Mutagenicity

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Mutagenicity: Assays and Applications

Author : Ashutosh Kumar
Publisher : Academic Press
ISBN 13 : 0128092602
Total Pages : 350 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Mutagenicity: Assays and Applications by : Ashutosh Kumar

Download or read book Mutagenicity: Assays and Applications written by Ashutosh Kumar and published by Academic Press. This book was released on 2017-09-26 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. Presents an up-to-date and in-depth review of the current state of mutagenesis research Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials

Handbook of Mutagenicity Test Procedures

Author : B.J. Kilbey
Publisher : Elsevier
ISBN 13 : 0444600981
Total Pages : 876 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Handbook of Mutagenicity Test Procedures by : B.J. Kilbey

Download or read book Handbook of Mutagenicity Test Procedures written by B.J. Kilbey and published by Elsevier. This book was released on 2012-12-02 with total page 876 pages. Available in PDF, EPUB and Kindle. Book excerpt: The compilation of this book was prompted by the necessity of a bench volume which could provide the necessary background information on materials, experimental design, pitfalls and dificulties, in order to perform a particular test in an acceptable way with a minimal need for additional expert help. This Second Edition updates this information, providing: - a comprehensive bench guide - methods known to be reliable - a broad spectrum of approaches - tips to avoid pitfalls when using unfamiliar techniques - data from population records - safety aspects of mutagens and carcinogens - basic statistical concepts for experiment design This `on the bench' methodological text provides the necessary information for most of the common assays for genetic damage in use. The book includes methods which have been sufficiently used and tested to make their use reliable, but also presents methods which are not widely used at present, but which might prove most useful in screening for mutagenic effects.

The Mutagenicity of Pesticides

Author : Samuel S. Epstein
Publisher : MIT Press (MA)
ISBN 13 :
Total Pages : 248 pages
Book Rating : 4.:/5 (51 download)

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Book Synopsis The Mutagenicity of Pesticides by : Samuel S. Epstein

Download or read book The Mutagenicity of Pesticides written by Samuel S. Epstein and published by MIT Press (MA). This book was released on 1971 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to present recently developed mammalian methodologies for evaluating mutagenic hazards of chemicals such as pesticides.

Review of the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens

Author : National Research Council (U.S.). Committee to Review the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens
Publisher : National Academy Press
ISBN 13 : 9780309301787
Total Pages : 178 pages
Book Rating : 4.3/5 (17 download)

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Book Synopsis Review of the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens by : National Research Council (U.S.). Committee to Review the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens

Download or read book Review of the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens written by National Research Council (U.S.). Committee to Review the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens and published by National Academy Press. This book was released on 2014 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction -- Review of the styrene profile in the National Toxicology Program 12th report on carcinogens -- Independent assessment of styrene -- Biographic Information on the Committee to Review the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens -- Statement of task of the Committee to Review the Styrene Assessment in the National Toxicology Program 12th report on carcinogens -- Review of the literature search used in the National Toxicology Program 12th report on carcinogens -- Literature search strategies used in support of the committee's independent assessment of styrene.

Short-Term Test Systems for Detecting Carcinogens

Author : K.H. Norpoth
Publisher : Springer Science & Business Media
ISBN 13 : 3642672027
Total Pages : 424 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Short-Term Test Systems for Detecting Carcinogens by : K.H. Norpoth

Download or read book Short-Term Test Systems for Detecting Carcinogens written by K.H. Norpoth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: The varying cancer incidence from country to country and region to region suggests that en vironmental factors play a considerable role in the aetiology of cancer. Whether these factors in the environment moderate the effect of car cinogenic chemicals or whether they might them selves be carcinogenic is not known at the present time. What is known is that there are various chemicals, both naturally occurring and man-made, which can induce cancer in man. In the Western world estimates vary as to how much cancer is occupational in origin; the figures range from 1% to 40%. It is our feeling that probably about 10% of cancer has a direct oc cupational origin. Nevertheless this number is considerable and it behoves us therefore to identify those chemicals which are carcinogenic and to reduce human exposure. Recent work on the mode of action of carcinogenic chemicals suggests that the majority exert their effect through an activation step to give elec trophilic metabolites. Such metabolites have as a common feature the ability to react with cel lular nucleophiles to give covalently bound products. Such reaction will occur after carcino gen treatment of animals with nucleic acids par ticularly in target organs. It is reaction with nucleic acids that provides the basis of a num ber of short-term tests for carcinogens, since the basic composition of DNA is similar in micro-organisms and in human cells.

