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New Advancement In Tumor Microenvironment Remodeling And Cancer Therapy
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Book Synopsis New Advancement in Tumor Microenvironment Remodeling and Cancer Therapy by : Xiangsheng Zuo
Download or read book New Advancement in Tumor Microenvironment Remodeling and Cancer Therapy written by Xiangsheng Zuo and published by Frontiers Media SA. This book was released on 2024-03-18 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor microenvironment (TME) refers to the area with non-malignant cells, signaling molecules and blood vessels that surrounds and feeds tumor cells. A tumor can change its microenvironment, and TME is also known to profoundly impact the occurrence, growth, metastasis and therapeutic response and resistance of tumors. The special paracrine characteristics, microvascular system, extracellular matrix components and stromal cells in TME promote local tumor immune suppression and could alter the penetration and distribution of drugs into tumor tissues. Accumulating evidence demonstrates that currently available tumor therapies (i.e., chemotherapy, radiotherapy, anti-vascular therapy, small molecule targeted therapy, immune checkpoint inhibitors) also in turn greatly affect the structure, function, and physical and chemical properties of TME, leading to TME remodeling. However, whether and how interaction of tumor cells and TME modeling can be dissected and targeted to further understand the underlying molecular mechanisms and establish effective new tumor therapies remains elusive.
Book Synopsis The Tumor Microenvironment: Recent Advances and Novel Therapeutic Approaches by : Sandra Orsulic
Download or read book The Tumor Microenvironment: Recent Advances and Novel Therapeutic Approaches written by Sandra Orsulic and published by Frontiers Media SA. This book was released on 2021-12-03 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Tumor Microenvironment by : Jacinta Serpa
Download or read book Tumor Microenvironment written by Jacinta Serpa and published by Springer Nature. This book was released on 2020-03-04 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: The way a cell undergoes malignant transformation should meet their capacity of surviving in the microenvironment of the organ where the cancer will develop. Metabolic adaptation is for sure one of the criteria that must be accomplished, driven by metabolic plasticity that allows the adaptation of cancer cells to the availability of energy and biomass sources that will sustain cell survival and proliferation. Each human organ has a particular microenvironment which depends on several cell types and in some cases also on symbiotic microorganisms. These biological partners are constantly sharing organic compounds and signaling molecules that will control mitogenesis, cell death and differentiation, accounting for the organ's function. Nevertheless, cancer cells are capable of taking advantage of this metabolic and signaling microenvironmental dynamics. In this book, we intend to present the different components of the microenvironment driving the metabolic fitness of cancer cells. The metabolic changes required for establishing a tumor in a given microenvironment and how these metabolic changes limit the response to drugs will generally be the major items addressed. It is important to mention not only aspects of the microenvironment that stimulate metabolic changes and that select better adapted tumor cells, but also how this regulation of cell plasticity is made. Thus, the signaling pathways that orchestrate and are orchestrated throughout this panoply of metabolic rearrangements will also be addressed in this book. The subjects will be presented from the conceptual point of view of the cross-cancer mechanisms and also particularizing some models that can be examples and enlightening within the different areas.
Book Synopsis Tumor Microenvironment by : Alexander Birbrair
Download or read book Tumor Microenvironment written by Alexander Birbrair and published by Springer Nature. This book was released on 2020-02-06 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses recent research advances in cancer biology, focusing on the role of the tumor microenvironment. Taken alongside its companion volumes, Tumor Microenvironment: Recent Advances covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.
Book Synopsis Tumor Microenvironment by : Jacinta Serpa
Download or read book Tumor Microenvironment written by Jacinta Serpa and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will allow readers to discover the crucial role of tumor microenvironment (TME) in the selection of cancer cells that are more prone to carry on cancer initiation and progression. The metabolic remodeling, as the basis of life overall, allows the adaptive establishment of a tumor in a certain TME, which in turn presents a variety of selective pressures. Coupled with the late diagnosis, the poor therapy response are the main hurdles limiting oncological disease control and eventual cure. Thus the metabolic plasticity of cancer cells often underlies chemoresistance. This edited work presents an exhaustive description and comprehensive view of cancer metabolism as a weapon used by cancer cells to adapt to TME. TME and the organ microenvironment is analyzed as a whole, considering cancer cells, stromal cells and microbiota. This complex circuit is observed as the support for disease development and therapy evasion but also as a valuable kernel, presenting new players to be targeted in a more precise cancer therapy. The various threads of cancer biology related to TME and metabolic adaptation will be addressed including: 1) key players in the metabolic network; 2) the way adaptive metabolic features are sustained by TME; 3) TME and metabolic signaling, accounting for cancer cells survival; 4) metabolic fitness driven limitations in therapy response, and 5) the way TME and cancer metabolism can be helpful in the design of new drugs. In addition, the usefulness, technical strengths and weaknesses of analytical techniques useful in cancer metabolomics will be presented in an integrative way. Moreover, the use of innovative and traditional in vitro and in vivo cancer models, as powerful tools to address the influence of TME in cancer progression and metabolic reprogramming will be also presented. This work was written by experts and dedicated to researchers with interests in cancer biology, TME, cancer metabolism and therapy. It will interest the Advances in Experimental Medicine and Biology readership, including basic researchers, analytic researchers, bio-engineers and clinicians.
