Natural Killer Cells

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Author :
Publisher : Springer
ISBN 13 : 3319239163
Total Pages : 251 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Natural Killer Cells by : Eric Vivier

Download or read book Natural Killer Cells written by Eric Vivier and published by Springer. This book was released on 2016-02-15 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: To celebrate the 40th anniversary of the discovery of Natural Killer (NK) cells, this volume focuses on the recent advances in our understanding of NK cell development and differentiation and their acquisition of functional properties, as well as the latest models for NK-cell analysis in mice and applications in clinical medicine. NK cells have travelled a circuitous path from their initial description as ‘spontaneous killers’ (for some simply an experimental artifact) to being a bona fide subset of innate lymphoid cells with a complementary mode of action in immune defense and an important mediator of immune reactivity in health and disease. Together, these reviews provide a timely and concise picture of the evolution of NK cells as essential agents in immunity and as potent weapons against disease. This book offers an appealing and insightful resource for scientists and clinicians.

Natural Killer Cells

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Publisher : Humana Press
ISBN 13 : 9781493936823
Total Pages : 365 pages
Book Rating : 4.9/5 (368 download)

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Book Synopsis Natural Killer Cells by : Srinivas S. Somanchi

Download or read book Natural Killer Cells written by Srinivas S. Somanchi and published by Humana Press. This book was released on 2016-05-13 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains collection of Natural Killer Cell methodologies relevant for both basic and translational research. These methodologies present new developments in the natural killer (NK) cell field, such as understanding the influence of NK cells metabolism on its function, identifying complexity of NK cell subsets through mass cytometry, and determining the emergence of memory NK cells in murine model of MCMV infection. Methods that study NK cell migration and cytotoxicity through endpoint analysis or live single cell imaging are also discussed. Chapters also describe methods pertaining to translational application of NK cells, such as ex vivo expansion of NK cells on K562 cell lines genetically modified to express either membrane bound IL-15 or membrane bound IL-21, large scale NK cell culture, current techniques for engineering NK cells to express chimeric antigen receptors or chemokine receptors using retroviral vectors, electroporation of mRNA, and the natural phenomenon of trogocytosis. Written in the highly successful Methods in Molecular Biology series format, these chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and thorough, Natural Killer Cells: Methods and Protocols is a valuable resource for researchers who not only want to understand mechanisms that govern NK cell behavior and diversity, but also for those who want to understand how to systematically evaluate NK cells for adoptive immunotherapy applications.

Natural Born Celebrities

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Publisher : University of Chicago Press
ISBN 13 : 0226738701
Total Pages : 336 pages
Book Rating : 4.2/5 (267 download)

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Book Synopsis Natural Born Celebrities by : David Schmid

Download or read book Natural Born Celebrities written by David Schmid and published by University of Chicago Press. This book was released on 2008-09-15 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jeffrey Dahmer. Ted Bundy. John Wayne Gacy. Over the past thirty years, serial killers have become iconic figures in America, the subject of made-for-TV movies and mass-market paperbacks alike. But why do we find such luridly transgressive and horrific individuals so fascinating? What compels us to look more closely at these figures when we really want to look away? Natural Born Celebrities considers how serial killers have become lionized in American culture and explores the consequences of their fame. David Schmid provides a historical account of how serial killers became famous and how that fame has been used in popular media and the corridors of the FBI alike. Ranging from H. H. Holmes, whose killing spree during the 1893 Chicago World's Fair inspired The Devil in the White City, right up to Aileen Wuornos, the lesbian prostitute whose vicious murder of seven men would serve as the basis for the hit film Monster, Schmid unveils a new understanding of serial killers by emphasizing both the social dimensions of their crimes and their susceptibility to multiple interpretations and uses. He also explores why serial killers have become endemic in popular culture, from their depiction in The Silence of the Lambs and The X-Files to their becoming the stuff of trading cards and even Web sites where you can buy their hair and nail clippings. Bringing his fascinating history right up to the present, Schmid ultimately argues that America needs the perversely familiar figure of the serial killer now more than ever to manage the fear posed by Osama bin Laden since September 11. "This is a persuasively argued, meticulously researched, and compelling examination of the media phenomenon of the 'celebrity criminal' in American culture. It is highly readable as well."—Joyce Carol Oates

