NAS Colloquium Links Between Recombination and Replication

Download NAS Colloquium Links Between Recombination and Replication PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (83 download)

DOWNLOAD NOW!


Book Synopsis NAS Colloquium Links Between Recombination and Replication by : Proceedings of the National Academy of Sciences (

Download or read book NAS Colloquium Links Between Recombination and Replication written by Proceedings of the National Academy of Sciences ( and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Links Between Recombination and Replication

Download Links Between Recombination and Replication PDF Online Free

Author :
Publisher : National Academies Press
ISBN 13 : 030907424X
Total Pages : 303 pages
Book Rating : 4.3/5 (9 download)

DOWNLOAD NOW!


Book Synopsis Links Between Recombination and Replication by : Proceedings of the National Academy of Sciences

Download or read book Links Between Recombination and Replication written by Proceedings of the National Academy of Sciences and published by National Academies Press. This book was released on 2002-09-18 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a sea change in how we view genetic recombination. When germ cells are produced in higher organisms, genetic recombination assures the proper segregation of like chromosomes. In the course of that process, called meiosis, recombination not only assures segregation of one chromosome of each type to progeny germ cells, but also further shuffles the genetic deck, contributing to the unique inheritance of individuals. In a nutshell, that is the classical view of recombination. We have also known for many years that in bacteria recombination plays a role in horizontal gene transfer and in replication itself, the latter by establishing some of the replication forks that are the structural scaffolds for copying DNA. In recent years, however, we have become increasingly aware that replication, which normally starts without any help from recombination, is a vulnerable process that frequently leads to broken DNA. The enzymes of recombination play a vital role in the repair of those breaks. The recombination enzymes can function via several different pathways that mediate the repair of breaks, as well as restoration of replication forks that are stalled by other kinds of damage to DNA. Thus, to the classical view of recombination as an engine of inheritance we must add the view of recombination as a vital housekeeping function that repairs breaks suffered in the course of replication. We have also known for many years that genomic instability--including mutations, chromosomal rearrangements, and aneuploidy--is a hallmark of cancer cells. Although genomic instability has many contributing causes, including faulty replication, there are many indications that recombination, faulty or not, contributes to genome instability and cancer as well. The (Nas colloquium) Links Between Recombination and Replication: Vital Roles of Recombination was convened to broaden awareness of this evolving area of research. Papers generated by this colloquium are published here. To encourage the desired interactions of specialists, we invited some contributions that deal only with recombination or replication in addition to contributions on the central thesis of functional links between recombination and replication. To aid the nonspecialist and specialist alike, we open the set of papers with a historical overview by Michael Cox and we close the set with a commentary on the meeting and the field by Andrei Kuzminov.

Colloquium on Links Between Recombination and Replication

Download Colloquium on Links Between Recombination and Replication PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 303 pages
Book Rating : 4.:/5 (895 download)

DOWNLOAD NOW!


Book Synopsis Colloquium on Links Between Recombination and Replication by :

Download or read book Colloquium on Links Between Recombination and Replication written by and published by . This book was released on 2000 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Proceedings of the National Academy of Sciences of the United States of America

Download Proceedings of the National Academy of Sciences of the United States of America PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 1328 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!


Book Synopsis Proceedings of the National Academy of Sciences of the United States of America by : National Academy of Sciences (U.S.)

Download or read book Proceedings of the National Academy of Sciences of the United States of America written by National Academy of Sciences (U.S.) and published by . This book was released on 2001 with total page 1328 pages. Available in PDF, EPUB and Kindle. Book excerpt:

(Sackler NAS Colloquium) Frontiers of Bioinformatics

Download (Sackler NAS Colloquium) Frontiers of Bioinformatics PDF Online Free

Author :
Publisher : National Academies Press
ISBN 13 : 0309181984
Total Pages : 59 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!


Book Synopsis (Sackler NAS Colloquium) Frontiers of Bioinformatics by : Samuel Karlin

Download or read book (Sackler NAS Colloquium) Frontiers of Bioinformatics written by Samuel Karlin and published by National Academies Press. This book was released on 2005-09-28 with total page 59 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Effects of Over-expressing the Proteins of the DnaA Operon in Wild-type and Mutant Escherichia Coli Cells

Download The Effects of Over-expressing the Proteins of the DnaA Operon in Wild-type and Mutant Escherichia Coli Cells PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 268 pages
Book Rating : 4.:/5 (318 download)

DOWNLOAD NOW!


