Nanohybrides A Coeur Doxyde De Gadolinium Pour Le Developpement De Sondes Irm Multimodales

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Nanohybrides à coeur d'Oxyde de gadolinium pour le développement de sondes IRM multimodales

Author : Jean-Luc Bridot
Publisher :
ISBN 13 :
Total Pages : 268 pages
Book Rating : 4.:/5 (494 download)

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Book Synopsis Nanohybrides à coeur d'Oxyde de gadolinium pour le développement de sondes IRM multimodales by : Jean-Luc Bridot

Download or read book Nanohybrides à coeur d'Oxyde de gadolinium pour le développement de sondes IRM multimodales written by Jean-Luc Bridot and published by . This book was released on 2007 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Le caractère particuliaire permet de combiner plusieurs techniques de détection pour une meilleure fiabilité des résultats (imageries de fluorescence par résonance magnétique) ou d'effectuer plusieurs actions différentes mais complémentaires (diagnostic et thérapie). Sur ce dernier point, la plupart des travaux portent sur des nanoparticules à base d'or ou d'oxyde de fer. Une alternative originale aux nanoparticules dejà étudiées, pour combiner diagnostic et thérapie, pourrait concerner des nanoparticules hybrides à base d'oxyde de gadolinium : Gd203@SiOx[fluo]. Ces particules peuvent être détectées à la fois par luminescence grâce aux fluorophores organiques liés au réseau de polysiloxane enrobant le coeur et par des méthodes magnétiques, attendu que le gadolinium est largement utilisé comme agent de crontraste en IRM. De plus, son isotope 157 est cartaérisé par une forte section efficace de capture des neutrons, ces particules d'oxyde de gadolnium apparaissent comme un substitut très prometteur aux agents neutrophages actuellement utilisé en neutronthérapie. Les études ont montrées que ces nanoparticules pouvaient être suivis par des techniques d'imagerie optique et par résonance magnétique ; en in vitro, où les nanoparticules hybrides se sont relevées être des marqueurs cellulaire ; en in vivo, où, grâce à des modifications de la couche externe, ces nanoparticules ont pu être injectées par voie intraveineuse et dont leur suivis n'a pas révélé d'accumulation indésirable. Il ressort également de cette étude que les nanoparticules de Gd203@SiOx permettent d'améliorer la thérapie par capture neutronique

Nanosondes multimodales pour l'imagerie simultanée IRM

Author : Farhan Bouraleh Hoch
Publisher :
ISBN 13 :
Total Pages : 229 pages
Book Rating : 4.:/5 (123 download)

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Book Synopsis Nanosondes multimodales pour l'imagerie simultanée IRM by : Farhan Bouraleh Hoch

Download or read book Nanosondes multimodales pour l'imagerie simultanée IRM written by Farhan Bouraleh Hoch and published by . This book was released on 2020 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: L'imagerie médicale est devenue la pierre angulaire de la lutte contre diverses maladies (cancer, maladies cardiovasculaires) puisqu'elle permet de détecter et de suivre l'évolution de la maladie et d'orienter le traitement. La tendance actuelle consiste à combiner plusieurs techniques d'imagerie complémentaires pour exploiter les avantages de chacune d'elles tout en surmontant leurs limites. Parmi les nombreuses possibilités, la combinaison de l'imagerie par résonance magnétique (IRM) et de la tomographie par émission de positon (TEP) semble très intéressante, car elle allie la haute résolution de l'IRM à la sensibilité exceptionnelle de la TEP. Si le développement de ce dispositif constitue en soi un défi de taille, la conception de sondes multimodales constitue également une étape essentielle pour l'exploitation d'imageurs intégrés IRM/TEP. Pour réaliser le développement de sondes multimodales pour l'imagerie simultanée IRM/TEP, deux stratégies basées sur le caractère multifonctionnel des nanoparticules ont été explorées, en gardant à l'esprit que ces agents d'imagerie doivent être éliminés par clairance rénale (Dh ˂ 10 nm). La première a consisté en la synthèse de nanoparticules d'or ultrapetites revêtues par deux types différents de chélateur pour une complexation sélective des ions gadolinium (IRM) et des émetteurs de positons (TEP). La deuxième stratégie a reposé sur la réduction d'un sel d'or en présence de molécules dithiolées contenant deux sites de complexation spécifiques. La réduction du sel d'or en présence d'un mélange de deux différents chélateurs ou en présence de molécules dithiolées contenant deux sites de complexation spécifiques a fourni des nanoparticules d'or ultrapetites (taille du cœur d'or (TEM) : 2 à 3 nm et diamètre hydrodynamique (DLS) : 6 - 8 nm) capables d'immobiliser à la fois les ions gadolinium et les ions cuivre-64. En conséquence, la biodistribution de ces nanoparticules a pu être suivie simultanément par IRM et TEP sur un même animal avec le même dispositif d'imagerie IRM/TEP intégré et après une seule injection intraveineuse. Cette étude a également confirmé une libre circulation des nanoparticules et une excrétion rénale sans aucune accumulation indésirable dans l'organisme sain. Ce travail a montré que les nanoparticules d'or ultrapetites revêtues par deux types différents de chélateurs ou des molécules contenant deux sites de complexation spécifiques possèdent un fort potentiel pour l'imagerie bimodale IRM/TEP.

