Neurodegeneration Advances In Neuroscience

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Neurodegeneration: Advances in Neuroscience

Author : Elena Poole
Publisher : American Medical Publishers
ISBN 13 : 9781639273102
Total Pages : 227 pages
Book Rating : 4.2/5 (731 download)

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Book Synopsis Neurodegeneration: Advances in Neuroscience by : Elena Poole

Download or read book Neurodegeneration: Advances in Neuroscience written by Elena Poole and published by American Medical Publishers. This book was released on 2021-11-16 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegeneration is the gradual loss of neurons, and neuronal structure and function. This is the cause of neurodegenerative diseases, such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, etc. Research in neurodegeneration suggests that there exists several similarities between these disorders such as induced cell death and atypical protein assemblies. DNA damage accumulation has been proposed to be the causative link between neurodegeneration and aging. Several mechanisms have been implicated in the occurrence and progression of neurodegeneration, such as protein misfolding, programmed cell death, genetic mutations, various intracellular mechanisms, etc. Protein degradation is a therapeutic option for preventing the synthesis and degradation of irregular proteins that are formed in neurodegenerative disease. This book is a compilation of chapters that discuss the most vital concepts and emerging trends in neurodegeneration. Different approaches, evaluations and advanced studies have been included herein. The extensive content of this book provides with a thorough understanding of the subject.

Advances in Research on Neurodegeneration

Author : R. Horowski
Publisher : Springer Science & Business Media
ISBN 13 : 3709106435
Total Pages : 230 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Advances in Research on Neurodegeneration by : R. Horowski

Download or read book Advances in Research on Neurodegeneration written by R. Horowski and published by Springer Science & Business Media. This book was released on 2013-04-09 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 10th International Winter Conference on Neurodegeneration (lWCN) has taken place from February 14-16,2002, at the lovely "SchloB Ziethen", an old prussian manor (in Prussia, 'faute de mieux', called 'SchloB', i. e. cas tle or residence). This place is 20 km off Tegel Airport, Berlin's main airport, and has been beautifully restored by baroness Edith von Thiingen (nee von BUlow, i. e. of historical Prussian aristocracy); it lends itself rather perfectly for the IWCN type of small interdisciplinary workshops on neurodegenera tion which combine short lectures with plenty of discussion. In this context, we could quote Alexander von Humboldt's famous opening words for one of the first international scientific meetings held at Berlin, on September 18, 1828: "The main purpose ... does not consist in a mutual reading of manuscripts all to be printed after at least one year in specialised publications, but in the personal communication amongst those who work in similar scientific fields; the oral and thus more stimulating exchange of ideas, might they represent facts, opinions or doubts; the foundation of friendly relations which convey illumination to our sciences, serene grace to our lives and tolerance and mildness to our habits ... Berlin, Sept. 18, 1828 Alexander von Humboldt To the IWCN aficionado, it may come as a little surprise that this is the pub lication of the 10th Winter Conference as this might mean that they must have missed number 9.

Recent Advances in Neurodegeneration

Author : Antonella Borreca
Publisher : BoD – Books on Demand
ISBN 13 : 1838812334
Total Pages : 102 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Recent Advances in Neurodegeneration by : Antonella Borreca

Download or read book Recent Advances in Neurodegeneration written by Antonella Borreca and published by BoD – Books on Demand. This book was released on 2019-10-09 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Edited Volume Recent Advances in Neurodegeneration is a is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field of neurodegeneration. The book comprises single chapters authored by various researchers and edited by an expert active in the neurodegeneration research area. All chapters are complete in itself but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on neurodegeneration, and open new possible research paths for further novel developments.

