Neurobiology Of Alzheimers Disease

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The Neurobiology of Alzheimer's Disease

Author : Study Group on the Pharmacology of Memory Disorders Associated with Aging. Meeting
Publisher :
ISBN 13 :
Total Pages : 460 pages
Book Rating : 4.X/5 (4 download)

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Book Synopsis The Neurobiology of Alzheimer's Disease by : Study Group on the Pharmacology of Memory Disorders Associated with Aging. Meeting

Download or read book The Neurobiology of Alzheimer's Disease written by Study Group on the Pharmacology of Memory Disorders Associated with Aging. Meeting and published by . This book was released on 1996 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: The overall goal of the International Study Group on the Pharmacology of Memory Disorders Associated with Ageing is to point out discoveries that shed light on the potential causes of Alzheimer's disease, its pathogenesis, and the biological mechanisms that could underlie its cure. This eighth meeting in the series, aims to stimulate research in dementia and increase the transfer of information from the basic sciences to physicians and the pharmaceutical industry."

Neurology in Clinical Practice

Author : Walter George Bradley
Publisher :
ISBN 13 : 9780750674690
Total Pages : 1672 pages
Book Rating : 4.6/5 (746 download)

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Book Synopsis Neurology in Clinical Practice by : Walter George Bradley

Download or read book Neurology in Clinical Practice written by Walter George Bradley and published by . This book was released on 2004 with total page 1672 pages. Available in PDF, EPUB and Kindle. Book excerpt: New edition, completely rewritten, with new chapters on endovascular surgery and mitochrondrial and ion channel disorders.

Magnesium in the Central Nervous System

Author : Robert Vink
Publisher : University of Adelaide Press
ISBN 13 : 0987073052
Total Pages : 354 pages
Book Rating : 4.9/5 (87 download)

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Book Synopsis Magnesium in the Central Nervous System by : Robert Vink

Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

The Biology of Alzheimer Disease

Author : Dennis J. Selkoe
Publisher : Cold Spring Harbor Perspective
ISBN 13 : 9781936113446
Total Pages : 0 pages
Book Rating : 4.1/5 (134 download)

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Book Synopsis The Biology of Alzheimer Disease by : Dennis J. Selkoe

Download or read book The Biology of Alzheimer Disease written by Dennis J. Selkoe and published by Cold Spring Harbor Perspective. This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer disease causes the gradual deterioration of cognitive function, including severe memory loss and impairments in abstraction and reasoning. Understanding the complex changes that occur in the brain as the disease progressesincluding the accumulation of amyloid plaques and neurofibrillary tanglesis critical for the development of successful therapeutic approaches. Written and edited by leading experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine includes contributions covering all aspects of Alzheimer disease, from our current molecular understanding to therapeutic agents that could be used to treat and, ultimately, prevent it. Contributors discuss the biochemistry and cell biology of amyloid -protein precursor (APP), tau, presenilin, -secretase, and apolipoprotein E and their involvement in Alzheimer disease. They also review the clinical, neuropathological, imaging, and biomarker phenotypes of the disease; genetic alterations associated with the disorder; and epidemiological insights into its causation and pathogenesis. This comprehensive volume, which includes discussions of therapeutic strategies that are currently used or under development, is a vital reference for neurobiologists, cell biologists, pathologists, and other scientists pursuing the biological basis of Alzheimer disease, as well as investigators, clinicians, and students interested in its pathogenesis, treatment, and prevention.

A Multidisciplinary Approach to Capability in Age and Ageing

Author : Hanna Falk Erhag
Publisher : Springer Nature
ISBN 13 : 3030780635
Total Pages : 254 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis A Multidisciplinary Approach to Capability in Age and Ageing by : Hanna Falk Erhag

Download or read book A Multidisciplinary Approach to Capability in Age and Ageing written by Hanna Falk Erhag and published by Springer Nature. This book was released on 2022-01-10 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides insight on how to interpret capability in ageing – one’s individual ability to perform actions in order to reach goals one has reason to value – from a multidisciplinary approach. With for the first time in history there being more people in the world aged 60 years and over than there are children below the age of 5, the book describes this demographic trends as well as the large global challenges and important societal implications this will have such as a worldwide increase in the number of persons affected with dementia, and in the ratio of retired persons to those still in the labor market. Through contributions from many different research areas, it discussed how capability depends on interactions between the individual (e.g. health, genetics, personality, intellectual capacity), environment (e.g. family, friends, home, work place), and society (e.g. political decisions, ageism, historical period). The final chapter summarizes the differences and similarities in these contributions. As such this book provides an interesting read for students, teachers and researchers at different levels and from different fields interested in capability and multidisciplinary research.

