New Discoveries On The Hydride Elimination

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New Discoveries on the β-Hydride Elimination

Author : Thomas M. Gøgsig
Publisher : Springer Science & Business Media
ISBN 13 : 3642320996
Total Pages : 133 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis New Discoveries on the β-Hydride Elimination by : Thomas M. Gøgsig

Download or read book New Discoveries on the β-Hydride Elimination written by Thomas M. Gøgsig and published by Springer Science & Business Media. This book was released on 2012-09-06 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: The work presented in Thomas M. Gøgsig's thesis deals with the discovery of new metal-catalyzed transformations ranging from Kumada-, Heck- and Suzuki-type reactions. The thesis starts with a formidable introduction to Pd-catalyzed cross-coupling reactions. New results have been obtained on: (i) Pd-catalyzed 1,2-migration reactions, (ii) Pd-catalyzed Heck reactions employing heteroaromatic tosylates, (iii) Ni-catalyzed Heck reactions, and (iv) Pd-catalyzed carbonylative Heck reaction. Metal-catalyzed cross-coupling reactions are today a highly competititve field (the 2010 Nobel Prize in Chemistry was awarded "for palladium-catalyzed cross couplings in organic synthesis", the 2001 and 2005 Nobel Prizes in closely related fields). Thomas M. Gøgsig obtained new results in his thesis that will help to improve the outcome of catalytic processes and improve their scope. The results will thus become key references for tomorrow's new applications. All chapters include insightful discussions and in-depth descriptions of the key principles of these new discoveries.

New Discoveries on the ?-Hydride Elimination

Author : Thomas M. Gøgsig
Publisher :
ISBN 13 :
Total Pages : 122 pages
Book Rating : 4.:/5 (16 download)

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Book Synopsis New Discoveries on the ?-Hydride Elimination by : Thomas M. Gøgsig

Download or read book New Discoveries on the ?-Hydride Elimination written by Thomas M. Gøgsig and published by . This book was released on 2012 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: The work presented in Thomas M. Gøgsig's thesis deals with the discovery of new metal-catalyzed transformations ranging from Kumada-, Heck- and Suzuki-type reactions. The thesis starts with a formidable introduction to Pd-catalyzed cross-coupling reactions. New results have been obtained on: (i) Pd-catalyzed 1,2-migration reactions, (ii) Pd-catalyzed Heck reactions employing heteroaromatic tosylates, (iii) Ni-catalyzed Heck reactions, and (iv) Pd-catalyzed carbonylative Heck reactions. Metal-catalyzed cross-coupling reactions are today a highly competititve field (the 2010 Nobel Prize in Chemistry was awarded "for palladium-catalyzed cross couplings in organic synthesis", the 2001 and 2005 Nobel Prizes in closely related fields). Thomas M. Gøgsig obtained new results in his thesis that will help to improve the outcome of catalytic processes and improve their scope. The results will thus become key references for tomorrow's new applications. All chapters include insightful discussions and in-depth descriptions of the key principles of these new discoveries.

New Discoveries on the β-Hydride Elimination

Author : Thomas M. Gogsig
Publisher : Springer
ISBN 13 : 9783642320989
Total Pages : 0 pages
Book Rating : 4.3/5 (29 download)

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Book Synopsis New Discoveries on the β-Hydride Elimination by : Thomas M. Gogsig

Download or read book New Discoveries on the β-Hydride Elimination written by Thomas M. Gogsig and published by Springer. This book was released on 2012-09-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The work presented in Thomas M. Gøgsig's thesis deals with the discovery of new metal-catalyzed transformations ranging from Kumada-, Heck- and Suzuki-type reactions. The thesis starts with a formidable introduction to Pd-catalyzed cross-coupling reactions. New results have been obtained on: (i) Pd-catalyzed 1,2-migration reactions, (ii) Pd-catalyzed Heck reactions employing heteroaromatic tosylates, (iii) Ni-catalyzed Heck reactions, and (iv) Pd-catalyzed carbonylative Heck reaction. Metal-catalyzed cross-coupling reactions are today a highly competititve field (the 2010 Nobel Prize in Chemistry was awarded "for palladium-catalyzed cross couplings in organic synthesis", the 2001 and 2005 Nobel Prizes in closely related fields). Thomas M. Gøgsig obtained new results in his thesis that will help to improve the outcome of catalytic processes and improve their scope. The results will thus become key references for tomorrow's new applications. All chapters include insightful discussions and in-depth descriptions of the key principles of these new discoveries.

