Myeloma Therapy

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Multiple Myeloma

Author : Morie A. Gertz
Publisher : Springer Science & Business Media
ISBN 13 : 1461485207
Total Pages : 311 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Multiple Myeloma by : Morie A. Gertz

Download or read book Multiple Myeloma written by Morie A. Gertz and published by Springer Science & Business Media. This book was released on 2013-10-01 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders. Edited and written by a multidisciplinary group of recognized authorities from the Mayo Clinic, it presents clear guidelines on diagnosis and therapy and covers all aspects of multiple myeloma, from molecular classification and diagnosis, to risk stratification and therapy. Closely related plasma cell disorders such as solitary plasmacytoma, Waldenstrom macroglobulinemia, and light chain amyloidosis are discussed in detail as well. The book addresses often overlooked topics, including the role of radiation therapy, vertebral augmentation, and supportive care. Our understanding of this group of disorders is developing at an unprecedented rate, and Multiple Myeloma meets the need among oncologists and hematologists for a clear, timely, and authoritative resource on their biology, diagnosis, and treatment.

Resistance to Targeted Therapies in Multiple Myeloma

Author : Silvia CW Ling
Publisher : Springer Nature
ISBN 13 : 3030734404
Total Pages : 154 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Resistance to Targeted Therapies in Multiple Myeloma by : Silvia CW Ling

Download or read book Resistance to Targeted Therapies in Multiple Myeloma written by Silvia CW Ling and published by Springer Nature. This book was released on 2021-07-23 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple Myeloma remains an incurable malignancy. As the disease progresses, it invariably becomes resistant to treatment and almost all patients develop refractory disease. There are multiple different types of targeted therapies and many of them are used in combination at different stages of disease. Targeted therapies that are approved to be used include Proteasome Inhibitors, Immunomodulatory Drugs and Monoclonal Antibodies. Second and third generations of these drugs are developed to overcome resistance and they have unique mechanism of actions. Targeted therapies that are undergoing clinical trials include CAR-T cells, bi-specific antibodies, vaccines, ubiquitin ligase inhibitors and BCL-2 inhibitors. This book will help to develop an understanding of targeted therapies in Multiple Myeloma. Its goal is to provide a unique review of the mechanism of action and resistance of the many targeted therapies in Multiple Myeloma by leaders of the field. The book will be useful for students in medical science, clinicians, health professionals, scientists, pharmaceutical professionals, drug developers, and policy makers. This book will provide an insightful knowledge of the biology of Multiple Myeloma, the mechanism of action and resistance of targeted therapies, application of biomarkers and genomics and possible strategies in overcoming resistance and future development.

Handbook of Multiple Myeloma

Author : Mohamad Mohty
Publisher : Springer
ISBN 13 : 3319182188
Total Pages : 109 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Handbook of Multiple Myeloma by : Mohamad Mohty

Download or read book Handbook of Multiple Myeloma written by Mohamad Mohty and published by Springer. This book was released on 2015-07-14 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is an in-depth and comprehensive guide to the pathophysiology, diagnosis, staging, treatment and management of patients with multiple myeloma. The Handbook was commissioned to address an unmet need for a book of this kind in the myeloma field and to provide busy healthcare professionals with an informative and educational review of the current and emerging treatment recommendations for multiple myeloma. Myeloma is a type of bone marrow cancer arising from plasma cells and is the second most common form of bone marrow cancer, but represents just 1% of all cancers. The causes of myeloma are not fully understood but it is thought to be caused by an interaction of both genetic and environmental factors. This Handbook discusses these issues as well the latest developments in the field and will be an invaluable source of topical information for all healthcare professionals with an interest in multiple myeloma.

Myeloma Therapy

Author : Sagar Lonial
Publisher : Springer Science & Business Media
ISBN 13 : 1597455644
Total Pages : 674 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Myeloma Therapy by : Sagar Lonial

Download or read book Myeloma Therapy written by Sagar Lonial and published by Springer Science & Business Media. This book was released on 2009-01-01 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic options for patients with myeloma have dramatically changed over the past 10 years. Beginning with the advances in therapy resulting from the use of high-dose therapy and autologous bone marrow or stem cell tra- plant, we have more than doubled the median survival for patients as a whole, and have now have a wealth of different biology -based treatment approaches for our patients in all disease stages. This book represents state-of-the-art information from many of the leaders in the plasma cell disorders world. Sections focusing on disease pathogenesis and biology, chemotherapy-based approaches, immune -based therapies, currently approved novel agents, developing targets, supportive care, and other plasma cell disorders provides a comprehensive collection and an excellent resource in this time of rapid change in clinical and preclinical disease knowledge. It is important to realize that these changes did not occur in a vacuum. Partnerships between academic institutions, the pharmaceutical industry, patient advocacy groups, the National Cancer Institute, community onco- gists, and ultimately our patients worked closely together to realize these advances, and to effect the radical changes in therapy we have witnessed over the past few years. This book would not have been possible without contri- tions from each of the gifted scientists and clinicians who worked tirelessly to prepare their individual chapters all the while maintaining commitment to the scientific and clinical mission of advancing care.

