Multiple Imputation Of Missing Data In Practice

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Multiple Imputation of Missing Data in Practice

Author : Yulei He
Publisher : CRC Press
ISBN 13 : 0429530978
Total Pages : 419 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis Multiple Imputation of Missing Data in Practice by : Yulei He

Download or read book Multiple Imputation of Missing Data in Practice written by Yulei He and published by CRC Press. This book was released on 2021-11-20 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple Imputation of Missing Data in Practice: Basic Theory and Analysis Strategies provides a comprehensive introduction to the multiple imputation approach to missing data problems that are often encountered in data analysis. Over the past 40 years or so, multiple imputation has gone through rapid development in both theories and applications. It is nowadays the most versatile, popular, and effective missing-data strategy that is used by researchers and practitioners across different fields. There is a strong need to better understand and learn about multiple imputation in the research and practical community. Accessible to a broad audience, this book explains statistical concepts of missing data problems and the associated terminology. It focuses on how to address missing data problems using multiple imputation. It describes the basic theory behind multiple imputation and many commonly-used models and methods. These ideas are illustrated by examples from a wide variety of missing data problems. Real data from studies with different designs and features (e.g., cross-sectional data, longitudinal data, complex surveys, survival data, studies subject to measurement error, etc.) are used to demonstrate the methods. In order for readers not only to know how to use the methods, but understand why multiple imputation works and how to choose appropriate methods, simulation studies are used to assess the performance of the multiple imputation methods. Example datasets and sample programming code are either included in the book or available at a github site (https://github.com/he-zhang-hsu/multiple_imputation_book). Key Features Provides an overview of statistical concepts that are useful for better understanding missing data problems and multiple imputation analysis Provides a detailed discussion on multiple imputation models and methods targeted to different types of missing data problems (e.g., univariate and multivariate missing data problems, missing data in survival analysis, longitudinal data, complex surveys, etc.) Explores measurement error problems with multiple imputation Discusses analysis strategies for multiple imputation diagnostics Discusses data production issues when the goal of multiple imputation is to release datasets for public use, as done by organizations that process and manage large-scale surveys with nonresponse problems For some examples, illustrative datasets and sample programming code from popular statistical packages (e.g., SAS, R, WinBUGS) are included in the book. For others, they are available at a github site (https://github.com/he-zhang-hsu/multiple_imputation_book)

Flexible Imputation of Missing Data, Second Edition

Author : Stef van Buuren
Publisher : CRC Press
ISBN 13 : 0429960352
Total Pages : 444 pages
Book Rating : 4.4/5 (299 download)

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Book Synopsis Flexible Imputation of Missing Data, Second Edition by : Stef van Buuren

Download or read book Flexible Imputation of Missing Data, Second Edition written by Stef van Buuren and published by CRC Press. This book was released on 2018-07-17 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Missing data pose challenges to real-life data analysis. Simple ad-hoc fixes, like deletion or mean imputation, only work under highly restrictive conditions, which are often not met in practice. Multiple imputation replaces each missing value by multiple plausible values. The variability between these replacements reflects our ignorance of the true (but missing) value. Each of the completed data set is then analyzed by standard methods, and the results are pooled to obtain unbiased estimates with correct confidence intervals. Multiple imputation is a general approach that also inspires novel solutions to old problems by reformulating the task at hand as a missing-data problem. This is the second edition of a popular book on multiple imputation, focused on explaining the application of methods through detailed worked examples using the MICE package as developed by the author. This new edition incorporates the recent developments in this fast-moving field. This class-tested book avoids mathematical and technical details as much as possible: formulas are accompanied by verbal statements that explain the formula in accessible terms. The book sharpens the reader’s intuition on how to think about missing data, and provides all the tools needed to execute a well-grounded quantitative analysis in the presence of missing data.

