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Nitric Oxide And The Kidney
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Book Synopsis Nitric Oxide in the Kidney by : Jennifer M. Sasser
Download or read book Nitric Oxide in the Kidney written by Jennifer M. Sasser and published by Biota Publishing. This book was released on 2015-05-01 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric oxide (NO) is a key regulator of various cellular signaling pathways throughout the body and plays an important role in renal function under normal physiological and pathophysiological conditions. NO plays a major role in the regulation of renal hemodynamics, tubuloglomerular feedback, sodium transport in the nephron, pressure natriuresis, and renal fibrosis and injury; moreover, a deficiency in NO is characteristic of chronic kidney disease in both human patients and in experimental animal models. The goal of this book is to highlight the actions of NO within the kidney and its effects on the regulation of renal blood flow and tubular transport.
Author :Michael S. Goligorsky Publisher :Springer Science & Business Media ISBN 13 :146156039X Total Pages :477 pages Book Rating :4.4/5 (615 download)
Book Synopsis Nitric Oxide and the Kidney by : Michael S. Goligorsky
Download or read book Nitric Oxide and the Kidney written by Michael S. Goligorsky and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of remarkable recent breakthroughs have made the study of nitric oxide one of the most exciting fields in physiology and pathophysiology. This authoritative edited volume reviews the progress to date and opens perspectives to novel diagnostic and therapeutic strategies. The contributors are leading authorites, in most cases the investigators who have pioneered the ideas explored in the book.
Book Synopsis Nitric Oxide and Kidney Function by : David Mattson
Download or read book Nitric Oxide and Kidney Function written by David Mattson and published by . This book was released on 2012-06-01 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Controversies in Acute Kidney Injury by : John A. Kellum
Download or read book Controversies in Acute Kidney Injury written by John A. Kellum and published by Karger Medical and Scientific Publishers. This book was released on 2011 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely update Acute kidney injury (AKI) is a serious and as yet incompletely understood disorder in which sudden impairment of kidney function occurs secondary to one or more of a variety of underlying conditions. This disorder is very common in (elderly) ICU patients and is associated with very high mortality. Many of those who survive suffer from permanent kidney failure and other long-term morbidities, which may include cardiovascular disease and immune dysfunction. Epidemiologic evidence suggests that AKI is not a single disease, but a syndrome comprised of multiple, often coexisting, etiologies. Being usually part of multiorgan failure syndrome, it calls for multiple organ support therapy. The publication at hand contains sections on prerenal azotemia syndromes, dying of' or with' AKI, pathophysiology of sepsis- induced acute kidney injury, developments in prevention / treatment / rehabilitation, and renal support. Reporting the latest recommendations from experts, it provides valuable information for those that are interested in understanding the disorder and its treatment options.
Book Synopsis Neural Control of Renal Function, Second Edition by : Ulla C. Kopp
Download or read book Neural Control of Renal Function, Second Edition written by Ulla C. Kopp and published by Biota Publishing. This book was released on 2018-07-17 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: The kidney is innervated with efferent sympathetic nerve fibers reaching the renal vasculature, the tubules, the juxtaglomerular granular cells, and the renal pelvic wall. The renal sensory nerves are mainly found in the renal pelvic wall. Increases in efferent renal sympathetic nerve activity reduce renal blood flow and urinary sodium excretion by activation of α1-adrenoceptors and increase renin secretion rate by activation of β1-adrenoceptors. In response to normal physiological stimulation, changes in efferent renal sympathetic nerve activity contribute importantly to homeostatic regulation of sodium and water balance. The renal mechanosensory nerves are activated by stretch of the renal pelvic tissue produced by increases in renal pelvic tissue of a magnitude that may occur during increased urine flow rate. Under normal conditions, the renal mechanosensory nerves activated by stretch of the sensory nerves elicits an inhibitory renorenal reflex response consisting of decreases in efferent renal sympathetic nerve activity leading to natriuresis. Increasing efferent sympathetic nerve activity increases afferent renal nerve activity which, in turn, decreases efferent renal sympathetic nerve activity by activation of the renorenal reflexes. Thus, activation of the afferent renal nerves buffers changes in efferent renal sympathetic nerve activity in the overall goal of maintaining sodium balance. In pathological conditions of sodium retention, impairment of the inhibitory renorenal reflexes contributes to an inappropriately increased efferent renal sympathetic nerve activity in the presence of sodium retention. In states of renal disease or injury, there is a shift from inhibitory to excitatory reflexes originating in the kidney. Studies in essential hypertensive patients have shown that renal denervation results in long-term reduction in arterial pressure, suggesting an important role for the efferent and afferent renal nerves in hypertension.
