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Multiscale Modeling Of The Skeletal System
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Book Synopsis Multiscale Modeling of the Skeletal System by : Marco Viceconti
Download or read book Multiscale Modeling of the Skeletal System written by Marco Viceconti and published by Cambridge University Press. This book was released on 2012 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systematically working from the whole body down to cellular levels, this book presents a multiscale, integrative approach to skeletal research.
Book Synopsis Multiscale Mechanobiology of Bone Remodeling and Adaptation by : Peter Pivonka
Download or read book Multiscale Mechanobiology of Bone Remodeling and Adaptation written by Peter Pivonka and published by Springer. This book was released on 2017-06-20 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.
Book Synopsis Multiscale Modelling in Biomedical Engineering by : Dimitrios I. Fotiadis
Download or read book Multiscale Modelling in Biomedical Engineering written by Dimitrios I. Fotiadis and published by John Wiley & Sons. This book was released on 2023-05-05 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiscale Modelling in Biomedical Engineering Discover how multiscale modeling can enhance patient treatment and outcomes In Multiscale Modelling in Biomedical Engineering, an accomplished team of biomedical professionals delivers a robust treatment of the foundation and background of a general computational methodology for multi-scale modeling. The authors demonstrate how this methodology can be applied to various fields of biomedicine, with a particular focus on orthopedics and cardiovascular medicine. The book begins with a description of the relationship between multiscale modeling and systems biology before moving on to proceed systematically upwards in hierarchical levels from the molecular to the cellular, tissue, and organ level. It then examines multiscale modeling applications in specific functional areas, like mechanotransduction, musculoskeletal, and cardiovascular systems. Multiscale Modelling in Biomedical Engineering offers readers experiments and exercises to illustrate and implement the concepts contained within. Readers will also benefit from the inclusion of: A thorough introduction to systems biology and multi-scale modeling, including a survey of various multi-scale methods and approaches and analyses of their application in systems biology Comprehensive explorations of biomedical imaging and nanoscale modeling at the molecular, cell, tissue, and organ levels Practical discussions of the mechanotransduction perspective, including recent progress and likely future challenges In-depth examinations of risk prediction in patients using big data analytics and data mining Perfect for undergraduate and graduate students of bioengineering, biomechanics, biomedical engineering, and medicine, Multiscale Modelling in Biomedical Engineering will also earn a place in the libraries of industry professional and researchers seeking a one-stop reference to the basic engineering principles of biological systems.
Book Synopsis Multiscale Modeling in Biomechanics and Mechanobiology by : Suvranu De
Download or read book Multiscale Modeling in Biomechanics and Mechanobiology written by Suvranu De and published by Springer. This book was released on 2014-10-10 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models. Biomechanics involves the study of the interactions of physical forces with biological systems at all scales – including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces – bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines. Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology.
Book Synopsis Multiscale Modeling of Cancer by : Vittorio Cristini
Download or read book Multiscale Modeling of Cancer written by Vittorio Cristini and published by Cambridge University Press. This book was released on 2010-09-09 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical modeling, analysis and simulation are set to play crucial roles in explaining tumor behavior, and the uncontrolled growth of cancer cells over multiple time and spatial scales. This book, the first to integrate state-of-the-art numerical techniques with experimental data, provides an in-depth assessment of tumor cell modeling at multiple scales. The first part of the text presents a detailed biological background with an examination of single-phase and multi-phase continuum tumor modeling, discrete cell modeling, and hybrid continuum-discrete modeling. In the final two chapters, the authors guide the reader through problem-based illustrations and case studies of brain and breast cancer, to demonstrate the future potential of modeling in cancer research. This book has wide interdisciplinary appeal and is a valuable resource for mathematical biologists, biomedical engineers and clinical cancer research communities wishing to understand this emerging field.