Advances in Research on Neurodegeneration

Author : Werner Poewe
Publisher : Springer Science & Business Media
ISBN 13 : 9783211832622
Total Pages : 170 pages
Book Rating : 4.8/5 (326 download)

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Book Synopsis Advances in Research on Neurodegeneration by : Werner Poewe

Download or read book Advances in Research on Neurodegeneration written by Werner Poewe and published by Springer Science & Business Media. This book was released on 1999-04-15 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book contains original articles and reviews presented at the 6th International Winter Conference on Neurodegeneration, held from November 20a "23, 1997 in KitzbA1/4hel/Austria. The aim of this conference was to present and discuss recent data on the interface between neuroimmunology and neurodegeneration, in particular susceptibility to autoimmune and neurodegenerative processes, neuroprotection and restorative treatment strategies. These issues were discussed in the light of recent developments in multiple sclerosis, Parkinsona (TM)s disease, amyotrophic lateral sclerosis, Huntingtona (TM)s disease and multisystem atrophy. The articles highlight topics, which are particularly interesting for the clinician and the neuroscientist. Some of the neuroprotective strategies have already been developed or are at present clinically investigated. The neuroprotective role of deep brain stimulation, antiglutamatergic therapy and apomorphine will be verified in clinical studies in the near future. This is also the case for future therapeutic approaches to restoration of the damaged nervous system, such as somatic gene therapy, implantation of genetically modified cell-lines and medically controlled and directed development of embryonic cells. The conference highlighted the role of the glia, which seems to play a key role, both in traditionally as neuroimmunological and neurodegenerative disorders classified diseases, as indicated above. The topics discussed in the book are significant for recent developments in clinical neurology and neuroscience, as shown in the current literature and at international congresses.

Advances in Research on Neurodegeneration

Author : P. Riederer
Publisher : Springer Science & Business Media
ISBN 13 : 3709168422
Total Pages : 215 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Advances in Research on Neurodegeneration by : P. Riederer

Download or read book Advances in Research on Neurodegeneration written by P. Riederer and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 5 of the series "Advances in Research on Neurodegeneration" is concerned with themes which are currently the focus of intensive research, and in which advances in our understanding of the pathological mechanisms un derlying neurodegenerative diseases are expected in the near future. The first section contains five reviews devoted to the various neuroimaging technolo gies. The discussion is concerned with the question of whether neuroimaging techniques make it possible to follow the process of degeneration as it occurs, and which methods offer the required sensitivity and quantifiability for this purpose. However, the question needs to be examined of whether, given the physical and chemical limitations of these techniques, even under optimal conditions, anatomical resolution can be improved to the extent that neuro degenerative diseases can be diagnosed earlier than currently possible and a confident diagnosis made. The possibilities of using neuroimaging techniques to provide information regarding the effects of neuroprotective or neuroregen erative therapeutic strategies, and for correlating the results of neuropsycho logical research with imaging data are also discussed. The second section is concerned with the significance of endogenous or exogenous neurotoxins as triggers for neurodegenerative processes that may lead to Parkinsonism. Vulnerability factors, which include such factors as nerve ending sensitivity, the synergistic effects of drugs and the various mechanisms underlying different toxins are discussed.

Advances in Research on Neurodegeneration

Author : P. Riederer
Publisher : Springer Science & Business Media
ISBN 13 : 3709163013
Total Pages : 442 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Advances in Research on Neurodegeneration by : P. Riederer

Download or read book Advances in Research on Neurodegeneration written by P. Riederer and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 8th International Winter Conference on Neurodegeneration from Febru ary 9 to 13, 2000 took place in Tegernsee, Bavaria, Germany. The interest shown in this symposium, which was carried by invited speakers only, was striking. 28 lectures in 5 sessions dealt with themes on basic science and therapy strategies for neurodegenerative illness. This time especially basic mechanism of cell death and resulting causal treatment possibilities were centre themes of the lectures and lively discussions. In accordance with tradi tion 5 lectures on Multiple Sclerosis finished the convention. 60 scientists from 13 countries discussed current questions to these themes. The Symposium started with a lecture on the history of the develop ment of modern-L-DOPA-therapy. Lectures on cell death of dopaminergic nerve cells, new valuation regarding assembly, built up and function of neuromelanin of Substantia nigra and with this, the question of the physio logic and pathobiochemical role of dopamine and neuromelanin built the first block of themes which consequently extended to molecular and genetic aspects of cell death. Highlights of the symposium were neuroprotective and neuroregenerative future therapy strategies together with discussions on the difficulties of clinical neuroprotection. Developmental biological aspects on nerve cells, reorganisation and neurodegeneration showed a stimulating point of view of momentary and future development possibilities of new and more causal forms of therapy of neurodegenerative illness.

