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Nitric Oxide In Bone And Joint Disease
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Book Synopsis Nitric Oxide in Bone and Joint Disease by : Mika V. J. Hukkanen
Download or read book Nitric Oxide in Bone and Joint Disease written by Mika V. J. Hukkanen and published by Cambridge University Press. This book was released on 1998-10-15 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric oxide research has emerged as one of the most important areas in bone and joint diseases. First published in 1998, this book draws together knowledge on the actions of this mediator and its role in such common diseases as arthritis and osteoporosis. It introduces the basic biology and biochemistry of nitric oxide, the immune response and bone biology. It reviews in depth the facts we know today and the future promise of this exciting area of research. The book will give scientists and clinicians a unique insight into this increasingly important area. It also emphasises potential treatments which exploit our understanding of the role of nitric oxide in bone and joint disease.
Book Synopsis Nitric Oxide Donors by : Peng George Wang
Download or read book Nitric Oxide Donors written by Peng George Wang and published by John Wiley & Sons. This book was released on 2005-08-16 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric oxide donors, from organic nitrates to nitroso compounds, guanidines and metal-NO complexes. In addition to a detailed treatment of the chemistry of NO donors, numerous examples of successful diagnostic and pharmacological applications are discussed, as well as further therapeutic targets for these substances.
Book Synopsis WHO Guidelines for Indoor Air Quality by :
Download or read book WHO Guidelines for Indoor Air Quality written by and published by World Health Organization. This book was released on 2010 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents WHO guidelines for the protection of public health from risks due to a number of chemicals commonly present in indoor air. The substances considered in this review, i.e. benzene, carbon monoxide, formaldehyde, naphthalene, nitrogen dioxide, polycyclic aromatic hydrocarbons (especially benzo[a]pyrene), radon, trichloroethylene and tetrachloroethylene, have indoor sources, are known in respect of their hazardousness to health and are often found indoors in concentrations of health concern. The guidelines are targeted at public health professionals involved in preventing health risks of environmental exposures, as well as specialists and authorities involved in the design and use of buildings, indoor materials and products. They provide a scientific basis for legally enforceable standards.
Book Synopsis Bone Research Protocols by : Miep H. Helfrich
Download or read book Bone Research Protocols written by Miep H. Helfrich and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last decade has seen a tremendous advance in our understanding of bone biology. The genes responsible for the majority of rare inherited bone disorders have been identified and much progress has been made in the identification of genes in polygenic disorders such as Paget’s disease and complex multigene diseases such as osteoporosis. Transgenic technology has identified further genes, sometimes unexpectedly, with profound effects on bone. This wealth of new genetic information will undoubtedly lead to extensive cell biological studies to understand the mechanisms by which these gene products affect bone mass and bone strength. In Bone Research Protocols a catalogue of protocols has been assembled to perform such mechanistic studies. In the tradition of the Methods in Molecular Medicine series, the chapters are practical laboratory protocols that should enable the reader to carry out the techniques from scratch. To our knowledge this is the first time such a truly practical manual on well-established bone methods has been assembled, and this volume aims to be complementary to and follow on from the more theoretical Methods in Bone Biology, edited by Arnett and Henderson (1).
Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Author :Andrea Giustina Publisher :Karger Medical and Scientific Publishers ISBN 13 :3805572964 Total Pages :213 pages Book Rating :4.8/5 (55 download)
Book Synopsis Glucocorticoid-induced Osteoporosis by : Andrea Giustina
Download or read book Glucocorticoid-induced Osteoporosis written by Andrea Giustina and published by Karger Medical and Scientific Publishers. This book was released on 2002 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteoporosis is one of the most clinically relevant disabling chronic disease encountered in clinical practice. A common cause of osteoporosis is glucocorticoid excess, as glucocorticoids may increase bone resorption, inhibit bone formation, have indirect actions on bone by decreasing intestinal calcium absorption and induce hypercalciuria. This book presents a comprehensive overview of the effects of glucocorticoids on bone metabolism and structure and on the diagnosis and treatment of glucocorticoid-induced osteoporosis. It aims at providing updated information on the pathogenesis, diagnosis and treatment of this often dramatic complication of glucocorticoid excess. Being one of the few publications completely devoted to glucocorticoid-induced osteoporosis it will heighten the awareness of specialists who prescribe glucocorticoids of the clinical relevance of this treatment complication. 'Glucocorticoid-Induced Osteoporosis' is addressed to clinical experts as well as to general practitioners who will both benefit from the comprehensive and integrative view of the management of patients exposed to glucocorticoids.
