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New Insights In Sepsis Pathogenesis And Renal Dysfunction Immune Mechanisms And Novel Management Strategies
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Book Synopsis New Insights in Sepsis Pathogenesis and Renal Dysfunction: Immune Mechanisms and Novel Management Strategies by : Alessandra Stasi
Download or read book New Insights in Sepsis Pathogenesis and Renal Dysfunction: Immune Mechanisms and Novel Management Strategies written by Alessandra Stasi and published by Frontiers Media SA. This book was released on 2023-04-03 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Community Series in New Insights in Sepsis Pathogenesis and Renal Dysfunction: Immune Mechanisms and Novel Management Strategies, volume II by : Alessandra Stasi
Download or read book Community Series in New Insights in Sepsis Pathogenesis and Renal Dysfunction: Immune Mechanisms and Novel Management Strategies, volume II written by Alessandra Stasi and published by Frontiers Media SA. This book was released on 2023-11-17 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic is the second volume of the “New Insights in Sepsis Pathogenesis and Renal Dysfunction: Immune Mechanisms and Novel Management Strategies” Community Series. Please see the first volume here. Sepsis is a systemic inflammatory response to an active infectious process in the host; the symptoms are mainly produced by host defense systems rather than by the invading pathogens, involving pro-inflammatory and anti-inflammatory processes. The association of Acute Kidney Injury (AKI) and sepsis ranges from 45% to 70% of cases, with a significantly increased risk of death, progression toward chronic kidney disease and increased health resource utilization. Despite relevant therapeutic advances, sepsis-related AKI remains associated with an unacceptably high morbidity/mortality risk, increased health resource utilization, as well as - in survivors - with increased risk of transition to chronic kidney disease. Currently there are no approved treatments for sepsis-related AKI. The main objective of this research topic is to shed new light on sepsis pathogenesis and provide new potential therapeutic strategies to prevent the progression to AKI.
Book Synopsis Controversies in Acute Kidney Injury by : John A. Kellum
Download or read book Controversies in Acute Kidney Injury written by John A. Kellum and published by Karger Medical and Scientific Publishers. This book was released on 2011 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely update Acute kidney injury (AKI) is a serious and as yet incompletely understood disorder in which sudden impairment of kidney function occurs secondary to one or more of a variety of underlying conditions. This disorder is very common in (elderly) ICU patients and is associated with very high mortality. Many of those who survive suffer from permanent kidney failure and other long-term morbidities, which may include cardiovascular disease and immune dysfunction. Epidemiologic evidence suggests that AKI is not a single disease, but a syndrome comprised of multiple, often coexisting, etiologies. Being usually part of multiorgan failure syndrome, it calls for multiple organ support therapy. The publication at hand contains sections on prerenal azotemia syndromes, dying of' or with' AKI, pathophysiology of sepsis- induced acute kidney injury, developments in prevention / treatment / rehabilitation, and renal support. Reporting the latest recommendations from experts, it provides valuable information for those that are interested in understanding the disorder and its treatment options.
Book Synopsis Handbook of Sepsis by : W. Joost Wiersinga
Download or read book Handbook of Sepsis written by W. Joost Wiersinga and published by Springer. This book was released on 2018-04-13 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the intensive care unit. Readers will find information on the involvement of the coagulation and endocrine systems during sepsis and on the use of biomarkers to diagnose sepsis and allow early intervention. International clinical practice guidelines for the management of sepsis are presented, and individual chapters focus on aspects such as fluid resuscitation, vasopressor therapy, response to multiorgan failure, antimicrobial therapy, and adjunctive immunotherapy. The closing section looks forward to the coming decade, discussing novel trial designs, sepsis in low- and middle-income countries, and emerging management approaches. The book is internatio nal in scope, with contributions from leading experts worldwide. It will be of value to residents and professionals/practitioners in the fields of infectious diseases and internal medicine, as well as to GPs and medical students.
