Neurobiology Of The Trace Amines

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Neurobiology of the Trace Amines

Author : Alan A. Boulton
Publisher : Springer Science & Business Media
ISBN 13 : 1461253128
Total Pages : 584 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Neurobiology of the Trace Amines by : Alan A. Boulton

Download or read book Neurobiology of the Trace Amines written by Alan A. Boulton and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many of the trace amines-more correctly called biogenic amines have been known for decades, but because of their tiny concentra tions (0. 01-100 ng/g) in brain, it was only after the development of sophisticated analytical techniques (such as mass spectrometry) that they could be identified and quantitated in nervous tissue. There are now more than 20 of them and most are related to the catecholamines and 5-hydroxytryptamine both structurally and metabolically. Their pharmacological and physiological properties make them prime candidates for a transmitter or neuromodulator role and many of them elicit profound behavioral syndromes after injection--one of them, phenylethylamine, has even been referred to as nature's amphetamine. In the clinical sphere several have been shown to be involved in: Parkinsonism, schizophrenia, depression, agoraphobia, aggression, hyperkinesis, migraine, hypertensive crises, hypertyrosinemia, he patic encephalopathy, epilepsy, and cystic fibrosis. Thus the research reported here on these intriguing "new" substances will be of great interest to psychiatrists, neurologists, biochemists, pharmacologists, physiologists, psychologists, behaviorists and indeed to all those working in the neurosciences and related fields today. ACKNOWLEDGMENTS This book is based on the proceedings of Trace Amines and the Neurosciences, a meeting held at the University of Alberta, Edmonton, July 19-21, 1983. This meeting was organized as a Satellite Meeting of the Ninth Meeting of the International Society for Neurochemistry, held in Vancouver, July 10-15, 1983. International organizers of the satellite meeting were Drs. A.A. Boulton (Saskatoon), W.G. Dewhurst (Edmonton), G.B. Baker (Edmonton), and M. Sandler (London)

Trace Amines

Author : Alan A. Boulton
Publisher : Springer Science & Business Media
ISBN 13 : 1461246024
Total Pages : 473 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Trace Amines by : Alan A. Boulton

Download or read book Trace Amines written by Alan A. Boulton and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the third Proceedings book to arise from biennial conferen ces on the Trace Amines. Since our first meeting in 1983 in Edmonton, Canada, progress has been brisk and, as will be seen from the ensuing pages, it is now possible to include major contributions from inverte brate neurobiologists as well as receptorologists. In the opening ses sion we heard about the distribution of the trace amines-now clear ly a misnomer-in insects and the pharmacological, receptor, and syn aptic characteristics of octopamine and tryptamine as well as the pos sibility of monoamines in general being targets for insecticide discov ery. In mammalian brain the distribution and characterization of the tryptamine receptor has proceeded to the point where two types have been described as well as novel agonists and antagonists, and, for the first time, a binding site for p-tyramine has been described. The com bination of lesions and pharmacological and metabolic manipulations now permits the mapping of trace aminergic pathways, and the rap idly accumulating evidence from releasing drugs, in situ microdialy sis, iontophoresis, and second messenger systems lends credence to the claim that the trace amines possess neuromodulatory functions.

Neuropsychopharmacology of the Trace Amines

Author : Alan A. Boulton
Publisher : Springer Science & Business Media
ISBN 13 : 1461250102
Total Pages : 508 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Neuropsychopharmacology of the Trace Amines by : Alan A. Boulton

Download or read book Neuropsychopharmacology of the Trace Amines written by Alan A. Boulton and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: A probable neurobiological role for the trace amines began to emerge as soon as techniques sufficiently sophisticated to detect them were developed. Techniques for quantitative analyses included radioenzymatic procedures and, more recently, HPlC-EC and auto mated GC-MS. The methods are applied after separation of the sub stances to be analyzed and after their purification by physicochemical procedures that are becoming more and more efficient. The identification and quantitative analysis of minute amounts of trace amines in biological fluids or tissues is in itself a remarkable technological achievement. The enormous task that several teams of research workers have set themselves is to investigate the origin of the trace amines, to understand their metabolism, and to discover whether or not they possess an important biological role. The 2nd Trace Amines Symposium at Weitenburg Castle near Tubingen from the 15th to the 19th May 1985 was held to gain a somewhat clearer insight into the present state of knowledge. Since the first meeting in 1983 our knowledge has increased and interest is deepening. Hence the idea proposed at that first meeting, of organizing similar gather ings at regular intervals, has come to fruition. Covered in the Neuropsychopharmacology section of this book are studiesof the effects of certain trace amines on different forms of be havior, on neurotransmission mediated by . the classical neuro transmitters, on their biosynthesis or on catabolism, on their possible occurrence as a result of alternative metabolic pathways for the amino acids, and in some instances their neuroanatomical distributions.