Multiple Imputation of Missing Data Using SAS

Author : Patricia Berglund
Publisher : SAS Institute
ISBN 13 : 162959203X
Total Pages : 164 pages
Book Rating : 4.6/5 (295 download)

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Book Synopsis Multiple Imputation of Missing Data Using SAS by : Patricia Berglund

Download or read book Multiple Imputation of Missing Data Using SAS written by Patricia Berglund and published by SAS Institute. This book was released on 2014-07-01 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Find guidance on using SAS for multiple imputation and solving common missing data issues. Multiple Imputation of Missing Data Using SAS provides both theoretical background and constructive solutions for those working with incomplete data sets in an engaging example-driven format. It offers practical instruction on the use of SAS for multiple imputation and provides numerous examples that use a variety of public release data sets with applications to survey data. Written for users with an intermediate background in SAS programming and statistics, this book is an excellent resource for anyone seeking guidance on multiple imputation. The authors cover the MI and MIANALYZE procedures in detail, along with other procedures used for analysis of complete data sets. They guide analysts through the multiple imputation process, including evaluation of missing data patterns, choice of an imputation method, execution of the process, and interpretation of results. Topics discussed include how to deal with missing data problems in a statistically appropriate manner, how to intelligently select an imputation method, how to incorporate the uncertainty introduced by the imputation process, and how to incorporate the complex sample design (if appropriate) through use of the SAS SURVEY procedures. Discover the theoretical background and see extensive applications of the multiple imputation process in action. This book is part of the SAS Press program.

Multiple Imputation in Practice

Author : Trivellore Raghunathan
Publisher : CRC Press
ISBN 13 : 1351650319
Total Pages : 246 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Multiple Imputation in Practice by : Trivellore Raghunathan

Download or read book Multiple Imputation in Practice written by Trivellore Raghunathan and published by CRC Press. This book was released on 2018-07-20 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple Imputation in Practice: With Examples Using IVEware provides practical guidance on multiple imputation analysis, from simple to complex problems using real and simulated data sets. Data sets from cross-sectional, retrospective, prospective and longitudinal studies, randomized clinical trials, complex sample surveys are used to illustrate both simple, and complex analyses. Version 0.3 of IVEware, the software developed by the University of Michigan, is used to illustrate analyses. IVEware can multiply impute missing values, analyze multiply imputed data sets, incorporate complex sample design features, and be used for other statistical analyses framed as missing data problems. IVEware can be used under Windows, Linux, and Mac, and with software packages like SAS, SPSS, Stata, and R, or as a stand-alone tool. This book will be helpful to researchers looking for guidance on the use of multiple imputation to address missing data problems, along with examples of correct analysis techniques.

Multiple Imputation and its Application

Author : James Carpenter
Publisher : John Wiley & Sons
ISBN 13 : 1119942276
Total Pages : 368 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Multiple Imputation and its Application by : James Carpenter

Download or read book Multiple Imputation and its Application written by James Carpenter and published by John Wiley & Sons. This book was released on 2012-12-21 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical guide to analysing partially observeddata. Collecting, analysing and drawing inferences from data iscentral to research in the medical and social sciences.Unfortunately, it is rarely possible to collect all the intendeddata. The literature on inference from the resultingincomplete data is now huge, and continues to grow both asmethods are developed for large and complex data structures, and asincreasing computer power and suitable software enable researchersto apply these methods. This book focuses on a particular statistical method foranalysing and drawing inferences from incomplete data, calledMultiple Imputation (MI). MI is attractive because it is bothpractical and widely applicable. The authors aim is to clarify theissues raised by missing data, describing the rationale for MI, therelationship between the various imputation models and associatedalgorithms and its application to increasingly complex datastructures. Multiple Imputation and its Application: Discusses the issues raised by the analysis of partiallyobserved data, and the assumptions on which analyses rest. Presents a practical guide to the issues to consider whenanalysing incomplete data from both observational studies andrandomized trials. Provides a detailed discussion of the practical use of MI withreal-world examples drawn from medical and social statistics. Explores handling non-linear relationships and interactionswith multiple imputation, survival analysis, multilevel multipleimputation, sensitivity analysis via multiple imputation, usingnon-response weights with multiple imputation and doubly robustmultiple imputation. Multiple Imputation and its Application is aimed atquantitative researchers and students in the medical and socialsciences with the aim of clarifying the issues raised by theanalysis of incomplete data data, outlining the rationale for MIand describing how to consider and address the issues that arise inits application.