Personalized Therapy for Multiple Myeloma

Author : Saad Z. Usmani
Publisher : Springer
ISBN 13 : 3319618725
Total Pages : 178 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Personalized Therapy for Multiple Myeloma by : Saad Z. Usmani

Download or read book Personalized Therapy for Multiple Myeloma written by Saad Z. Usmani and published by Springer. This book was released on 2017-10-30 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the clinician with concise, practical guidance on risk stratification and therapeutic decision making in patients with multiple myeloma. In addition, the available clinical trial and research data are summarized into meaningful reviews and evidence-based recommendations for treatment are presented. The coverage encompasses all phases and forms of disease, including high-risk myeloma. Over recent decades, greater understanding of the biology of myeloma has fostered the development of new, more effective drugs, leading to remarkable improvements in survival. To continue this momentum, several recent prospective trials have aimed to identify further potential therapeutic targets or to evaluate various combinations of anti-myeloma agents. The increasing abundance of management options makes the decision making complex in different phases of the disease. This book will offer the clinician valuable assistance in the choice and sequencing of therapies, highlighting the need for a personalized approach that reflects the growing recognition that myeloma is not one uniform disease.

Multiple Myeloma

Author : Thomas Moehler
Publisher : Springer Science & Business Media
ISBN 13 : 3540857729
Total Pages : 349 pages
Book Rating : 4.5/5 (48 download)

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Book Synopsis Multiple Myeloma by : Thomas Moehler

Download or read book Multiple Myeloma written by Thomas Moehler and published by Springer Science & Business Media. This book was released on 2011-04-21 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple myeloma is currently still an incurable disease, but during the past decade knowledge of its molecular pathogenesis has increased rapidly. This has led to remarkable progress in both diagnosis and therapy, including in particular the approval of novel and first-in-class drugs such as thalidomide, bortezomib, and lenalidomide. This book, written by internationally acknowledged experts, covers a wide range of topics relating to multiple myeloma, including history, epidemiology, pathophysiology, clinical features, staging, and prognostic systems. The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable. Individualized therapy and the variety of supportive treatment options, as described in this volume, will help in achieving this goal, as well as in reducing adverse events and improving quality of life.

The EBMT/EHA CAR-T Cell Handbook

Author : Nicolaus Kröger
Publisher : Springer Nature
ISBN 13 : 3030943534
Total Pages : 221 pages
Book Rating : 4.0/5 (39 download)

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Book Synopsis The EBMT/EHA CAR-T Cell Handbook by : Nicolaus Kröger

Download or read book The EBMT/EHA CAR-T Cell Handbook written by Nicolaus Kröger and published by Springer Nature. This book was released on 2022-02-07 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first open access European CAR-T Handbook, co-promoted by the European Society for Blood and Marrow Transplantation (EBMT) and the European Hematology Association (EHA), covers several aspects of CAR-T cell treatments, including the underlying biology, indications, management of side-effects, access and manufacturing issues. This book, written by leading experts in the field to enhance readers’ knowledge and practice skills, provides an unparalleled overview of the CAR-T cell technology and its application in clinical care, to enhance readers’ knowledge and practice skills.

Update on Multiple Myeloma

Author : Khalid Ahmed Al-Anazi
Publisher :
ISBN 13 : 178985217X
Total Pages : 236 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Update on Multiple Myeloma by : Khalid Ahmed Al-Anazi

Download or read book Update on Multiple Myeloma written by Khalid Ahmed Al-Anazi and published by . This book was released on 2019-02 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive overview of the recent developments in the clinical and research fields of multiple myeloma. It is divided into three main sections that cover a wide range of topics, including: epidemiology and pathogenesis of the disease, genetic targets and pathways, resistance to novel therapies, angiogenesis and anti-angiogenesis, hematopoietic stem cell transplantation, role of radiology and radiotherapy in myeloma, infectious complications, and management of multiple myeloma in resource-poor countries.

