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Non Invasive Retinal Imaging In Mice With Fluorescent Scanning Laser Ophthalmoscopy And Fourier Domain Optical Coherence Tomography
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Book Synopsis Non-invasive Retinal Imaging in Mice with Fluorescent Scanning Laser Ophthalmoscopy and Fourier Domain Optical Coherence Tomography by : Nima Hossein-Javaheri
Download or read book Non-invasive Retinal Imaging in Mice with Fluorescent Scanning Laser Ophthalmoscopy and Fourier Domain Optical Coherence Tomography written by Nima Hossein-Javaheri and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Visualization of the internal structures of the retina is critical for clinical diagnosis and monitoring of pathology as well as for medical research investigating the root causes of retinal degeneration. The aim of this thesis is to develop multi-modal non-invasive imaging technology for studying retinal degeneration and gene therapy in mice. We have constructed a FD-OCT prototype and combined it with a Scanning Laser Ophthalmoscope (SLO) to permit real time alignment of the retinal field of view. Fluorescence detection was integrated with the SLO to enable the en face localization of a molecular contrast signal, which is important for retinal angiography and retinal auto-fluorescence imaging. The integrated FD-OCT/fSLO system was investigated for imaging the retina of mice In vivo. The results of this research have demonstrated that the state of art FD-OCT/fSLO system OCT is a powerful tool to conduct research retinal degeneration and gene therapy in mice.
Book Synopsis High Resolution Imaging in Microscopy and Ophthalmology by : Josef F. Bille
Download or read book High Resolution Imaging in Microscopy and Ophthalmology written by Josef F. Bille and published by Springer. This book was released on 2019-08-13 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
Book Synopsis Non-invasive Imaging of Retinal Degeneration in Small Animals Using Fourier Domain Optical Coherence Tomography by : Jing Xu
Download or read book Non-invasive Imaging of Retinal Degeneration in Small Animals Using Fourier Domain Optical Coherence Tomography written by Jing Xu and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A prototype spectrometer based on Fourier Domain Optical Coherence Tomography (FD OCT) system was used as a non-invasive depth resolved medical imaging tool for diagnostic visualization of the retinal structures In vivo. This thesis investigated so-called Spectral Domain (SD) OCT to detect and monitor pathological signs of retinal degeneration in small animals such as mice, rats and Xenopus laevis larvae. Non-invasive SD OCT imaging was validated against invasive retinal cross sectional images (histology) acquired from a nearby region for comparison of specific retinal layers. The retinal layers were manually segmented for quantitative thickness measurements, and followed by statistical analysis to determine the onset of detectable retinal degeneration. The results of this research have demonstrated that FD OCT is a powerful tool for quantitative in vivo measurement of retinal degeneration in small animals.
Book Synopsis Spectral/ Fourier Domain Doppler Optical Coherence Tomography in the Rodent Retina by : Jonathan Jaoshin Liu
Download or read book Spectral/ Fourier Domain Doppler Optical Coherence Tomography in the Rodent Retina written by Jonathan Jaoshin Liu and published by . This book was released on 2008 with total page 69 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography (OCT) is an emerging imaging technique based on low-coherence interferometry for noninvasive, high- resolution, cross-sectional imaging in a variety of biomedical fields. In ophthalmology, OCT has rapidly become a standard clinical diagnostic tool for retinal diseases, providing visualization of the retina with unprecedented detail. However, conventional time domain OCT systems are limited by low imaging speeds. Conventional time domain OCT systems use a mechanically scanned reference mirror to adjust the reference arm path length in time. Spectral / Fourier domain OCT systems use a spectrometer to detect the interference spectrum and do not require mechanical scanning of the reference mirror. This technology significantly improves imaging speed and sensitivity. Spectral / Fourier domain OCT detection methods enable imaging speeds -50-100x faster than conventional time domain OCT systems, providing the capability for three dimensional retinal imaging and blood flow quantification using Doppler OCT measurements. A pre-objective scanning spectral / Fourier domain OCT system for in vivo rodent retinal imaging is designed and built. The system includes a broadband light source to achieve ~-3[mu]m resolution and a CCD camera spectrometer with imaging speed at 25,000 axial scans per second. Applications of spectral / Fourier domain OCT for in vivo rodent retinal imaging are illustrated, including three-dimensional OCT imaging of retinal structure, OCT imaging of the retina preand post-injection, and Doppler OCT imaging providing quantitative measurements of pulsatile blood flow in a retinal vessel. These results demonstrate the ability of spectral / Fourier domain OCT to visualize rodent retinal structure in vivo, perform longitudinal studies by evaluating disease progression in an individual animal, and quantitatively measure rodent retinal blood flow.
