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Non Viral Gene Delivery Vectors Based On New Unsymmetrical Bolaamphiphiles
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Book Synopsis Non-viral Gene Delivery Vectors Based on New Unsymmetrical Bolaamphiphiles by : Namrata Jain
Download or read book Non-viral Gene Delivery Vectors Based on New Unsymmetrical Bolaamphiphiles written by Namrata Jain and published by . This book was released on 2010 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: The success in gene therapy relies strongly on new efficient gene delivery vectors. Non-viral vectors are highly attractive, since they can deliver large quantities of genetic information and are low immunogenic. In this respect, unsymmetrical bolaamphiphiles (bolas) bearing two different hydrophilic head-groups connected by a hydrophobic spacer could be an attractive alternative for vector design, as they can form well-defined supramolecular nanostructures (nanovesicles and nanotubes) that are more stable than those formed with lipids. The aim of the present work was to develop new gene delivery vectors based on bolas capable to form such nanostructures hosting a DNA molecule and exposing at their external surface neutral ligands. For this purpose, a variety of bolas, bearing cationic and neutral groups connected by a hydrophobic spacer, were obtained by multi-step organic synthesis. Their characterization by different instrumental techniques suggested that the nature of the head groups as well as the hydrophobic spacer defines the bola self-assembly, their interaction with DNA and the morphology of their complexes (bolaplexes). While the first two generations of bolas lack the essential features of nonviral vectors, the final third generation was found highly promising. The latter showed a strong interaction with DNA, the formation of small bolaplexes and good transfection efficiency in different cell lines. The increase in transfection efficiency in presence of DOPE or chloroquine suggested that the key barrier for their internalization could be the lipid fusion and the endosomal escape. Some bolaplex formulations showed a transfection efficiency comparable to the best commercial transfection agents. Thus, the present work introduces a new class of efficient transfection agents based on unsymmetrical bolaamphiphiles.
Book Synopsis Advances in Planar Lipid Bilayers and Liposomes by : Ales Iglic
Download or read book Advances in Planar Lipid Bilayers and Liposomes written by Ales Iglic and published by Academic Press. This book was released on 2012-09-04 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Planar Lipid Bilayers and Liposomes volumes cover a broad range of topics, including main arrangements of the reconstituted system, namely planar lipid bilayers as well as spherical liposomes. The invited authors present the latest results of their own research groups in this exciting multidisciplinary field. Incorporates contributions from newcomers and established and experienced researchers Explores the planar lipid bilayer systems and spherical liposomes from both theoretical and experimental perspectives Serves as an indispensable source of information for new scientists
Book Synopsis Biomedical Materials and Diagnostic Devices by : Ashutosh Tiwari
Download or read book Biomedical Materials and Diagnostic Devices written by Ashutosh Tiwari and published by John Wiley & Sons. This book was released on 2012-10-16 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical Materials and Diagnostics Devices provides an up-to-date overview of the fascinating and emerging field of biomedical materials and devices, fabrication, performance, and uses The biomedical materials with the most promising potential combine biocompatibility with the ability to adjust precisely the biological phenomena in a controlled manner. The world market for biomedical and diagnostic devices is expanding rapidly and the pace of academic research resulted in about 50,000 published papers in recent years. It is timely, therefore, to assemble a volume on this important subject. The chapters in the book seek to address progress in successful design strategies for biomedical materials and devices such as the use of collagen, crystalline calcium orthophosphates, amphiphilic polymers, polycaprolactone, biomimetic assembly, bio-nanocomposite matrices, bio-silica, theranostic nanobiomaterials, intelligent drug delivery systems, elastomeric nanobiomaterials, electrospun nano-matrices, metal nanoparticles, and a variety of biosensors. This large and comprehensive volume includes twenty chapters authored by some of the leading researchers in the field, and is divided into four main areas: biomedical materials; diagnostic devices; drug delivery and therapeutics; and tissue engineering and organ regeneration.
Book Synopsis Supramolecular Amphiphiles by : Xi Zhang
Download or read book Supramolecular Amphiphiles written by Xi Zhang and published by Royal Society of Chemistry. This book was released on 2017-06-15 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: An amphiphile is a molecule that contains a hydrophilic part and a hydrophobic part, linked by covalent bonding. Supramolecular amphiphiles (supra-amphiphiles) are amphiphiles linked by non-covalent interactions. As they employ non-covalent interactions, these species demonstrate adaptability and reversibility in conformational transformation, making them one of the most important emerging species in supramolecular chemistry. They have proven important in bridging the gap between molecular architecture and functional assembly. This book is written and edited by the current leaders in the topic and contains a foreword from Professor Jean-Marie Lehn, a father of the supramolecular chemistry field. Bringing together supramolecular chemistry and colloidal and interfacial science, the book provides a detailed and systematic introduction to supramolecular amphiphiles. Chapters explain how to employ non-covalent interactions to fabricate supra-amphiphiles. The book opens with an introduction to the history and development of the field, followed by chapters focussing on each type of interaction, including host-guest interaction, electrostatic interaction, charge-transfer interaction, hydrogen bonding and dynamic covalent bonds. This book will be a valuable resource for students new to this field and experienced researchers wanting to explore the wider context of their work.