Book Synopsis The Effects of Over-expressing the Proteins of the DnaA Operon in Wild-type and Mutant Escherichia Coli Cells by : Aline V. Grigorian

Download or read book The Effects of Over-expressing the Proteins of the DnaA Operon in Wild-type and Mutant Escherichia Coli Cells written by Aline V. Grigorian and published by . This book was released on 2002 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Tempo and Mode in Evolution

Download Tempo and Mode in Evolution PDF Online Free

Author :
Publisher : National Academies Press
ISBN 13 : 0309552672
Total Pages : 336 pages
Book Rating : 4.3/5 (95 download)

DOWNLOAD NOW!


Book Synopsis Tempo and Mode in Evolution by : for the National Academy of Sciences

Download or read book Tempo and Mode in Evolution written by for the National Academy of Sciences and published by National Academies Press. This book was released on 1995-02-09 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since George Gaylord Simpson published Tempo and Mode in Evolution in 1944, discoveries in paleontology and genetics have abounded. This volume brings together the findings and insights of today's leading experts in the study of evolution, including Ayala, W. Ford Doolittle, and Stephen Jay Gould. The volume examines early cellular evolution, explores changes in the tempo of evolution between the Precambrian and Phanerozoic periods, and reconstructs the Cambrian evolutionary burst. Long-neglected despite Darwin's interest in it, species extinction is discussed in detail. Although the absence of data kept Simpson from exploring human evolution in his book, the current volume covers morphological and genetic changes in human populations, contradicting the popular claim that all modern humans descend from a single woman. This book discusses the role of molecular clocks, the results of evolution in 12 populations of Escherichia coli propagated for 10,000 generations, a physical map of Drosophila chromosomes, and evidence for "hitchhiking" by mutations.

Membership Directory

Download Membership Directory PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 372 pages
Book Rating : 4.:/5 (318 download)

DOWNLOAD NOW!


Book Synopsis Membership Directory by : National Academy of Sciences (U.S.)

Download or read book Membership Directory written by National Academy of Sciences (U.S.) and published by . This book was released on 2000 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Gene Drives on the Horizon

Download Gene Drives on the Horizon PDF Online Free

Author :
Publisher : National Academies Press
ISBN 13 : 0309437873
Total Pages : 231 pages
Book Rating : 4.3/5 (94 download)

DOWNLOAD NOW!


Book Synopsis Gene Drives on the Horizon by : National Academies of Sciences, Engineering, and Medicine

Download or read book Gene Drives on the Horizon written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-08-28 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.

Frontiers of Bioinformatics

Download Frontiers of Bioinformatics PDF Online Free

Author :
Publisher : National Academies Press
ISBN 13 : 0309100291
Total Pages : 59 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!


Book Synopsis Frontiers of Bioinformatics by :

Download or read book Frontiers of Bioinformatics written by and published by National Academies Press. This book was released on 2005 with total page 59 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Evolution

Download Evolution PDF Online Free

Author :
Publisher : Pearson Education
ISBN 13 : 0132780933
Total Pages : 273 pages
Book Rating : 4.1/5 (327 download)

DOWNLOAD NOW!


Book Synopsis Evolution by : James Alan Shapiro

Download or read book Evolution written by James Alan Shapiro and published by Pearson Education. This book was released on 2011 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book proposes an important new paradigm for understanding biological evolution. Shapiro demonstrates why traditional views of evolution are inadequate to explain the latest evidence, and presents an alternative. His information- and systems-based approach integrates advances in symbiogenesis, epigenetics, and saltationism, and points toward an emerging synthesis of physical, information, and biological sciences.

Preparing for Future Products of Biotechnology

Download Preparing for Future Products of Biotechnology PDF Online Free

Author :
Publisher : National Academies Press
ISBN 13 : 0309452058
Total Pages : 231 pages
Book Rating : 4.3/5 (94 download)

DOWNLOAD NOW!