Natural Born Killers

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Author :
Publisher : Grove Press
ISBN 13 : 9780802134486
Total Pages : 132 pages
Book Rating : 4.1/5 (344 download)

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Book Synopsis Natural Born Killers by : Quentin Tarantino

Download or read book Natural Born Killers written by Quentin Tarantino and published by Grove Press. This book was released on 2000 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: This original screenplay offers fans and film buffs the opportunity to compare Tarantino's original vision with Oliver Stone's version of the story of Mickey and Mallory, outlaw lovers on the run.

Natural Born Killers

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Author :
Publisher : Signet Book
ISBN 13 : 9780451182647
Total Pages : 252 pages
Book Rating : 4.1/5 (826 download)

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Book Synopsis Natural Born Killers by : John August

Download or read book Natural Born Killers written by John August and published by Signet Book. This book was released on 1994 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Woody Harrelson and Juliette Lewis star in this startling film about serial killers. Natural Born Killers is the inside story of Mickey and Mallory, two devil-crossed lovers who come close to destroying the American Dream. Scheduled for release in August 1994, the film is directed by Oliver Stone.

Natural Born Killers

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Publisher :
ISBN 13 : 9781088134177
Total Pages : 0 pages
Book Rating : 4.1/5 (341 download)

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Book Synopsis Natural Born Killers by : Lucy Smoke

Download or read book Natural Born Killers written by Lucy Smoke and published by . This book was released on 2023-05-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rule No. 3: Never let anyone think they can hurt you and get away with it. I thought I'd seen and felt the worst of it, but there's nothing worse than betrayal. Corina knows who's behind what happened to me and she may think hiding will keep her safe, but after everything that's happened, nothing can keep her safe from me and the Sick Boys. She's a pawn in all of this, but I'll get that information even if it means I have to cut it out of her - piece by fucking piece. This little charade is about to end. They thought they could drag me down into the dirt and grind my soul into the dust. What they failed to realize is that there's nothing left of my soul and I don't mind getting a little dirty if it means getting my revenge. I may have let her fool me once, but there's no way in hell I'll let her fool me twice. After I'm done with her, I'm going after the big boys.

Natural Born Killer

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Author :
Publisher : Metro Publishing, Limited
ISBN 13 :
Total Pages : 230 pages
Book Rating : 4.X/5 (4 download)

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Book Synopsis Natural Born Killer by : Sandy Fawkes

Download or read book Natural Born Killer written by Sandy Fawkes and published by Metro Publishing, Limited. This book was released on 2004 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: When Sandy Fawkes met a tall, handsome American in a hotel bar in Atlanta, she could never have dreamed what lay in store. The man told her he was completing a 20,000-mile journey across America. As he was going her way, Sandy accepted his invitation of a lift and they quickly became lovers. What Paul John Knowles failed to tell her was that he had left a trail of bloody murder along his route, a trail which had yet to end. Natural Born Killers is the astonishing true story of one woman and an 18-time killer, how he charmed her, and how she nearly became his 19th victim. This is the intimate account of one of the most gruesome and terrible serial killers in history, told by the woman who survived his fearsome attentions.