Book Synopsis Nanomaterials Chemistry by : C. N. R. Rao
Download or read book Nanomaterials Chemistry written by C. N. R. Rao and published by John Wiley & Sons. This book was released on 2007-09-24 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: With this handbook, the distinguished team of editors has combined the expertise of leading nanomaterials scientists to provide the latest overview of this field. They cover the whole spectrum of nanomaterials, ranging from theory, synthesis, properties, characterization to application, including such new developments as quantum dots, nanoparticles, nanoporous materials, nanowires, nanotubes, and nanostructured polymers. The result is recommended reading for everybody working in nanoscience: Newcomers to the field can acquaint themselves with this exciting subject, while specialists will find answers to all their questions as well as helpful suggestions for further research.
Download or read book Gemini Surfactants written by Raoul Zana and published by CRC Press. This book was released on 2003-10-07 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: Generating much interest in both academic and scientific circles, Gemini Surfactants gathers the most up-to-date research in gemini surfactantproduction and demonstrates how their propertiesand performance can revolutionize the current industrial application of these surfactants. It surveys the state of special gemini surfactants, including nonionic, zwitterionic, fluorinated, and amino-acid-based surfactants. Gemini Surfactants considers the synthesis, phase behavior, and rheology of gemini and related surfactants and clarifies the adsorption and surface tension behavior of gemini surfactants at air–water, oil–water, and solid–water interfaces. The book also details the physicochemical properties and microstructure of aqueous micellar solutions of gemini surfactants and describes mixed micellization between gemini surfactants and conventional surfactants.
Book Synopsis Molecular- and Nano-Tubes by : Oliver Hayden
Download or read book Molecular- and Nano-Tubes written by Oliver Hayden and published by Springer Science & Business Media. This book was released on 2011-08-04 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular- and Nano-Tubes summarizes recent advancements in the synthesis, fabrication and applications of tubular structures. An interdisciplinary overview of innovative science focused on tubular structures is provided. The reader is offered an overview of the different fields that molecular and nano tubes appear in, in order to learn the fundamental basics as well as the applications of these materials. This book also: Shows how nanotechnology creates novel materials by crossing the barriers between biology and material science, electronics and optics, medicine and more Demonstrates that tubes are a fundamental element in nature and used in disparate applications such as ion channels and carbon nanotubes Molecular- and Nano-Tubes is an ideal volume for researchers and engineers working in materials science and nanotechnology.
Download or read book Carotenoids written by John T. Landrum and published by CRC Press. This book was released on 2009-12-21 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carotenoids are of great interest due to their essential biological functions in both plants and animals. However, the properties and functions of carotenoids in natural systems are surprisingly complex. With an emphasis on the chemical aspects of these compounds, Carotenoids: Physical, Chemical, and Biological Functions and Properties presents a b
Book Synopsis Advances in Macromolecular Chemistry by : Wallace M. Pasika
Download or read book Advances in Macromolecular Chemistry written by Wallace M. Pasika and published by . This book was released on 1968 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Introduction to Graphene by : Challa Vijaya Kumar
Download or read book Introduction to Graphene written by Challa Vijaya Kumar and published by Elsevier. This book was released on 2017-08-10 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Graphene: Chemical and Biochemical Applications addresses a broad range of graphene research, including the prehistory and background of graphene, synthetic approaches, characterization techniques, composites/derivatives, inorganic graphene analogues, and applications of graphene. The book’s special emphasis on solution chemistry and graphene sets it apart from less practical titles in that its concepts are immediately implementable in the laboratories of chemists and biochemists. The book presents a variety of experimental approaches from the authors’ research laboratories and others around the world for graphene preparation in the solution phase, especially under aqueous conditions or in animal serum—the most practical kind of graphene for chemists and biochemists. The book is ideally suited for a broad range of readers, including advanced undergraduates, graduate research students and professionals in state-of-the-art research labs who want to use graphene to develop novel applications. Features reviews of the most recent advances in graphene research across chemistry and biochemistry Emphasizes chemical and biological applications for specialists, aiding more multi-disciplinary research Presents a variety of experimental approaches for graphene preparation in the solution phase, especially under aqueous conditions or even in animal serum
Book Synopsis Self-assembling Biomaterials by : Helena S. Azevedo