Author :Badri Ahmadi Moridani Publisher :National Library of Canada = Bibliothèque nationale du Canada ISBN 13 :9780612211223 Total Pages :234 pages Book Rating :4.2/5 (112 download)
Book Synopsis Influence of Dietary Salt Intake on Nitric Oxide Synthase Activity in the Rat Kidney [microform] by : Badri Ahmadi Moridani
Download or read book Influence of Dietary Salt Intake on Nitric Oxide Synthase Activity in the Rat Kidney [microform] written by Badri Ahmadi Moridani and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 1996 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric oxide (NO), plays an important role in sodium excretion. The hypothesis that renal nitric oxide synthase (NOS) activity is directly related to salt intake was studied in rats fed low (0.05% NaCI, LSD), normal (0.3%, NSD), or high (8%, HSD) salt diet for 14 days. NOS activity was measured in kidney tissue by conversion of L-$\sp$C-arginine to L-$\sp$C-citrulline. Ca$\sp{2+}$-dependent NOS activity which was 10-20 times higher in the outer and inner medulla compared to cortex was similar in all dietary groups. HSD increased urinary nitrite/nitrate (U$\sb{\rm NOx}$) excretion significantly by 3 days, however no significant differences were observed in NOS activity, serum NOx, or clearance of creatinine. Inhibition of NOS activity in vivo abolished the increase in UNOx excretion seen with HSD, and decreased fractional excretion of sodium. It is concluded that HSD increases NO production by the kidney but this is not due to an induction of NOS enzyme.
Book Synopsis Macula Densa Derived Nitric Oxide and Kidney Function by : Anna Ollerstam
Download or read book Macula Densa Derived Nitric Oxide and Kidney Function written by Anna Ollerstam and published by Uppsala Universitet. This book was released on 2002 with total page 47 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Hiromichi Suzuki (M.D.) Publisher :Karger Medical and Scientific Publishers ISBN 13 :3805577516 Total Pages :181 pages Book Rating :4.8/5 (55 download)
Book Synopsis Kidney and Blood Pressure Regulation by : Hiromichi Suzuki (M.D.)
Download or read book Kidney and Blood Pressure Regulation written by Hiromichi Suzuki (M.D.) and published by Karger Medical and Scientific Publishers. This book was released on 2004 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic kidney disease is one of the world's major public health problems, and the prevalence of kidney failure is rising steadily. Among the risk factors for a faster progression of renal disease are hypertension and proteinuria, many studies clearly demonstrating that hypertension is both a cause and consequence of chronic kidney disease. Namely, renal blood pressure regulation seems to be involved in five major pathophysiological mechanisms (all closely related to the renin-angiotensin system): Pressure-natriuresis, renal sympathetic nervous system, renal blood flow, intraglomerular pressure and tubuloglomerular feedback. This book reviews experimental data which form the basis of our current understanding of the association between hypertension and kidney diseases: The pathogenesis of increased blood pressure, the mechanisms by which systemic hypertension promotes progressive kidney failure, and the impact of antihypertensive agents on experimental renal mechanisms involved in hypertension. Furthermore, the role of angiotensin II receptor blockers in both the control of systemic blood pressure and the reduction of proteinuria is examined in an attempt to define optimal therapeutic strategies to prevent the otherwise inexorable deterioration of renal function in patients with chronic kidney disease.
Book Synopsis Cigarette Smoking and the Kidney by : A. Sessa
Download or read book Cigarette Smoking and the Kidney written by A. Sessa and published by Karger Medical and Scientific Publishers. This book was released on 2000-01-01 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cigarette smoking is also a risk factor for diffuse atherosclerosis, ischemic heart disease and peripheral vascular lesions, renal microvessels being another potential target. Furthermore, the relationships of chronic cigarette smoking and nitric oxide with endothelial dysfunction and vascular disease are well proven, and the association between eNOS gene polymorphisms and vascular disease and their dependence on chronic tobacco smoking has been stressed. But although there is definite evidence that the risk of progression of acquired or genetic renal disease is higher in chronic cigarette smokers and the negative effect on patient survival in chronic dialytic treatment is well known, these issues are still neglected by clinical nephrologists and the mechanisms involved have not yet been classified.
Download or read book Organic Nitrates written by P. Needleman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitroglycerin and other organic nitrates have been used for over a century in the treatment of angina pectoris. Millions of patients, throughout the world, have placed nitroglycerin tablets under the tongue and have experienced rapid and dramatic relief from the chest pain that frequently occurs as a manifestation of disease of the coronary arteries. The empirical observation of the safe use of nitrates for tile alleviation of the symptoms of angina have led to their widespread medical acceptance. The use of organic nitrates preceded any knowledge of their mechanism of action or their ultimate metabolic fate. Thus, more simply stated, although sub lingual nitrates helped the patients, little was known concerning what these drugs do to the body or what the body does to the drugs. A substantial number of investigators have focused on these questions especially during the last two decades. We now have considerably more insight into the pathways of degradation of organic nitrates and the relationship of the metabolic processes to the biological action of these agents. Similarly, considerable effort has been expended in understanding the mechanism of action of these agents directly on vascular smooth muscle and on cardiac work and performance. Finally, there is a more substantive understanding of the physiology of the coronary circulation as well as the" pathophysiologic manifestations of myocardial disease.
