearts now in the sleep of ignorance may be awakened and converted. In all countries and cities the gospel is to be proclaimed....