Neuronal Activity Regulates The Nuclear Proteome To Promote Activity Dependent Transcription

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Neuronal Activity Regulates the Nuclear Proteome to Promote Activity-Dependent Transcription

Author : Wendy Herbst
Publisher :
ISBN 13 :
Total Pages : 161 pages
Book Rating : 4.:/5 (129 download)

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Book Synopsis Neuronal Activity Regulates the Nuclear Proteome to Promote Activity-Dependent Transcription by : Wendy Herbst

Download or read book Neuronal Activity Regulates the Nuclear Proteome to Promote Activity-Dependent Transcription written by Wendy Herbst and published by . This book was released on 2021 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: The formation and plasticity of neuronal circuits relies on dynamic activity-dependent gene expression. While recent work has revealed the identity of important transcriptional regulators and of genes that are transcribed and translated in response to activity, relatively little is known about the cell biological mechanisms by which activity alters the nuclear proteome of neurons to link neuronal stimulation to transcription. Using nucleus-specific proteomic mapping in silenced and stimulated neurons, we uncovered an understudied mechanism of nuclear proteome regulation: activity-dependent proteasome-mediated degradation. We found that the tumor suppressor protein PDCD4 undergoes rapid stimulus-induced degradation in the nucleus of neurons. We demonstrate that degradation of PDCD4 is required for normal activity-dependent transcription, and that PDCD4 target genes include those encoding proteins critical for synapse formation, remodeling, and transmission. Our findings highlight the importance of the nuclear proteasome in regulating the activity-dependent nuclear proteome, and point to a specific role for PDCD4 as a regulator of activity-dependent transcription in neurons.

Transcriptional Regulation by Neuronal Activity

Author : Serena Dudek
Publisher : Springer Science & Business Media
ISBN 13 : 0387736093
Total Pages : 426 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Transcriptional Regulation by Neuronal Activity by : Serena Dudek

Download or read book Transcriptional Regulation by Neuronal Activity written by Serena Dudek and published by Springer Science & Business Media. This book was released on 2007-11-24 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulation of gene transcription by neuronal activity is evident in a large number of neuronal processes ranging from neural development and refinement of neuronal connections to learning and response to injury. In the field of activity-dependent gene expression, rapid progress is being made that can impact these, and many other areas of neuroscience. This book offers an up-to-date picture of the field.

Regulation and Transcriptional Role of CRTC1 During Activity in Neurons

Author : Martina DeSalvo
Publisher :
ISBN 13 :
Total Pages : 192 pages
Book Rating : 4.:/5 (14 download)

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Book Synopsis Regulation and Transcriptional Role of CRTC1 During Activity in Neurons by : Martina DeSalvo

Download or read book Regulation and Transcriptional Role of CRTC1 During Activity in Neurons written by Martina DeSalvo and published by . This book was released on 2016 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Long term memory is mediated by long-lasting forms of synaptic plasticity that require new gene transcription for their persistence. Previous work has shown that neuronal CREB-regulated transcriptional coactivator 1 (CRTC1) plays a crucial role during learning and memory by regulating activity-dependent gene expression. We have shown that CRTC1 undergoes synapse-to-nucleus translocation to regulate transcription of CREB target genes in response to neuronal activity. In this thesis, we investigate the regulation and retrograde transport of CRTC1 in neurons and examine the nuclear role of CRTC1 in activity-dependent gene transcription. Our first goal was to identify the mechanisms by which CRTC1 responds to activity. We describe key synaptic processes necessary to trigger dephosphorylation of three serine residues that are required for dynein-mediated transport of CRTC1 to the nucleus. Our second goal was to understand the role of CRCT1 as a transcriptional coactivator. We use a combination of ChIP-seq, ATAC-seq and RNA-seq to understand how CRTC1 binding to CREB and other transcription factors correlates with changes in chromatin accessibility and transcription of activity-induced genes. Finally, we summarize a series of projects that attempt to elucidate how regulation of CRTC1's phosphorylation code may influence its function in neurons. These studies highlight the complexities of CRTC1 as an intrinsically disordered protein with 50 phosphorylated residues and a variety of potential interacting partners.

Transcriptional Regulation by Neuronal Activity

Author : Ramendra N. Saha
Publisher : Springer
ISBN 13 : 9783031685491
Total Pages : 0 pages
Book Rating : 4.6/5 (854 download)

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Book Synopsis Transcriptional Regulation by Neuronal Activity by : Ramendra N. Saha

Download or read book Transcriptional Regulation by Neuronal Activity written by Ramendra N. Saha and published by Springer. This book was released on 2024-11-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the regulation of gene transcription by neuronal activity that is evident in a large number of neuronal processes ranging from neural development and refinement of neuronal connections to learning and response to injury. Transcriptional Regulation by Neuronal Activity: To the Nucleus and Back, 2nd edition illustrates how signals are transmitted to the nucleus in response to neuronal activity, which genes are regulated and how this is achieved, and how these changes in gene expression alter neuronal function. The aim of this second edition is to highlight key advances in the field since the first edition. The book is divided into four sections. The first highlights how signals get to the nucleus from the membrane in response to synaptic or neuronal activity. Included are chapters on the pathways that transmit signals from synapses to nuclei. The second section focuses on epigenetic regulatory processes of activity-induced gene transcription, an area that has exploded in the past few years. The third section navigates the role of activity-induced genes in physiological processes such as learning and memory, and human developmental disorders such as those associated with the autism spectrum. The fourth section highlights groundbreaking technological advances in the field, which have allowed activity-regulated transcription to be used as a tool to study learning and memory.