Advances in Research on Neurodegeneration

Author : Y. Mizuno
Publisher : Springer Science & Business Media
ISBN 13 : 370916284X
Total Pages : 228 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Advances in Research on Neurodegeneration by : Y. Mizuno

Download or read book Advances in Research on Neurodegeneration written by Y. Mizuno and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: We organized the Seventh International Winter Conference on Neurodegeneration and Neuroinflammation in a small town of Karuizawa in Nagano Prefecture in Japan on January 20 to 22, 1999. Karuizawa is a nice summer as well as winter resort close to the place for winter Olympic game in the year of 1998. Over 40 scientists gathered together and made hot discussion. Neurodegeneration and neuroinflammation are two major and important neurologic disorders, in which satisfactory neuroprotective and neurorestorative treatment is not available yet. For this purpose, understanding of molecular mechanisms of neuronal cell death in these two disorders is imperative. Recently, pathologic processes common to these two groups of disorders have been identified such as the involvement of inflammatory changes, microglia, cytokines, and apoptosis. We intended to involve scientists working in these two major fields together to participate in hot and fruitful discussion for the understanding of neuronal death and for developing newer methods of treatment. The science is progressing so rapidly today and we are working in a very narrow specialized area. Sometimes, we are ignorant about important discoveries in other fields. This conference was a nice opportunity for scien tists working different areas to meet together and to exchange their experi ence. This volume is the proceedings of this Winter Conference.

Recent Advances in the Treatment of Neurodegenerative Disorders

Author : Sachchida Nand Rai
Publisher : Bentham Science Publishers
ISBN 13 : 1681087731
Total Pages : 232 pages
Book Rating : 4.6/5 (81 download)

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Book Synopsis Recent Advances in the Treatment of Neurodegenerative Disorders by : Sachchida Nand Rai

Download or read book Recent Advances in the Treatment of Neurodegenerative Disorders written by Sachchida Nand Rai and published by Bentham Science Publishers. This book was released on 2021-04-26 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Researchers have tried various effective treatments that prevent the progressive neurodegeneration of neurons within the brain. Parkinson’s disease (PD), Alzheimer’s disease (AD), and Multiple sclerosis (MS) are some of the most common neurodegenerative diseases (NDDs). Recent Advances in the Treatment of Neurodegenerative Disorders provides interesting updates on treatments of these neurological disorders. Ten chapters have been contributed by experts in pharmacology and give a unique perspective to reader on special topics in this area, including the treatment of neurodegenerative treatment of neurodegenerative disease through ayurveda and phytochemicals, the therapeutic role of vitamins in Parkinson’s disease, mushrooms in NDD treatment, MS treatment, ALS treatment and the use of nanoparticles and nano formulations in NDD treatment. This is an informative reference for pharmacologists, medicinal chemists and healthcare professionals (general practitioners and neurologists) seeking updates in the treatment of some common neurodegenerative disorders.

Neurodegenerative Diseases

Author : Philip Beart
Publisher : Springer
ISBN 13 : 3319571931
Total Pages : 546 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Neurodegenerative Diseases by : Philip Beart

Download or read book Neurodegenerative Diseases written by Philip Beart and published by Springer. This book was released on 2017-07-03 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies. The editors bring together contributions from internationally recognized workers in the field to provide an up to date account of how and why molecular and cellular neurobiology is such an important area for clinical neuroscience. Understanding the molecular aspects of a number of neurodegenerative conditions such as Parkinson's or Alzheimer's disease for the purpose of improving patient management remains a major challenge of neurobiology be it from the basic or clinical perspective. A strategic evaluation of research contributions and the power of modern methods will help advance knowledge over the next years.