Book Synopsis Continuous Renal Replacement Therapy by : John A. Kellum
Download or read book Continuous Renal Replacement Therapy written by John A. Kellum and published by Oxford University Press. This book was released on 2016 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuous Renal Replacement Therapy (CRRT) is the standard of care for management of critically ill patients with acute renal failure. Part of the Pittsburgh Critical Care series, Continuous Renal Replacement Therapy provides concise, evidence-based, bedside guidance about this treatment modality, offering quick reference answers to clinicians' questions about treatments and situations encountered in daily practice. Organized into sections on theory, practice, special situations, and organizational issues, this volume provides a complete view of CRRT theory and practice. Tables summarize and highlight key points, and key studies and trials are included in each chapter. The second edition has been updated to include a new chapter on the use of biomarkers to aid in patient selection and timing, extensive revisions on terminology and nomenclature to match current standards, and the most up-to-date information on newly developed CRRT machines.
Book Synopsis Understanding Pathophysiology - E-Book by : Sue E. Huether
Download or read book Understanding Pathophysiology - E-Book written by Sue E. Huether and published by Elsevier Health Sciences. This book was released on 2015-12-23 with total page 1160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Master the important pathophysiology concepts you need to know with the most engaging and reader-friendly text available. Filled with vibrant illustrations and complemented by online resources that bring pathophysiology concepts to life, Understanding Pathophysiology, 6th Edition continues its tradition of delivering the most accurate information on treatments, manifestations, and mechanisms of disease across the lifespan, giving you the fundamental knowledge needed to move forward in your nursing education and career. New additions include a new chapter on epigenetics, new content on rare diseases, a separate chapter for male and female reproductive alterations, streamlined features, simplified language, and fully updated information throughout. Introduction to Pathophysiology in the front matter section provides intro to the subject of pathophysiology and explains why it is important. Consistent presentation helps readers better distinguish pathophysiology, clinical manifestations, and evaluation and treatment for each disease. More than 1,000 high-quality illustrations vividly depict clinical manifestations and cellular mechanisms underlying diseases. Lifespan coverage details age-specific conditions affecting pediatric, adult, and aging patients in depth. Algorithms throughout the text clarify disease progression. Risk Factor boxes alert readers to important safety considerations associated with specific diseases. Health Alert boxes highlight new developments in biologic research, diagnostic studies, preventive care, treatments, and more. Quick Check boxes test readers’ retention of important chapter concepts. Geriatric Considerations boxes and Pediatric Considerations boxes highlight key considerations for these demographics in relevant chapters. Did You Understand? sections provide a fast and efficient review of chapter content. Chapter outlines help readers find specific information with ease. Chapter introductions explain why chapter content is important and how it fits into a broader health care context. Key terms are bolded throughout the text for fast, easy reference. Glossary of selected terms familiarizes readers with the most difficult or important terminology. Additional online resources on Evolve companion website offers access to animations, review questions, key terms matching exercises, and more.
Download or read book Sepsis written by Nicholas S. Ward and published by Humana Press. This book was released on 2017-05-29 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed to provide a comprehensive and state-of-the-art resource for clinicians who care for patients with sepsis and research scientist alike, . Patients with severe sepsis requiring ICU admission have very high rates of ICU and overall hospital mortality, with estimates ranging from 18 to 50%. Risk factors for death from sepsis include underlying illness, increased age, and multi-system organ failure. This is compounded by the significant variation in the management of early severe sepsis. Care of these patients and clinical conditions can be quite complex, and materials are collected from the most current, evidence-based resources. Book sections have been structured to review the overall definitions and epidemiology of sepsis as well as current insights into the pathophysiology of sepsis. This review summarizes the evidence for the international consensus guidelines for the identification and management of sepsis. The latter part of this book reviews emerging concepts and approaches in the diagnosis and management of sepsis that may significantly reduce mortality in the future. Sepsis: Pathophysiology, Definitions and the Challenge of Bedside Management represents a collaboration between authors drawn from a variety of disciplines and contributions from basic scientists and highly recognized clinical opinion leaders with expertise in clinical trials.