Biology of the NMDA Receptor

Author : Antonius M. VanDongen
Publisher : CRC Press
ISBN 13 : 142004415X
Total Pages : 368 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Biology of the NMDA Receptor by : Antonius M. VanDongen

Download or read book Biology of the NMDA Receptor written by Antonius M. VanDongen and published by CRC Press. This book was released on 2008-10-29 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Hippocampus Book

Author : Per Andersen
Publisher : Oxford University Press
ISBN 13 : 9780195100273
Total Pages : 892 pages
Book Rating : 4.1/5 (2 download)

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Book Synopsis The Hippocampus Book by : Per Andersen

Download or read book The Hippocampus Book written by Per Andersen and published by Oxford University Press. This book was released on 2007 with total page 892 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hippocampus is one of a group of remarkable structures embedded within the brain's medial temporal lobe. Long known to be important for memory, it has been a prime focus of neuroscience research for many years. The Hippocampus Book promises to facilitate developments in the field in a major way by bringing together, for the first time, contributions by leading international scientists knowledgeable about hippocampal anatomy, physiology, and function. This authoritative volume offers the most comprehensive, up-to-date account of what the hippocampus does, how it does it, and what happens when things go wrong. At the same time, it illustrates how research focusing on this single brain structure has revealed principles of wider generality for the whole brain in relation to anatomical connectivity, synaptic plasticity, cognition and behavior, and computational algorithms. Well-organized in its presentation of both theory and experimental data, this peerless work vividly illustrates the astonishing progress that has been made in unraveling the workings of the brain. The Hippocampus Book is destined to take a central place on every neuroscientist's bookshelf.

Subcellular Proteomics

Author : Eric Bertrand
Publisher : Springer Science & Business Media
ISBN 13 : 1402059434
Total Pages : 397 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Subcellular Proteomics by : Eric Bertrand

Download or read book Subcellular Proteomics written by Eric Bertrand and published by Springer Science & Business Media. This book was released on 2007-08-29 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes the new developments that made subcellular proteomics a rapidly expanding area. It examines the different levels of subcellular organization and their specific methodologies. In addition, the book includes coverage of systems biology that deals with the integration of the data derived from these different levels to produce a synthetic description of the cell as a system.

The Fine Structure of the Nervous System

Author : Alan Peters
Publisher : Oxford University Press, USA
ISBN 13 :
Total Pages : 538 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Fine Structure of the Nervous System by : Alan Peters

Download or read book The Fine Structure of the Nervous System written by Alan Peters and published by Oxford University Press, USA. This book was released on 1991 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents the most complete and authoritative description on the fine structure of the nervous system available in a single volume. Beginning with background material on the neuron, the book then examines specific portions of the nerve cell, and of the various supporting cells. Structure is first described in a general fashion, followed by detailed coverage of the fine structure of each component, with full discussion of how the structural features relate to their functions. Extensively revised and rewritten, this book will bring readers up to date with the many important developments that have taken place since publication of the previous edition. It includes over 130 electron micrographs and line drawings, many of which are new to this edition.

Neuroproteomics

Author : Oscar Alzate
Publisher : CRC Press
ISBN 13 : 1420076264
Total Pages : 356 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Neuroproteomics by : Oscar Alzate

Download or read book Neuroproteomics written by Oscar Alzate and published by CRC Press. This book was released on 2009-10-26 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg

Cyclin Dependent Kinase 5 (Cdk5)

Author : Nancy Y. Ip
Publisher : Springer Science & Business Media
ISBN 13 : 0387788875
Total Pages : 326 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Cyclin Dependent Kinase 5 (Cdk5) by : Nancy Y. Ip

Download or read book Cyclin Dependent Kinase 5 (Cdk5) written by Nancy Y. Ip and published by Springer Science & Business Media. This book was released on 2009-02-28 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.