Killer Instinct

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Publisher : National Geographic Books
ISBN 13 : 0767900758
Total Pages : 0 pages
Book Rating : 4.7/5 (679 download)

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Book Synopsis Killer Instinct by : Jane Hamsher

Download or read book Killer Instinct written by Jane Hamsher and published by National Geographic Books. This book was released on 1998-06-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fresh out of film school, aspiring producer Jane Hamsher and her partner Don Murphy stumbled onto a screenplay by a geeky filmmaker-wannabe named Quentin Tarantino. For $10,000, Jane and Don optioned Natural Born Killers and set off on a two-year roller coaster ride no classroom could have prepared them for. With an outrageous cast of real-life characters including Oliver Stone, Woody Harrelson, Robert Downey, Jr., and Juliette Lewis--along with a slew of film-crew leeches and behind-the-scenes studio pitbulls--Killer Instinct rivals the most mesmerizing, gut-wrenching movie scenes. A wild joyride like no other, Hamsher's tale provides a fresh, insider's perspective on stardom and the real balance of power in Hollywood.

Thieves, Deceivers, and Killers

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Author :
Publisher : Princeton University Press
ISBN 13 : 1400830834
Total Pages : 248 pages
Book Rating : 4.4/5 (8 download)

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Book Synopsis Thieves, Deceivers, and Killers by : William Agosta

Download or read book Thieves, Deceivers, and Killers written by William Agosta and published by Princeton University Press. This book was released on 2009-07-02 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The tobacco plant synthesizes nicotine to protect itself from herbivores. The female moth broadcasts sex pheromones to attract a mate, while a soldier ant deploys an alarm pheromone to call for help. The carbon dioxide on a mammal's breath beckons hungry ticks and mosquitoes, while a flower's fragrance speaks to the honey bee. Indeed, much of the communication that occurs within and between various species of organisms is done not by sight, sound, or touch, but with chemicals. From mating to parenting, foraging to self-defense, plant and animal activities are accomplished largely by the secretion or exchange of organic chemicals. The fascinating and fast-developing science that encompasses these diverse phenomena is introduced here, by William Agosta, in a series of remarkable stories absolutely accessible to the general reader yet revelatory to chemists and biologists. Among Agosta's characters are the organisms that steal, counterfeit, or interpret the chemical signals of other species for their own ends. We learn of seeds that mimic ant odors to facilitate their own dispersion and flies that follow the scent of truffles to lay their eggs. We read about pit vipers that react in terror when their flicking tongues detect a king snake, and slave-making ants incapable of finding their own food. And we meet ice-age people who ate birch fungus to relieve whipworms and early human hunters who used the urine of wolves to maneuver deer to favorable sites. Agosta also chronicles the rapid development of the applied science that makes use of chemical ecology. As researchers deepen our understanding of the biological world, they are making economically significant discoveries (such as enzymes that remain stable in extreme heat), finding ways to reduce our reliance on manufactured pesticides, identifying new uses for traditional medicines, and developing sophisticated new pharmaceuticals effective in treating malaria and several cancers. On the horizon are antiviral agents derived from the chemical defenses of marine species. From the exploits of flies to the high-stakes effort to cure human disease, Agosta's tour of chemical ecology grants any reader entrance to the invisible realm where chemistry determines life and death.

Killers of the Flower Moon

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Author :
Publisher : Vintage
ISBN 13 : 0307742482
Total Pages : 417 pages
Book Rating : 4.3/5 (77 download)

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Book Synopsis Killers of the Flower Moon by : David Grann

Download or read book Killers of the Flower Moon written by David Grann and published by Vintage. This book was released on 2018-04-03 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: #1 NEW YORK TIMES BESTSELLER • A twisting, haunting true-life murder mystery about one of the most monstrous crimes in American history, from the author of The Wager and The Lost City of Z, “one of the preeminent adventure and true-crime writers working today."—New York Magazine • NATIONAL BOOK AWARD FINALIST • NOW A MARTIN SCORSESE PICTURE “A shocking whodunit…What more could fans of true-crime thrillers ask?”—USA Today “A masterful work of literary journalism crafted with the urgency of a mystery.” —The Boston Globe In the 1920s, the richest people per capita in the world were members of the Osage Nation in Oklahoma. After oil was discovered beneath their land, the Osage rode in chauffeured automobiles, built mansions, and sent their children to study in Europe. Then, one by one, the Osage began to be killed off. The family of an Osage woman, Mollie Burkhart, became a prime target. One of her relatives was shot. Another was poisoned. And it was just the beginning, as more and more Osage were dying under mysterious circumstances, and many of those who dared to investigate the killings were themselves murdered. As the death toll rose, the newly created FBI took up the case, and the young director, J. Edgar Hoover, turned to a former Texas Ranger named Tom White to try to unravel the mystery. White put together an undercover team, including a Native American agent who infiltrated the region, and together with the Osage began to expose one of the most chilling conspiracies in American history. Look for David Grann’s latest bestselling book, The Wager!