Book Synopsis Multiscale Modeling to Tackle the Complexity of Load-Bearing Organ and Tissue Regulation by : Jerome Noailly
Download or read book Multiscale Modeling to Tackle the Complexity of Load-Bearing Organ and Tissue Regulation written by Jerome Noailly and published by Frontiers Media SA. This book was released on 2022-03-11 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Nadia Magnenat-Thalmann Publisher :Springer Science & Business Media ISBN 13 :1447162757 Total Pages :319 pages Book Rating :4.4/5 (471 download)
Book Synopsis 3D Multiscale Physiological Human by : Nadia Magnenat-Thalmann
Download or read book 3D Multiscale Physiological Human written by Nadia Magnenat-Thalmann and published by Springer Science & Business Media. This book was released on 2013-12-23 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3D Multiscale Physiological Human aims to promote scientific exchange by bringing together overviews and examples of recent scientific and technological advancements across a wide range of research disciplines. As a result, the variety in methodologies and knowledge paradigms are contrasted, revealing potential gaps and opportunities for integration. Chapters have been contributed by selected authors in the relevant domains of tissue engineering, medical image acquisition and processing, visualization, modeling, computer aided diagnosis and knowledge management. The multi-scale and multi-disciplinary research aspects of articulations in humans are highlighted, with a particular emphasis on medical diagnosis and treatment of musculoskeletal diseases and related disorders. The need for multi-scale modalities and multi-disciplinary research is an emerging paradigm in the search for a better biological and medical understanding of the human musculoskeletal system. This is particularly motivated by the increasing socio-economic burden of disability and musculoskeletal diseases, especially in the increasing population of elderly people. Human movement is generated through a complex web of interactions between embedded physiological systems on different spatiotemporal scales, ranging from the molecular to the organ level. Much research is dedicated to the understanding of each of these systems, using methods and modalities tailored for each scale. Nevertheless, combining knowledge from different perspectives opens new venues of scientific thinking and stimulates innovation. Integration of this mosaic of multifaceted data across multiple scales and modalities requires further exploration of methods in simulations and visualization to obtain a comprehensive synthesis. However, this integrative approach cannot be achieved without a broad appreciation for the multiple research disciplines involved.
Book Synopsis Image-based Multiscale Modeling of Poroelastic Biological Materials with Application to Bones by : Judy Ping Yang
Download or read book Image-based Multiscale Modeling of Poroelastic Biological Materials with Application to Bones written by Judy Ping Yang and published by . This book was released on 2012 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biot's theory has been widely used to construct the poroelasticity models for describing the mechanical behavior of biological materials. This phenomenological framework, however, does not take the explicit microstructural configuration and the corresponding solid-fluid coupling into consideration. This work investigates how the microstructural configuration and material properties of porous materials constitute the macroscopic poroelastic material behavior described by the classical Biot's theory. We introduced an asymptotic based homogenization method to correlate the macro- and micro-mechanical behaviors of poroelastic materials, where an elastic solid and Newtonian fluid of low viscosity are considered. Through this homogenization process, the generalized Darcy's law, homogenized macroscopic continuity equation, and homogenized macroscopic equilibrium equation were obtained, where the homogenized macroscopic continuity and equilibrium equations reassemble the governing equations in Biot's theory. For an effective modeling of microstructures, a numerical solution for PDEs based on a strong form collocation that employs image pixels as the discretization points is proposed. To achieve this objective, a gradient reproducing kernel collocation method (G-RKCM) formulated based on the partition of nullity and gradient reproducing conditions was developed. This approach reduces the order of differentiation to the first order when solving second order PDEs with strong form collocation. We showed that the same number of collocation points and source points can be used in G-RKCM for optimal convergence, unlike other strong form collocation methods. In addition, same order of convergence rate in the solution and its first order derivative are achieved, owing to the imposition of gradient reproducing conditions. The computational complexity of G-RKCM is also shown to be an enhancement over other strong form collocation methods, such as the reproducing kernel collocation method (RKCM). In this work, we introduced the active contour model based on variational level set formulation for interface identification and boundary segmentation for the discretization of microstructures based on medical images. Using pixel point discretization, we introduced the RKCM and G-RKCM to solve the level set equation. In particular, the G-RKCM has been shown be effective since the second derivatives of the level set function involved in the regularization term are approximated by the first order differentiations of the gradient RK shape functions. We further showed that a B-spline kernel function with lower continuity can be preferably used to avoid the oscillation of level set functions in the two-color images. The image based G-RKCM was applied to model trabecular bone microstructures with complex geometry for both solid and fluid phases. The corresponding numerical issues such as interface discretization and kernel function support size selection have been addressed. The investigation on the proper choice of unit cell dimension and image resolution has been performed, which provides guidance in the image-based trabecular bone modeling. The validation of the proposed image based multiscale modeling framework has been carried out by comparing the numerical prediction of effective material properties with experimental data of trabecular bone in the literature and solving a macroscopic trabecular bone problem using the homogenized material constants.