Book Synopsis Oxford Textbook of Critical Care by : Webb
Download or read book Oxford Textbook of Critical Care written by Webb and published by Oxford University Press. This book was released on 2020-01-10 with total page 1961 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in paperback, the second edition of the Oxford Textbook of Critical Care is a comprehensive multi-disciplinary text covering all aspects of adult intensive care management. Uniquely this text takes a problem-orientated approach providing a key resource for daily clinical issues in the intensive care unit. The text is organized into short topics allowing readers to rapidly access authoritative information on specific clinical problems. Each topic refers to basic physiological principles and provides up-to-date treatment advice supported by references to the most vital literature. Where international differences exist in clinical practice, authors cover alternative views. Key messages summarise each topic in order to aid quick review and decision making. Edited and written by an international group of recognized experts from many disciplines, the second edition of the Oxford Textbook of Critical Careprovides an up-to-date reference that is relevant for intensive care units and emergency departments globally. This volume is the definitive text for all health care providers, including physicians, nurses, respiratory therapists, and other allied health professionals who take care of critically ill patients.
Author : Publisher :Harvard School of Public Health, Frangois-Xavier Bagnoud Cen ISBN 13 :9780674061484 Total Pages :95 pages Book Rating :4.0/5 (614 download)
Book Synopsis Health Professionals for a New Century by :
Download or read book Health Professionals for a New Century written by and published by Harvard School of Public Health, Frangois-Xavier Bagnoud Cen. This book was released on 2011 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: One hundred years ago a series of seminal documents, starting with the Flexner Report of 1910, sparked an enormous burst of energy to harness the power of science to transform higher education in health. Professional education, however, has not been able to keep pace with the challenges of the 21st century. A new generation of reforms is needed to meet the demands of health systems in an interdependent world. The report of the Commission on the Education of Health Professionals for the 21st Century, a global independent initiative consisting of 20 leaders from diverse disciplinary backgrounds and institutional affiliations, articulates a fresh vision and recommends renewed actions. Building on a rich legacy of educational reforms during the past century, the Commission's findings and recommendations adopt a global and multi-professional perspective using a systems approach to analyze education and health, with a focus on institutional and instructional reforms.
Book Synopsis Mechanisms of Vascular Disease by : Robert Fitridge
Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Book Synopsis Sepsis and Organ Dysfunction by : A.E. Baue
Download or read book Sepsis and Organ Dysfunction written by A.E. Baue and published by Springer. This book was released on 2000 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: An experienced physician knows how to recognize a patient suffering from sepsis, but cannot accurately determine whether the patient will survive. Cardinal elements of the treatment for sepsis include specific antibiotic and vasoactive drugs, enteral and parenteral nutrition, artificial respiration, and optimization of the oxygen transport to tissues. Nonetheless, with a certain frequency, these techniques are insufficient to ensure the recovery of a critically ill patient, especially when it is necessary to overcome functional alterations subsequent to organ and vital-system overload. The key elements in the progression of the sepsis-MODS syndrome are tied to numerous factors. These include: the severity and location of the lesion; the patient's age; the remaining functional reserve; the presence of mediatory which may be stimulatory, inhibitory or both.
Download or read book Podocytopathy written by Z.-H. Liui and published by Karger Medical and Scientific Publishers. This book was released on 2014-05-16 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The podocyte is a key cell that forms the last barrier of the kidney filtration unit. One of the most exciting developments in the field of nephrology in the last decade has been the elucidation of its biology and its role in the pathophysiology of inherited and acquired glomerular disease, termed podocytopathy. In this publication, world-renowned experts summarize the most recent findings and advances in the field: they describe the unique biological features and injury mechanisms of the podocyte, novel techniques used in their study, and diagnosis and potential therapeutic approaches to glomerular diseases. Due to its broad scope, this publication is of great value not only for clinical nephrologists and researchers, but also for students, residents, fellows, and postdocs.
