Nimesulide Actions And Uses

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Nimesulide - Actions and Uses

Author : K. D. Rainsford
Publisher : Springer Science & Business Media
ISBN 13 : 3764374101
Total Pages : 445 pages
Book Rating : 4.7/5 (643 download)

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Book Synopsis Nimesulide - Actions and Uses by : K. D. Rainsford

Download or read book Nimesulide - Actions and Uses written by K. D. Rainsford and published by Springer Science & Business Media. This book was released on 2006-01-16 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which acts as a cyclooxygenase- 2 inhibitor but also has other novel pharmacological features which account for its effect in the control of pain and inflammation. It has become a leading NSAID in over 50 countries worldwide. This book provides a comprehensive and fully up-to-date critical review of the published literature on nimesulide, including comparisons with anti-inflammatory, analgesic and antipyretic agents. The emphasis is on the action of nimesulide in relation to its therapeutic and side effects in comparison with other established NSAIDs, including the new class of Coxibs. The chapters are written by leading experts and cover development of nimesulide, including synthesis and production, introduction, and approved uses and applications, followed by pharmacokinetics and toxicological properties, adverse reactions and their mechanisms.

Hepatotoxicity

Author : Hyman J. Zimmerman
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781719520
Total Pages : 848 pages
Book Rating : 4.7/5 (195 download)

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Book Synopsis Hepatotoxicity by : Hyman J. Zimmerman

Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Drug-Induced Liver Disease

Author : Neil Kaplowitz
Publisher : CRC Press
ISBN 13 : 0203909127
Total Pages : 790 pages
Book Rating : 4.2/5 (39 download)

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Book Synopsis Drug-Induced Liver Disease by : Neil Kaplowitz

Download or read book Drug-Induced Liver Disease written by Neil Kaplowitz and published by CRC Press. This book was released on 2002-10-16 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring more than 4100 references, Drug-Induced Liver Disease will be an invaluable reference for gastroenterologists, hepatologists, family physicians, internists, pathologists, pharmacists, pharmacologists, and clinical toxicologists, and graduate and medical school students in these disciplines.

Drug-Induced Liver Injury

Author :
Publisher : Academic Press
ISBN 13 : 0128173173
Total Pages : 288 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Drug-Induced Liver Injury by :

Download or read book Drug-Induced Liver Injury written by and published by Academic Press. This book was released on 2019-07-13 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Textbook of Rabbit Medicine E-Book

Author : Molly Varga
Publisher : Elsevier Health Sciences
ISBN 13 : 0702054194
Total Pages : 464 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Textbook of Rabbit Medicine E-Book by : Molly Varga

Download or read book Textbook of Rabbit Medicine E-Book written by Molly Varga and published by Elsevier Health Sciences. This book was released on 2013-08-19 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Textbook of Rabbit Medicine second edition is the completely revised and updated new edition of Frances Harcourt Brown’s acclaimed text covering all aspects of rabbit medicine. While the authoritative and evidence-based approach that made the original book so successful has been retained, in this new second edition well-known rabbit expert Molly Varga adds a stronger clinical focus that makes the Textbook invaluable as a point-of-care resource as well as a respected reference. With many additional features introduced for this update, the Textbook of Rabbit Medicine second edition remains the definitive and comprehensive reference of choice for all veterinary practitioners seeking information on the pet rabbit. Comprehensive, in-depth and authoritative coverage of the health and diseases of the domestic rabbit Detailed and explicit line artwork provides a clear understanding of physiological processes A practical, evidence-based resource for the effective treatment of pet rabbits. Entire text reviewed and updated by a leading expert, with major revision of therapeutics, anaesthesia, abscesses and neurology chapters. New clinical emphasis with clinical tips boxes throughout the text increase its practical focus Ancillary website presents clips of key procedures, an image library and podcasts Completely redesigned with more user-friendly text layout and full colour throughout. Many more illustrations specially commissioned for this edition

Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors

Author : Sir John R. Vane
Publisher : Springer Science & Business Media
ISBN 13 : 9401090297
Total Pages : 249 pages
Book Rating : 4.4/5 (1 download)

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Book Synopsis Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors by : Sir John R. Vane