Download or read book Self-assembling Biomaterials written by Helena S. Azevedo and published by Woodhead Publishing. This book was released on 2018-04-17 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Self-assembling biomaterials: molecular design, characterization and application in biology and medicine provides a comprehensive coverage on an emerging area of biomaterials science, spanning from conceptual designs to advanced characterization tools and applications of self-assembling biomaterials, and compiling the recent developments in the field. Molecular self-assembly, the autonomous organization of molecules, is ubiquitous in living organisms and intrinsic to biological structures and function. Not surprisingly, the exciting field of engineering artificial self-assembling biomaterials often finds inspiration in Biology. More important, materials that self-assemble speak the language of life and can be designed to seamlessly integrate with the biological environment, offering unique engineering opportunities in bionanotechnology. The book is divided in five parts, comprising design of molecular building blocks for self-assembly; exclusive features of self-assembling biomaterials; specific methods and techniques to predict, investigate and characterize self-assembly and formed assemblies; different approaches for controlling self-assembly across multiple length scales and the nano/micro/macroscopic properties of biomaterials; diverse range of applications in biomedicine, including drug delivery, theranostics, cell culture and tissue regeneration. Written by researchers working in self-assembling biomaterials, it addresses a specific need within the Biomaterials scientific community. Explores both theoretical and practical aspects of self-assembly in biomaterials Includes a dedicated section on characterization techniques, specific for self-assembling biomaterials Examines the use of dynamic self-assembling biomaterials
Book Synopsis Modern Applications of Cycloaddition Chemistry by : Paolo Quadrelli
Download or read book Modern Applications of Cycloaddition Chemistry written by Paolo Quadrelli and published by Elsevier. This book was released on 2019-03-20 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern Applications of Cycloaddition Chemistry examines this area of organic chemistry, with special attention paid to cycloadditions in synthetic and mechanistic applications in modern organic chemistry. While many books dedicated to cycloaddition reactions deal with the synthesis of heterocycles, general applications, specific applications in natural product synthesis, and the use of a class of organic compounds, this work sheds new light on pericyclic reactions by demonstrating how these valuable tools elegantly solve synthetic and mechanistic problems. The work examines how pericyclic reactions have been extensively applied to different chemistry areas, such as chemical biology, biological processes, catalyzed cycloaddition reactions, and more. This work will be useful for organic chemists who deal with organic chemistry, medicinal chemistry, agrochemistry and material chemistry. Provides details on the synthesis of antiviral and anticancer compounds, marking the key role of unconventional catalyzed cycloaddition reactions for preparing new derivatives in a unique reaction pathway that is scalable in industrial processes Contains the most up-to-date review of the use of pericyclic reactions in drug delivery Includes the enzyme-catalyzed processes involving cycloaddition reactions for different targets, demonstrating that cycloaddition is more common in nature than expected Features new applications for cycloadditions in material chemistry and provides a general view of the most recent results in the area
Book Synopsis Nanotechnology Characterization Tools for Tissue Engineering and Medical Therapy by : Challa S.S.R. Kumar
Download or read book Nanotechnology Characterization Tools for Tissue Engineering and Medical Therapy written by Challa S.S.R. Kumar and published by Springer Nature. This book was released on 2019-11-22 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ninth volume of a 40 volume series on nanoscience and nanotechnology, edited by the renowned scientist Challa S.S.R. Kumar. This handbook gives a comprehensive overview about Nanotechnology Characterization Tools for Tissue Engineering and Medical Therapy. Modern applications and state-of-the-art techniques are covered and make this volume an essential reading for research scientists in academia and industry.
Book Synopsis Cancer Therapeutics And Imaging: Molecular And Cellular Engineering And Nanobiomedicine by : Kaushal Rege
Download or read book Cancer Therapeutics And Imaging: Molecular And Cellular Engineering And Nanobiomedicine written by Kaushal Rege and published by World Scientific. This book was released on 2017-12-05 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the latest advancements in molecular and cellular engineering approaches in addition to nanotechnology for cancer therapeutics and imaging. It also provides an excellent background and state-of-the-art developments in the fields of drug and gene delivery, engineering nanoparticles for therapy and diagnostics, and cancer imaging techniques.The contents of this book include chapters on cutting-edge science in molecular and cellular engineering and nanotechnology as applied to therapeutics and imaging in cancer diseases. The chapters also provide a comprehensive overview on gene therapy and delivery methods for cancer treatment, oral drug delivery and barriers, cancer imaging for diagnostics and therapy, and the latest developments in these fields.