Trace Amines and the Brain

Author : Earl Usdin
Publisher : Marcel Dekker
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.:/5 (45 download)

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Book Synopsis Trace Amines and the Brain by : Earl Usdin

Download or read book Trace Amines and the Brain written by Earl Usdin and published by Marcel Dekker. This book was released on 1976 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Trace Amines and Neurological Disorders

Author : Tahira Farooqui
Publisher : Academic Press
ISBN 13 : 0128036168
Total Pages : 432 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Trace Amines and Neurological Disorders by : Tahira Farooqui

Download or read book Trace Amines and Neurological Disorders written by Tahira Farooqui and published by Academic Press. This book was released on 2016-07-12 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders. Focuses on recent findings on trace amines, providing insights into the functional significance, molecular mechanisms, and biological relevance of TAARS in neurological disorders Edited work with chapters authored by leaders in the field from around the globe, the broadest, most expert coverage available Provides cutting-edge research on trace amines-mediated signaling in vertebrate model systems

Trace Amines and the Brain

Author : Earl Usdin
Publisher :
ISBN 13 : 9780783706719
Total Pages : 319 pages
Book Rating : 4.7/5 (67 download)

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Book Synopsis Trace Amines and the Brain by : Earl Usdin

Download or read book Trace Amines and the Brain written by Earl Usdin and published by . This book was released on with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Basis of Odor

Author : John E. Amoore
Publisher :
ISBN 13 :
Total Pages : 224 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Molecular Basis of Odor by : John E. Amoore

Download or read book Molecular Basis of Odor written by John E. Amoore and published by . This book was released on 1970 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neuroanatomical Tract-Tracing

Author : Laszlo Zaborszky
Publisher : Springer Science & Business Media
ISBN 13 : 0387289429
Total Pages : 703 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Neuroanatomical Tract-Tracing by : Laszlo Zaborszky

Download or read book Neuroanatomical Tract-Tracing written by Laszlo Zaborszky and published by Springer Science & Business Media. This book was released on 2006-11-22 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first two editions of this title had a tremendous impact in neuroscience. Between the Second edition in 1989 and today, there has been an explosion of information in the field, including advances in molecular techniques, such as genomics and proteomics, which have become increasing important in neuroscience. A renaissance in fluorescence has occurred, driven by the development of new probes, new microscopes, live imagers, and computer processing. The introduction of new markers has enormously stimulated the field, moving it from tissue culture to neurophysiology to functional MRI techniques.

Catecholamine Research in the 21st Century

Author : Tatyana D. Sotnikova
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128075325
Total Pages : 328 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Catecholamine Research in the 21st Century by : Tatyana D. Sotnikova

Download or read book Catecholamine Research in the 21st Century written by Tatyana D. Sotnikova and published by Elsevier Inc. Chapters. This book was released on 2013-12-05 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Neurobiology of Olfaction

Author : Anna Menini
Publisher : CRC Press
ISBN 13 : 9781420071993
Total Pages : 448 pages
Book Rating : 4.0/5 (719 download)

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Book Synopsis The Neurobiology of Olfaction by : Anna Menini