New Discoveries on the -Hydride Elimination

Author : Thomas Meyer G Gsig
Publisher : Springer
ISBN 13 : 9783662522646
Total Pages : 142 pages
Book Rating : 4.5/5 (226 download)

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Book Synopsis New Discoveries on the -Hydride Elimination by : Thomas Meyer G Gsig

Download or read book New Discoveries on the -Hydride Elimination written by Thomas Meyer G Gsig and published by Springer. This book was released on 2016-05-01 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book details newly discovered metal-catalyzed transformations ranging from Kumada-, Heck- and Suzuki-type reactions. It describes the development of a number of significant transition metal-catalyzed reactions for the synthesis of organic compounds.

New Discoveries on the β-Hydride Elimination

Author : Thomas M. Gogsig
Publisher : Springer
ISBN 13 : 9783642320989
Total Pages : 0 pages
Book Rating : 4.3/5 (29 download)

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Book Synopsis New Discoveries on the β-Hydride Elimination by : Thomas M. Gogsig

New discoveries on the &-hydride elimination

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (777 download)

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Book Synopsis New discoveries on the &-hydride elimination by :

Download or read book New discoveries on the &-hydride elimination written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Synthetic Methods in Drug Discovery

Author : David C Blakemore
Publisher : Royal Society of Chemistry
ISBN 13 : 178262208X
Total Pages : 474 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Synthetic Methods in Drug Discovery by : David C Blakemore

Download or read book Synthetic Methods in Drug Discovery written by David C Blakemore and published by Royal Society of Chemistry. This book was released on 2016-07-15 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic Methods in Drug Discovery Volume 1 focusses on the hugely important area of transition metal mediated methods used in industry. Current methods of importance such as the Suzuki-Miyaura coupling, Buchwald-Hartwig couplings and CH activation are discussed. In addition, exciting emerging areas such as decarboxylative coupling, and the uses of iron and nickel in coupling reactions are also covered. This book provides both academic and industrial perspectives on some key reactions giving the reader an excellent overview of the techniques used in modern synthesis. Reaction types are conveniently framed in the context of their value to industry and the challenges and limitations of methodologies are discussed with relevant illustrative examples. Edited and authored by leading scientists from both academia and industry, this book will be a valuable reference for all chemists involved in drug discovery as well as postgraduate students in medicinal chemistry.

Gold-Catalyzed Cycloisomerization Reactions Through Activation of Alkynes

Author : Antoine Simonneau
Publisher : Springer
ISBN 13 : 3319067079
Total Pages : 261 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Gold-Catalyzed Cycloisomerization Reactions Through Activation of Alkynes by : Antoine Simonneau

Download or read book Gold-Catalyzed Cycloisomerization Reactions Through Activation of Alkynes written by Antoine Simonneau and published by Springer. This book was released on 2014-05-21 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antoine Simonneau's thesis highlights the development of new cycloisomerization reactions through the activation of alkynes with gold complexes. First Simonneau describes 1,6-enynes and their direct conversion into allenes through 1,5-hydride or ester migration processes. The author and his team used appropriate propargylic functional groups to achieve this conversion. This study shows that O-tethered 1,6-enynes carrying a strained cycloalkane at the propargylic position could undergo a cyclopropanation/ring expansion cascade reaction. The author employed this rearrangement as the starting point in the design of a new macro cycle synthesis. The next part of the thesis focuses on the cycloisomerization of diynes involving as the first step of the process the rearrangement of one alkyne partner into an allene thanks to a gold-catalyzed 1,3-shift of a propargylic ester. The thesis discloses a new cycloisomerization pattern featuring a 1,5-carbonyl transfer, giving rise to unprecedented cross-conjugated diketones. In the final part of the research, Simmoneau investigates the gold-catalyzed cycloisomerization mechanism of 1,6-enynes and questions the intermediacy of gold acetylides. By the means of NMR and mass spectrometry analysis, theoretical treatment and solution experiments, it was possible to rule out the involvement of these species in the catalytic cycle. This thesis has led to a number of publications in high-impact journals.