Book Synopsis Preparing for Future Products of Biotechnology by : National Academies of Sciences, Engineering, and Medicine

Download or read book Preparing for Future Products of Biotechnology written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-07-28 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Between 1973 and 2016, the ways to manipulate DNA to endow new characteristics in an organism (that is, biotechnology) have advanced, enabling the development of products that were not previously possible. What will the likely future products of biotechnology be over the next 5â€"10 years? What scientific capabilities, tools, and/or expertise may be needed by the regulatory agencies to ensure they make efficient and sound evaluations of the likely future products of biotechnology? Preparing for Future Products of Biotechnology analyzes the future landscape of biotechnology products and seeks to inform forthcoming policy making. This report identifies potential new risks and frameworks for risk assessment and areas in which the risks or lack of risks relating to the products of biotechnology are well understood.

Health Risks from Exposure to Low Levels of Ionizing Radiation

Download Health Risks from Exposure to Low Levels of Ionizing Radiation PDF Online Free

Author :
Publisher : National Academies Press
ISBN 13 : 0309133343
Total Pages : 422 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!


Book Synopsis Health Risks from Exposure to Low Levels of Ionizing Radiation by : Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation

Download or read book Health Risks from Exposure to Low Levels of Ionizing Radiation written by Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation and published by National Academies Press. This book was released on 2006-03-23 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.

Human Genome Editing

Download Human Genome Editing PDF Online Free

Author :
Publisher : National Academies Press
ISBN 13 : 0309452880
Total Pages : 329 pages
Book Rating : 4.3/5 (94 download)

DOWNLOAD NOW!


Book Synopsis Human Genome Editing by : National Academies of Sciences, Engineering, and Medicine

Download or read book Human Genome Editing written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-08-13 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Impacts of Applied Genetics

Download Impacts of Applied Genetics PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 348 pages
Book Rating : 4.:/5 (319 download)

DOWNLOAD NOW!


Book Synopsis Impacts of Applied Genetics by :

Download or read book Impacts of Applied Genetics written by and published by . This book was released on 1981 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Threat of Pandemic Influenza

Download The Threat of Pandemic Influenza PDF Online Free

Author :
Publisher : National Academies Press
ISBN 13 : 0309095042
Total Pages : 431 pages
Book Rating : 4.3/5 (9 download)

DOWNLOAD NOW!


Book Synopsis The Threat of Pandemic Influenza by : Institute of Medicine

Download or read book The Threat of Pandemic Influenza written by Institute of Medicine and published by National Academies Press. This book was released on 2005-04-09 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Public health officials and organizations around the world remain on high alert because of increasing concerns about the prospect of an influenza pandemic, which many experts believe to be inevitable. Moreover, recent problems with the availability and strain-specificity of vaccine for annual flu epidemics in some countries and the rise of pandemic strains of avian flu in disparate geographic regions have alarmed experts about the world's ability to prevent or contain a human pandemic. The workshop summary, The Threat of Pandemic Influenza: Are We Ready? addresses these urgent concerns. The report describes what steps the United States and other countries have taken thus far to prepare for the next outbreak of "killer flu." It also looks at gaps in readiness, including hospitals' inability to absorb a surge of patients and many nations' incapacity to monitor and detect flu outbreaks. The report points to the need for international agreements to share flu vaccine and antiviral stockpiles to ensure that the 88 percent of nations that cannot manufacture or stockpile these products have access to them. It chronicles the toll of the H5N1 strain of avian flu currently circulating among poultry in many parts of Asia, which now accounts for the culling of millions of birds and the death of at least 50 persons. And it compares the costs of preparations with the costs of illness and death that could arise during an outbreak.

Human Health and Performance Risks of Space Exploration Missions

Download Human Health and Performance Risks of Space Exploration Missions PDF Online Free

Author :
Publisher : U. S. National Aeronautics & Space Administration
ISBN 13 :
Total Pages : 396 pages
Book Rating : 4.3/5 ( download)

DOWNLOAD NOW!


Book Synopsis Human Health and Performance Risks of Space Exploration Missions by : Jancy C. McPhee

Download or read book Human Health and Performance Risks of Space Exploration Missions written by Jancy C. McPhee and published by U. S. National Aeronautics & Space Administration. This book was released on 2009 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: