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NF-κB-Related Genetic Diseases

Author : Gilles Courtois
Publisher : Springer
ISBN 13 : 3319258508
Total Pages : 78 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis NF-κB-Related Genetic Diseases by : Gilles Courtois

Download or read book NF-κB-Related Genetic Diseases written by Gilles Courtois and published by Springer. This book was released on 2015-12-29 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the diverse clinical, cellular and molecular manifestations of NF-KB-related genetic diseases. It shows that studying patient-related pathologies affecting the components of the NF-KB signaling pathway offers the opportunity to understand the various functions of NF-KB in humans, complementing studies performed with mouse models. In addition, people treating those patients acquire a deeper understanding of the molecular basis of the pathophysiological processes.

NF-kappa B

Author : Michael J. May
Publisher : Humana
ISBN 13 : 9781493948116
Total Pages : 0 pages
Book Rating : 4.9/5 (481 download)

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Book Synopsis NF-kappa B by : Michael J. May

Download or read book NF-kappa B written by Michael J. May and published by Humana. This book was released on 2016-10-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on essential insight into the methods and techniques required to dissect the complex mechanisms of NF-κB activation, regulation, and function. NF-kappa B: Methods and Protocols guides readers through standard approaches to detect NF-κB pathway activation, detection and analysis of NF-κB signaling, and methods to study the control of NF-κB signaling. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, NF-Kappa B: Methods and Protocols provides a timely and invaluable resource for researchers seeking to perform experiments aimed at understanding the role of NF-κB signaling in health and disease.

Myeloma Bone Disease

Author : G. David Roodman
Publisher : Springer Science & Business Media
ISBN 13 : 1607615541
Total Pages : 257 pages
Book Rating : 4.6/5 (76 download)

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Book Synopsis Myeloma Bone Disease by : G. David Roodman

Download or read book Myeloma Bone Disease written by G. David Roodman and published by Springer Science & Business Media. This book was released on 2010-04-28 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the forefront in the science and clinical management of myeloma bone disease. Coverage begins with sections on clinical presentation, imaging, and biochemical markers and goes on to discuss radiation, surgical, and medical therapies.

Innovative Medicine

Author : Kazuwa Nakao
Publisher : Springer
ISBN 13 : 4431556516
Total Pages : 330 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Innovative Medicine by : Kazuwa Nakao

Download or read book Innovative Medicine written by Kazuwa Nakao and published by Springer. This book was released on 2015-10-13 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Proteasome Inhibitors in Cancer Therapy

Author : Julian Adams
Publisher : Springer Science & Business Media
ISBN 13 : 1592597947
Total Pages : 319 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Proteasome Inhibitors in Cancer Therapy by : Julian Adams

Download or read book Proteasome Inhibitors in Cancer Therapy written by Julian Adams and published by Springer Science & Business Media. This book was released on 2004-05-25 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: A panel of leading academic and pharmaceutical investigators takes stock of the remarkable work that has been accomplished to date with proteasome inhibitors in cancer, and examines emerging therapeutic possibilities. The topics range from a discussion of the chemistry and cell biology of the proteasome and the rationale for proteasome inhibitors in cancer to a review of current clinical trials underway. The discussion of rationales for testing proteasome inhibitors in cancer models covers the role of the proteasome in NF-kB activation, the combining of conventional chemotherapy and radiation with proteasome inhibition, notably PS-341, new proteasome methods of inhibiting viral maturation, and the role of protesome inhibition in the treatment of AIDS. The authors also document the development of bortezomib (VelcadeTM) in Phase I clinical trials and in a multicentered Phase II clinical trials in patients with relapsed and refractory myeloma.