Comprehensive Organic Synthesis

Author :
Publisher : Newnes
ISBN 13 : 008097743X
Total Pages : 9815 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Comprehensive Organic Synthesis by :

Download or read book Comprehensive Organic Synthesis written by and published by Newnes. This book was released on 2014-02-14 with total page 9815 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Comprehensive Organic Synthesis—winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers—builds upon the highly respected first edition in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline. Fully revised and updated, this new set forms an essential reference work for all those seeking information on the solution of synthetic problems, whether they are experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find Comprehensive Organic Synthesis, Second Edition, Nine Volume Set an invaluable source, providing an authoritative overview of core concepts. Winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers Contains more than170 articles across nine volumes, including detailed analysis of core topics such as bonds, oxidation, and reduction Includes more than10,000 schemes and images Fully revised and updated; important growth areas—including combinatorial chemistry, new technological, industrial, and green chemistry developments—are covered extensively

Small Molecule Drug Discovery

Author : Andrea Trabocchi
Publisher : Elsevier
ISBN 13 : 0128183500
Total Pages : 358 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Small Molecule Drug Discovery by : Andrea Trabocchi

Download or read book Small Molecule Drug Discovery written by Andrea Trabocchi and published by Elsevier. This book was released on 2019-11-23 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The last section comprises an exciting collection of selected case studies on drug discovery enabled by small molecules in the fields of cancer research, CNS diseases and infectious diseases. The discovery of novel molecular entities capable of specific interactions represents a significant challenge in early drug discovery. Small molecules are low molecular weight organic compounds that include natural products and metabolites, as well as drugs and other xenobiotics. When the biological target is well defined and understood, the rational design of small molecule ligands is possible. Alternatively, small molecule libraries are being used for unbiased assays for complex diseases where a target is unknown or multiple factors contribute to a disease pathology. Outlines modern concepts and synthetic strategies underlying the building of small molecules and their chemical libraries useful for drug discovery Provides modern biophysical methods to screening small molecule libraries, including high-throughput screening, small molecule microarrays, phenotypic screening and chemical genetics Presents the most advanced chemoinformatics tools to characterize the structural features of small molecule libraries in terms of chemical diversity and complexity, also including the application of virtual screening approaches Gives an overview of structural features and classification of natural product-derived small molecules, including carbohydrate derivatives, peptides and peptidomimetics, and alkaloid-inspired small molecules

Heterocyclic Chemistry in Drug Discovery

Author : Jie Jack Li
Publisher : John Wiley & Sons
ISBN 13 : 1118354435
Total Pages : 688 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Heterocyclic Chemistry in Drug Discovery by : Jie Jack Li

Download or read book Heterocyclic Chemistry in Drug Discovery written by Jie Jack Li and published by John Wiley & Sons. This book was released on 2013-04-26 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.

Organometallic Chemistry

Author : Ian J S Fairlamb
Publisher : Royal Society of Chemistry
ISBN 13 : 1847558461
Total Pages : 189 pages
Book Rating : 4.8/5 (475 download)

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Book Synopsis Organometallic Chemistry by : Ian J S Fairlamb

Download or read book Organometallic Chemistry written by Ian J S Fairlamb and published by Royal Society of Chemistry. This book was released on 2008-02-01 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organometallic chemistry is an interdisciplinary science which continues to grow at a rapid pace. Although there is continued interest in synthetic and structural studies the last decade has seen a growing interest in the potential of organometallic chemistry to provide answers to problems in catalysis synthetic organic chemistry and also in the development of new materials. This Specialist Periodical Report aims to reflect these current interests reviewing progress in theoretical organometallic chemistry, main group chemistry, the lanthanides and all aspects of transition metal chemistry. Volume 34 covers literature published up to January 2006.