Missing Data Analysis in Practice

Author : Trivellore Raghunathan
Publisher : CRC Press
ISBN 13 : 1482211939
Total Pages : 227 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Missing Data Analysis in Practice by : Trivellore Raghunathan

Download or read book Missing Data Analysis in Practice written by Trivellore Raghunathan and published by CRC Press. This book was released on 2015-10-28 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Missing Data Analysis in Practice provides practical methods for analyzing missing data along with the heuristic reasoning for understanding the theoretical underpinnings. Drawing on his 25 years of experience researching, teaching, and consulting in quantitative areas, the author presents both frequentist and Bayesian perspectives. He describes ea

Handbook of Missing Data Methodology

Author : Geert Molenberghs
Publisher : CRC Press
ISBN 13 : 1439854610
Total Pages : 600 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Handbook of Missing Data Methodology by : Geert Molenberghs

Download or read book Handbook of Missing Data Methodology written by Geert Molenberghs and published by CRC Press. This book was released on 2014-11-06 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Missing data affect nearly every discipline by complicating the statistical analysis of collected data. But since the 1990s, there have been important developments in the statistical methodology for handling missing data. Written by renowned statisticians in this area, Handbook of Missing Data Methodology presents many methodological advances and the latest applications of missing data methods in empirical research. Divided into six parts, the handbook begins by establishing notation and terminology. It reviews the general taxonomy of missing data mechanisms and their implications for analysis and offers a historical perspective on early methods for handling missing data. The following three parts cover various inference paradigms when data are missing, including likelihood and Bayesian methods; semi-parametric methods, with particular emphasis on inverse probability weighting; and multiple imputation methods. The next part of the book focuses on a range of approaches that assess the sensitivity of inferences to alternative, routinely non-verifiable assumptions about the missing data process. The final part discusses special topics, such as missing data in clinical trials and sample surveys as well as approaches to model diagnostics in the missing data setting. In each part, an introduction provides useful background material and an overview to set the stage for subsequent chapters. Covering both established and emerging methodologies for missing data, this book sets the scene for future research. It provides the framework for readers to delve into research and practical applications of missing data methods.

Flexible Imputation of Missing Data, Second Edition

Author : Stef van Buuren
Publisher : CRC Press
ISBN 13 : 0429960344
Total Pages : 329 pages
Book Rating : 4.4/5 (299 download)

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Book Synopsis Flexible Imputation of Missing Data, Second Edition by : Stef van Buuren

Download or read book Flexible Imputation of Missing Data, Second Edition written by Stef van Buuren and published by CRC Press. This book was released on 2018-07-17 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Missing data pose challenges to real-life data analysis. Simple ad-hoc fixes, like deletion or mean imputation, only work under highly restrictive conditions, which are often not met in practice. Multiple imputation replaces each missing value by multiple plausible values. The variability between these replacements reflects our ignorance of the true (but missing) value. Each of the completed data set is then analyzed by standard methods, and the results are pooled to obtain unbiased estimates with correct confidence intervals. Multiple imputation is a general approach that also inspires novel solutions to old problems by reformulating the task at hand as a missing-data problem. This is the second edition of a popular book on multiple imputation, focused on explaining the application of methods through detailed worked examples using the MICE package as developed by the author. This new edition incorporates the recent developments in this fast-moving field. This class-tested book avoids mathematical and technical details as much as possible: formulas are accompanied by verbal statements that explain the formula in accessible terms. The book sharpens the reader’s intuition on how to think about missing data, and provides all the tools needed to execute a well-grounded quantitative analysis in the presence of missing data.

Analysis of Incomplete Multivariate Data

Author : J.L. Schafer
Publisher : CRC Press
ISBN 13 : 9781439821862
Total Pages : 478 pages
Book Rating : 4.8/5 (218 download)

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Book Synopsis Analysis of Incomplete Multivariate Data by : J.L. Schafer

Download or read book Analysis of Incomplete Multivariate Data written by J.L. Schafer and published by CRC Press. This book was released on 1997-08-01 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last two decades have seen enormous developments in statistical methods for incomplete data. The EM algorithm and its extensions, multiple imputation, and Markov Chain Monte Carlo provide a set of flexible and reliable tools from inference in large classes of missing-data problems. Yet, in practical terms, those developments have had surprisingly little impact on the way most data analysts handle missing values on a routine basis. Analysis of Incomplete Multivariate Data helps bridge the gap between theory and practice, making these missing-data tools accessible to a broad audience. It presents a unified, Bayesian approach to the analysis of incomplete multivariate data, covering datasets in which the variables are continuous, categorical, or both. The focus is applied, where necessary, to help readers thoroughly understand the statistical properties of those methods, and the behavior of the accompanying algorithms. All techniques are illustrated with real data examples, with extended discussion and practical advice. All of the algorithms described in this book have been implemented by the author for general use in the statistical languages S and S Plus. The software is available free of charge on the Internet.