The Medicinal Chemist's Guide to Solving ADMET Challenges

Author : Patrick Schnider
Publisher : Royal Society of Chemistry
ISBN 13 : 1788012275
Total Pages : 541 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis The Medicinal Chemist's Guide to Solving ADMET Challenges by : Patrick Schnider

Download or read book The Medicinal Chemist's Guide to Solving ADMET Challenges written by Patrick Schnider and published by Royal Society of Chemistry. This book was released on 2021-08-27 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is a complex science that lies at the very heart of drug discovery. Poor solubility, complex metabolism, tissue retention and slow elimination are just some of the properties of investigational compounds that present a challenge to the design and conduct of ADMET studies. Medicinal chemistry experience and knowledge relating to how a lead structure was modified to solve a specific problem is generally very challenging to retrieve. Presented in a visual and accessible style, this book provides rapid solutions to overcome the universal challenges to optimizing ADMET.

Handbook of Hazardous Materials

Author :
Publisher : Academic Press
ISBN 13 : 0323139558
Total Pages : 791 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Handbook of Hazardous Materials by :

Download or read book Handbook of Hazardous Materials written by and published by Academic Press. This book was released on 2012-12-02 with total page 791 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Hazardous Materials is a one-volume compendium of hazardous materials that discusses the toxic effects of these materials on human health and the global environment. It provides comprehensive coverage of individual toxic elements, covers hazardous material groups, and includes more general articles such as evaluation and testing of carcinogens, transport of pollutants, and inhalation toxicology. The fully referenced articles are presented in alphabetical order. The book features a subject index as well as numerous cross-references. Individual articles are preceded by a topical outline and discuss the origin, prevalence, mechanisms of toxicity and damaging effects of each hazardous material.Comprehensive coverage of individual toxic elements, includingAsbestosAlarLeadMercuryCoverage of hazardous material groups, such asPesticidesFood additivesNitrogen compoundsMore general articles, such asEvaluation and testing of carcinogensTransport of pollutantsInhalation toxicology

Mutagenicity Testing

Author : S. Venitt
Publisher :
ISBN 13 :
Total Pages : 378 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Mutagenicity Testing by : S. Venitt

Download or read book Mutagenicity Testing written by S. Venitt and published by . This book was released on 1984 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: LABORATORY MANUAL. GENETIC TOXICOLOGY. BACTERIA. YEAST. FRUIT FLY. CULTURED MAMMALIAN CELLS. CYTOGENETIC TESTING. RODENTS. DOMINANT LETHAL TEST.

Mutation, Cancer, and Malformation

Author : Ernest H.Y. Chu
Publisher : Springer Science & Business Media
ISBN 13 : 1461323991
Total Pages : 852 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Mutation, Cancer, and Malformation by : Ernest H.Y. Chu

Download or read book Mutation, Cancer, and Malformation written by Ernest H.Y. Chu and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the early 1930s, when I was a graduate student and later a post-doctoral researcher at the National Research Council for the University of Wisconsin at Madison, we had the opportunity to get acquainted with many graduate students from China who were sent to the University for training in modern basic sciences as well as social sciences. The University of Wisconsin continues to graduate a large number of Chinese students. Economic conditions in the 1930s were very precarious for the United States and other parts of the world. Many of us students grew closer together because we were living on similarly tight budgets. As a matter of fact, we subleased a part of our apartment in Madison to some Chinese graduate students. This was a very nice opportunity for us to learn about the scientific and cultural back ground of our Chinese friends. Many of them came from the interior of China and had had very little opportunity to become acquainted with people from a western culture. Living with these students was a very pleasant and educational experience which gave us a good pic ture of the cultural life and educational system of China at that time--an intimate picture that one normally would not see without travelling in that country.

Mutagenicity

Author : John A. Heddle
Publisher : Elsevier
ISBN 13 : 1483271226
Total Pages : 490 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Mutagenicity by : John A. Heddle

Download or read book Mutagenicity written by John A. Heddle and published by Elsevier. This book was released on 2013-10-22 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mutagenicity: New Horizons in Genetic Toxicology provides an overview of the various applications and studies in the field of genetic toxicology and environmental mutagenesis. The book is composed of selected scientific papers written by experts in the field. The text presents topics on naturally occurring mutagens; occupational carcinogen; and evaluation of cooking methods. Experiments on mammalian cell mutation; chromosomal aberrations; and organisms that can be used as environmental monitors of toxicity are discussed as well. Ecologists, environmental and sanitary engineers, toxicologists, and anyone interested in environmental mutagenesis, genetic toxicology, occupational health, or the regulation of toxic substances will find the book a good source of insight.

Basic Mutagenicity Tests

Author : David J. Kirkland
Publisher : Cambridge University Press
ISBN 13 : 9780521393478
Total Pages : 164 pages
Book Rating : 4.3/5 (934 download)

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Book Synopsis Basic Mutagenicity Tests by : David J. Kirkland

Download or read book Basic Mutagenicity Tests written by David J. Kirkland and published by Cambridge University Press. This book was released on 1990-08-31 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: A summary of the essential texts that must be performed on all new compounds before they can be registered for use in the UK.

Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants

Author : Micheline Kirsch-Volders
Publisher : Springer Science & Business Media
ISBN 13 : 1461326435
Total Pages : 348 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants by : Micheline Kirsch-Volders

Download or read book Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants written by Micheline Kirsch-Volders and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is intended for anyone who cares about the health of people exposed to industrial pollutants. Attention is given to those pollutants which present a possible risk to the genetic material of exposed workers. Chapters are devoted to heavy metals such as arsenic, beryllium, cadmium, chromium, lead, mercury, nickel, etc.; insecticides (chlorinated, organophosphorus, and carbonate insecticides); monomers such as vinyl-chloride, acrylonitrile, styrene, vinylidene chloride, butadiene, chlorobutadiene, hexachlorobuta diene, etc.; and halogenated hydrocarbon solvents such as chloroform, carbon tetrachloride, trichloroethylene, I, 2-dichloroethane, tetrachloroethyl ene, dichloromethane, and I, I, I-trichloroethane. The main aim of this work is to provide the physician, the biologist, the pharmacologist, or anyone involved in genetic toxicology with a useful compendium of up-to-date information and references. Efforts are made to open the field to nonspecialists. An introductory chapter deals with the mechanisms whereby a given compound, reaching genetic material, either directly or indirectly, may increase the risk of a cancer developing in the exposed individual and of abnormalities being passed on to his or her progeny. Efforts are also made to allow easy and efficient reading for those who are not interested in detailed results. Comparative tables provide the following data on the compounds studied: chemical properties, production, occurrence, accepted standards in the industry, and positive or negative results with different test systems. Finally, senior research workers might find good descriptions in this book of the most recent results from mutagenesis and carcinogenesis testing in plant, nonmammalian, and mammalian systems.

Mutagenicity of Puget Sound Sediment Extracts

Author : R. N. Dexter
Publisher :
ISBN 13 :
Total Pages : 46 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis Mutagenicity of Puget Sound Sediment Extracts by : R. N. Dexter

Download or read book Mutagenicity of Puget Sound Sediment Extracts written by R. N. Dexter and published by . This book was released on 1979 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Statistical Evaluation of Mutagenicity Test Data

Author : David J. Kirkland
Publisher : Cambridge University Press
ISBN 13 : 9780521048149
Total Pages : 316 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Statistical Evaluation of Mutagenicity Test Data by : David J. Kirkland

Download or read book Statistical Evaluation of Mutagenicity Test Data written by David J. Kirkland and published by Cambridge University Press. This book was released on 2008-01-03 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: This rigorous and practical account of the interpretation of mutagenicity test data draws upon the expertise of toxicologists and statisticians. Chemicals, such as drugs, food additives and pesticides, all need careful screening to eliminate potentially mutagenic compounds.

New Trends in Genetic Risk Assessment

Author : Georges Jolles
Publisher :
ISBN 13 :
Total Pages : 520 pages
Book Rating : 4.:/5 (45 download)

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Book Synopsis New Trends in Genetic Risk Assessment by : Georges Jolles

Download or read book New Trends in Genetic Risk Assessment written by Georges Jolles and published by . This book was released on 1989 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Acute Toxicology Testing

Author : Shayne C. Gad
Publisher : Academic Press
ISBN 13 : 008052592X
Total Pages : 561 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Acute Toxicology Testing by : Shayne C. Gad

Download or read book Acute Toxicology Testing written by Shayne C. Gad and published by Academic Press. This book was released on 1997-10-27 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute toxicology testing provides the first line of defense against potentially dangerous chemicals. This book is a complete and practical guide to conducting and interpreting all regulatory required and commonly used acute toxicity tests. It presents detailed protocols for all of the common test designs and reviews their development and objectives. Acute Toxicology Testing, Second Edition will interest not only workers in the pharmaceutical industry, but also researchers and students in toxicology and public health. Key Features * Over 100 tables summarizing and interpreting results * Complete coverage of all major test designs and their limitations and advantages * Current status of alternative test designs and models

Genetic Toxicology and Cancer Risk Assessment

Author : Wai Nang Choy
Publisher : CRC Press
ISBN 13 : 0824745221
Total Pages : 405 pages
Book Rating : 4.8/5 (247 download)

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Book Synopsis Genetic Toxicology and Cancer Risk Assessment by : Wai Nang Choy

Download or read book Genetic Toxicology and Cancer Risk Assessment written by Wai Nang Choy and published by CRC Press. This book was released on 2001-08-31 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization. Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines! Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models discusses the threshold concept of carcinogenesis demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens considers structural activity relationship (SAR) analysis of chemical carcinogenicity describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays illustrates the use of genetic biomarkers for dosimetry analysis and more! Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.