Download or read book The Neurobiology of Olfaction written by Anna Menini and published by CRC Press. This book was released on 2009-11-24 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Overview of Advances in Olfaction The common belief is that human smell perception is much reduced compared with other mammals, so that whatever abilities are uncovered and investigated in animal research would have little significance for humans. However, new evidence from a variety of sources indicates this traditional view is likely overly simplistic. The Neurobiology of Olfaction provides a thorough analysis of the state-of-the-science in olfactory knowledge and research, reflecting the growing interest in the field. Authors from some of the most respected laboratories in the world explore various aspects of olfaction, including genetics, behavior, olfactory systems, odorant receptors, odor coding, and cortical activity. Until recently, almost all animal research in olfaction was carried out on orthonasal olfaction (inhalation). It is only in recent years, especially in human flavor research, that evidence has begun to be obtained regarding the importance of retronasal olfaction (exhalation). These studies are beginning to demonstrate that retronasal smell plays a large role to play in human behavior. Highlighting common principles among various species – including humans, insects, Xenopus laevis (African frog), and Caenorhabditis elegans (nematodes) – this highly interdisciplinary book contains chapters about the most recent discoveries in odor coding from the olfactory epithelium to cortical centers. It also covers neurogenesis in the olfactory epithelium and olfactory bulb. Each subject-specific chapter is written by a top researcher in the field and provides an extensive list of reviews and original articles for students and scientists interested in further readings.

Neurobiology of Chemical Communication

Author : Carla Mucignat-Caretta
Publisher : CRC Press
ISBN 13 : 1466553413
Total Pages : 614 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Neurobiology of Chemical Communication by : Carla Mucignat-Caretta

Download or read book Neurobiology of Chemical Communication written by Carla Mucignat-Caretta and published by CRC Press. This book was released on 2014-02-14 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intraspecific communication involves the activation of chemoreceptors and subsequent activation of different central areas that coordinate the responses of the entire organism—ranging from behavioral modification to modulation of hormones release. Animals emit intraspecific chemical signals, often referred to as pheromones, to advertise their presence to members of the same species and to regulate interactions aimed at establishing and regulating social and reproductive bonds. In the last two decades, scientists have developed a greater understanding of the neural processing of these chemical signals. Neurobiology of Chemical Communication explores the role of the chemical senses in mediating intraspecific communication. Providing an up-to-date outline of the most recent advances in the field, it presents data from laboratory and wild species, ranging from invertebrates to vertebrates, from insects to humans. The book examines the structure, anatomy, electrophysiology, and molecular biology of pheromones. It discusses how chemical signals work on different mammalian and non-mammalian species and includes chapters on insects, Drosophila, honey bees, amphibians, mice, tigers, and cattle. It also explores the controversial topic of human pheromones. An essential reference for students and researchers in the field of pheromones, this is also an ideal resource for those working on behavioral phenotyping of animal models and persons interested in the biology/ecology of wild and domestic species.

Basic Neurochemistry

Author : Scott Brady
Publisher : Academic Press
ISBN 13 : 0080959016
Total Pages : 1120 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Basic Neurochemistry by : Scott Brady

Download or read book Basic Neurochemistry written by Scott Brady and published by Academic Press. This book was released on 2011-11-02 with total page 1120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, the outstanding and comprehensive classic text on neurochemistry, is now newly updated and revised in its Eighth Edition. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. It is also an excellent source of current information on basic biochemical and cellular processes in brain function and neurological diseases for continuing medical education and qualifying examinations. This text continues to be the standard reference and textbook for exploring the translational nature of neuroscience, bringing basic and clinical neuroscience together in one authoritative volume. Our book title reflects the expanded attention to these links between neurochemistry and neurologic disease. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from: Intracellular trafficking; Stem cells, adult neurogenesis, regeneration; Lipid messengers; Expanded coverage of all major neurodegenerative and psychiatric disorders; Neurochemistry of addiction; Neurochemistry of pain; Neurochemistry of hearing and balance; Neurobiology of learning and memory; Sleep; Myelin structure, development, and disease; Autism; and Neuroimmunology. Completely updated text with new authors and material, and many entirely new chapters Over 400 fully revised figures in splendid color 61 chapters covering the range of cellular, molecular and medical neuroscience Translational science boxes emphasizing the connections between basic and clinical neuroscience Companion website at http://elsevierdirect.com/companions/9780123749475

The Neurology of Olfaction

Author : Christopher H. Hawkes
Publisher : Cambridge University Press
ISBN 13 : 0521682169
Total Pages : 265 pages
Book Rating : 4.5/5 (216 download)

