Networking Of Mutagens In Environmental Toxicology

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Networking of Mutagens in Environmental Toxicology

Author : Kavindra Kumar Kesari
Publisher : Springer
ISBN 13 : 3319965115
Total Pages : 183 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Networking of Mutagens in Environmental Toxicology by : Kavindra Kumar Kesari

Download or read book Networking of Mutagens in Environmental Toxicology written by Kavindra Kumar Kesari and published by Springer. This book was released on 2019-05-25 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the latest environmental issues based on current research objectives. All chapters are fundamentally interlinked and focus on deciphering the networking of mutagens in environmental toxicity and human health. Our changing environment, climate, and lifestyle factors are growing concerns in the 21st century. The existing mutagens, either physical or chemical, are responsible for environmental toxicity. These toxicants are carcinogenic and not limited to naturally occurring chemicals or biologicals, but can also be man-made, such as 'radiation'. The networking of mutagens can have a broad range of effects on both the environment and human health. Accordingly, the respective chapters explore the networking of mutagens in connection with environmental toxicity, and address: 1. Extant types of man-made radiation and their effects on the environment and biological systems2. Heavy metal contaminations: Effects on environmental health3. Networking of environmental pollutants in the air, dust, soil, water, and natural toxins in the environment: Exposure and health4. The molecular interaction of environmental carcinogens with DNA: An oncoinformatics approach5. Fundamentals of nonotoxicity, carcinogenicity, mutagenic and neurotoxicity in environmental health6. The role of antioxidants and medicinal plants in reducing the impacts of disease-causing pollutants A sequel to Perspectives in Environmental Toxicology, this book highlights the latest developments in the field of environmental toxicology. It offers a valuable resource for researchers, scholars and graduate students alike.

Chemical Consequences

Author : Scott Frickel
Publisher : Rutgers University Press
ISBN 13 : 9780813534138
Total Pages : 220 pages
Book Rating : 4.5/5 (341 download)

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Book Synopsis Chemical Consequences by : Scott Frickel

Download or read book Chemical Consequences written by Scott Frickel and published by Rutgers University Press. This book was released on 2004 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hereis the first historical and sociological account of the formation of an interdisciplinary science known as genetic toxicology, and of the scientists' social movement that created it. After research geneticists discovered that synthetic chemicals were capable of changing the genetic structure of living organisms, scientists began to explore how these chemicals affected gene structure and function. In the late 1960s, a small group of biologists became concerned that chemical mutagens represented a serious and possibly global environmental threat. Genetic toxicology is nurtured as much by public culture as by professional practices, reflecting the interplay of genetics research and environmental politics. Drawing on a wealth of resources, Scott Frickel examines the creation of this field through the lens of social movement theory. He reveals how a committed group of scientist-activists transformed chemical mutagens into environmental problems, mobilized existing research networks, recruited scientists and politicians, secured financial resources, and developed new ways of acquiring knowledge. The result is a book that vividly illustrates how science and activism were interwoven to create a discipline that remains a defining feature of environmental health science.

Chemical Mutagens

Author : Alexander Hollaender
Publisher : Springer Science & Business Media
ISBN 13 : 1461321476
Total Pages : 316 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Chemical Mutagens by : Alexander Hollaender

