New Therapies In Advanced Cutaneous Malignancies

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New Therapies in Advanced Cutaneous Malignancies

Author : Piotr Rutkowski
Publisher : Springer Nature
ISBN 13 : 3030640094
Total Pages : 457 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis New Therapies in Advanced Cutaneous Malignancies by : Piotr Rutkowski

Download or read book New Therapies in Advanced Cutaneous Malignancies written by Piotr Rutkowski and published by Springer Nature. This book was released on 2021-02-17 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a detailed overview of the activity and efficacy of new treatments and promising perspectives in the field of cutaneous malignancies. The first part of the book covers the basic molecular and immunological mechanisms. It then goes on to cover specific strategies in melanoma and non-melanoma skin cancers that, starting from the basic mechanisms, translate this information into clinical routine or translational research. This unique handbook comprises very practical structured descriptions of more than 10 new agents used in treatment of melanomas and skin carcinomas together with biological background of their mechanisms of action. It provides structured and up-to-date information about all therapeutics in cutaneous malignancies, making it extremely useful in clinical practice, for clinicians that need timely and focused information. Prepared by a group of international authors from expert melanoma centres in Europe, the book provides knowledge distilled from the diverse perspectives of the contributing authors (pathologists, translational scientists and clinicians). This book is of interest to medical oncologists, oncological surgeons, dermatologists and immunologists as well as biologists and pharmacologists.

New Therapies and Immunological Findings in Melanoma and Other Skin Cancers

Author : Atsushi Otsuka
Publisher : Frontiers Media SA
ISBN 13 : 2889457125
Total Pages : 137 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis New Therapies and Immunological Findings in Melanoma and Other Skin Cancers by : Atsushi Otsuka

Download or read book New Therapies and Immunological Findings in Melanoma and Other Skin Cancers written by Atsushi Otsuka and published by Frontiers Media SA. This book was released on 2019-01-15 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: New therapies are currently being developed in the field of skin cancer. In particular, advances in melanoma now represent the frontline of cancer immunotherapy, as immunological findings in the disease have led to the development of highly effective immune-checkpoint inhibitors. However, these immune-checkpoint inhibitors are only effective in a subset of patients, and may not work in other skin cancer types, thus highlighting the need for further innovation in the field of skin cancer treatment. The purpose of this Research Topic is therefore to provide an up-to-date overview of immune processes and new therapies for melanoma and other skin cancers in order to further stimulate the development of new and even more successful treatments.

Advanced Skin Cancer

Author : Debjani Sahni
Publisher : CRC Press
ISBN 13 : 0429648987
Total Pages : 290 pages
Book Rating : 4.4/5 (296 download)

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Book Synopsis Advanced Skin Cancer by : Debjani Sahni

Download or read book Advanced Skin Cancer written by Debjani Sahni and published by CRC Press. This book was released on 2022-04-28 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced skin cancer is one that has already metastasized beyond its primary origin, or one that has invaded underlying tissues such that surgical resection either is technically impossible or would lead to an unacceptable functional or cosmetic outcome. These skin cancers present a complex problem that requires the input of multiple specialties to delineate the best management plan. National guidelines utilize the best available data to guide management decisions. However, there is considerable leeway within the guidelines, enabling the ultimate care decision to be molded to best fit each individual patient. This book aims to provide instructional examples of patient cases where the input of the multidisciplinary team is critical in providing the most suitable care plan for the patient. CONTENTS: Melanoma * Squamous Cell Carcinoma * Basal Cell Carcinoma * Cutaneous Lymphoma * Kaposi’s Sarcoma * Dermatofibrosarcoma Protuberans * Merkel Cell Carcinoma * Rare Cancer Presentations

Skin Cancer

Author : Oby Dulla
Publisher : Independently Published
ISBN 13 : 9781731503817
Total Pages : 44 pages
Book Rating : 4.5/5 (38 download)

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Book Synopsis Skin Cancer by : Oby Dulla

Download or read book Skin Cancer written by Oby Dulla and published by Independently Published. This book was released on 2018-11-18 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt: Skin cancers are by far the most common malignancy of humans, particularly in the white population. The growing incidence of cutaneous malignancies has heralded the need for multiple treatment options. Although surgical modalities remain the mainstay of treatment, new research and fresh innovation are still required to reduce morbidity and mortality. Approaches for skin cancer may pass through new technological methods instead of new molecules. The first part of this paper provides a review of the state of the art regarding skin cancer disease as well as epidemiology data. Then, it describes the gold standards of the current recommended therapies worldwide and the actual needs of these patients. This is the first book that highlights the novel and future therapeutic perspectives for the treatment of skin malignancies, new therapeutic agents and promising technological approaches, from nanotechnology to immunotherapy.