Structural Immunology

Author : Tengchuan Jin
Publisher : Springer Nature
ISBN 13 : 9811393672
Total Pages : 226 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Structural Immunology by : Tengchuan Jin

Download or read book Structural Immunology written by Tengchuan Jin and published by Springer Nature. This book was released on 2019-10-18 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a comprehensive overview of important immune molecules and their structure-function relationships. The immune system is highly complex, consisting of a network of molecules, cells, tissues and organs, and the immune reaction is involved in various physiological as well as pathological processes, including development, self-tolerance, infection, immunity, and cancer. Numerous molecules participate in immune recognition, inhibition and activation, and these important immune molecules can be roughly divided into cell surface receptors, intracellular receptors and intracellular signaling molecules. The study of how these immune molecules function at molecular level has laid the foundation for understanding the immune system. The book provides researchers and students with the latest research advances concerning the structural biology of key immune molecules/pathways, and offers immunologists essential insights into how these immune molecules function.

Muscle Atrophy

Author : Junjie Xiao
Publisher : Springer
ISBN 13 : 9811314357
Total Pages : 618 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Muscle Atrophy by : Junjie Xiao

Download or read book Muscle Atrophy written by Junjie Xiao and published by Springer. This book was released on 2018-11-02 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book addresses the development of muscle atrophy, which can be caused by denervation, disuse, excessive fasting, aging, and a variety of diseases including heart failure, chronic kidney diseases and cancers. Muscle atrophy reduces quality of life and increases morbidity and mortality worldwide. The book is divided into five parts, the first of which describes the general aspects of muscle atrophy including its characteristics, related economic and health burdens, and the current clinical therapy. Secondly, basic aspects of muscle atrophy including the composition, structure and function of skeletal muscle, muscle changes in response to atrophy, and experimental models are summarized. Thirdly, the book reviews the molecular mechanisms of muscle atrophy, including protein degradation and synthesis pathways, noncoding RNAs, inflammatory signaling, oxidative stress, mitochondria signaling, etc. Fourthly, it highlights the pathophysiological mechanisms of muscle atrophy in aging and disease. The book’s fifth and final part covers the diagnosis, treatment strategies, promising agents and future prospects of muscle atrophy. The book will appeal to a broad readership including scientists, undergraduate and graduate students in medicine and cell biology.

NF-kB in Health and Disease

Author : Michael Karin
Publisher : Springer Science & Business Media
ISBN 13 : 3642160174
Total Pages : 273 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis NF-kB in Health and Disease by : Michael Karin

Download or read book NF-kB in Health and Disease written by Michael Karin and published by Springer Science & Business Media. This book was released on 2011-04-26 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nearly 25 years of intensive research have uncovered many diverse functions for the dimeric transcription factor known as NF-kappaB (nuclear factor-kappaB). NF-kappaB affects most aspects of cellular physiology—from immunity and inflammation to apoptosis, cell survival, growth, and proliferation

Role of Oxidative Stress in Pathophysiology of Diseases

Author : Pawan K. Maurya
Publisher : Springer Nature
ISBN 13 : 9811515689
Total Pages : 297 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Role of Oxidative Stress in Pathophysiology of Diseases by : Pawan K. Maurya

Download or read book Role of Oxidative Stress in Pathophysiology of Diseases written by Pawan K. Maurya and published by Springer Nature. This book was released on 2020-06-15 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the importance and significance of oxidative stress in the pathophysiology of various human diseases. The book initially introduces the phenomenon of oxidative stress, basic chemical characteristics of the species involved and summarizes the cellular oxidant and anti-oxidant system and the cellular effects and metabolism of the oxidative stress. In addition, it reviews the current understanding of the potential impact of oxidative stress on telomere shortening, aging, and age-related diseases. It also examines the role of oxidative stress in chronic diseases, including cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders. Further, the book presents novel technologies for the detection of oxidative stress biomarkers using nanostructure biosensors, as well as in vitro and in vivo models to monitor oxidative stress. Lastly, the book addresses the drug delivery carriers that can help in combating oxidative stress.