Alzheimer’s Disease

Author : Ralph W. Richter
Publisher : Springer Science & Business Media
ISBN 13 : 1592596614
Total Pages : 577 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Alzheimer’s Disease by : Ralph W. Richter

Download or read book Alzheimer’s Disease written by Ralph W. Richter and published by Springer Science & Business Media. This book was released on 2003-10-10 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer’s disease (AD) is a devastating and dehumanizing illness affecting increasingly large numbers of elderly and even middle-aged persons in a worldwide epidemic. Alzheimer’s Disease: A Physician’s Guide to Practical Management was written by selected clinicians and scientists who represent some of the world’s leading centers of excellence in AD research. The editors are proud and grateful for their profound contributions. This book is particularly designed to assist physicians and other health-care professionals in the evaluation, assessment, and treatment of individuals with AD. At the same time, by illuminating the basic scientific background, we hope to provide state-of-the art information about the disease and possible future therapeutic strategies. The recent psychiatric treatment aspects of AD are also clearly presented. Because the early diagnosis of the dementia process is now considered of increasing importance, we focus particularly in several chapters on early changes and preclinical conditions, such as mild cognitive impairment and predementia AD.

The Hippocampus in Clinical Neuroscience

Author : K. Szabo
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318025682
Total Pages : 174 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis The Hippocampus in Clinical Neuroscience by : K. Szabo

Download or read book The Hippocampus in Clinical Neuroscience written by K. Szabo and published by Karger Medical and Scientific Publishers. This book was released on 2014-04-23 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hippocampus is one of the most intriguing structures of the human brain. Damage to this part causes symptoms ranging from transient disorders accompanied by tiny lesions to severely debilitating cognitive disorders with marked tissue loss. This publication provides a predominantly clinical approach to the complex workings of the hippocampus from different perspectives, ranging from basic principles to specific diseases. The first part of the book summarizes current knowledge regarding the structure and physiology of the hippocampus and establishes the ties to basic neuroscience. The second part deals with the function and assessment of the human hippocampus, including memory function, neuropsychological measures, and conventional and functional imaging studies. The chapters of the third part are devoted to the hippocampus in neurological disorders, e.g. the interaction between stress and memory function, and the pathological conditions of common as well as selected rare neurological diseases affecting the hippocampus. The book is highly recommended to clinical neurologists who wish to gain a broad understanding of this complex and fascinating organ in terms of basic principles, modern imaging findings, and specific diseases.

The Handbook of Alzheimer's Disease and Other Dementias

Author : Andrew E. Budson
Publisher : John Wiley & Sons
ISBN 13 : 1444344099
Total Pages : 676 pages
Book Rating : 4.4/5 (443 download)

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Book Synopsis The Handbook of Alzheimer's Disease and Other Dementias by : Andrew E. Budson

Download or read book The Handbook of Alzheimer's Disease and Other Dementias written by Andrew E. Budson and published by John Wiley & Sons. This book was released on 2011-09-09 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: The reference is a broad-ranging review of Alzheimer's disease and other dementias from both basic and clinical neuroscience perspectives; it provides scientists and medical professionals with an extensive introduction and an up-to-date review of cutting-edge scientific advances. Brings the reader up-to-date with cutting-edge developments in this exciting and fast-paced field Summarizes the most recent developments in the fields of Alzheimer's disease and dementia Brings together articles from a prominent and international group of contributors Encompasses a unique range of topics, combining basic molecular perspectives and cognitive neurosciences

Methods of Behavior Analysis in Neuroscience

Author : Jerry J. Buccafusco
Publisher : CRC Press
ISBN 13 : 1420041819
Total Pages : 341 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Methods of Behavior Analysis in Neuroscience by : Jerry J. Buccafusco