Book Synopsis Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy by : Pawel Kalinski
Download or read book Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy written by Pawel Kalinski and published by Springer. This book was released on 2017-12-22 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to moving the field forward, since there are many players in a tumor’s localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy aims to shed light on the mechanisms, factors, and mediators that are involved in the cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups are discussed under the lens of their role in promoting tumor growth, shielding the tumor from rejection and from standard forms of cancer therapies. They are emerging as targets and mediators of standard and new forms of potential therapy.
Book Synopsis Recent Advances in Cancer Research and Therapy by : Xin-Yuan Liu
Download or read book Recent Advances in Cancer Research and Therapy written by Xin-Yuan Liu and published by Elsevier. This book was released on 2012-05-18 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer continues to be one of the major causes of death throughout the developed world, which has led to increased research on effective treatments. Because of this, in the past decade, rapid progress in the field of cancer treatment has been seen. Recent Advances in Cancer Research and Therapy reviews in specific details some of the most effective and promising treatments developed in research centers worldwide. While referencing advances in traditional therapies and treatments such as chemotherapy, this book also highlights advances in biotherapy including research using Interferon and Super Interferon, HecI based and liposome based therapy, gene therapy, and p53 based cancer therapy. There is also a discussion of current cancer research in China including traditional Chinese medicine. Written by leading scientists in the field, this book provides an essential insight into the current state of cancer therapy and treatment. Includes a wide range of research areas including a focus on biotherapy and the development of novel cancer therapeutic strategies. Formatted for a broad audience including all working in researching cancer treatments and therapies. Discusses special traits and results of Chinese cancer research.
Book Synopsis Systems Biology of Tumor Microenvironment by : Katarzyna A. Rejniak
Download or read book Systems Biology of Tumor Microenvironment written by Katarzyna A. Rejniak and published by Springer. This book was released on 2016-10-13 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume discusses the complexity of tumor microenvironments during cancer development, progression and treatment. Each chapter presents a different mathematical model designed to investigate the interactions between tumor cells and the surrounding stroma and stromal cells. The topics covered in this book include the quantitative image analysis of a tumor microenvironment, the microenvironmental barriers in oxygen and drug delivery to tumors, the development of tumor microenvironmental niches and sanctuaries, intravenous transport of the circulating tumor cells, the role of the tumor microenvironment in chemotherapeutic interventions, the interactions between tumor cells, the extracellular matrix, the interstitial fluid, and the immune and stromal cells. Mathematical models discussed here embrace both continuous and agent-based approaches, as well as mathematical frameworks of solid mechanics, fluid dynamics and optimal control theory. The topics in each chapter will be of interest to a biological community wishing to apply the mathematical methods to interpret their experimental data, and to a biomathematical audience interested in exploring how mathematical models can be used to address complex questions in cancer biology.
Book Synopsis New progress in the treatment of bone and soft tissue tumors by : Zhiyu Zhang
Download or read book New progress in the treatment of bone and soft tissue tumors written by Zhiyu Zhang and published by Frontiers Media SA. This book was released on 2024-05-29 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cancer Microenvironment and Therapeutic Implications by : Gianfranco Baronzio
Download or read book Cancer Microenvironment and Therapeutic Implications written by Gianfranco Baronzio and published by Springer Science & Business Media. This book was released on 2009-04-10 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the post-genomic era, cancer is a genetic disease. However, cancer genotype does not always equal cancer phenotype. Cancers with the same genetic abnormalities don’t always behave the same. Understanding and eradicating cancers will require an appreciation for cancer’s ecology. This book is the first to comprehensively explore and critically appraise cancer microenvironments and host interactions with an eye towards exploiting our understanding for new treatments. The team of contributors share amongst them impressive experiences at the laboratory bench and in the clinic. These physician-scientists have dedicated themselves to the tension between the urgency for cures and the technical challenges of discovery. The target audience includes clinical oncologists, clinical hematologists, research oncologists, research hematologists, immunologists, stem cell researchers, oncology and hematology fellows (trainees), oncology educators (graduate and undergraduate levels), and course book for graduate students and undergraduate students.