Applications of Transition Metal Catalysis in Drug Discovery and Development

Author : Matthew L. Crawley
Publisher : John Wiley & Sons
ISBN 13 : 0470631325
Total Pages : 386 pages
Book Rating : 4.4/5 (76 download)

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Book Synopsis Applications of Transition Metal Catalysis in Drug Discovery and Development by : Matthew L. Crawley

Download or read book Applications of Transition Metal Catalysis in Drug Discovery and Development written by Matthew L. Crawley and published by John Wiley & Sons. This book was released on 2012-07-03 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development – it is a guide, a historical prospective, a practical compendium, and a source of future direction for the field.

Fundamental Research in Homogeneous Catalysis

Author : M. Tsutsui
Publisher : Springer Science & Business Media
ISBN 13 : 1461329582
Total Pages : 1040 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Fundamental Research in Homogeneous Catalysis by : M. Tsutsui

Download or read book Fundamental Research in Homogeneous Catalysis written by M. Tsutsui and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1040 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the 70's it has become drastically apparent that our natural resources, including energy, are not in unlimited supply. This realization is strongly felt in the economic turmoil that is occurring, but its effects will penetrate into other areas, even causing moderate social changes. Chemists playa major role in coverting the world's natural resources into products. The public consumes these products and now depends upon them to keep the high standard of living to which they have become accustomed. This topic could easily be expounded into a whole article, but it is sufficent to say that almost everything-from the use of lightweight, strong polymers which are replacing the use of metals in today's automobiles, to the curing of diseases with asymetrically synthesized drugs-is related to the endeavors of chemistry. Catalysts have played a major role in transforming resources to useful products. Since a catalyst lowers the activation energy required for a particular reaction, and often for only one specific pathway where normally many exist, it is not surprising within the extant climate that researchers are now increasing their efforts and focusing their priorities on improving and discovering more efficient and selective catalysts.

Energy Research Abstracts

Author :
Publisher :
ISBN 13 :
Total Pages : 368 pages
Book Rating : 4.:/5 (3 download)

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Book Synopsis Energy Research Abstracts by :

Download or read book Energy Research Abstracts written by and published by . This book was released on 1990 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:

New Trends in Cross-Coupling

Author : Thomas Colacot
Publisher : Royal Society of Chemistry
ISBN 13 : 1849738963
Total Pages : 914 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis New Trends in Cross-Coupling by : Thomas Colacot

Download or read book New Trends in Cross-Coupling written by Thomas Colacot and published by Royal Society of Chemistry. This book was released on 2015 with total page 914 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following on from its recognition in the 2010 Nobel Prize for Chemistry, contributors from across the globe present the latest cross-coupling trends in both academia and industry.

Polyolefin Fibres

Author : S C O Ugbolue
Publisher : Woodhead Publishing
ISBN 13 : 0081012519
Total Pages : 591 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Polyolefin Fibres by : S C O Ugbolue

Download or read book Polyolefin Fibres written by S C O Ugbolue and published by Woodhead Publishing. This book was released on 2017-06-09 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polyolefin Fibres: Structure, Properties and Industrial Applications, Second Edition, explores one of the most widely used commercial polymers, with a focus on the most important polyolefins, namely polyethylene, polypropylene, and polyolefin bicomponent fibres. These versatile fibres are durable, chemically resistant, lightweight, economical, and functional. This new edition has been updated and expanded to include cutting-edge research on a broad range of advanced applications. Part I covers the structure and properties of polyolefin fibres, incorporating a new chapter on the environmental aspects of polyolefin use. Part II examines the methods for improving the functionality of polyolefins, providing essential information for those engaged in developing high-performance materials. A final group of chapters addresses how polyolefin fibres can be incorporated into specific textile applications, such as automotive, geotextile, biomedical, and hygiene products, and explores potential future development. This book is an essential reference for textile technologists and manufacturers, polymer and fibre scientists, yarn and fabric manufacturers, biomedical and device engineers, and industrialists and researchers. Introduces the types, properties and structure of polyolefin fibers for readers new to the polyolefins field Examines methods to improve the functionality of polyolefin fibers, providing essential information for textile technologists and research and development managers engaged in developing high-performance materials Presents existing and potential applications of polyolefin fibers, exploring how they can expand the range of commercial polyolefin-based products