Download or read book Methods of Behavior Analysis in Neuroscience written by Jerry J. Buccafusco and published by CRC Press. This book was released on 2000-08-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Alzheimer’s Disease - From Basic Research to Clinical Applications

Author : Hermann J. Gertz
Publisher : Springer Science & Business Media
ISBN 13 : 3709175089
Total Pages : 313 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Alzheimer’s Disease - From Basic Research to Clinical Applications by : Hermann J. Gertz

Download or read book Alzheimer’s Disease - From Basic Research to Clinical Applications written by Hermann J. Gertz and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: As human longevity continues to be extended, so will the impact of age-associated dementia on individual lives and society. Alzheimer’s disease as the most common cause of dementia in the elderly remains a sentinal problem and its underlying pathology is still poorly understood. Available therapeutic strategies require considerable refinement and the development of new therapeutic strategies need input from basic research. Thus continued efforts are necessary both to understand basic mechanisms of the condition and to achieve more powerfull therapies. This volume brings together the reports of basic scientists and clinical investigators. The chapters provide a spectrum of information valuable for clinicians and scientists. This issue bridges the gap between laboratory work in basic science and the development of urgently needed therapeutic strategies. Areas presented are the molecular and cellular biology of the disease, pathogenetic mechanisms and potential therapeutic targets, genetics, risk factors, strategies of prevention and treatment as well as practical aspects of medical and social care for patients with Alzheimer’s disease.

Ageing and Dementia

Author : Kurt Jellinger
Publisher : Springer Science & Business Media
ISBN 13 : 9783211837979
Total Pages : 400 pages
Book Rating : 4.8/5 (379 download)

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Book Synopsis Ageing and Dementia by : Kurt Jellinger

Download or read book Ageing and Dementia written by Kurt Jellinger and published by Springer Science & Business Media. This book was released on 2002-08-20 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epidemiological studies, modern clinical, neuroimaging, neuropsychological, molecular biological, and genetic studies have considerably enhanced our knowledge about ageing processes of the human brain, its sequelae, diagnostic, and therapeutic possibilities and limits. In addition to Alzheimer's disease and other degenerative dementias, the impact of cerebrovascular lesions and their risk factors in the pathogenesis of cognitive disorders of the aged are increasingly acknowledged, and the recognition of mild cognitive impairment as a frequent initial stage of developing dementia is becoming an increasingly important diagnostic and therapeutic problem. The included papers were presented at the 7th International Symposium in Graz, Sept. 2001 and give a timely overview of the current and future concepts of pathogenesis, diagnosis, and treatment strategies of pathological brain ageing and dementias, early recognition of mild cognitive impairment and future possiblities of prevention of dementing processes.

How Not to Study a Disease

Author : Karl Herrup
Publisher : MIT Press
ISBN 13 : 0262546019
Total Pages : 269 pages
Book Rating : 4.2/5 (625 download)

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Book Synopsis How Not to Study a Disease by : Karl Herrup

Download or read book How Not to Study a Disease written by Karl Herrup and published by MIT Press. This book was released on 2023-03-07 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authority on Alzheimer's disease offers a history of past failures and a roadmap that points us in a new direction in our journey to a cure. For decades, some of our best and brightest medical scientists have dedicated themselves to finding a cure for Alzheimer's disease. What happened? Where is the cure? The biggest breakthroughs occurred twenty-five years ago, with little progress since. In How Not to Study a Disease, neurobiologist Karl Herrup explains why the Alzheimer's discoveries of the 1990s didn't bear fruit and maps a direction for future research. Herrup describes the research, explains what's taking so long, and offers an approach for resetting future research. Herrup offers a unique insider's perspective, describing the red flags that science ignored in the rush to find a cure. He is unsparing in calling out the stubbornness, greed, and bad advice that has hamstrung the field, but his final message is a largely optimistic one. Herrup presents a new and sweeping vision of the field that includes a redefinition of the disease and a fresh conceptualization of aging and dementia that asks us to imagine the brain as a series of interconnected "neighborhoods." He calls for changes in virtually every aspect of the Alzheimer's disease research effort, from the drug development process, to the mechanisms of support for basic research, to the often-overlooked role of the scientific media, and more. With How Not to Study a Disease, Herrup provides a roadmap that points us in a new direction in our journey to a cure for Alzheimer's.