Multiple Myeloma and Other Plasma Cell Neoplasms

Author : Meletios A. Dimopoulos
Publisher : Springer
ISBN 13 : 331925586X
Total Pages : 245 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Multiple Myeloma and Other Plasma Cell Neoplasms by : Meletios A. Dimopoulos

Download or read book Multiple Myeloma and Other Plasma Cell Neoplasms written by Meletios A. Dimopoulos and published by Springer. This book was released on 2018-02-16 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive source of up-to-date information on plasma cell neoplasms. Key features include the provision of new criteria for the diagnosis of symptomatic multiple myeloma requiring treatment and the description of novel therapies for myeloma and other plasma cell neoplasms that have only very recently been licensed by the U.S. Food and Drug Administration. Examples include lenalidomide as first-line therapy, panobinostat in combination with bortezomib plus dexamethasone for relapsed/refractory myeloma, ibrutinib for Waldenström’s macroglobulinemia, and new therapeutic regimens for systemic amyloidosis and POEMS syndrome. Information is also provided on drug combinations that have shown encouraging results and are very near to approval. Other important aspects covered in the book are the role of different imaging modalities in workup and the significance of newly acquired data relating to prognosis and minimal residual disease. Readers will find Multiple Myeloma and Other Plasma Cell Neoplasms to be a rich source of knowledge that will be invaluable in improving patient management.

Towards Individualized Therapy for Multiple Myeloma

Author :
Publisher :
ISBN 13 : 9814469629
Total Pages : pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Towards Individualized Therapy for Multiple Myeloma by :

Download or read book Towards Individualized Therapy for Multiple Myeloma written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Towards Individualized Therapy for Multiple Myeloma

Author : Gerrard Teoh
Publisher : World Scientific
ISBN 13 : 9812835806
Total Pages : 201 pages
Book Rating : 4.8/5 (128 download)

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Book Synopsis Towards Individualized Therapy for Multiple Myeloma by : Gerrard Teoh

Download or read book Towards Individualized Therapy for Multiple Myeloma written by Gerrard Teoh and published by World Scientific. This book was released on 2009 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: This very provocative book takes the reader on a OC think-out-of-the-boxOCO journey through the development of a treatment regimen for multiple myeloma called OC dtZOCO. It is a firsthand account of how more than 50 patients with myeloma were given a non-toxic, precisely-targeted, anti-cancer treatment that was specifically adapted to their individual cancers. These Individualized Anti-Cancer Targeted Therapies (smart bombs) have produced amongst the best responses as well as survival rates for myeloma. Accordingly, the author argues that some patients might even have been OC curedOCO of their cancers. The concepts and logic behind OC dtZOCO are carefully presented in simple language so that both doctors and patients can easily understand them. Numerous tables and figures are provided, together with clear and simple explanations. This book is a valuable resource for all patients with myeloma who want to get the most out of their treatment by individualizing treatment to suit their needs, particularly for patients who have just been diagnosed with myeloma and who are taking that very important first step in their treatment. It is also a useful guide for doctors, nurses and researchers who treat and/or study myeloma.

Treatment of Multiple Myeloma and Related Disorders

Author : S. Vincent Rajkumar
Publisher : Cambridge University Press
ISBN 13 : 1139473492
Total Pages : 207 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Treatment of Multiple Myeloma and Related Disorders by : S. Vincent Rajkumar

Download or read book Treatment of Multiple Myeloma and Related Disorders written by S. Vincent Rajkumar and published by Cambridge University Press. This book was released on 2008-10-27 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to major advances in understanding the biology and pathogenesis of the disease, the management of multiple myeloma is changing rapidly. New diagnostic and prognostic criteria have been introduced, and treatment options are multiplying with high-dose chemotherapy regimens, stem cell transplants, and the development of novel agents and immune-based strategies that target tumor cells directly. This book is aimed at the practitioner who is looking to put these advances into clinical context. It will serve as an up-to-date resource for treatment of myeloma and related disorders. Chapters are written by international authorities and contain color photos, diagrams, and algorithms outlining preferred treatment strategies. Relevant scientific information is integrated throughout, but the focus here is on providing practical therapeutic guidance for oncologists and hematologists caring for myeloma patients. The book covers all myeloma subtypes and related disorders, including amyloidosis, Waldenstrom macroglobulinemia, plasmacytoma, MGUS, and POEMS syndrome.

Advances in Biology and Therapy of Multiple Myeloma

Author : Nikhil C. Munshi
Publisher : Springer Science & Business Media
ISBN 13 : 146144666X
Total Pages : 322 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Advances in Biology and Therapy of Multiple Myeloma by : Nikhil C. Munshi

Download or read book Advances in Biology and Therapy of Multiple Myeloma written by Nikhil C. Munshi and published by Springer Science & Business Media. This book was released on 2012-11-15 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.