Book Synopsis Studies on Arthritis and Joint Disorders by : Maria Jose Alcaraz
Download or read book Studies on Arthritis and Joint Disorders written by Maria Jose Alcaraz and published by Springer Science & Business Media. This book was released on 2013-02-20 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This next volume in our established series proposes to systematically review the basic science and clinical knowledge of the role of free radicals and antioxidants, collectively known as “oxidative stress”, in the pathology of arthritis and other joint diseases. It will describe the most current diagnostic tools , laboratory methods and technology, to suggest ways of prevention and treatment and to emphasize the concept of the bench-to-bedside approach. The book will also provide specific coverage on emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents and several more relevant aspects. In addition, the book will promote the concept of using biomarkers representative of oxidative stress reactions and free radical damage , as well as describe the effect of antioxidants in treating disease in clinical trials. The content will be valuable to researchers studying the development of arthritis/joint disease, and clinicians treating patients with these diagnoses.
Book Synopsis Pain in Osteoarthritis by : David T. Felson
Download or read book Pain in Osteoarthritis written by David T. Felson and published by John Wiley & Sons. This book was released on 2010-08-03 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative investigation of the sources andtreatment of osteoarthritic joint pain Millions of people throughout the world suffer from osteoarthritis (OA)—a medical condition causing its sufferers excruciating pain that is often disabling. This is the first book to offer clinicians an in-depth understanding of the biological sources of osteoarthritic pain and how they can be treated. Here, a team of leading international authorities has contributed state-of-the-art information on: The Neuroscience of Articular Pain—spinal and peripheral mechanisms of joint pain; experimental models for the study of osteoarthritic pain; inflammatory mediators and nociception in arthritis; phantoms in rheumatology; and more Osteoarthritis and Pain—joint mechanisms and neuromuscular aspects of OA; bone pain and pressure in OA joints; structural correlates of OA pain; and more Treatment of Osteoarthritic Pain—general approaches to treatment; treatments targeting pain receptors; treatments targeting biomechanical abnormalities; and treatments targeting inflammation Whether you're a medical professional, researcher, student, or a generalist or specialist focusing on pain or arthritis, this is your one-stop reference for understanding and treating joint pain in osteoarthritis.
Book Synopsis Bone and Osteoarthritis by : Felix Bronner
Download or read book Bone and Osteoarthritis written by Felix Bronner and published by Springer Science & Business Media. This book was released on 2007-09-26 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: The molecular and cellular approaches to the relationship of joint and bone problems distinguish this from other books on the topic. Advances in bone and joint biology enable practitioners to approach clinical problems more comprehensively. Emphasis on genetics and on newer viewpoints and approaches, exemplified by the possible effect of subchondral bone on osteoarthritis, gives a wider viewpoint to the reader and may enable novel approaches to solving a clinical problem.
Book Synopsis Research of Pathogenesis and Novel Therapeutics in Arthritis by : Chih-Hsin Tang
Download or read book Research of Pathogenesis and Novel Therapeutics in Arthritis written by Chih-Hsin Tang and published by MDPI. This book was released on 2019-06-04 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arthritis has a high prevalence globally and includes over 100 different types, the most common of which are rheumatoid arthritis, osteoarthritis, psoriatic arthritis, and inflammatory arthritis. The exact etiology of arthritis remains unclear and no cure exists. Anti-inflammatory drugs are commonly used in the treatment of arthritis but are associated with significant side effects. Novel modes of therapy and additional prognostic biomarkers are urgently needed for arthritis patients. This book summarizes and discusses the global picture of the current understanding of arthritis.
Book Synopsis Atlas of Osteoarthritis by : Nigel Arden
Download or read book Atlas of Osteoarthritis written by Nigel Arden and published by Springer. This book was released on 2015-01-19 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Atlas provides an up-to-date and comprehensive overview of the historical and current perspectives on osteoarthritis, including the pathophysiology and epidemiology of the disease. Written by leading authors in the field of osteoarthritis, the book discusses classification, etiology and risk factors for osteoarthritis, the disease course and determinants of osteoarthritis progression, clinical features and diagnosis as well as imaging methods to assess joint damage. The Atlas of Osteoarthritis concludes with the latest treatment updates including both nonpharmacological and pharmacological treatments, as well as surgical recommendations for patients with the disease. Osteoarthritis is the most common form of joint disease causing joint pain, stiffness, and physical disability among adults. It is an important issue for both the individual and society with its impact on public health continuing to grow as a result of the aging population, the rising prevalence of obesity, and the lack of definitive treatments to prevent or halt the progress of the disease.