Antibody Fc

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Publisher : Academic Press
ISBN 13 : 0123948185
Total Pages : 376 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Antibody Fc by : Margaret Ackerman

Download or read book Antibody Fc written by Margaret Ackerman and published by Academic Press. This book was released on 2013-08-06 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells. - Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro - Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies - Color illustrations enhance explanations of the immune system

The Oliver Stone Experience

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Publisher : Abrams
ISBN 13 : 1613128142
Total Pages : 480 pages
Book Rating : 4.6/5 (131 download)

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Book Synopsis The Oliver Stone Experience by : Matt Zoller Seitz

Download or read book The Oliver Stone Experience written by Matt Zoller Seitz and published by Abrams. This book was released on 2016-09-13 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stone himself serves as guide to this no-holds-barred retrospective—an extremely candid and comprehensive monograph of the renowned and controversial writer, director, and cinematic historian in interview form. Over the course of five years, Academy Award-winning filmmaker Oliver Stone (Midnight Express, Scarface, Platoon, JFK, Natural Born Killers, Snowden) and New York Times bestselling author Matt Zoller Seitz (The Wes Anderson Collection) discussed, debated, and deconstructed the arc of Stone's outspoken, controversial life and career with extraordinary candor. This book collects those conversations for the first time, including anecdotes about Stone's childhood, Vietnam, his struggles with post-traumatic stress disorder, and his continual struggle to reinvent himself as an artist. Their dialogue is illustrated by hundreds of never-before-seen photographs and documents from Stone's personal archive, dating back to Stone's birth: personal snapshots, private correspondence, annotated script pages and storyboards, behind-the-scenes photography, and production files from all of his films to date—through 2016's Snowden, and including Stone's epic Showtime mini-series Untold HIstory of the United States. Critical commentary from Seitz on each of Stone's films is joined by original essays from filmmaker Ramin Bahrani; writer, editor, and educator Kiese Laymon; writer and actor Jim Beaver; and film critics Walter Chaw, Michael Guarnieri, Kim Morgan, and Alissa Wilkinson. At once a complex analysis of a master director’s vision and a painfully honest critical biography in widescreen technicolor, The Oliver Stone Experience is as daring, intense, and provocative as Stone’s films—it's an Oliver Stone movie about Oliver Stone, in the form of a book. Both this book and Stone’s highly anticipated film, Snowden, will be released in September 2016 to coincide with Stone’s seventieth birthday (September 15, 1946). Also available from Matt Zoller Seitz: Mad Men Carousel, The Wes Anderson Collection: Bad Dads, The Wes Anderson Collection: The Grand Budapest Hotel, and The Wes Anderson Collection.