Download or read book Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors written by Sir John R. Vane and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1971, Vane proposed that the mechanism of action of the aspirin-like drugs was through their inhibition of prostaglandin biosynthesis. Since then, there has been intense interest in the interaction between this diverse group of inhibitors and the enzyme known as cyclooxygenase (COX). It exists in two isoforms, COX-l and COX-2 (discovered some 5 years ago). Over the last two decades several new drugs have reached the market based on COX-l enzyme screens. Elucidation of the three-dimensional structure of COX-l has provided a new understanding for the actions of COX inhibitors. The constitutive isoform of COX, COX-l has clear physiological functions. Its activation leads, for instance, to the production of prostacyclin which when released by the endothelium is anti-thrombogenic and anti-atherosclerotic, and in the gastric mucosa is cyto protective. COX-l also generates prostaglandins in the kidney, where they help to maintain blood flow and promote natriuresis. The inducible isoform, COX-2, was discovered through its activity being increased in a number of cells by pro inflammatory stimuli. A year or so later, COX-2 was identified as a distinct isoform encoded by a different gene from COX-I. COX-2 is induced by inflammatory stimuli and by cytokines in migratory and other cells. Thus the anti-inflammatory actions of non-steroid anti-inflammatory drugs (NSAIDs) may be due to the inhibition of COX-2, whereas the unwanted side-effects such as irritation of the stomach lining and toxic effects on the kidney are due to inhibition of the constitutive enzyme, COX-I.

Security Technology Convergence Insights

Author : Ray Bernard
Publisher : Elsevier
ISBN 13 : 0128030011
Total Pages : 160 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Security Technology Convergence Insights by : Ray Bernard

Download or read book Security Technology Convergence Insights written by Ray Bernard and published by Elsevier. This book was released on 2015-04-02 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Security technology convergence, which refers to the incorporation of computing, networking, and communications technologies into electronic physical security systems, was first introduced in the 1970s with the advent of computer-based access control and alarm systems. As the pace of information technology (IT) advances continued to accelerate, the physical security industry continued to lag behind IT advances by at least two to three years. Security Technology Convergence Insights explores this sometimes problematic convergence of physical security technology and information technology and its impact on security departments, IT departments, vendors, and management. Includes material culled directly from author's column in Security Technology Executive Easy-to-read question and answer format Includes real-world examples to enhance key lessons learned

Selective COX-2 Inhibitors

Author : Sir John R. Vane
Publisher : Springer Science & Business Media
ISBN 13 : 9401148724
Total Pages : 153 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Selective COX-2 Inhibitors by : Sir John R. Vane

Download or read book Selective COX-2 Inhibitors written by Sir John R. Vane and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mainstay of therapy for rheumatoid disease is the non-steroid antiinflammatory drugs (NSAIDs), despite their inherent gastrointestinal toxicity and ability to cause renal damage in susceptible patients. The theory that the beneficial and toxic effects of NSAIDs stem from a reduction in prostanoid production through inhibition of cyclooxygenase implied that particular toxicities were inevitable with NSAIDs and would always be correlated with efficacy. However, over the years, it became apparent that at therapeutic doses, some NSAIDs had greater toxic side-effects than others, a fact not explained by the general theory. A significant clarification arose from the discovery that there are two distinct isoforms of COX, a constitutive enzyme (COX-I) responsible for the production of prostanoids necessary for platelet aggregation and protection of the gastric mucosa and kidney; and an inducible enzyme (COX-2) that is newly synthesized at sites of tissue damage and produces prostaglandins that manifest pathological effects. It became clear that different NSAIDs had greater or lesser effects on COX-I when used in therapeutic doses, explaining the variation in side-effects. ' The elucidation of the crystal structure of these different enzymes and the skills of medicinal chemists have led to the synthesis of new chemicals with a selectivity for the inducible enzyme, and thus with therapeutic efficacy without those toxic effects result ing from inhibition of the constitutive enzyme.

Artificial Cells, Cell Engineering and Therapy

Author : S Prakash
Publisher : Elsevier
ISBN 13 : 1845693078
Total Pages : 544 pages
Book Rating : 4.8/5 (456 download)

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Book Synopsis Artificial Cells, Cell Engineering and Therapy by : S Prakash

Download or read book Artificial Cells, Cell Engineering and Therapy written by S Prakash and published by Elsevier. This book was released on 2007-05-31 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Artificial cells, cell engineering and therapy are emerging technologies which will make a significant impact on the future of medicine and healthcare. However, research within the field is vast. This unique book provides a comprehensive study of the most recent advances in the field and its practical applications. The first part of the book offers the reader an introduction to the basics of artificial cell technology with chapters on its origins, design, current status within medicine and future prospects. Part two covers apoptosis, the use of bone marrow stromal cells in myocardial regeneration together with signalling and tissue engineering. Part three discusses artificial cells for therapy, procedures for various clinical conditions and the current status of the discipline within the field. The book concludes with a final section on the role of artificial cells in medicine with particular focus on the use of artificial cells as blood substitutes and their potential use in myocardial regeneration, drug delivery and in treating kidney and bowel diseases, diabetes and cancer. Artificial cells, cell engineering and therapy is a valuable reference for researchers, students and practitioners within the field. Introduces the basics of artificial cell technology Provides a comprehensive study of the most recent advances in artificial cells, cell engineering and cell therapy Discusses the design, engineering and uses of artificial cells