Author :United States. Public Health Service. Office of the Surgeon General Publisher : ISBN 13 : Total Pages :728 pages Book Rating :4.:/5 (318 download)
Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Download or read book Groin Pain Syndrome written by Raul Zini and published by Springer. This book was released on 2017-05-08 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides accurate descriptions of the injuries responsible for groin pain, which tend to occur in association with particular sports. The approach is multidisciplinary, ensuring that the book will be of broad appeal, and the focus is especially on epidemiology, etiology, and possible treatment options. Throughout, care has been taken to depict the state of the art in this constantly evolving field. A new classification of groin pain syndrome is presented, and the coverage encompasses hip, visceral, tendon/muscle, bone, and neurologic pathology. In addition, guidance is provided in selection of the rehabilitation program that will best meet the patient’s needs, taking into account individual circumstances. Groin pain is among the most prevalent lower limb symptoms. The pain may occur immediately after an injury or develop gradually and is often exacerbated by continued use of the injured area. In presenting the latest knowledge on groin pain syndrome and its management, this book will be of value to a range of practitioners, including sports medicine specialists, primary care providers, urologists, orthopedists, and physiatrists.
Book Synopsis Bone Disorders, An Issue of Endocrinology and Metabolism Clinics of North America by : Albert Shieh
Download or read book Bone Disorders, An Issue of Endocrinology and Metabolism Clinics of North America written by Albert Shieh and published by Elsevier Health Sciences. This book was released on 2017-02-02 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Endocrinology and Metabolism Clinics, guest edited by Dr. Albert Shieh of UCLA, is devoted to Bone Disorders. Articles in this outstanding issue include: Role of Osteocyte in Bone and Non-Bone Disease; Bone-Fat Interaction; Imaging Beyond DXA; Vitamin D in African-Americans; Pre-Menopausal Osteoporosis; Combined Pharmacologic Therapy in Osteoporosis; Drug-Related Adverse Events in Osteoporosis; Novel Therapies for Osteoporosis; Diabetes and Bone Disease; Bariatric Surgery and Bone Metabolism; Hyperparathyroidism and Bone Microarchitecture; FGF-23 Mediated Bone Disease; and Endothelin-Related Bone Disorder.
Book Synopsis Biological Mechanisms of Tooth Movement by : Vinod Krishnan
Download or read book Biological Mechanisms of Tooth Movement written by Vinod Krishnan and published by John Wiley & Sons. This book was released on 2021-05-24 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological Mechanisms of Tooth Movement This new edition continues to be an authoritative reference to the scientific foundations underpinning clinical orthodontics The newly and thoroughly revised Third Edition of Biological Mechanisms of Tooth Movement delivers a comprehensive reference for orthodontic trainees and specialists. It is fully updated to include new chapters on personalized orthodontics as well as the inflammatory process occurring in the dental and paradental tissues. It is heavily illustrated throughout, making it easier for readers to understand and retain the information discussed within. The topics covered range from bone biology, the effects of mechanical loading on tissues and cells, genetics, tissue remodeling, and the effects of diet, drugs, and systemic diseases. The Third Edition of Biological Mechanisms of Tooth Movement features seven sections that cover subjects such as: The development of biological concepts in orthodontics, including the cellular and molecular biology behind orthodontic tooth movement Mechanics meets biology, including the effects of mechanical loading on hard and soft tissues and cells, and biological reactions to temporary anchorage devices Inflammation and orthodontics, including markers for tissue remodeling in the gingival crevicular fluid and saliva Personalized diagnosis and treatment based on genomic criteria, including the genetic influences on orthodontic tooth movement Rapid orthodontics, including methods to accelerate or decelerate orthodontic tooth movement Perfect for residents and PhD students of orthodontic and periodontal programs, Biological Mechanisms of Tooth Movement is also useful to academics, clinicians, bone biologists, and researchers with an interest in the mechanics and biology of tooth movement.
Book Synopsis Selected Methods in Cellular Immunology by : Barbara B. Mishell
Download or read book Selected Methods in Cellular Immunology written by Barbara B. Mishell and published by W H Freeman & Company. This book was released on 1980-01-01 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Systems Biology of Free Radicals and Antioxidants by : Ismail Laher
Download or read book Systems Biology of Free Radicals and Antioxidants written by Ismail Laher and published by Springer. This book was released on 2014-06-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The focus of this collection of illustrated reviews is to discuss the systems biology of free radicals and anti-oxidants. Free radical induced cellular damage in a variety of tissues and organs is reviewed, with detailed discussion of molecular and cellular mechanisms. The collection is aimed at those new to the field, as well as clinicians and scientists with long standing interests in free radical biology. A feature of this collection is that the material also brings insights into various diseases where free radicals are thought to play a role. There is extensive discussion of the success and limitations of the use of antioxidants in several clinical settings.