Zinc Enzyme Inhibitors

Author : Claudiu T. Supuran
Publisher : Springer
ISBN 13 : 3319461125
Total Pages : 163 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Zinc Enzyme Inhibitors by : Claudiu T. Supuran

Download or read book Zinc Enzyme Inhibitors written by Claudiu T. Supuran and published by Springer. This book was released on 2016-11-04 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

The Immune Response

Author : Tak W. Mak
Publisher : Academic Press
ISBN 13 : 0080534481
Total Pages : 1217 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Immune Response by : Tak W. Mak

Download or read book The Immune Response written by Tak W. Mak and published by Academic Press. This book was released on 2005-11-11 with total page 1217 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Immune Response is a unique reference work covering the basic and clinical principles of immunology in a modern and comprehensive fashion. Written in an engaging conversational style, the book conveys the broad scope and fascinating appeal of immunology. The book is beautifully illustrated with superb figures as well as many full color plates. This extraordinary work will be an invaluable resource for lecturers and graduate students in immunology, as well as a vital reference for research scientists and clinicians studying related areas in the life and medical sciences. Current and thorough 30 chapter reference reviewed by luminaries in the field Unique ‘single voice' ensures consistency of definitions and concepts Comprehensive and elegant illustrations bring key concepts to life Provides historical context to allow fuller understanding of key issues Introductory chapters 1-4 serve as an ‘Immunology Primer' before topics are discussed in more detail

NF-KB , a Network Hub Controlling Immunity, Inflammation, and Cancer

Author : Michael Karin
Publisher :
ISBN 13 : 9781936113552
Total Pages : 0 pages
Book Rating : 4.1/5 (135 download)

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Book Synopsis NF-KB , a Network Hub Controlling Immunity, Inflammation, and Cancer by : Michael Karin

Download or read book NF-KB , a Network Hub Controlling Immunity, Inflammation, and Cancer written by Michael Karin and published by . This book was released on 2011-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: NF-kB is a critical signaling molecule in the immune system that regulates cell survival and cell death, lymphocyte responses, and inflammation. Acting as a transcription factor that can receive several inputs, it coordinates distinct gene expression programs in response to a wide variety of stimuli. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology includes contributions covering the structure of NF-kB, its DNA-binding activity and specificity, the role of the inhibitor I-kB, and canonical and alternative mechanisms of NF-kB activation. The contributors examine the physiological role of NF-kB in immune cells, as well as its functions in other tissues, such as the nervous system. They also discuss work indicating that NF-kB represents a critical link between inflammation and cancer. Including clinical perspectives on the use of NF-kB inhibitors in cancer therapy and a historical introduction by David Baltimore, in whose lab NF-kB was discovered, this volume is a vital reference for cell and molecular biologists, immunologists, and pathologists interested in regulation of cell function.

The Link Between Inflammation and Cancer

Author : Angus G. Dalgleish
Publisher : Springer Science & Business Media
ISBN 13 : 0387262830
Total Pages : 260 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis The Link Between Inflammation and Cancer by : Angus G. Dalgleish

Download or read book The Link Between Inflammation and Cancer written by Angus G. Dalgleish and published by Springer Science & Business Media. This book was released on 2006-03-05 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: A link between inflammation and cancer has been established many years ago, yet it is only recently that the potential significance of this connection has become apparent. Although several examples of chronic inflammatory conditions, often induced by persistent irritation and/or infection, developing into cancer have been known for some time, there has been a notable resistance to contemplate the possibility that this association may apply in a causative way to other cancers. Examples for such progression from chronic inflammation to cancer are colon carcinoma developing with increased frequency in patients with ulcerative colitis, and the increased incidence of bladder cancer in patients suffering from chronic Schistosoma infection. Inflammation and cancer have been recognized to be linked in another context for many years, i.e., with regards to pathologies resembling chronic lacerations or 'wounds that do not heal.' More recently, the immunology of wound healing has given us clues as to the mechanistic link between inflammation and cancer, in as much as wounds and chronic inflammation turn off local cell-mediated immune responses and switch on growth factor release as well the growth of new blood vessels - angiogenesis. Both of these are features of most types of tumours, which suggest that tumours may require an immunologically shielded milieu and a growth factor-rich environment.