Neuroprotection in Alzheimer's Disease

Author : Illana Gozes
Publisher : Academic Press
ISBN 13 : 0128037121
Total Pages : 344 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Neuroprotection in Alzheimer's Disease by : Illana Gozes

Download or read book Neuroprotection in Alzheimer's Disease written by Illana Gozes and published by Academic Press. This book was released on 2016-12-30 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroprotection in Alzheimer's Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer's disease will pave the path to better disease management and novel therapeutics. - Comprehensive reference detailing neuroprotection in Alzheimer's Disease, with details on nerve cell protection and new advances in disease management - Combines the knowledge and points-of-view of both medical doctors and basic scientists, putting the subject at the forefront for further clinical development - Edited by one of the leading researchers in Alzheimer's Disease

Limbic-predominant Age-related TDP-43 Encephalopathy

Author : Beller Health
Publisher : Independently Published
ISBN 13 : 9781097268511
Total Pages : 114 pages
Book Rating : 4.2/5 (685 download)

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Book Synopsis Limbic-predominant Age-related TDP-43 Encephalopathy by : Beller Health

Download or read book Limbic-predominant Age-related TDP-43 Encephalopathy written by Beller Health and published by Independently Published. This book was released on 2019-05-13 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Book 9 focuses on a new dementia type, LATE, mistaken as Alzheimer's disease until now.LATE stands for Limbic-predominant age-related TDP-43 encephalopathy, the protein buildup responsible for this dementia. This book is organic, like the series, meaning we never consider our books as finished. Science evolves, which is why our books go through continuous updates. Since LATE is a new dementia classification, we expect continuous further information to emerge. Watch Amazon alerts for potential digital updates. We provide free digital copies on all paperback purchases, so everybody receives free updates.

The Neuroscience of Dementia

Author : Colin R Martin
Publisher : Academic Press
ISBN 13 : 0128160446
Total Pages : 1866 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis The Neuroscience of Dementia by : Colin R Martin

Download or read book The Neuroscience of Dementia written by Colin R Martin and published by Academic Press. This book was released on 2020-12-23 with total page 1866 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neuroscience of Dementia brings together different fields of dementia research into a single book, covering a wide range of subjects, including Alzheimer's disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, molecular biology, and more. This foundational, comprehensive book compiles the latest understanding on all forms of dementia and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. - Offers comprehensive coverage of a broad range of topics related to dementia - Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding - Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations - Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations - Serves as a "one-stop" source for everything you need to know about dementia

Neurodegenerative Diseases

Author : Donald Brian Calne
Publisher : Saunders
ISBN 13 :
Total Pages : 992 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Neurodegenerative Diseases by : Donald Brian Calne

Download or read book Neurodegenerative Diseases written by Donald Brian Calne and published by Saunders. This book was released on 1994 with total page 992 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is a comprehensive book dedicated to normal neural aging and neurodegenerative disorders. The first section of the text discusses topics relevant to the basic science of neurodegenerative disease such as organic and inorganic neurotoxins, virus and neurodegeneration, lewy bodies, and neurofibrillary tangle. Dr. Calne and over 75 international experts next focus on specific disease entities such as Parkinson's, ALS, Alzheimers, and a host of other common and rare diseases and present the pathology, clinical features, natural history and treatment of each. In addition, emphasis is placed on the practical problems of diagnosis and treatment.

The American Psychiatric Publishing Textbook of Alzheimer Disease and Other Dementias

Author : Myron F. Weiner
Publisher : American Psychiatric Pub
ISBN 13 :
Total Pages : 596 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis The American Psychiatric Publishing Textbook of Alzheimer Disease and Other Dementias by : Myron F. Weiner

Download or read book The American Psychiatric Publishing Textbook of Alzheimer Disease and Other Dementias written by Myron F. Weiner and published by American Psychiatric Pub. This book was released on 2009 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering a comprehensive overview of dementia for psychiatrists and other health care practitioners, the authors review pharmacologic, behavioral, and environmental treatments, and present information on nearly every subject related to dementing conditions or illnesses.