Contrast Agents for MRI

Author : Valérie C Pierre
Publisher : Royal Society of Chemistry
ISBN 13 : 1788012542
Total Pages : 612 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Contrast Agents for MRI by : Valérie C Pierre

Download or read book Contrast Agents for MRI written by Valérie C Pierre and published by Royal Society of Chemistry. This book was released on 2017-11-09 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a practical reference guide for designing and performing experiments, this book focuses on the five most common classes of contrast agents for MRI namely gadolinium complexes, chemical exchange saturation transfer agents, iron oxide nanoparticles, manganese complexes and fluorine contrast agents. It describes how to characterize and evaluate them and for each class, a description of the theory behind their mechanisms is discussed briefly to orient the new reader. Detailed subchapters discuss the different physical chemistry methods used to characterize them in terms of their efficacy, safety and in vivo behavior. Important consideration is also given to the different physical properties that affect the performance of the contrast agents. The editors and contributors are at the forefront of research in the field of MRI contrast agents and this unique, cutting edge book is a timely addition to the literature in this area.

Iron Oxide Nanoparticles for Biomedical Applications

Author : Sophie Laurent
Publisher : Elsevier
ISBN 13 : 9780081019252
Total Pages : 0 pages
Book Rating : 4.0/5 (192 download)

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Book Synopsis Iron Oxide Nanoparticles for Biomedical Applications by : Sophie Laurent

Download or read book Iron Oxide Nanoparticles for Biomedical Applications written by Sophie Laurent and published by Elsevier. This book was released on 2017-10-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron Oxide Nanoparticles for Biomedical Applications: Synthesis, Functionalization and Application begins with several chapters covering the synthesis, stabilization, physico-chemical characterization and functionalization of iron oxide nanoparticles. The second part of the book outlines the various biomedical imaging applications that currently take advantage of the magnetic properties of iron oxide nanoparticles. Brief attention is given to potential iron oxide based therapies, while the final chapter covers nanocytotoxicity, which is a key concern wherever exposure to nanomaterials might occur. This comprehensive book is an essential reference for all those academics and professionals who require thorough knowledge of recent and future developments in the role of iron oxide nanoparticles in biomedicine.

Magnetic Nanoparticles in Human Health and Medicine

Author : Costica Caizer
Publisher : John Wiley & Sons
ISBN 13 : 1119754747
Total Pages : 512 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis Magnetic Nanoparticles in Human Health and Medicine by : Costica Caizer