Advances in Research on Neurodegeneration

Author : Y. Mizuno
Publisher : Springer Science & Business Media
ISBN 13 : 3709168449
Total Pages : 428 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Advances in Research on Neurodegeneration by : Y. Mizuno

Download or read book Advances in Research on Neurodegeneration written by Y. Mizuno and published by Springer Science & Business Media. This book was released on 2013-03-07 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegeneration is one of the most important subjects of the investigation now and in the coming 21st century. Alzheimer's disease is the leading cause of dementia in the elderly people and Parkinson's disease is one of the major neurologic disorders with the prevalence between 1 and 2/1 000 population in advanced countries. Many others are suffering from intractable neurodegener ative disorders such as amyotrophic lateral sclerosis, Huntington's disease, or spinocerebellar degeneration. No truly effective treatment is available for any of these neurodegenerative disorders except for Parkinson's disease; even in Parkinson's disease, still it is impossible to slow down the disease process with the currently available treatment. It is urgently needed to develop new effective technique to halt or slow down the disease process in each of those disorders. Recent advance in the molecular biological and molecular genetic technique has brought us great progress in the understanding of etiology and pathogenesis of these disorders, but still it is not known how neurons are going to die in these disorders. To explore the question, mutual cooperation and exchange of ideas between basic scientists and clinical peoples are of utmost importance.

Frontiers in Clinical Neuroscience

Author : Laszlo Vecsei
Publisher : Springer
ISBN 13 : 0306480387
Total Pages : 195 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis Frontiers in Clinical Neuroscience by : Laszlo Vecsei

Download or read book Frontiers in Clinical Neuroscience written by Laszlo Vecsei and published by Springer. This book was released on 2003-11-30 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, the considerable progress made in biochemistry, molecular biology, genetics and neuropharmacology has revealed some ofthe intimate mechanisms ofthe neurodegenerative disorders. There is increasing evidence linking genetic defects affecting mitochondria to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease and some other neurological disorders. Advances in knowledge are fueled through improved animal models that use mitochondrial toxins, excitotoxins, and transgenic animals. Therapeutic studies in these models have strengthened the possibility for effective treatments in man. By defining the pathomechanisms, we hope to be in the position to prevent cell death by protecting neurons. Indeed serious preclinical and clinical research is going on in the field of neuroprotection in stroke, Parkinson's disease, epilepsy, demyelinating disorders and dementia. Based on these scientific ideas, the Symposium in honour of Professor Abel Lajtha was organized by the European Society for ClinicalNeuropharmacology(ESCNP) and the Danube Symposium for Neurological Sciences in Budapest, Hungary, October 24-25, 2002. Professor Lajtha was born in Budapest in 1922 and his home town is an ideal venue for strengthening the bonds between Western and Eastern European Neuroscientists. Professor Peter Riederer (Wurzburg) held the 2002 special "Dezso Miskolczy Memorial Lecture" in Abel Lajtha's Honour. Thanks are due to the invited speakersofthis Symposium for their excellentcontribution. Laszlo Vecsei vii CONTENTS Advances in Neuroprotection Research for Neurodegenerative Diseases 1 Mario E. Gotz and Peter Riederer Neurotransmitter Release in Experimental Stroke Models: The Role of Glutamate-GABA Interaction 21 Laszlo G. Harsing, Jr.