Managing Skin Cancer

Author : Eggert Stockfleth
Publisher : Springer Science & Business Media
ISBN 13 : 354079347X
Total Pages : 232 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Managing Skin Cancer by : Eggert Stockfleth

Download or read book Managing Skin Cancer written by Eggert Stockfleth and published by Springer Science & Business Media. This book was released on 2010-02-26 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Skin cancer is the most common malignant neoplasm and its incidence is rising worldwide. The epidemic increase in such tumors calls for efficient management by the application of appropriate guidelines for therapy and prevention. Clinicians managing these patients need to keep up to date with the latest advances, allowing them to provide optimal treatment. This practical guide offers the reader a comprehensive overview of the options for the diagnosis, treatment, and prevention of cutaneous cancer. It covers all common skin cancers and also rarer lesions. Employing an "evidence-based medicine" approach, this truly international work presents a well-illustrated text in a reader-friendly format with step-by-step guidelines and visual flowcharts. Dermatologists, oncologists, and all other interested physicians will find this book an extraordinarily valuable resource for the clinical management of cutaneous cancer in their daily practice.

Cutaneous Melanoma

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (112 download)

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Book Synopsis Cutaneous Melanoma by :

Download or read book Cutaneous Melanoma written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Immune Checkpoint Inhibition Therapy for Advanced Skin Cancer in Patients with Concomitant Hematological Malignancy: a Retrospective Multicenter DeCOG Study of 84 Patients

Download Immune Checkpoint Inhibition Therapy for Advanced Skin Cancer in Patients with Concomitant Hematological Malignancy: a Retrospective Multicenter DeCOG Study of 84 Patients PDF Online Free

Author : Ulrike Leiter-Stöppke
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (123 download)

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Book Synopsis Immune Checkpoint Inhibition Therapy for Advanced Skin Cancer in Patients with Concomitant Hematological Malignancy: a Retrospective Multicenter DeCOG Study of 84 Patients by : Ulrike Leiter-Stöppke

Download or read book Immune Checkpoint Inhibition Therapy for Advanced Skin Cancer in Patients with Concomitant Hematological Malignancy: a Retrospective Multicenter DeCOG Study of 84 Patients written by Ulrike Leiter-Stöppke and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Background Skin cancers are known for their strong immunogenicity, which may contribute to a high treatment efficacy of immune checkpoint inhibition (ICI). However, a considerable proportion of patients with skin cancer is immuno-compromised by concomitant diseases. Due to their previous exclusion from clinical trials, the ICI treatment efficacy is poorly investigated in these patients. The present study analyzed the ICI treatment outcome in advanced patients with skin cancer with a concomitant hematological malignancy. Methods This retrospective multicenter study included patients who were treated with ICI for locally advanced or metastatic melanoma (MM), cutaneous squamous cell carcinoma (cSCC), or Merkel cell carcinoma (MCC), and had a previous diagnosis of a hematological malignancy irrespective of disease activity or need of therapy at ICI treatment start. Comparator patient cohorts without concomitant hematological malignancy were extracted from the prospective multicenter skin cancer registry ADOREG. Treatment outcome was measured as best overall response, progression-free (PFS), and overall survival (OS). Results 84 patients (MM, n=52; cSCC, n=15; MCC, n=17) with concomitant hematological malignancy were identified at 20 skin cancer centers. The most frequent concomitant hematological malignancies were non-Hodgkin's lymphoma (n=70), with chronic lymphocytic leukemia (n=32) being the largest entity. While 9 patients received ICI in an adjuvant setting, 75 patients were treated for advanced non-resectable disease (55 anti-PD-1; 8 anti-PD-L1; 5 anti-CTLA-4; 7 combinations). In the latter 75 patients, best objective response (complete response+partial response) was 28.0%, disease stabilization was 25.3%, and 38.6% showed progressive disease (PD). Subdivided by skin cancer entity, best objective response was 31.1% (MM), 26.7% (cSCC), and 18.8% (MCC). Median PFS was 8.4 months (MM), 4.0 months (cSCC), and 5.7 months (MCC). 1-year OS rates were 78.4% (MM), 65.8% (cSCC), and 47.4% (MCC). Comparison with respective ADOREG patient cohorts without hematological malignancy (n=392) revealed no relevant differences in ICI therapy outcome for MM and MCC, but a significantly reduced PFS for cSCC (p=0.002). Conclusions ICI therapy showed efficacy in advanced patients with skin cancer with a concomitant hematological malignancy. Compared with patients without hematological malignancy, the observed ICI therapy outcome was impaired in cSCC, but not in MM or MCC patients