Fundamentals of Anaesthesia

Author : Colin Pinnock
Publisher : Cambridge University Press
ISBN 13 : 9780521690799
Total Pages : 990 pages
Book Rating : 4.6/5 (97 download)

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Book Synopsis Fundamentals of Anaesthesia by : Colin Pinnock

Download or read book Fundamentals of Anaesthesia written by Colin Pinnock and published by Cambridge University Press. This book was released on 2002-12 with total page 990 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Fundamentals of Anaesthesia builds upon the success of the first edition, and encapsulates the modern practice of anaesthesia in a single volume. Written and edited by a team of expert contributors, it provides a comprehensive but easily readable account of all of the information required by the FRCA Primary examination candidate and has been expanded to include more detail on all topics and to include new topics now covered in the examination. As with the previous edition, presentation of information is clear and concise, with the use of lists, tables, summary boxes and line illustrations where necessary to highlight important information and aid the understanding of complex topics. Great care has been taken to ensure an unrivalled consistency of style and presentation throughout.

Advances in Eicosanoid Research

Author : C.N. Serhan
Publisher : Springer Science & Business Media
ISBN 13 : 9783540667476
Total Pages : 286 pages
Book Rating : 4.6/5 (674 download)

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Book Synopsis Advances in Eicosanoid Research by : C.N. Serhan

Download or read book Advances in Eicosanoid Research written by C.N. Serhan and published by Springer Science & Business Media. This book was released on 2000-04-10 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last few years, we have witnessed tremendous progress in the field of eicosanoids and their therapeutic applications. Receptor an tagonists for leukotrienes have been tested as anti-inflammatories and are on the market as a treatment for asthma. Receptor agonists for pro stacyclin are being tested for the treatment of peripheral vascular dis ease, and selective inhibitors of cyclooxygenase type II were just ap proved for the treatment of rheumatoid arthritis. All these developments are the culmination of many years and man-hours of careful research. The field has now entered an upswing that will result in novel thera peutic applications within the next 10 years. New molecules and me diators have been identified, new enzymes and pathways elucidated and new therapeutic approaches have emerged. The concept of ei cosanoids as "pro-inflammatory" molecules is being challenged, and their role as regulators is increasingly recognized. In fact, some of these molecules may be important endogenous anti-inflammatory agents.

Anti-Inflammatory Diet

Author : Emily Hudson
Publisher :
ISBN 13 : 9781914128738
Total Pages : 172 pages
Book Rating : 4.1/5 (287 download)

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Book Synopsis Anti-Inflammatory Diet by : Emily Hudson

Download or read book Anti-Inflammatory Diet written by Emily Hudson and published by . This book was released on 2021-02-14 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anti-inflammatory diet is one of the best diets if you want to boost your immune system and support your organism during virus time. Anti-inflammatory diet is a lifestyle, the way of eating which you can follow all your life. The diet will be good for people who want to lose weight, have Autoimmune Issues, asthma, depression, diabetes, etc. Doctors suggest to eat the food that is high in antioxidants, omega-3 fatty acids, the use of spices and herbs such as ginger, turmeric, chili pepper, rosemary, garlic, etc. are also important. Fresh berries, cherries, avocado, artichokes, broccoli, cauliflower, nuts, beans, whole-grains, and oily fish should be main in your diet. The weight loss is the first very pleasant effect of the diet which is seen already in 2 weeks. This anti-inflammatory recipe book will be your guide in the world of healthy and delicious food. Let's consider the benefits of the anti-inflammatory diet cookbook: - Anti-inflammatory diet for beginners. The book contains recipes that will be good for freshmen in cooking as for pros. - Every recipe in the anti-inflammatory cookbook has clear directions and a detailed ingredient list. - Only easy to find ingredients. - Nutrition info and number of servings are included for every recipe. It will ease your daily routine. - Every food lover will be satisfied. There are many recipes for vegetarians and meat lovers. Today is the exact right time to change your life for the better. Hurry up to get your copy of the anti-inflammatory journal and start better care about your health from today!

Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research

Author : Helmut Sinzinger
Publisher : Springer Science & Business Media
ISBN 13 : 9780306457760
Total Pages : 480 pages
Book Rating : 4.4/5 (577 download)

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Book Synopsis Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research by : Helmut Sinzinger

Download or read book Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research written by Helmut Sinzinger and published by Springer Science & Business Media. This book was released on 1997 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: One hundred papers treat advances in research of the effects and uses of prostaglandins, thromboxanes, and leukotrienes in such medical fields as organ transplantation, male erectile dysfunction, amniotic fluid infection and labour, renal function, anti-inflammatory drugs, allergic and aspirin-intolerant asthma, angioplasty and heart ischemia, Alzheimer's disease, vessel wall hyperplasia, and more. Annotation copyrighted by Book News, Inc., Portland, OR

Analytical Profiles of Drug Substances and Excipients

Author :
Publisher : Academic Press
ISBN 13 : 9780080861197
Total Pages : 619 pages
Book Rating : 4.8/5 (611 download)

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Book Synopsis Analytical Profiles of Drug Substances and Excipients by :

Download or read book Analytical Profiles of Drug Substances and Excipients written by and published by Academic Press. This book was released on 1996-08-30 with total page 619 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the official compendia define a drug substance as to identity, purity, strength, and quality, they normally do not provide other physical or chemical data, nor do they list methods of synthesis or pathways of physical or biological degradation and metabolism. Such information is scattered throughout the scientific literature and the files of pharmaceutical laboratories. Edited by the Associate Director of Analytical Research and Development for the AmericanAssociation of Pharmaceutical Scientists, Analytical Profiles of Drug Substances and Excipients brings this information together into one source. The scope of the series has recently been expanded to include profiles of excipient materials.

Anesthetic Pharmacology

Author : Alex S. Evers
Publisher : Cambridge University Press
ISBN 13 : 1139497022
Total Pages : 2902 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Anesthetic Pharmacology by : Alex S. Evers

Download or read book Anesthetic Pharmacology written by Alex S. Evers and published by Cambridge University Press. This book was released on 2011-03-10 with total page 2902 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.

Non-steroidal Anti-inflammatory Drugs

Author : IARC Working Group on the Evaluation of Cancer-preventive Agents
Publisher : IARC
ISBN 13 : 9789283230014
Total Pages : 230 pages
Book Rating : 4.2/5 (3 download)

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Book Synopsis Non-steroidal Anti-inflammatory Drugs by : IARC Working Group on the Evaluation of Cancer-preventive Agents

Download or read book Non-steroidal Anti-inflammatory Drugs written by IARC Working Group on the Evaluation of Cancer-preventive Agents and published by IARC. This book was released on 1997 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Practical Management of Pain

Author : Honorio MD Benzon
Publisher : Elsevier Health Sciences
ISBN 13 : 0323083404
Total Pages : 1379 pages
Book Rating : 4.3/5 (23 download)

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Book Synopsis Practical Management of Pain by : Honorio MD Benzon

Download or read book Practical Management of Pain written by Honorio MD Benzon and published by Elsevier Health Sciences. This book was released on 2013-09-12 with total page 1379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Obtain all the core knowledge in pain management you need from one of the most trusted resources in the field. The new edition of Practical Management of Pain gives you completely updated, multidisciplinary overview of every aspect of pain medicine, including evaluation, diagnosis of pain syndromes, rationales for management, treatment modalities, and much more. In print and online, it is all the expert guidance necessary to offer your patients the best possible relief. "In summary, this is the best explanation of what lies behind MRI that I have read, taking what can be a dry subject and making it readily understandable and really interesting. I would recommend it to anyone starting their MRI training and anyone trying to teach MRI to others." Reviewed by RAD Magazine, June 2015 Understand and apply the latest developments in pain medicine with brand-new chapters covering disability assessment, central post-stroke pain, chronic widespread pain, and burn pain. Effectively ease your patients' pain with today's best management techniques, including joint injections, ultrasound-guided therapies, and new pharmacologic agents (such as topical analgesics). Access up-to-the-minute knowledge on all aspects of pain management, from general principles to specific management techniques, with contributions from renowned experts in the field. Read the full text and view all the images online at expertconsult.com. Understand and apply the latest developments in pain management with brand-new chapters covering disability assessment, central post-stroke pain, widespread chronic pain, and burn pain. Effectively ease your patients' pain with today's best management techniques, including joint injections, ultrasound-guided therapies, and new pharmacologic agents (such as topical analgesics).