Neuronal Degeneration and Regeneration: From Basic Mechanisms to Prospects for Therapy

Author : F.W. Van Leeuwen
Publisher : Elsevier
ISBN 13 : 008086242X
Total Pages : 551 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis Neuronal Degeneration and Regeneration: From Basic Mechanisms to Prospects for Therapy by : F.W. Van Leeuwen

Download or read book Neuronal Degeneration and Regeneration: From Basic Mechanisms to Prospects for Therapy written by F.W. Van Leeuwen and published by Elsevier. This book was released on 1998-11-09 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the result of the 20th International Summer School in Brain Research, organized in August 1997 in Amsterdam, by the Netherlands Institute for Brain Research at the Royal Netherlands Academy of Sciences. It is the first book that provides a complete overview of the field of neurodegeneration and regeneration including spinal cord injury, neurodegenerative diseases and therapy. Divided into five sections, the first two sections give an overview of fundamental research on nerve cell death, neuronal survival, neurite outgrowth and guidance. Extensive attention is given to the role of neurotrophins, their receptor tyrosine kinases and cell-adhesion molecules in development and regeneration of the nervous system. The third section of the book is devoted to research involving human neurodegenerative diseases and emerging treatment strategies. Section four focusses on recent advances in the understanding of pathophysiological mechanisms underlying neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases along with prion diseases. Novel insights into the neuropathological hallmarks of these diseases, as well as into transgenic animal models, the involvement of environmental factors, and genomic and mRNA changes that can cause neurodegeneration. The final section of this volume reveals recent developments in the use of cell and gene therapy to treat neurodegenerative disease and lesion-related deficits. Implantation of genetically modified cells, direct gene transfer with viral vectors and the first clinical trials with encapsulated genetically modified cells in patients suffering from amyotrophic lateral scelerosis are examples of new therapeutic strategies treating neurodegenerative diseases. The book is of particular interest to departments of neuroscience, neurological clinics and departments, the pharmalogical industry and medical libraries.

Pathogenesis of Neurodegenerative Disorders

Author : Mark P. Mattson
Publisher : Springer Science & Business Media
ISBN 13 : 159259106X
Total Pages : 296 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Pathogenesis of Neurodegenerative Disorders by : Mark P. Mattson

Download or read book Pathogenesis of Neurodegenerative Disorders written by Mark P. Mattson and published by Springer Science & Business Media. This book was released on 2001-06-01 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the average life expectancy of many populations throughout the world increases, so to does the incidence of such age-related neurodegenerative disorders as Alzheimer's, Parkinson's, and Huntington's diseases. Rapid advances in our understanding of the molecular genetics and environmental factors that either cause or increase risk for age-related neurodegenerative disor ders have been made in the past decade. The ability to evaluate, at the cellular and molecular level, abnormalities in postmortem brain tissue from patients, when taken together with the development of valuable animal and cell-culture models of neurodegenerative disorders has allowed the identification of sequences of events within neurons that result in their demise in specific neurodegenerative disorders. Though the genetic and environmental factors that pro mote neurodegeneration may differ among disorders, shared biochemical cascades that will ultimately lead to the death of neurons have been identified. These cascades involve oxyradical production, aberrant regulation of cellular ion homeostasis and activation of a stereotyped sequence of events involving mitochondrial dysfunction and activa tion of specific proteases. Pathogenesis of Neurodegenerative Disorders provides a timely compilation of articles that encompasses fundamental mechanisms involved in neurodegenerative disorders. In addition, mechanisms that may prevent age-related neurodegenerative disorders are presented. Each chapter is written by an expert in the particular neurodegenerative disorder or mechanism or neuronal death discussed.

Neurodegenerative Diseases

Author : M. Flint Beal
Publisher : Cambridge University Press
ISBN 13 : 1139443453
Total Pages : 1009 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Neurodegenerative Diseases by : M. Flint Beal

Download or read book Neurodegenerative Diseases written by M. Flint Beal and published by Cambridge University Press. This book was released on 2005-06-02 with total page 1009 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases are major contributors to disability and disease, with Alzheimer's and Parkinson's diseases the most prevalent. This major reference reviews the rapidly advancing knowledge of pathogenesis and treatment of neurodegenerative diseases in the context of a comprehensive survey of each disease and its clinical features. The editors and contributors are among the leading experts in the field internationally. Covering basic science, diagnostic tools and therapeutic approaches, the book focuses on all aspects of neurodegenerative disease, including the normal aging process. The dementias, prion diseases, Parkinson's disease and atypical parkinsonisms, neurodegenerative ataxias, motor neuron diseases, degenerative diseases with chorea, iron and copper disorders, and mitochondrial diseases, are all methodically presented and discussed, with extensive illustrations. In each case the underlying genetics, neuropathological and clinical issues are fully reviewed, making this the most complete as well as the most authoritative reference available to clinicians and neuroscientists.