Skin Cancer - A World-Wide Perspective

Author : Reinhard Dummer
Publisher : Springer
ISBN 13 : 9783662518557
Total Pages : 398 pages
Book Rating : 4.5/5 (185 download)

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Book Synopsis Skin Cancer - A World-Wide Perspective by : Reinhard Dummer

Download or read book Skin Cancer - A World-Wide Perspective written by Reinhard Dummer and published by Springer. This book was released on 2016-08-23 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decades the incidence of skin cancers is dramatically increasing world-wide. This is not only confined to the incidence of melanoma but includes also other skin cancers such as basal cell carcinomas. Based on the recent WHO classification of skin cancers, this lavishly illustrated reference book covers comprehensively the epidemiology, histology and pathology, as well as diagnostic signs and treatment options of skin cancers. Homogenously and reader-friendly structured, it links the diagnostic and genetic features of each disease in order to guide the reader to the most appropriate therapeutic strategies for the best possible treatment outcome. In order to demonstrate the world wide activities in the field, all chapters cover the variations of the individual experiences and expertise in different nations.

The Intersection of Dermatology and Oncology, An Issue of Dermatologic Clinics

Author : Lindsay C. Strowd
Publisher : Elsevier Health Sciences
ISBN 13 : 0323708951
Total Pages : pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis The Intersection of Dermatology and Oncology, An Issue of Dermatologic Clinics by : Lindsay C. Strowd

Download or read book The Intersection of Dermatology and Oncology, An Issue of Dermatologic Clinics written by Lindsay C. Strowd and published by Elsevier Health Sciences. This book was released on 2019-09-03 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Dermatologic Clinics, guest edited by Dr. Lindsay C. Strowd of Wake Forest Baptist Health, is devoted to the Intersection of Dermatology and Oncology. This issue focuses on Melanoma, Nonmelanoma Skin Cancer, Cutaneous Lymphoma, Other Cutaneous Malignancies, Special Topics in Skin Cancer Diagnosis and Treatment, Dermatology in the Diagnosis of Non-cutaneous Malignancy, Dermatology in the Management of Non-cutaneous Malignancy, and Genodermatoses with Neoplastic Behavior. Articles in this issue include: Update on current treatment recommendations for primary cutaneous melanoma; Nonsurgical treatments for advanced melanoma; Update on current treatment recommendations for NMSC; Nonsurgical treatments for NMSC; Diagnosis and management of CBCL; Diagnosis and management of CTCL; Lymphomatoid papulosis and other lymphoma-like diseases (PLC, PLEVA, CD30+ disease); Dermatofibrosarcoma protuberans updates; Merkel cell carcinoma updates; Kaposi sarcoma updates; Skin cancer in skin of color patients; Skin cancer detection technology; Paraneoplastic diseases; Cutaneous metastases of internal tumors; Cutaneous side effects of chemotherapy agents; GVHD treatment updates; Phakomatoses (NF, TS); and Hereditary tumor syndromes with skin involvement (Gorlins, Lynch, XP, etc.).

Human Skin Cancers

Author : Miroslav Blumenberg
Publisher : BoD – Books on Demand
ISBN 13 : 1789230942
Total Pages : 214 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Human Skin Cancers by : Miroslav Blumenberg

Download or read book Human Skin Cancers written by Miroslav Blumenberg and published by BoD – Books on Demand. This book was released on 2018-05-02 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human skin cancers, the most common type of tumors, represent a significant health burden. The deadliest is unquestionably melanoma. Half of melanomas have an activating mutation in the BRAF gene, prompting development of novel drugs, vemurafenib and dabrafenib, specifically targeting mutated BRAF. Trametinib and cobimetinib, which block MEK, a BRAF effector protein, have been used in combination with BRAF inhibitors. A promising new melanoma treatment is immunotherapy, approach that boosts patient's own immune system to attack cancer. Pembrolizumab and nivolumab inhibit PD-1, whereas Ipilimumab targets CTLA-4, another immunity check point, to boost the immune response. Here we focus on pathways, mechanisms, targets and treatments of human skin cancers, with particular emphasis on the new developments in the research on melanomas.