Trends in Stem Cell Proliferation and Cancer Research

Author : Rodrigo R. Resende
Publisher : Springer Science & Business Media
ISBN 13 : 9400762119
Total Pages : 663 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Trends in Stem Cell Proliferation and Cancer Research by : Rodrigo R. Resende

Download or read book Trends in Stem Cell Proliferation and Cancer Research written by Rodrigo R. Resende and published by Springer Science & Business Media. This book was released on 2013-08-13 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book will discuss the molecular mechanisms of cancer diseases, stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell biology. Some of the key oncogenic events in cancer and their signaling pathways that regulate cell division cycle progression will be described considering prospects for using such knowledge in advanced cancer therapy. Each chapter shall provide an invaluable resource for information on the most current advances in the field, with discussion of controversial issues and areas of emerging importance

Molecular Targeting and Signal Transduction

Author : Rakesh Kumar
Publisher : Springer Science & Business Media
ISBN 13 : 1402078226
Total Pages : 331 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Molecular Targeting and Signal Transduction by : Rakesh Kumar

Download or read book Molecular Targeting and Signal Transduction written by Rakesh Kumar and published by Springer Science & Business Media. This book was released on 2004-04-30 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our limited understanding of cellular regulatory signal-transduction-networks has been a barrier to progress in improving the overall cure-rate of human cancers. Delineation of the physiologic roles of the specific regulatory signaling components, with known association with metastatic phenotypes, is a highly promising area which will likely provide the next generation of targeted strategies in the future of molecular cancer medicine. These signaling components are likely to be used in diagnosis, prognosis, and as novel targets for therapeutic development. This book brings together up-to-date summaries by leading cancer researchers on the major principles of cancer cell biology: survival, apoptosis, adhesion, and cell cycle deregulation. It is directed at clinicians and scientists working in the areas of experimental and molecular therapeutics, molecular medicine, translational cancer research, and bio-medical sciences in general.

The Impact of Food Bioactives on Health

Author : Kitty Verhoeckx
Publisher : Springer
ISBN 13 : 3319161040
Total Pages : 341 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis The Impact of Food Bioactives on Health by : Kitty Verhoeckx

Download or read book The Impact of Food Bioactives on Health written by Kitty Verhoeckx and published by Springer. This book was released on 2015-04-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Infogest” (Improving Health Properties of Food by Sharing our Knowledge on the Digestive Process) is an EU COST action/network in the domain of Food and Agriculture that will last for 4 years from April 4, 2011. Infogest aims at building an open international network of institutes undertaking multidisciplinary basic research on food digestion gathering scientists from different origins (food scientists, gut physiologists, nutritionists...). The network gathers 70 partners from academia, corresponding to a total of 29 countries. The three main scientific goals are: Identify the beneficial food components released in the gut during digestion; Support the effect of beneficial food components on human health; Promote harmonization of currently used digestion models Infogest meetings highlighted the need for a publication that would provide researchers with an insight into the advantages and disadvantages associated with the use of respective in vitro and ex vivo assays to evaluate the effects of foods and food bioactives on health. Such assays are particularly important in situations where a large number of foods/bioactives need to be screened rapidly and in a cost effective manner in order to ultimately identify lead foods/bioactives that can be the subject of in vivo assays. The book is an asset to researchers wishing to study the health benefits of their foods and food bioactives of interest and highlights which in vitro/ex vivo assays are of greatest relevance to their goals, what sort of outputs/data can be generated and, as noted above, highlight the strengths and weaknesses of the various assays. It is also an important resource for undergraduate students in the ‘food and health’ arena.

Handbook of Transcription Factor NF-kappaB

Author : Sankar Ghosh
Publisher : CRC Press
ISBN 13 : 1420004271
Total Pages : 246 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Handbook of Transcription Factor NF-kappaB by : Sankar Ghosh

Download or read book Handbook of Transcription Factor NF-kappaB written by Sankar Ghosh and published by CRC Press. This book was released on 2006-10-20 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent evidence proving the molecular link between unchecked, chronic inflammation and cancer has implicated the transcription factor NF-kB as a key factor in both inhibiting apoptosis and promoting cell proliferation. Since its initial identification 20 years ago as a simple regulating factor in one small part of the immune response, NF-kB is prov