Book Synopsis Comprehensive Supramolecular Chemistry II by : George W. Gokel
Download or read book Comprehensive Supramolecular Chemistry II written by George W. Gokel and published by Elsevier. This book was released on 2017-06-22 with total page 4627 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Supramolecular Chemistry II, Second Edition, Nine Volume Set is a ‘one-stop shop’ that covers supramolecular chemistry, a field that originated from the work of researchers in organic, inorganic and physical chemistry, with some biological influence. The original edition was structured to reflect, in part, the origin of the field. However, in the past two decades, the field has changed a great deal as reflected in this new work that covers the general principles of supramolecular chemistry and molecular recognition, experimental and computational methods in supramolecular chemistry, supramolecular receptors, dynamic supramolecular chemistry, supramolecular engineering, crystallographic (engineered) assemblies, sensors, imaging agents, devices and the latest in nanotechnology. Each section begins with an introduction by an expert in the field, who offers an initial perspective on the development of the field. Each article begins with outlining basic concepts before moving on to more advanced material. Contains content that begins with the basics before moving on to more complex concepts, making it suitable for advanced undergraduates as well as academic researchers Focuses on application of the theory in practice, with particular focus on areas that have gained increasing importance in the 21st century, including nanomedicine, nanotechnology and medicinal chemistry Fully rewritten to make a completely up-to-date reference work that covers all the major advances that have taken place since the First Edition published in 1996
Book Synopsis Supramolecular Photosensitive and Electroactive Materials by : Hari Singh Nalwa
Download or read book Supramolecular Photosensitive and Electroactive Materials written by Hari Singh Nalwa and published by Gulf Professional Publishing. This book was released on 2001-05-21 with total page 995 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade, much progress has been made in these materials. This book presents a highly coherent coverage of supramolecular, photosensitive and electroactive materials, namely those that have been extensively investigated for applications in fields of electronic and photonic technologies. This extensive reference provides broad coverage of on different types of materials, their processing, spectroscopic characterization, physical properties and device applications.The implications reach from molecular recognition in synthetic and natural complexes to exciting new applications in chemical technologies, materials, nanostructures, functional materials, new generation catalysts, signal transducers, medical and biomedical applications and novel separation techniques. All these applications rely on supramolecular properties such as molecular recognition, molecular information, and tailored molecular assemblies.This book is aimed to present a highly coherent coverage of supramolecular, photosenstive and electroactive materials and their applications in electronic and photonic technologies. The research behind these materials constitute some of the most actively pursued fields of science. Key Features* Covers supramolecular photosensitive and electroactive materials* Provides recent developments on metallophthalocyanines and polydiacetylenes* Include various types of supramolecular materials, their processing, fabrication, physical properties and device applications* Role of polyimides in microelectronic and tribology* Describes Photosynthetic and respiratory proteins, Dendrimers* A very special topic presented in a timely manner and in a format
Book Synopsis New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications by : Marc J.M. Abadie
Download or read book New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications written by Marc J.M. Abadie and published by Springer. This book was released on 2022-05-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume applies the insights of supramolecular chemistry to biomedical applications such as ions/water transport through nano-scale channels, gene therapy, tissue engineering and drug delivery, to cite some of the major investigations.The challenge is to understand the mechanisms of transport through tissues particularly in the therapeutic treatment of a disease where the active drug must be delivered directly to diseased cells without affecting healthy cells. As a result, smaller quantities of active substances can be used to treat the disease. Another interest concerns new ways to administer gene therapy. If genes are often delivered to their target cells by adapted viruses, the supramolecular non-viral ‘vectors’ using dynamic nano-frameworks and nano-structures are presented. In addition, it is important to reconstruct damaged tissues by mimicking natural processes in cells and polymers, such as tissue engineering and self-healing. Different options are here discussed: e.g. hydrogels based on chitosan, a carbohydrate polymer, are proving especially promising for tissue engineering and drug delivery. For controlled delivery of drugs or other biologically active compounds, hydrogels sensitive to the most important stimuli in the human body, such as temperature, pH, ionic strength, glucose and biomolecules released by the organism in pathological conditions have been developed. Finally, to assist and validate the experimental studies, computer modelling and simulations of large-sized molecular structures and systems using different molecular dynamics and quantum mechanical techniques are developed based on the experimental and chemistry synthesis. This book is of great interest for graduate students, researchers and health professionals interested in acquiring a better understanding of the mechanisms of medical treatments. In addition, it provides numerous tools to develop better therapies for human diseases.