Book Synopsis Cellular and Molecular Biology of Nitric Oxide by : Jeffrey D. Laskin
Download or read book Cellular and Molecular Biology of Nitric Oxide written by Jeffrey D. Laskin and published by CRC Press. This book was released on 1999-02-26 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Provides the latest advances in the explosive growth of nitric oxide (NO) study-covering the behavior of this highly reactive molecule in a wide variety of physiologicial processes, including respiration, blood pressure, neurotransmission, nospecific host defense, and wound healing."
Book Synopsis Cellular and Molecular Biology of Nitric Oxide by : Jeffrey D. Laskin
Download or read book Cellular and Molecular Biology of Nitric Oxide written by Jeffrey D. Laskin and published by CRC Press. This book was released on 1999-02-26 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Provides the latest advances in the explosive growth of nitric oxide (NO) study-covering the behavior of this highly reactive molecule in a wide variety of physiologicial processes, including respiration, blood pressure, neurotransmission, nospecific host defense, and wound healing."
Book Synopsis The Kidney in Hypertension by : Norman M. Kaplan
Download or read book The Kidney in Hypertension written by Norman M. Kaplan and published by Lippincott Williams & Wilkins. This book was released on 1987 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nitric Oxide written by B. Mayer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 667 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric oxide (NO) has been discovered to play a fundamental role in a number of biological phenomena. This book describes various aspects of nitric oxide biology, physiology and pharmacology. It is divided into three sections. The first part deals with the basic chemistry and enzymology of NO, thus laying a molecular basis for what follows. The middle part surveys the physiological roles of NO under normal conditions. The concluding part explores the relevance of NO to disease, both as a pathogenic factor and a therapeutic target. The book thus provides detailed information on NO biology to the reader unfamiliar with the field and represents a reference work for scientists working in an NO-related field of biomedical research. Each chapter, written by experts in their fields, gives a broad introduction followed by a comprehensive review of the current knowledge and a detailed reference list.
Book Synopsis Nitric Oxide and Inflammation by : Daniela Salvemini
Download or read book Nitric Oxide and Inflammation written by Daniela Salvemini and published by Springer. This book was released on 2013-03-11 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Literally thousands of papers have been published on nitric oxide over the past ten years. But there is no single monograph available that has previously attempted to summarize the important features of the roles of nitric oxide in inflammation. The voluminous literature regarding the incredible range of chemical and biological effects of nitric oxide and reactive nitrogen oxide species, RNOS, may present a tangle of confusing information to the researcher. This volume brings together experts from nitric oxide and inflammation research and presents a concise up-to-date overview as well as future aspects of this rapidly growing field.
Book Synopsis The Kidney and Hypertension by : GEORGE L BAKRIS
Download or read book The Kidney and Hypertension written by GEORGE L BAKRIS and published by CRC Press. This book was released on 2003-11-28 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hypertension is common in patients with kidney disease for a number of reasons, including retention, inappropriate action by the renin-angiotensin system, and overactivity of the sympathetic nervous system. Of all causes of hypertension, renal artery stenosis (narrowing) has attracted considerable attention, because it was once thought to be a rare cause of hypertension, but is now known to be the most common cause of secondary hypertension. In The Kidney and Hypertension, George Bakris and a host of international contributors examine all aspects of hypertension in the renal patient. A reference book covering specific and common topics in the area of kidney disease and hypertension, it is an essential guide to the effective management of the renovascular patient. It covers everything from how to properly measure blood pressure to the assessment and treatment of elevated blood pressure in high-risk groups such as dialysis patients and pregnant women. Kidney and Hypertension also thoroughly discusses reducing cardiovascular risk in people with kidney disease due to its role as a leading cause of death among kidney patients. Additionally, there is a chapter on diabetes and its role as a common cause of kidney failure. As an introduction to basic concepts in the treatment of hypertension, Dr. Bakris's book will serve as an excellent reference to nephrologists, cardiologists, and cardiovascular surgeons in their efforts to reduce the risks of advanced kidney disease and cardiovascular disease.
Book Synopsis Avoiding Common ICU Errors by : Lisa Marcucci
Download or read book Avoiding Common ICU Errors written by Lisa Marcucci and published by Lippincott Williams & Wilkins. This book was released on 2012-01-03 with total page 908 pages. Available in PDF, EPUB and Kindle. Book excerpt: This pocket book succinctly describes 318 errors commonly made by attendings, residents, interns, nurses, and nurse-anesthetists in the intensive care unit, and gives practical, easy-to-remember tips for avoiding these errors. The book can easily be read immediately before the start of a rotation or used for quick reference on call. Each error is described in a short, clinically relevant vignette, followed by a list of things that should always or never be done in that context and tips on how to avoid or ameliorate problems. Coverage includes all areas of ICU practice except the pediatric intensive care unit.
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