Gene Mapping, Discovery, and Expression

Author : Minou Bina
Publisher : Springer Science & Business Media
ISBN 13 : 1597450979
Total Pages : 335 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Gene Mapping, Discovery, and Expression by : Minou Bina

Download or read book Gene Mapping, Discovery, and Expression written by Minou Bina and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completion of the sequence of the human genome represents an unpar- leled achievement in the history of biology. The project has produced nearly complete, highly accurate, and comprehensive sequences of genomes of s- eral organisms including human, mouse, drosophila, and yeast. Furthermore, the development of high-throughput technologies has led to an explosion of projects to sequence the genomes of additional organisms including rat, chimp, dog, bee, chicken, and the list is expanding. The nearly completed draft of genomic sequences from numerous species has opened a new era of research in biology and in biomedical sciences. In keeping with the interdisciplinary nature of the new scientific era, the chapters in Gene Mapping, Discovery, and Expression: Methods and Protocols recapitulate the necessity of integration of experimental and computational tools for solving - portant research problems. The general underlying theme of this volume is DNA sequence-based technologies. At one level, the book highlights the importance of databases, genome-browsers, and web-based tools for data access and ana- sis. More specifically, sequencing projects routinely deposit their data in p- licly available databases including GenBank, at the National Center of Biotechnology (NCBI) in the United States; EMBL, maintained by the European Bioinformatics Institute; and DDBJ, the DNA Data Bank of Japan. Currently, several browsers offer facile access to numerous genomic DNA sequences for gene mapping and data retrieval.

Neuronal Development and Degeneration

Author : Wenbo Zhang
Publisher : Frontiers Media SA
ISBN 13 : 2889633454
Total Pages : 161 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Neuronal Development and Degeneration by : Wenbo Zhang

Download or read book Neuronal Development and Degeneration written by Wenbo Zhang and published by Frontiers Media SA. This book was released on 2020-01-23 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Heat Shock Proteins in Cancer

Author : Stuart K. Calderwood
Publisher : Springer Science & Business Media
ISBN 13 : 1402064012
Total Pages : 399 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Heat Shock Proteins in Cancer by : Stuart K. Calderwood

Download or read book Heat Shock Proteins in Cancer written by Stuart K. Calderwood and published by Springer Science & Business Media. This book was released on 2007-09-09 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.

Synaptic Function

Author : Neurosciences Institute (New York, N.Y.)
Publisher : Wiley-Interscience
ISBN 13 :
Total Pages : 808 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Synaptic Function by : Neurosciences Institute (New York, N.Y.)

Download or read book Synaptic Function written by Neurosciences Institute (New York, N.Y.) and published by Wiley-Interscience. This book was released on 1987 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book consists of five sections. The first section details methods for analyzing both presynaptic and postsynaptic function and emphasizes the molecular aspects of synapses. It describes ongoing studies of neurotransmitter release, voltage- sensitive ion channels, and electronic transmission at gap junctions. The second section focuses on the growing menagerie of neurotransmitters: their catagorization into chemical families, their relation to ion channels, their modulation by second messenger systems and their role in pharmacologic action. The third section considers the important relationship of transmitter diversity and synaptic types to the behavior of actual cellular networks. All of the studies described in these sections point to the necessity of considering interactions between anatomy, chemistry, physiology and pharmacology if synaptic function is to be understood at any one of these levels of analysis.

Applied Bioinformatics

Author : Paul Maria Selzer
Publisher : Springer Science & Business Media
ISBN 13 : 3540728007
Total Pages : 297 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Applied Bioinformatics by : Paul Maria Selzer

Download or read book Applied Bioinformatics written by Paul Maria Selzer and published by Springer Science & Business Media. This book was released on 2008-01-18 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: At last, here is a baseline book for anyone who is confused by cryptic computer programs, algorithms and formulae, but wants to learn about applied bioinformatics. Now, anyone who can operate a PC, standard software and the internet can also learn to understand the biological basis of bioinformatics, of the existence as well as the source and availability of bioinformatics software, and how to apply these tools and interpret results with confidence. This process is aided by chapters that introduce important aspects of bioinformatics, detailed bioinformatics exercises (including solutions), and to cap it all, a glossary of definitions and terminology relating to bioinformatics.

Molecular Neuroendocrinology

Author : David Murphy
Publisher : John Wiley & Sons
ISBN 13 : 1119162181
Total Pages : 682 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Molecular Neuroendocrinology by : David Murphy

Download or read book Molecular Neuroendocrinology written by David Murphy and published by John Wiley & Sons. This book was released on 2016-01-19 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Neuroendocrinology: From Genome to Physiology, provides researchers and students with a critical examination of the steps being taken to decipher genome complexity in the context of the expression, regulation and physiological functions of genes in neuroendocrine systems. The 19 chapters are divided into four sectors: A) describes and explores the genome, its evolution, expression and the mechanisms that contribute to protein, and hence biological, diversity. B) discusses the mechanisms that enhance peptide and protein diversity beyond what is encoded in the genome through post-translational modification. C) considers the molecular tools that today’s neuroendocrinologists can use to study the regulation and function of neuroendocrine genes within the context of the intact organism. D) presents a range of case studies that exemplify the state-of-the-art application of genomic technologies in physiological and behavioural experiments that seek to better understand complex biological processes. • Written by a team of internationally renowned researchers • Both print and enhanced e-book versions are available • Illustrated in full colour throughout This is the third volume in a new Series ‘Masterclass in Neuroendocrinology’ , a co- publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology. Series Editors: John A. Russell, University of Edinburgh, UK and William E. Armstrong, The University of Tennessee, USA