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Book Synopsis The Neurology of Olfaction by : Christopher H. Hawkes

Download or read book The Neurology of Olfaction written by Christopher H. Hawkes and published by Cambridge University Press. This book was released on 2009-02-12 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Written by two experts in the field, this book provides information useful to physicians for assessing and managing chemosensory disorders - with appropriate case-histories - and summarizes the current scientific knowledge of human olfaction. It will be of particular interest to neurologists, otolaryngologists, psychologists, psychiatrists, and neuroscientists."--BOOK JACKET.

Neuromodulation

Author : Leonard K. Kaczmarek
Publisher : Oxford University Press, USA
ISBN 13 : 9780195040975
Total Pages : 316 pages
Book Rating : 4.0/5 (49 download)

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Book Synopsis Neuromodulation by : Leonard K. Kaczmarek

Download or read book Neuromodulation written by Leonard K. Kaczmarek and published by Oxford University Press, USA. This book was released on 1987 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an introduction to the general principles of neuromodulation--the key neurobiological process for understanding how the brain works. Emphasizing ion channels and biochemical mechanisms of protein phosphorylation, the book shows how neurons regulate their intracellular calcium concentration by modulating the activity of certain ion channels. It goes on to explain the function of intracellular calcium and describes some fascinating neuromodulatory phenomena in the mammalian brain that have long awaited the kind of mechanistic investigations possible in simpler systems. Bridging the gap between neurochemistry and neurophysiology, the authors make complex concepts and research approaches comprehensible to scientists in either field.

Fundamental Neuroscience

Author : Larry Squire
Publisher : Academic Press
ISBN 13 : 0080561020
Total Pages : 1277 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Fundamental Neuroscience by : Larry Squire

Download or read book Fundamental Neuroscience written by Larry Squire and published by Academic Press. This book was released on 2008-04-02 with total page 1277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamental Neuroscience, Third Edition introduces graduate and upper-level undergraduate students to the full range of contemporary neuroscience. Addressing instructor and student feedback on the previous edition, all of the chapters are rewritten to make this book more concise and student-friendly than ever before. Each chapter is once again heavily illustrated and provides clinical boxes describing experiments, disorders, and methodological approaches and concepts.Capturing the promise and excitement of this fast-moving field, Fundamental Neuroscience, 3rd Edition is the text that students will be able to reference throughout their neuroscience careers! 30% new material including new chapters on Dendritic Development and Spine Morphogenesis, Chemical Senses, Cerebellum, Eye Movements, Circadian Timing, Sleep and Dreaming, and Consciousness Additional text boxes describing key experiments, disorders, methods, and concepts Multiple model system coverage beyond rats, mice, and monkeys Extensively expanded index for easier referencing

Neurotransmitters, Drugs and Brain Function

Author : Roy Webster
Publisher : John Wiley & Sons
ISBN 13 : 9780471978190
Total Pages : 550 pages
Book Rating : 4.9/5 (781 download)

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Book Synopsis Neurotransmitters, Drugs and Brain Function by : Roy Webster

Download or read book Neurotransmitters, Drugs and Brain Function written by Roy Webster and published by John Wiley & Sons. This book was released on 2001-11-28 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurotransmitters, Drugs and Brain Function aims to link basic aspects of the activity of neurotransmitters at the receptor and synaptic level with their role in normal brain function, disease states, and drug action. Thus, the material considers to what extent our knowledge of the central synaptic action of certain drugs can explain their possible roles in the cause of diseases and in the modes of action of drugs effective in those conditions. It offers a working explanation of drug and neurotransmitter action in CNS function, with a clear, comprehensive, and challenging style of writing. The authors review the chemical basis for drugs and the conditions they treat. It also, includes numerous illustrations and schematic diagrams.

Magnesium in the Central Nervous System

Author : Robert Vink
Publisher : University of Adelaide Press
ISBN 13 : 0987073052
Total Pages : 354 pages
Book Rating : 4.9/5 (87 download)

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Book Synopsis Magnesium in the Central Nervous System by : Robert Vink

Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.