Download or read book Chemical Mutagens written by Alexander Hollaender and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 9 of Chemical Mutagens consists mainly of chapters discussing the development and validation of short-term assays to detect the mutagenic effects of environmental chemicals. These chapters include an assay with the grasshopper neuroblast, a comparison of mutagenic responses of human lung-derived and skin-derived diploid fibroblasts, a forward-mutation assay in Salmonella, a multigene sporulation test in Bacillus subtilis, a specific locus assay in mouse lymphoma cells, a study of the induction of bacteriophage lambda, and the granuloma pouch assay. In addition, there are two chapters on the identification of mutagens in cooked food and in human feces. Frederick 1. de Serres Research Triangle Park, North Carolina vii Contents Chapter 1 The Grasshopper Neuroblast Short-Term Assay for Evaluating the Effects of Environmental Chemicals on Chromosomes and Cell Kinetics 1 Mary Esther Gaulden, Jan C. Liang, and Martha J. Ferguson 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. Embryo Supply. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. 1. Species. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. 2. Origin of Colonies . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. 3. Life Cycle . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2. 4. Colony Maintenance . . . . . . . . . . . . . . . . . . . . . . . . . 6 2. 5. Pathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 2. 6. Allergy to Grasshoppers . . . . . . . . . . . . . . . . . . . . . . 14 3. Grasshopper Egg, Embryo, and Cells . . . . . . . . . . . . . . . . . 14 3. 1. The Egg Shell and Membranes . . . . . . . . . . . . . . . . . 14 3. 2. Embryonic Development . . . . . . . . . . . . . . . . . . . . . . 17 3. 3. Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 4. Methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 4. 1. Exposure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 4. 2. Preparation of Embryos for Cell Analysis . . . . . . . . . 34 4. 3. Analysis of Mutagen Effects. . . . . . . . . . . . . . . . . 40 . . . 5. Response of the Grasshopper Neuroblast to Mutagens . . . . 50 5. 1. Reproducibility of Data . . . . . . . . . . . . . . . . . . . . . . . 50 5. 2. Radiation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 5. 3. Chemical Mutagens . . . . . . . . . . . . . . . . . . . . . . . . . .

Environmental Mutagen Society 20th Anniversary Issue

Author :
Publisher :
ISBN 13 :
Total Pages : 113 pages
Book Rating : 4.:/5 (923 download)

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Book Synopsis Environmental Mutagen Society 20th Anniversary Issue by :

Download or read book Environmental Mutagen Society 20th Anniversary Issue written by and published by . This book was released on 1989 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Environmental Mutagen Information Center (EMIC) Database

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (431 download)

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Book Synopsis Environmental Mutagen Information Center (EMIC) Database by :

Download or read book Environmental Mutagen Information Center (EMIC) Database written by and published by . This book was released on 199? with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: EMIC is a bibliographic database available on the National Library of Medicine's (NLM) Toxicology Data Network (TOXNET). It covers chemical, biological, and physical agents that have been tested for genotoxic activity, and it contains nearly 100,000 references to literature published since 1965.

Genetic Toxicology Testing

Author : Ray Proudlock
Publisher : Academic Press
ISBN 13 : 0128010061
Total Pages : 458 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Genetic Toxicology Testing by : Ray Proudlock

Download or read book Genetic Toxicology Testing written by Ray Proudlock and published by Academic Press. This book was released on 2016-05-28 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Toxicology Testing: A Laboratory Manual presents a practical guide to genetic toxicology testing of chemicals in a GLP environment. The most commonly used assays are described, from laboratory and test design to results analysis. In a methodical manner, individual test methods are described step-by-step, along with equipment, suggested suppliers, recipes for reagents, and evaluation criteria. An invaluable resource in the lab, this book will help to troubleshoot any assay problems you may encounter to optimise quality and efficiency in your genetic toxicology tests. Genetic Toxicology Testing: A Laboratory Manual is an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own. Offers practical and consistent guidance on the most commonly-performed tests and procedures in a genetic toxicology lab Describes standard genetic toxicology assays, their methodology, reagents, suppliers, and analysis of their results Includes guidance on general approaches: formulation for in vitro assays, study monitoring, and Good Laboratory Practice (GLP) Serves as an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own lab

Environmental Epigenetics

Author : L. Joseph Su
Publisher : Springer
ISBN 13 : 1447166787
Total Pages : 327 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Environmental Epigenetics by : L. Joseph Su

Download or read book Environmental Epigenetics written by L. Joseph Su and published by Springer. This book was released on 2015-05-18 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

How Tobacco Smoke Causes Disease

Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Environmental Toxicants

Author : Morton Lippmann
Publisher : John Wiley & Sons
ISBN 13 : 0470442883
Total Pages : 1189 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Environmental Toxicants by : Morton Lippmann