Book Synopsis Infections and Sepsis Development by : Vincenzo Neri
Download or read book Infections and Sepsis Development written by Vincenzo Neri and published by BoD – Books on Demand. This book was released on 2021-10-27 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infection is a common clinical condition that may cause local inflammation but, in some cases, can lead to systemic inflammation, with sepsis and organ dysfunction. Septic shock is a condition of inadequate tissue perfusion and cellular use of oxygen due to the cytotoxic action of bacterial toxins. There is no relationship between the pathological characteristics and the severity of the primary septic outbreak and the development of septic shock, and the time that elapses until the start of the shock is not predictable. Thus, knowledge of the pathophysiology of septic shock is fundamental for treatment. This book presents a comprehensive overview of infectious agents and their therapeutic control, pathological conditions with infective etiology such as diabetic foot osteomyelitis and infections in neurosurgery, and the pathophysiology, diagnosis, and management of sepsis.
Download or read book Endourology written by Culley C. Carson and published by . This book was released on 1985 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Abdominal Sepsis by : Massimo Sartelli
Download or read book Abdominal Sepsis written by Massimo Sartelli and published by Springer. This book was released on 2018-03-20 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines in detail the topic of sepsis, with a focus on intra-abdominal sepsis. Particular attention is devoted to source control in the management of the infection, antimicrobial therapy and sepsis support, which represent the cornerstones of treating patients with this problem. The importance of a multidisciplinary approach is highlighted not only by the instructive and informative sections on the acute manifestations of appendicitis, cholecystitis, and cholangitis, perforations and diverticulitis, Clostridium difficile infection and the role of candida in abdominal sepsis, but also by an extensive discussion of issues including antimicrobial resistance, damage control surgery, principles of antimicrobial therapy, hemodynamic support, adjunctive therapies, and thromboprophylaxis. Abdominal sepsis is the host’s systemic inflammatory response to intra-abdominal infections. It is associated with significant morbidity and mortality rates, and represents the second most common cause of sepsis-related mortality at intensive care units. Gathering contributions by authoritative experts from all around the world, this book will allow acute care surgeons, abdominal surgeons, intensive care clinicians, and students to broaden their understanding of intra-abdominal sepsis in daily clinical practice.
Book Synopsis Clinical Trials for the Treatment of Sepsis by : W.J. Sibbald
Download or read book Clinical Trials for the Treatment of Sepsis written by W.J. Sibbald and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: The incidence of sepsis is increasing as new medical and surgical technologies are applied to an increasingly aging patient population. The treatment of sepsis emphasizes strategies to avoid multiple organ dysfunction, with particular attention to establishing source control, and then modifies the host's response to the excessive inflammatory response which characterizes sepsis. This book is a comprehensive review by internationally recognized experts of the epidemiology, monitoring and treatment of sepsis. Using an "evidence-based" approach, it comprises an extensive review of the literature on sepsis, provides up-to-date recommendations for monitoring and treating sepsis patients, and concludes with explicit recommendations for the design and monitoring of future clinical trials.
Book Synopsis Leptospirosis and the Kidney by : Chih-Wei Yang
Download or read book Leptospirosis and the Kidney written by Chih-Wei Yang and published by S. Karger AG (Switzerland). This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leptospirosis is the most common zoonotic disease worldwide, involving at least 1 million patients annually. Kidney is the preferential colonization site where Leptospira accumulates during systemic infection, primarily in the interstitium and in renal tubule epithelial cells. In acute kidney injury (AKI), the main histological findings are acute tubulo-interstitial nephritis and acute tubular necrosis, characterized by hypokalemia and non-oliguria. The injury caused by leptospira outer membrane protein components involves innate immunity Toll-like receptor pathways and activation of complement and immune cascades in the kidney, together with extracellular matrix accumulation when the kidney infection progress to chronic kidney disease (CKD). Significantly, recent studies indicate that leptospira may induce CKD in humans either with AKI-CKD continuum or subclinical leptospira infection leading to CKD. Leptospirosis kidney disease thus represents a newly discovered and previously overlooked area requiring intensive medical and public health attention and investigation. In this book, leading experts in the field contribute their cutting-edge clinical and research experiences for the understanding of leptospirosis kidney disease. The outstanding feature of this publication is emphasizing kidney injury and disease induced by leptospirosis, an underestimated infection involving multiple organs. The book contributes information on current knowledge of leptospirosis kidney disease and a new perspective for future research.