Metals and Neurodegeneration: Restoring the Balance

Author : Anthony R. White
Publisher : Frontiers Media SA
ISBN 13 : 2889197395
Total Pages : 134 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Metals and Neurodegeneration: Restoring the Balance by : Anthony R. White

Download or read book Metals and Neurodegeneration: Restoring the Balance written by Anthony R. White and published by Frontiers Media SA. This book was released on 2016-02-02 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biometals such as copper, zinc and iron have key biological functions, however, aberrant metabolism can lead to detrimental effects on cell function and survival. These biometals have important roles in the brain, driving cellular respiration, antioxidant activity, intracellular signaling and many additional structural and enzymatic functions. There is now considerable evidence that abnormal biometal homeostasis is a key feature of many neurodegenerative diseases and may have an important role in the onset and progression of disorders such as Alzheimer’s, Parkinson’s, prion and motor neuron diseases. Recent studies also support biometal roles in a number of less common neurodegenerative disorders. The role of biometals in a growing list of brain disorders is supported by evidence from a wide range of sources including molecular genetics, biochemical studies and biometal imaging. These studies have spurred a growing interest in understanding the role of biometals in brain function and disease as well as the development of therapeutic approaches that may be able to restore the altered biometal chemistry of the brain. These approaches range from genetic manipulation of biometal transport to chelation of excess metals or delivery of metals where levels are deficient. A number of these approaches are offering promising results in cellular and animal models of neurodegeneration with successful translation to pre-clinical and clinical trials. At a time of aging populations and slow progress in development of neurotherapeutics to treat age-related neurodegenerative diseases, there is now a critical need to further our understanding of biometals in neurodegeneration. This issue covers a broad range of topics related to biometals and their role in neurodegeneration. It is hoped that this will inspire greater discussion and exchange of ideas in this crucial area of research and lead to positive outcomes for sufferers of these neurodegenerative diseases.

Biometals in Neurodegenerative Diseases

Author : Anthony R. White
Publisher : Academic Press
ISBN 13 : 0128045639
Total Pages : 468 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Biometals in Neurodegenerative Diseases by : Anthony R. White

Download or read book Biometals in Neurodegenerative Diseases written by Anthony R. White and published by Academic Press. This book was released on 2017-04-28 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer’s Disease, Parkinson’s Disease, Motor Neuron Disease, Autism and lysosomal storage disorders. This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases. Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics. Authoritative and timely resource bringing together the major findings in the field for those with an interest in metals and their role in the brain function, disease, and as therapeutic targets Written for academic researchers, clinicians, and advanced graduate students studying, or treating, patients in neurodegeneration, neurochemistry, neurology and neurotoxicology Edited by international leaders in the field who have contributed greatly to the study of metals in neurodegenerative diseases

TDP-43 and Neurodegeneration

Author : Vijay Kumar
Publisher : Academic Press
ISBN 13 : 0128204400
Total Pages : 272 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis TDP-43 and Neurodegeneration by : Vijay Kumar

Download or read book TDP-43 and Neurodegeneration written by Vijay Kumar and published by Academic Press. This book was released on 2021-10-23 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43’s structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders. Reviews TDP-43 structure, folding, function, and pathology Identifies TDP-43 role in ALS, FTP, and other neurodegenerative diseases Presents a systems and precision biology perspective of TDP-43 Discusses therapeutics of TDP-43 proteinopathies Translates bench research to application bedside