Mohs Micrographic Surgery

Author : Stephen N. Snow
Publisher : Univ of Wisconsin Press
ISBN 13 : 9780299204709
Total Pages : 464 pages
Book Rating : 4.2/5 (47 download)

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Book Synopsis Mohs Micrographic Surgery by : Stephen N. Snow

Download or read book Mohs Micrographic Surgery written by Stephen N. Snow and published by Univ of Wisconsin Press. This book was released on 2004 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mohs Micrographic Surgery, an advanced treatment procedure for skin cancer, offers the highest potential for recovery--even if the skin cancer has been previously treated. This procedure is a state-of-the-art treatment in which the physician serves as surgeon, pathologist, and reconstructive surgeon. It relies on the accuracy of a microscope to trace and ensure removal of skin cancer down to its roots. This procedure allows dermatologists trained in Mohs Surgery to see beyond the visible disease and to precisely identify and remove the entire tumor, leaving healthy tissue unharmed. This procedure is most often used in treating two of the most common forms of skin cancer: basal cell carcinoma and squamous cell carcinoma. The cure rate for Mohs Micrographic Surgery is the highest of all treatments for skin cancer--up to 99 percent even if other forms of treatment have failed. This procedure, the most exact and precise method of tumor removal, minimizes the chance of regrowth and lessens the potential for scarring or disfigurement

Cutaneous Oncology and Skin Cancer Genomics

Author : Bahar Dasgeb
Publisher : Frontiers Media SA
ISBN 13 : 283255332X
Total Pages : 146 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Cutaneous Oncology and Skin Cancer Genomics by : Bahar Dasgeb

Download or read book Cutaneous Oncology and Skin Cancer Genomics written by Bahar Dasgeb and published by Frontiers Media SA. This book was released on 2024-09-19 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic of Frontiers in Medicine is focused on the new diagnostic and therapeutic protocols in the field of skin (solid tumors and lymphoma) and soft tissue oncology with an emphasis on challenging, complex, and advanced clinical scenarios as follows; • patients presenting with numerous and or recurring skin and soft tissue malignancies. • immune deficiencies, including but not limited to organ transplant patients. • management of patients with adverse events due to underlying oncological treatments such as life-saving clinical trials or treatment protocols. • describing the cutaneous adverse events of emerging oncological treatment not yet reported in the literature. • germ-line or tumor mutations that are believed to play a role in the severity or complexity of the phenotype of the skin and soft tissue tumors • the role of oncoviruses in the development of cutaneous malignancies and using such understating and etiology towards immunization, therapeutic and preventive measures. This Research Topic in Frontiers in Medicine will also be a platform to present the new and emerging technologies applied to cutaneous and soft tissue oncology, such as: • radiation therapy • imaging technologies, • supervised or non-supervised computed algorithms and AI applied to the skin and soft tissue. • bio-photonics and optical technology applied to the skin and soft tissue Additionally, innovative molecular histopathology for diagnostic, risk stratifying, or therapeutic measures in the field of dermatopathology is within the scope of this Research Topic. Moreover, surgical approaches or a combination of surgical and non-surgical protocols with emphasis on the outcome, or the data analysis of surgical outcome that has is more comprehensive and preferably prospective compare to existing information in the literature. Investigator-initiated clinical trials and commentaries with a point of view towards prevention, early detection, or better risk stratification of patients at higher risk for skin malignancies compare to the general population are also of interest for this Research Topic on cutaneous oncology and skin cancer genomics. It is with deepest sorrow that we share with you the passing of our co-editor Professor Jouni Uitto, to whom we dedicate this collection.

Skin Cancers

Author : Caterina La Porta
Publisher : BoD – Books on Demand
ISBN 13 : 9533077220
Total Pages : 288 pages
Book Rating : 4.5/5 (33 download)

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Book Synopsis Skin Cancers by : Caterina La Porta

Download or read book Skin Cancers written by Caterina La Porta and published by BoD – Books on Demand. This book was released on 2011-11-14 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Skin cancers are the fastest growing type of cancer in the United States and represent the most commonly diagnosed malignancy, surpassing lung, breast, colorectal and prostate cancer. In Europe, the British Isles have been the highest rates of skin cancer in children and adolescents. The overall idea of this book is to provide the reader with up to date information on the possible tools to use for prevention, diagnosis and treatment of skin cancer. Three main issues are discussed: risk factors, new diagnostic tools for prevention and strategies for prevention and treatment of skin cancer using natural compounds or nano-particle drug delivery and photodynamic therapy.