Download or read book Magnetic Nanoparticles in Human Health and Medicine written by Costica Caizer and published by John Wiley & Sons. This book was released on 2021-09-08 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic Nanoparticles in Human Health and Medicine Explores the application of magnetic nanoparticles in drug delivery, magnetic resonance imaging, and alternative cancer therapy Magnetic Nanoparticles in Human Health and Medicine addresses recent progress in improving diagnosis by magnetic resonance imaging (MRI) and using non-invasive and non-toxic magnetic nanoparticles for targeted drug delivery and magnetic hyperthermia. Focusing on cancer diagnosis and alternative therapy, the book covers both fundamental principles and advanced theoretical and experimental research on the magnetic properties, biocompatibilization, biofunctionalization, and application of magnetic nanoparticles in nanobiotechnology and nanomedicine. Chapters written by a panel of international specialists in the field of magnetic nanoparticles and their applications in biomedicine cover magnetic hyperthermia (MHT), MRI contrast agents, biomedical imaging, modeling and simulation, nanobiotechnology, toxicity issues, and more. Readers are provided with accurate information on the use of magnetic nanoparticles in diagnosis, drug delivery, and alternative cancer therapeutics—featuring discussion of current problems, proposed solutions, and future research directions. Topics include current applications of magnetic iron oxide nanoparticles in nanomedicine and alternative cancer therapy: drug delivery, magnetic resonance imaging, superparamagnetic hyperthermia as alternative cancer therapy, magnetic hyperthermia in clinical trials, and simulating the physics of magnetic particle heating for cancer therapy. This comprehensive volume: Covers both general research on magnetic nanoparticles in medicine and specific applications in cancer therapeutics Discusses the use of magnetic nanoparticles in alternative cancer therapy by magnetic and superparamagnetic hyperthermia Explores targeted medication delivery using magnetic nanoparticles as a future replacement of conventional techniques Reviews the use of MRI with magnetic nanoparticles to increase the diagnostic accuracy of medical imaging Magnetic Nanoparticles in Human Health and Medicine is a valuable resource for researchers in the fields of nanomagnetism, magnetic nanoparticles, nanobiomaterials, nanobioengineering, biopharmaceuticals nanobiotechnologies, nanomedicine, and biopharmaceuticals, particularly those focused on alternative cancer diagnosis and therapeutics.

Field-cycling NMR Relaxometry

Author : Rainer Kimmich
Publisher : Royal Society of Chemistry
ISBN 13 : 1788015509
Total Pages : 590 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Field-cycling NMR Relaxometry by : Rainer Kimmich

Download or read book Field-cycling NMR Relaxometry written by Rainer Kimmich and published by Royal Society of Chemistry. This book was released on 2018-10-11 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: Field-cycling NMR relaxometry is evolving into a methodology of widespread interest with recent technological developments resulting in powerful and versatile commercial instruments. Polymers, liquid crystals, biomaterials, porous media, tissue, cement and many other materials of practical importance can be studied using this technique. This book summarises the expertise of leading scientists in the area and the editor is well placed, after four decades of working in this field, to ensure a broad ranging and high quality title. Starting with an overview of the basic principles of the technique and the scope of its use, the content then develops to look at theory, instrumentation, practical limitations and applications in different systems. Newcomers to the field will find this book invaluable for successful use of the technique. Researchers already in academic and industrial settings, interested in molecular dynamics and magnetic resonance, will discover an important addition to the literature.

Clinical Applications of Magnetic Nanoparticles

Author : Nguyen TK Thanh
Publisher : CRC Press
ISBN 13 : 1351685422
Total Pages : 1137 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Clinical Applications of Magnetic Nanoparticles by : Nguyen TK Thanh

Download or read book Clinical Applications of Magnetic Nanoparticles written by Nguyen TK Thanh and published by CRC Press. This book was released on 2018-02-06 with total page 1137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering the latest information in magnetic nanoparticle (MNP) research, this book builds upon the success of the first volume and provides an updated and comprehensive review, from synthesis, characterization, and biofunctionalization to clinical applications of MNPs, including the diagnosis and treatment of cancers. The book captures some of emerging research area which was not available in the first volume. Good Manufacturing Practices and Commercialization of MNPs are also included. This volume, also written by some of the most qualified experts in the field, incorporates new developments in the literature, and continues to bridge the gaps between the different areas in this field.

MRI Contrast Agents

Author : Sophie Laurent
Publisher : Springer
ISBN 13 : 9811025290
Total Pages : 128 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis MRI Contrast Agents by : Sophie Laurent

Download or read book MRI Contrast Agents written by Sophie Laurent and published by Springer. This book was released on 2016-11-03 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the multiple aspects of (i) preparation of the magnetic core, (ii) the stabilization with different coatings, (iii) the physico-chemical characterization and (iv) the vectorization to obtain specific nanosystems. Several bio-applications are also presented in this book. In the early days of Magnetic Resonance Imaging (MRI), paramagnetic ions were proposed as contrast agents to enhance the diagnostic quality of MR images. Since then, academic and industrial efforts have been devoted to the development of new and more efficient molecular, supramolecular and nanoparticular systems. Old concepts and theories, like paramagnetic relaxation, were revisited and exploited, leading to new scientific tracks. With their high relaxivity payload, the superparamagnetic nanoparticles are very appealing in the context of molecular imaging but challenges are still numerous: absence of toxicity, specificity, ability to cross the biological barriers, etc.