Book Synopsis Fluorescence Lifetime Imaging Ophthalmoscopy by : Martin Zinkernagel
Download or read book Fluorescence Lifetime Imaging Ophthalmoscopy written by Martin Zinkernagel and published by Springer. This book was released on 2019-07-29 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the emerging non-invasive imaging technique of Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO). FLIO reveals unique information on retinal diseases, ranging from age-related macular degeneration and vascular diseases to hereditary retinal dystrophies. Fluorescence lifetimes enable the evaluation of disease progression before irreversible structural changes occur. The image acquisition is suitable for diagnostic purposes and follow-up examinations to investigate the natural course of disease, and to monitor the effects of possible therapies. This book fills the gap between available literature and gives state-of-the-art guidance on the principles of the FLIO technique, image acquisition, and data analysis. Written by a team of expert leaders within this field, this book will be relevant for scientists and clinicians with an interest in ophthalmoscopy.
Book Synopsis Wavefront Sensing and High Resolution Adaptive Optics Imaging in the Living Rodent Eye by : Ying Geng
Download or read book Wavefront Sensing and High Resolution Adaptive Optics Imaging in the Living Rodent Eye written by Ying Geng and published by . This book was released on 2011 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The rodent has become an increasingly valuable model for human diseases and development due to its availability for genetic manipulations. Non-invasive microscopic imaging of the rodent retina would allow tracking of retinal development, disease progression, and the efficacy of therapy in single animals. Correction of the eye's aberrations using adaptive optics (AO) could improve the resolution of in vivo rodent retinal images, but previous attempts have been limited by the small size of its eye and the difficulty in measuring its aberrations due to poor Shack-Hartmann wavefront sensor (SHWS) spot quality. The work in this thesis describes methods developed to measure the rodent eye optics and to optimize its retinal image quality in vivo. Our first attempt was modifying a confocal fluorescence adaptive optics scanning laser ophthalmoscope (AOSLO) originally built for imaging the primate and human eye to accommodate the rat eye. Despite achieving in vivo resolution sufficient to resolve sub-cellular structures in fluorescent ganglion cells, problems were identified with aberration measurements and AO image quality. We then constructed a SHWS customized for the small mouse eye, and found a solution to the aberration measurement problem. The custom designed SHWS can favor light from a specific retinal layer and provide good wavefront spot quality. This wavefront sensor was incorporated into a confocal AOSLO custom designed for the mouse eye. High quality images were obtained in the mouse retina revealing multiple cell layers, including the photoreceptor mosaic, nerve fiber bundles, fine capillaries/blood flow, and ganglion cell bodies and fine processes. The in vivo resolution of the system was directly characterized to be sub-[micrometer] laterally, and ~10 [micrometers] axially. This fine resolution has allowed classification of ganglion cells in vivo. The value of the instrument was also demonstrated in two functional imaging scientific studies"--Leaves vii-viii.
Book Synopsis Structural and Functional Imaging of the Human and Small Animal Eyes Using Ultrahigh Speed Fourier Domain Optical Coherence Tomography by : Woo Jhon Choi
Download or read book Structural and Functional Imaging of the Human and Small Animal Eyes Using Ultrahigh Speed Fourier Domain Optical Coherence Tomography written by Woo Jhon Choi and published by . This book was released on 2014 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is a non-invasive optical imaging technique that allows the three-dimensional structure of biological tissue to be visualized with micrometer resolution. In ophthalmology OCT has the unique advantage that it provides cross-sectional images of the retina and choroid noninvasively and in vivo, which have led OCT to be a clinical standard for the diagnosis of a variety of retinal diseases. Although current commercial Fourier domain OCT systems have high imaging speeds of 20-100kHz A-scan rates, these imaging speeds are not sufficient for more advanced structural and functional imaging techniques. Current state-of-the-art spectral domain and swept source OCT provide ultrahigh imaging speeds of >200kHz A-scan rates. These speeds enable functional imaging of retinal blood flow, OCT angiography of the retinal and choroidal microvasculature, and wide field volumetric structural imaging of the retina and choroid. In this thesis, advances in structural and functional ophthalmic imaging techniques for the human and small animal eyes are investigated using ultrahigh speed Fourier domain OCT. The following topics are discussed: (1) a method for numerically extracting and compensating dispersion mismatch in ultrahigh resolution spectral domain OCT, (2) ultrahigh speed spectral domain imaging in the small animal eye for measuring total retinal blood flow, (3) development of ultrahigh speed phase stable swept source OCT system for human retinal imaging, (4) OCT angiography of the choriocapillaris in the human eye, (5) clinical applications of OCT angiography in retinal diseases, including diabetic retinopathy and age-related macular degeneration, (6) small animal anesthesia protocol for functional hemodynamic imaging, and (7) imaging of neurovascular coupling in small animals using ultrahigh speed OCT.
Book Synopsis Real-time Retinal Blood Flow Imaging with Fourier Domain Optical Coherence Tomography by : Jing Xu
Download or read book Real-time Retinal Blood Flow Imaging with Fourier Domain Optical Coherence Tomography written by Jing Xu and published by . This book was released on 2014 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography (OCT) is a non-invasive micrometer-resolution depth resolved medical imaging tool for diagnostic visualization of the retinal structures in vivo. In this thesis, we first describe the capability of OCT for providing structural information by quantitative retinal thickness measurements in animal models of diseases causing vision loss. In the rest of the work described in this thesis, we focus on the development of an extension of OCT called speckle variance (sv) OCT, which provides functional information such as detecting capillaries within in the retina. Retinal capillary networks are critically linked to retinal neuronal health and disease. The ability to perform accurate in vivo examination of human retinal capillary networks is therefore valuable for studying mechanisms that govern retinal homeostasis and retinal vascular diseases. A real-time implementation of the svOCT provided by the GPU acceleration was described to provide visualization of en-face vasculature networks during acquisition. A qualitative comparison study was described in this thesis by comparing the retinal vasculature images acquired from svOCT and Florescence Angiography (FA) for both healthy and diseased patients. The capability of svOCT with respect to quantifying capillary network information has been also validated in this thesis. The results of these studies suggest that this GPU accelerated svOCT has the potential to non-invasively provide useful quantitative information about human retinal capillary networks, and may have clinical and research applications for the management of retinal microvascular diseases, a major cause of vision loss worldwide. To further adapt the svOCT to be more clinical friendly, preliminary work on enhancing the real-time visualization of vascular information from distinct retinal capillary beds during acquisition was proposed and implemented in this thesis.
Book Synopsis Adaptive Optics Optical Coherence Tomography for in Vivo Retinal Imaging by : Yifan Jian
Download or read book Adaptive Optics Optical Coherence Tomography for in Vivo Retinal Imaging written by Yifan Jian and published by . This book was released on 2014 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is a non-invasive micrometer-resolution volumetric imaging modality that has been employed in diverse applications. In this thesis, we first describe a GPU accelerated program to perform FDOCT data processing and real time 3D volumetric rendering. The real time visualization of volumetric images provided by the GPU acceleration was essential to the rest of the work described in this thesis. Small animal models of retinal diseases serve as a vital component in vision research, and non-invasive in vivo imaging is becoming an increasingly important tool in the field. We describe the first adaptive optics optical coherence tomography (AOOCT) imaging system for high resolution mouse retinal imaging. Images of mouse retina acquired with AOOCT showed significant improvement in the brightness and contrast of capillaries and nerve fiber bundles. However, the accuracy of wavefront sensing limited the performance of AOOCT. A novel wavefront sensorless adaptive optics (WSAO) OCT system was developed to overcome the issues associated with conventional wavefront sensing. Combination of WSAO with OCT allows coherence gated, depth resolved aberration correction. Images of both pigmented and albino mouse retinas acquired using WSAO OCT system demonstrated superior image quality. The real time high resolution WSAO OCT was leveraged for a time course study of laser exposure in the retina.