Cancer of the Skin E-Book

Author : Darrell S. Rigel
Publisher : Elsevier Health Sciences
ISBN 13 : 1437736149
Total Pages : 713 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis Cancer of the Skin E-Book by : Darrell S. Rigel

Download or read book Cancer of the Skin E-Book written by Darrell S. Rigel and published by Elsevier Health Sciences. This book was released on 2011-05-25 with total page 713 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer of the Skin, edited by Drs. Rigel, Robinson, Ross, Friedman, Cockerell, Lim, Stockfleth, and Kirkwood, is your complete, multimedia guide to early diagnosis and effective medical and surgical treatment of melanoma and other skin cancers. Thoroughly updated with 11 new chapters, this broad-based, comprehensive reference provides you with the latest information on clinical genetics and genomics of skin cancer, targeted therapy for melanoma, the Vitamin D debate concerning the risks and benefits of sun exposure, and other timely topics. A new, multi-disciplinary team of contributors and editors comprised of leading experts in this field offers truly diverse perspectives and worldwide best practices. - Broaden your understanding of all aspects of skin cancer—from the underlying biology to clinical manifestations of the disease to diagnosis, and medical and surgical treatment—with this easy-to-use, comprehensive, multimedia reference. - See conditions as they appear in practice with guidance from detailed full-color images and step-by-step procedural videos. - Stay current with the latest advancements and therapies! 11 new chapters cover clinical genetics and genomics of skin cancer, targeted therapy for melanoma, the Vitamin D debate concerning the risks and benefits of sun exposure, and other essential topics. - Get truly diverse perspectives and worldwide best practices from a new, multi-disciplinary team of contributors and editors comprised of the world's leading experts Access the complete text online—including image bank and video library—at www.expertconsult.com

Managing Skin Cancer

Author : Eggert Stockfleth
Publisher : Springer
ISBN 13 : 9783540872160
Total Pages : 226 pages
Book Rating : 4.8/5 (721 download)

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Book Synopsis Managing Skin Cancer by : Eggert Stockfleth

Download or read book Managing Skin Cancer written by Eggert Stockfleth and published by Springer. This book was released on 2011-08-26 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Skin cancer is the most common malignant neoplasm and its incidence is rising worldwide. The epidemic increase in such tumors calls for efficient management by the application of appropriate guidelines for therapy and prevention. Clinicians managing these patients need to keep up to date with the latest advances, allowing them to provide optimal treatment. This practical guide offers the reader a comprehensive overview of the options for the diagnosis, treatment, and prevention of cutaneous cancer. It covers all common skin cancers and also rarer lesions. Employing an "evidence-based medicine" approach, this truly international work presents a well-illustrated text in a reader-friendly format with step-by-step guidelines and visual flowcharts. Dermatologists, oncologists, and all other interested physicians will find this book an extraordinarily valuable resource for the clinical management of cutaneous cancer in their daily practice.

New Therapies and Immunological Findings in Melanoma and Other Skin Cancers

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)

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Book Synopsis New Therapies and Immunological Findings in Melanoma and Other Skin Cancers by :

Download or read book New Therapies and Immunological Findings in Melanoma and Other Skin Cancers written by and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: New therapies are currently being developed in the field of skin cancer. In particular, advances in melanoma now represent the frontline of cancer immunotherapy, as immunological findings in the disease have led to the development of highly effective immune-checkpoint inhibitors. However, these immune-checkpoint inhibitors are only effective in a subset of patients, and may not work in other skin cancer types, thus highlighting the need for further innovation in the field of skin cancer treatment. The purpose of this Research Topic is therefore to provide an up-to-date overview of immune processes and new therapies for melanoma and other skin cancers in order to further stimulate the development of new and even more successful treatments.

Head and Neck Cutaneous Cancer, An Issue of Otolaryngologic Clinics of North America

Author : Cecelia E Schmalbach
Publisher : Elsevier Health Sciences
ISBN 13 : 0323813186
Total Pages : 229 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Head and Neck Cutaneous Cancer, An Issue of Otolaryngologic Clinics of North America by : Cecelia E Schmalbach

Download or read book Head and Neck Cutaneous Cancer, An Issue of Otolaryngologic Clinics of North America written by Cecelia E Schmalbach and published by Elsevier Health Sciences. This book was released on 2021-03-23 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Otolaryngologic Clinics, guest edited by Drs. Cecelia E. Schmalbach and Kelly M. Malloy, is dedicated to Head and Neck Cutaneous Cancer. This issue is one of six selected each year by the series Consulting Editor, Dr. Sujana S. Chandrasekhar. Cutaneous cancer rates are growing at epidemic proportions and consequently lead to a significant health care burden. This issue opens with an overview of the related biology, epidemiology, and preventative measures. A contemporary review of cutaneous cancer management will be provided to include the roles of sentinel node biopsy, surgery, radiation therapy, and systemic therapy. Cutaneous cancers impact the geriatric patient population, so ethical considerations and non-surgical management are emphasized.