Download or read book Environmental Toxicants written by Morton Lippmann and published by John Wiley & Sons. This book was released on 2009-03-26 with total page 1189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides the most current information and research available for performing risk assessments on exposed individuals and populations, giving guidance to public health authorities, primary care physicians, and industrial managers Reviews current knowledge on human exposure to selected chemical agents and physical factors in the ambient environment Updates and revises the previous edition, in light of current scientific literature and its significance to public health concerns Includes new chapters on: airline cabin exposures, arsenic, endocrine disruptors, and nanoparticles

Predictive Toxicology

Author : Christoph Helma
Publisher : CRC Press
ISBN 13 : 0849350352
Total Pages : 522 pages
Book Rating : 4.8/5 (493 download)

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Book Synopsis Predictive Toxicology by : Christoph Helma

Download or read book Predictive Toxicology written by Christoph Helma and published by CRC Press. This book was released on 2005-03-17 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of techniques and systems currently utilized in predictive toxicology, this reference presents an in-depth survey of strategies, algorithms, and prediction methods to select, calculate, and represent the features and properties of chemical structures in biological systems. It provides sources of high-quality toxicity data, the most important commercial and noncommercial predictive toxicology programs, and advanced technologies in computational chemistry, biology, statistics, and data mining. Predictive Toxicology explores applications that go beyond classical structure-activity relationships and discusses programs such as OncoLogic, META, MC4PC, PASS, and lazar.

Manual on MUTATION BREEDING THIRD EDITION

Author : Food and Agriculture Organization of the United Nations
Publisher : Food & Agriculture Org.
ISBN 13 : 9251305269
Total Pages : 319 pages
Book Rating : 4.2/5 (513 download)

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Book Synopsis Manual on MUTATION BREEDING THIRD EDITION by : Food and Agriculture Organization of the United Nations

Download or read book Manual on MUTATION BREEDING THIRD EDITION written by Food and Agriculture Organization of the United Nations and published by Food & Agriculture Org.. This book was released on 2018-10-09 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: This paper provides guidelines for new high-throughput screening methods – both phenotypic and genotypic – to enable the detection of rare mutant traits, and reviews techniques for increasing the efficiency of crop mutation breeding.

Monitoring Human Tissues for Toxic Substances

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309044375
Total Pages : 224 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Monitoring Human Tissues for Toxic Substances by : National Research Council

Download or read book Monitoring Human Tissues for Toxic Substances written by National Research Council and published by National Academies Press. This book was released on 1991-02-01 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Human Monitoring Program (NHMP) identifies concentrations of specific chemicals in human tissues, including toxicologic testing and risk assessment determinations. This volume evaluates the current activities of the NHMP; identifies important scientific, technical, and programmatic issues; and makes recommendations regarding the design of the program and use of its products.

Genetic Toxicology

Author : James M. Parry
Publisher : Humana Press
ISBN 13 : 9781617794209
Total Pages : 433 pages
Book Rating : 4.7/5 (942 download)

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Book Synopsis Genetic Toxicology by : James M. Parry

Download or read book Genetic Toxicology written by James M. Parry and published by Humana Press. This book was released on 2011-12-07 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: The evaluation of potential mutagenic activity is a critical step in the assessment of the safety of both new and pre-existing chemical types. In Genetic Toxicology: Principles and Methods, expert contributors help to satisfy the demand for education in this tremendously important area of study. The volume covers three basic areas: the scientific basis of the discipline, the methodologies of the main test assays, and the application of the methods, all aimed primarily at scientists in the safety departments of the industries working with both natural and synthetic chemicals. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Intuitive and cutting-edge, Genetic Toxicology: Principles and Methods provides crucial support to both laboratory workers in providing quality information on the appropriate application of techniques and to study directors in their assay selection and protocol design in this vital field.