Book Synopsis Multiscale, Multiphysic Modeling of the Skeletal Muscle During Isometric Contraction by : Vincent Carriou
Download or read book Multiscale, Multiphysic Modeling of the Skeletal Muscle During Isometric Contraction written by Vincent Carriou and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The neuromuscular and musculoskeletal systems are complex System of Systems (SoS) that perfectly interact to provide motion. From this interaction, muscular force is generated from the muscle activation commanded by the Central Nervous System (CNS) that pilots joint motion. In parallel an electrical activity of the muscle is generated driven by the same command of the CNS. This electrical activity can be measured at the skin surface using electrodes, namely the surface electromyogram (sEMG). The knowledge of how these muscle out comes are generated is highly important in biomechanical and clinical applications. Evaluating and quantifying the interactions arising during the muscle activation are hard and complex to investigate in experimental conditions. Therefore, it is necessary to develop a way to describe and estimate it. In the bioengineering literature, several models of the sEMG and the force generation are provided. They are principally used to describe subparts of themuscular outcomes. These models suffer from several important limitations such lacks of physiological realism, personalization, and representability when a complete muscle is considered. In this work, we propose to construct bioreliable, personalized and fast models describing electrical and mechanical activities of the muscle during contraction. For this purpose, we first propose a model describing the electrical activity at the skin surface of the muscle where this electrical activity is determined from a voluntary command of the Peripheral Nervous System (PNS), activating the muscle fibers that generate a depolarization of their membrane that is filtered by the limbvolume. Once this electrical activity is computed, the recording system, i.e. the High Density sEMG (HD-sEMG) grid is define over the skin where the sEMG signal is determined as a numerical integration of the electrical activity under the electrode area. In this model, the limb is considered as a multilayered cylinder where muscle, adipose and skin tissues are described. Therefore, we propose a mechanical model described at the Motor Unit (MU) scale. The mechanical outcomes (muscle force, stiffness and deformation) are determined from the same voluntary command of the PNS, and is based on the Huxley sliding filaments model upscale at the MU scale using the distribution-moment theory proposed by Zahalak. This model is validated with force profile recorded from a subject implanted with an electrical stimulation device. Finally, we proposed three applications of the proposed models to illustrate their reliability and usefulness. A global sensitivity analysis of the statistics computed over the sEMG signals according to variation of the HD-sEMG electrode grid is performed. Then, we proposed in collaboration a new HDsEMG/force relationship, using personalized simulated data of the Biceps Brachii from the electrical model and a Twitch based model to estimate a specific force profile corresponding to a specific sEMG sensor network and muscle configuration. To conclude, a deformableelectro-mechanicalmodelcouplingthetwoproposedmodelsisproposed. This deformable model updates the limb cylinder anatomy considering isovolumic assumption and respecting incompressible property of the muscle.