The Myeloma Survival Guide

Author : Jim Tamkin, MD, FACP, FACE
Publisher : Demos Medical Publishing
ISBN 13 : 1617052248
Total Pages : 192 pages
Book Rating : 4.6/5 (17 download)

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Book Synopsis The Myeloma Survival Guide by : Jim Tamkin, MD, FACP, FACE

Download or read book The Myeloma Survival Guide written by Jim Tamkin, MD, FACP, FACE and published by Demos Medical Publishing. This book was released on 2014-05-28 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive guide to living a longer, fuller life with myeloma The Myeloma Survival Guide makes sense of the difficult questions myeloma patients face, dealing with every aspect of life after diagnosis, from creating a wellness team to navigating treatment options to building a financial safety net. Jim Tamkin, MD, who lived with myeloma for 11 years, and Dave Visel share the insights they've gained as a doctor, patient, and caregiver, including: Everything you need to know about drugs and treatments, including stem cell transplants How to deal with the pain and side effects of chemotherapy, radiation, and surgery Insurance and tax benefits to save money and get you the care you deserve Take-charge tools you can use today to feel better tomorrow

Advances in Biology and Therapy of Multiple Myeloma

Author : Nikhil C. Munshi
Publisher : Springer Science & Business Media
ISBN 13 : 1461452600
Total Pages : 291 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Advances in Biology and Therapy of Multiple Myeloma by : Nikhil C. Munshi

Download or read book Advances in Biology and Therapy of Multiple Myeloma written by Nikhil C. Munshi and published by Springer Science & Business Media. This book was released on 2012-12-09 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.

The Myeloma Survival Guide

Author : Jim Tamkin, MD, FACP, FACE
Publisher : Springer Publishing Company
ISBN 13 : 0826128238
Total Pages : 296 pages
Book Rating : 4.8/5 (261 download)

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Book Synopsis The Myeloma Survival Guide by : Jim Tamkin, MD, FACP, FACE

Download or read book The Myeloma Survival Guide written by Jim Tamkin, MD, FACP, FACE and published by Springer Publishing Company. This book was released on 2017-07-28 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive guide to living a longer, fuller life with myeloma The Myeloma Survival Guide makes sense of the difficult questions myeloma patients face, dealing with every aspect of life after diagnosis, from creating a wellness team to navigating treatment options to building a financial safety net. Jim Tamkin, MD, who lived with myeloma for 11 years, and Dave Visel share the insights they've gained as a doctor, patient, and caregiver, including: Everything you need to know about drugs and treatments, including stem cell transplants How to deal with the pain and side effects of chemotherapy, radiation, and surgery Insurance and tax benefits to save money and get you the care you deserve Take-charge tools you can use today to feel better tomorrow The second edition has been thoroughly updated and includes a new chapter on pills and medical adherence. "An invaluable guide to patients with newly diagnosed multiple myeloma. Not only have they provided clear information on the disease and its treatment, but most importantly also convey critical guidance on how to deal with the very personal life-impacting effects of this disease for patients and family members alike." –Kenneth C. Anderson, MD, Kraft Family Professor of Medicine, Harvard Medical School, and Director, Jerome Lipper Multiple Myeloma Center and LeBow Institute for Myeloma Therapeutics, Dana-Farber Cancer Institute Jim Tamkin, MD, FACP, FACE, lived with myeloma for 11 years. He co-founded the TBA (Their Best Advice) Foundation with Dave Visel in 2009 to provide myeloma patients with the resources they need to cope with the disease. He worked as an internist and endocrinologist in Los Angeles until his death in March 2011. Dave Visel is co-founder of the TBA Foundation and author of Living with Cancer: A Practical Guide. He is a retired advertising copywriter and marketing executive, and is a caregiver to his wife, Karen, who has leukemia. They live in Los Angeles. www.TBAfoundation.org

Multiple Myeloma - A New Era of Treatment Strategies

Author : Klaus Podar
Publisher : Bentham Science Publishers
ISBN 13 : 1608052974
Total Pages : 217 pages
Book Rating : 4.6/5 (8 download)

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Book Synopsis Multiple Myeloma - A New Era of Treatment Strategies by : Klaus Podar

Download or read book Multiple Myeloma - A New Era of Treatment Strategies written by Klaus Podar and published by Bentham Science Publishers. This book was released on 2012-01-03 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Multiple Myeloma (MM), the second most common blood cancer in adults, is a clonal plasma cell malignancy within the bone marrow characterized by osteolytic bone lesions, renal disease, and immunodeficiency. It is now well established that MM cell- induced"