The Naturals

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Publisher : Little, Brown Books for Young Readers
ISBN 13 : 1423181182
Total Pages : 254 pages
Book Rating : 4.4/5 (231 download)

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Book Synopsis The Naturals by : Jennifer Lynn Barnes

Download or read book The Naturals written by Jennifer Lynn Barnes and published by Little, Brown Books for Young Readers. This book was released on 2013-11-05 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cold cases are about to get hot. Don’t miss this exhilarating crime thriller—perfect for fans of Criminal Minds and A Good Girl’s Guide to Murder—from Jennifer Lynn Barnes, the #1 New York Times bestselling author of The Inheritance Games. Seventeen-year-old Cassie is a natural at reading people. Piecing together the tiniest details, she can tell you who you are and what you want. But, it's not a skill that she's ever taken seriously. That is, until the FBI come knocking: they've begun a classified program that uses exceptional teenagers to crack infamous cold cases, and they need Cassie. What Cassie doesn't realize is that there's more at risk than a few unsolved homicides-especially when she's sent to live with a group of teens whose gifts are as unusual as her own. Soon, it becomes clear that no one in the Naturals program is what they seem. And when a new killer strikes, danger looms close. Caught in a lethal game of cat and mouse with a killer, the Naturals are going to have to use all of their gifts just to survive. Think The Mentalist meets Pretty Little Liars -- Jennifer Lynn Barnes's The Naturals is a gripping psychological thriller with killer appeal, a to-die-for romance and the bones of a gritty and compelling new series. Praise for The Naturals "The Naturals is Criminal Minds for the YA world, and I loved every page." -New York Times best-selling author Ally Carter * "[A] tightly paced suspense novel that will keep readers up until the wee hours to finish." -VOYA (starred review) "This savvy thriller grabs readers right away." -Kirkus Reviews "It's a stay-up-late-to-finish kind of book, and it doesn't disappoint." -Publishers Weekly "In this high-adrenaline series opener...even a psychic won't anticipate all the twists and turns." -Booklist

The Anatomy of Violence

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Publisher : Pantheon
ISBN 13 : 0307378845
Total Pages : 501 pages
Book Rating : 4.3/5 (73 download)

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Book Synopsis The Anatomy of Violence by : Adrian Raine

Download or read book The Anatomy of Violence written by Adrian Raine and published by Pantheon. This book was released on 2013 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provocative and timely: a pioneering neurocriminologist introduces the latest biological research into the causes of--and potential cures for--criminal behavior. With an 8-page full-color insert, and black-and-white illustrations throughout.

Principles of Immunopharmacology

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Publisher : Springer Science & Business Media
ISBN 13 : 3034601352
Total Pages : 743 pages
Book Rating : 4.0/5 (346 download)

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Book Synopsis Principles of Immunopharmacology by : Frans P. Nijkamp

Download or read book Principles of Immunopharmacology written by Frans P. Nijkamp and published by Springer Science & Business Media. This book was released on 2011-09-01 with total page 743 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides a unique support in gaining essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The first section of the book, covering a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts. The second section on immunodiagnostics has been further expanded to describe widely used molecular techniques and is followed by a systematic coverage of drugs affecting the immune system, revised to cover recent developments. The book concludes with a chapter on immunotoxicology. This third edition continues the unique format dealing with four related topics in a single volume, obviating the need to refer to several different textbooks. New aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first edition.

Listening to Killers

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Author :
Publisher : Univ of California Press
ISBN 13 : 0520958748
Total Pages : 307 pages
Book Rating : 4.5/5 (29 download)

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Book Synopsis Listening to Killers by : James Garbarino

Download or read book Listening to Killers written by James Garbarino and published by Univ of California Press. This book was released on 2015-03-12 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Listening to Killers offers an inside look at twenty years' worth of murder files from Dr. James Garbarino, a leading expert psychological witness who listens to killers so that he can testify in court. The author offers detailed accounts of how killers travel a path that leads from childhood innocence to lethal violence in adolescence or adulthood. He places the emotional and moral damage of each individual killer within a larger scientific framework of social, psychological, anthropological, and biological research on human development. By linking individual cases to broad social and cultural issues and illustrating the social toxicity and unresolved trauma that drive some people to kill, Dr. Garbarino highlights the humanity we share with killers and the role of understanding and empathy in breaking the cycle of violence.

Janeway's Immunobiology

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Author :
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)

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Book Synopsis Janeway's Immunobiology by : Kenneth Murphy

Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.