Download or read book Glaucoma written by Franz Grehn and published by Springer Science & Business Media. This book was released on 2009-02-08 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: This third Glaucoma volume of the Essentials in Ophthalmology series, as in the first and the second, provides a picture of recent progress in the field of glaucoma, in both basic clinical research and applied clinical science. Its intention is not to replace textbooks on glaucoma, but to serve as a conceptual bridge between original research and textbook presentation. The editors have set out to provide the reader with diverse and interesting topics reflective of the evidence-based, modern approach to the field of glaucoma. The book’s well-structured text and new design is quick and easy to read.
Download or read book OCT Atlas written by Nagahisa Yoshimura and published by Springer. This book was released on 2014-06-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: OCT provided a great advantage over other diagnostic modalities, as it could noninvasively provide tomographic images of the retina of a living eye. As a result, a number of new findings in retinal diseases were made using the time-domain OCT. OCT has now become an essential medical equipment OCT has now become an essential medical equipment in ophthalmic care and quality textbooks describing the functionality of OCT are very important in the education of young ophthalmologists and eye care personnel. In this book are chosen high quality OCT images of rather common diseases as well as images of several rare diseases.
Book Synopsis Noninvasive Assessment of Retinal Morphology in Mice Using Optical Coherence Tomography by : Gesine Huber
Download or read book Noninvasive Assessment of Retinal Morphology in Mice Using Optical Coherence Tomography written by Gesine Huber and published by . This book was released on 2010 with total page 59 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Fundus Autofluorescence by : Noemi Lois
Download or read book Fundus Autofluorescence written by Noemi Lois and published by Lippincott Williams & Wilkins. This book was released on 2012-02-13 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring over 250 illustrations, this detailed full-color textbook provides up-to-date information on the use of fundus autofluorescence imaging in evaluation of retinal disease. Chapters describe the techniques available to image and quantify fundus autofluorescence and the autofluorescence patterns observed in the healthy eye and in various retinal diseases. Emphasis is on the value of fundus autofluorescence as a diagnostic and prognostic tool and its clinical utility in the context of other imaging techniques, such as fluorescein and indocyanine green angiography and optical coherence tomography. Each chapter also discusses the value of fundus autofluorescence in understanding the pathogenesis of the condition, and provides a comprehensive update on all aspects of the condition. A companion Website will offer the fully searchable text and an image bank.
Book Synopsis Handbook of Optics: Devices, measurements, and properties by : Michael Bass
Download or read book Handbook of Optics: Devices, measurements, and properties written by Michael Bass and published by . This book was released on 1995 with total page 1574 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation -- A new volume in the field's bestselling optics reference -- an entirely new opus focusing on x-ray, nonlinear, and vision optics -- Provides the same mix of tutorial writing with in-depth reference material that distinguished Volumes I & II.
Book Synopsis High-resolution Retinal Imaging Using Adaptive Optics and Fourier-domain Optical Coherence Tomography by :
Download or read book High-resolution Retinal Imaging Using Adaptive Optics and Fourier-domain Optical Coherence Tomography written by and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This invention permits retinal images to be acquired at high speed and with unprecedented resolution in three dimensions (4.times. 4.times. 6 .mu.m). The instrument achieves high lateral resolution by using adaptive optics to correct optical aberrations of the human eye in real time. High axial resolution and high speed are made possible by the use of Fourier-domain optical coherence tomography. Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.
Book Synopsis Pediatric Neuro-Ophthalmology by : Michael C. Brodsky
Download or read book Pediatric Neuro-Ophthalmology written by Michael C. Brodsky and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatric Neuroophthalmology details the diagnostic criteria, current concepts of pathogenesis, neuroradiological correlates, and clinical management of a large group of neuroophthalmic disorders that present in childhood. Surprisingly distinct from neuroophthalmic disorders afflicting adults, this set of diseases falls between the cracks of most ophthalmology training, and thus, warrants a practical, clinical guide for the practitioner in ophthalmology - the neuroophthalmologist, pediatric ophthalmologist, general ophthalmologist - as well as neurologists and for residents. The authors, leading pediatric ophthalmologists, have taken this difficult subject matter and developed an accessible, user-friendly manual with a detailed approach to the recognition, differential diagnosis, and management of pediatric neuroophthalmologic disorders.