Book Synopsis Multiscale Modeling of Developmental Systems by :
Download or read book Multiscale Modeling of Developmental Systems written by and published by Academic Press. This book was released on 2007-12-18 with total page 605 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical and computational biology is playing an increasingly important role in the biological sciences. This science brings forward unique challenges, many of which are, at the moment, beyond the theoretical techniques available. Developmental biology, due to its complexity, has lagged somewhat behind its sister disciplines (such as molecular biology and population biology) in making use of quantitative modeling to further biological understanding. This volume comprises work that is among the best developmental modeling available and we feel it will do much to remedy this situation. This book is aimed at all those with an interest in the interdisciplinary field of computer and mathematical modeling of multi-cellular and developmental systems. It is also a goal of the Editors to attract more developmental biologists to consider integrating modeling components into their research. Most importantly, this book is intended to serve as a portal into this research area for younger scientists – especially graduate students and post-docs, from both biological and quantitative backgrounds. * Articles written by leading exponents in the field * Provides techniques to address multiscale modeling * Coverage includes a wide spectrum of modeling approaches * Includes descriptions of the most recent advances in the field
Book Synopsis Encyclopedia of Bioinformatics and Computational Biology by :
Download or read book Encyclopedia of Bioinformatics and Computational Biology written by and published by Elsevier. This book was released on 2018-08-21 with total page 3421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics, Three Volume Set combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major reference work spans basic and cutting-edge methodologies authored by leaders in the field, providing an invaluable resource for students, scientists, professionals in research institutes, and a broad swath of researchers in biotechnology and the biomedical and pharmaceutical industries. Brings together information from computer science, information technology, mathematics, statistics and biotechnology Written and reviewed by leading experts in the field, providing a unique and authoritative resource Focuses on the main theoretical and methodological concepts before expanding on specific topics and applications Includes interactive images, multimedia tools and crosslinking to further resources and databases
Book Synopsis Multiscale Modeling of the Ventricles by : David Urs Josef Keller
Download or read book Multiscale Modeling of the Ventricles written by David Urs Josef Keller and published by KIT Scientific Publishing. This book was released on 2014-08-22 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work is focused on different aspects within the loop of multiscale modeling: On the cellular level, effects of adrenergic regulation and the Long-QT syndrome have been investigated.On the organ level, a model for the excitation conduction system was developed and the role of electrophysiological heterogeneities was analyzed.On the torso level a dynamic model of a deforming heart was created and the effects of tissue conductivities on the solution of the forward problem were evaluated
Book Synopsis Comprehensive Biomaterials II by : Kevin Healy
Download or read book Comprehensive Biomaterials II written by Kevin Healy and published by Elsevier. This book was released on 2017-05-18 with total page 4865 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Biomaterials II, Second Edition, Seven Volume Set brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications
Book Synopsis Multiphysics and Multiscale Modeling by : Young W. Kwon
Download or read book Multiphysics and Multiscale Modeling written by Young W. Kwon and published by CRC Press. This book was released on 2015-10-05 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written to appeal to a wide field of engineers and scientists who work on multiscale and multiphysics analysis, Multiphysics and Multiscale Modeling: Techniques and Applications is dedicated to the many computational techniques and methods used to develop man-made systems as well as understand living systems that exist in nature. Presenting a body
Book Synopsis Multiscale Modeling of Elastic Moduli and Strength of Bone by :
Download or read book Multiscale Modeling of Elastic Moduli and Strength of Bone written by and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Multiscale Model of Cancellous Bone by : Frederic L. Bouyge
Download or read book A Multiscale Model of Cancellous Bone written by Frederic L. Bouyge and published by . This book was released on 2000 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biomaterials for Implants and Scaffolds by : Qing Li
Download or read book Biomaterials for Implants and Scaffolds written by Qing Li and published by Springer. This book was released on 2016-11-30 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the latest, cutting-edge advances in implantable biomaterials. It brings together a class of advanced biomaterials in two highly active research areas, namely implants and tissue scaffolds, to underline their respective functional requirements for further development. It is unique in providing a full range of methodological procedures, including materials syntheses, characterisation, cellular tests and mathematical modelling. Covering metallic, ceramic, polymeric and composite materials commonly used in biological applications and clinical therapeutics, it is a valuable resource for anyone wanting to further their understanding of the latest developments in implantable biomaterials. Focusing on biomedical applications in implants and scaffolds, it provides methodological guides to this rapidly growing field. Qing Li and Yiu-Wing Mai are both professors at the University of Sydney, School of Aerospace, Mechanical and Mechatronic Engineering.