Toxicological Profile for Chlordane

Author :
Publisher :
ISBN 13 :
Total Pages : 286 pages
Book Rating : 4.:/5 (321 download)

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Book Synopsis Toxicological Profile for Chlordane by :

Download or read book Toxicological Profile for Chlordane written by and published by . This book was released on 1994 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of Carcinogenic Potency and Genotoxicity Databases

Author : Lois Swirsky Gold
Publisher : CRC Press
ISBN 13 : 9781439810644
Total Pages : 840 pages
Book Rating : 4.8/5 (16 download)

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Book Synopsis Handbook of Carcinogenic Potency and Genotoxicity Databases by : Lois Swirsky Gold

Download or read book Handbook of Carcinogenic Potency and Genotoxicity Databases written by Lois Swirsky Gold and published by CRC Press. This book was released on 1996-11-26 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique new reference contains the Carcinogenic Potency Database (CPDB), which analyzes results of decades of animal cancer tests, including all Technical Reports of the National Toxicology Program (NTP) and the general published literature. A guide to the literature of animal cancer tests, the CPDB includes references to each published experiment and never-before published analyses. For each of 5,000 long-term experiments on 1,300 chemicals, the user-friendly format includes data on the species, strain, and sex of the test animal; features of experimental protocol such as the route of administration, duration of dosing, dose levels, and duration of the experiment; histopathology and tumor incidence; the shape of the dose-response curve; published author's opinion about the carcinogenicity at each site; and reference to the original publication of the test results. In addition, a measure of carcinogenic potency, the TD50, its statistical significance and confidence limits, are given for each tumor site. An overview is provided of earlier publication updates, such as positivity rates, reproducibility, interspecies extrapolation, and ranking possible carcinogenic hazards. The book also includes a summary of the NTP genetic toxicity test results on 1,500 chemicals, which are referenced to the original publications, including the Salmonella (Ames) test, L5178Y mouse lymphoma cell mutation test, chromosome aberration and sister chromatid exchange tests in cultured Chinese hamster ovary cells, and the sex-linked recessive lethal mutation test in Drosophila melanogaster. An index with chemicals listed by CAS number allows cross referencing between the carcinogenicity and genotoxicity databases, making data easy to find.

Toxicological Profile for Polycyclic Aromatic Hydrocarbons

Author :
Publisher :
ISBN 13 :
Total Pages : 500 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Toxicological Profile for Polycyclic Aromatic Hydrocarbons by :

Download or read book Toxicological Profile for Polycyclic Aromatic Hydrocarbons written by and published by . This book was released on 1995 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Powerless Science?

Author : Soraya Boudia
Publisher :
ISBN 13 : 9781782382362
Total Pages : 280 pages
Book Rating : 4.3/5 (823 download)

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Book Synopsis Powerless Science? by : Soraya Boudia

Download or read book Powerless Science? written by Soraya Boudia and published by . This book was released on 2014 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: In spite of decades of research on toxicants, along with the growing role of scientific expertise in public policy and the unprecedented rise in the number of national and international institutions dealing with environmental health issues, problems surrounding contaminants and their effects on health have never appeared so important, sometimes to the point of appearing insurmountable. This calls for a reconsideration of the roles of scientific knowledge and expertise in the definition and management of toxic issues, which this book seeks to do. It looks at complex historical, social, and political dynamics, made up of public controversies, environmental and health crises, economic interests, and political responses, and demonstrates how and to what extent scientific knowledge about toxicants has been caught between scientific, economic, and political imperatives. Soraya Boudia is Professor of Science, Technology, and Innovation Studies at the University of Paris-Est Marne-la-Vallée. Her scholarly work focuses on the transnational government of technological and health environmental risks. She has co-edited a special issue of History and Technology, "Risk and risk Society in Historical Perspective" (2007), and Toxicants, Health and Regulations Since 1945 (Pickering & Chatto, 2013), both with Nathalie Jas. Nathalie Jas is a Senior Researcher at the French National Institute for Agricultural Research (INRA). A historian and a STS scholar, her scholarly work analyses the intensification of agriculture and its social, environmental, and health effects. She has co-edited a special issue of History and Technology, "Risk and risk Society in Historical Perspective" (2007), and Toxicants, Health and Regulations Since 1945 (Pickering & Chatto, 2013), both with Soraya Boudia.