Book Synopsis Tumor Microenvironment by : Dietmar W. Siemann
Download or read book Tumor Microenvironment written by Dietmar W. Siemann and published by John Wiley & Sons. This book was released on 2011-06-24 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: The microenvironment in which a tumor originates plays a critical role in its initiation and progression. Tumor Microenvironment reviews the importance of tumor microenvironment in cancer management. Particular emphasis is placed on discussing how the unique characteristics of the tumor microenvironment not only impact disease progression and response to conventional anticancer therapies, but have also led to the identification of potential new therapeutic targets and treatment possibilities for cancer patients. Tumor Microenvironment also reviews the fundamental basis of target development, preclinical assessment, and the current clinical status of these therapies.
Book Synopsis The Extracellular Matrix and the Tumor Microenvironment by : Ilona Kovalszky
Download or read book The Extracellular Matrix and the Tumor Microenvironment written by Ilona Kovalszky and published by Springer Nature. This book was released on 2022-07-06 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression. Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression. Two chapters focus specifically on the critical role of the ECM in tumor angiogenesis, linking this process to cellular infiltration and metastatic behavior of tumors. The final part describes how the ECM influences the success of immuno- and chemotherapy in cancer patients, its potential as biomarkers for diagnosis, prognosis, and therapeutic target, as well as the mechanism of resistance-associated changes in the ECM. This book is an interesting read for anyone who want to know more about ECM and cancer biology. Early career scientists can use it as an introduction to the field, offering an excellent tool for studying ECM. Advanced researchers and clinicians can gain a broader overview of the subject, considering the role of ECM for influencing every cancer hallmark as well as in the response of cancer treatments. The work serves to inspire future research and shows that the ECM should be considered as an important factor in the development of cancer therapeutics. The series "Biology of Extracellular Matrix" is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
Book Synopsis New Horizons in Tumor Microenvironment: Challenges and Opportunities by : Yu Sun
Download or read book New Horizons in Tumor Microenvironment: Challenges and Opportunities written by Yu Sun and published by LAP Lambert Academic Publishing. This book was released on 2015-03-30 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: The tumor microenvironment (TME) is being increasingly recognized as a key factor in multiple stages of disease progression, particularly local resistance, immune-escaping, and distant metastasis, thereby substantially impacting the future development of therapeutic interventions in clinical oncology. An appropriate understanding of the TME promotes evaluation and selection of candidate agents to control malignancies at both the primary sites as well as the metastatic settings. This book presents a timely outline of research advances in TME biology and highlights the prospect of targeting the TME as a critical strategy to overcome acquired resistance, prevent metastasis, and improve therapeutic efficacy. A body of frontline information is delivered to summarize recently emerging and rapidly progressing aspects of TME studies, and to provide a significant guideline for prospective development of personalized medicine, with the long term aim of providing a cure for cancer patients. The book is to shed new lights on the blooming fields of TME studies, should be especially useful to biomedical scientists and oncological clinicians, and people who care about personalized medicine.
Book Synopsis Second Harmonic Generation Imaging by : Francesco S. Pavone
Download or read book Second Harmonic Generation Imaging written by Francesco S. Pavone and published by Taylor & Francis. This book was released on 2016-04-19 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Second-harmonic generation (SHG) microscopy has shown great promise for imaging live cells and tissues, with applications in basic science, medical research, and tissue engineering. Second Harmonic Generation Imaging offers a complete guide to this optical modality, from basic principles, instrumentation, methods, and image analysis to biomedical a
Book Synopsis Biogenic Nanoparticles for Cancer Theranostics by : Chittaranjan Patra
Download or read book Biogenic Nanoparticles for Cancer Theranostics written by Chittaranjan Patra and published by Elsevier. This book was released on 2021-05-18 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biogenic Nanoparticles for Cancer Theranostics outlines the synthesis of biogenic nanoparticles to become cancer theranostic agents. The book also discusses their cellular interaction and uptake, pharmacokinetics, biodistribution, drug delivery efficiency, and other biological effects. Additionally, the book explores the mechanism of their penetration in cancerous tissue, its clearance, and its metabolism. Moreover, the in vitro and in vivo toxicological effects of biogenic nanoparticles are discussed. This book is an important reference source for materials scientists and biomedical scientists who are looking to increase their understanding of how biogenic nanoparticles are being used for a range of cancer treatment types. Metal nanoparticles have traditionally been synthesized by classical physico-chemical methods which have many drawbacks, such as high energy demand, high cost and potential ecotoxicity. As a result, the biosynthesis of metal nanoparticles is gaining increasing prominence. Biosynthesis approaches to metal nanoparticles are clean, safe, energy efficient and environment friendly. Explains the synthesis methods and applications of biogenic nanoparticles for cancer theranostics Outlines the distinctive features of biogenic nanoparticles that make them effective cancer treatment agents Assesses the major challenges of using biogenic nanoparticles on a mass scale
Book Synopsis Advances in Cancer Research by : Kenneth D. Tew
Download or read book Advances in Cancer Research written by Kenneth D. Tew and published by Academic Press. This book was released on 2014-05-29 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. Provides information on cancer research Outstanding and original reviews Suitable for researchers and students
Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le
Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