Multiple Imputation for Nonresponse in Surveys

Author : Donald B. Rubin
Publisher : John Wiley & Sons
ISBN 13 : 0470317361
Total Pages : 258 pages
Book Rating : 4.4/5 (73 download)

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Book Synopsis Multiple Imputation for Nonresponse in Surveys by : Donald B. Rubin

Download or read book Multiple Imputation for Nonresponse in Surveys written by Donald B. Rubin and published by John Wiley & Sons. This book was released on 2009-09-25 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Demonstrates how nonresponse in sample surveys and censuses can be handled by replacing each missing value with two or more multiple imputations. Clearly illustrates the advantages of modern computing to such handle surveys, and demonstrates the benefit of this statistical technique for researchers who must analyze them. Also presents the background for Bayesian and frequentist theory. After establishing that only standard complete-data methods are needed to analyze a multiply-imputed set, the text evaluates procedures in general circumstances, outlining specific procedures for creating imputations in both the ignorable and nonignorable cases. Examples and exercises reinforce ideas, and the interplay of Bayesian and frequentist ideas presents a unified picture of modern statistics.

Data Analysis Using Regression and Multilevel/Hierarchical Models

Author : Andrew Gelman
Publisher : Cambridge University Press
ISBN 13 : 9780521686891
Total Pages : 654 pages
Book Rating : 4.6/5 (868 download)

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Book Synopsis Data Analysis Using Regression and Multilevel/Hierarchical Models by : Andrew Gelman

Download or read book Data Analysis Using Regression and Multilevel/Hierarchical Models written by Andrew Gelman and published by Cambridge University Press. This book was released on 2007 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, first published in 2007, is for the applied researcher performing data analysis using linear and nonlinear regression and multilevel models.

Multiple Imputation in Practice

Author : Trivellore Raghunathan
Publisher : CRC Press
ISBN 13 : 1498770177
Total Pages : 250 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Multiple Imputation in Practice by : Trivellore Raghunathan

Download or read book Multiple Imputation in Practice written by Trivellore Raghunathan and published by CRC Press. This book was released on 2018-07-20 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple Imputation in Practice: With Examples Using IVEware provides practical guidance on multiple imputation analysis, from simple to complex problems using real and simulated data sets. Data sets from cross-sectional, retrospective, prospective and longitudinal studies, randomized clinical trials, complex sample surveys are used to illustrate both simple, and complex analyses. Version 0.3 of IVEware, the software developed by the University of Michigan, is used to illustrate analyses. IVEware can multiply impute missing values, analyze multiply imputed data sets, incorporate complex sample design features, and be used for other statistical analyses framed as missing data problems. IVEware can be used under Windows, Linux, and Mac, and with software packages like SAS, SPSS, Stata, and R, or as a stand-alone tool. This book will be helpful to researchers looking for guidance on the use of multiple imputation to address missing data problems, along with examples of correct analysis techniques.

Clinical Trials with Missing Data

Author : Michael O'Kelly
Publisher : John Wiley & Sons
ISBN 13 : 1118762533
Total Pages : 472 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Clinical Trials with Missing Data by : Michael O'Kelly

Download or read book Clinical Trials with Missing Data written by Michael O'Kelly and published by John Wiley & Sons. This book was released on 2014-02-14 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides practical guidance for statisticians, clinicians, and researchers involved in clinical trials in the biopharmaceutical industry, medical and public health organisations. Academics and students needing an introduction to handling missing data will also find this book invaluable. The authors describe how missing data can affect the outcome and credibility of a clinical trial, show by examples how a clinical team can work to prevent missing data, and present the reader with approaches to address missing data effectively. The book is illustrated throughout with realistic case studies and worked examples, and presents clear and concise guidelines to enable good planning for missing data. The authors show how to handle missing data in a way that is transparent and easy to understand for clinicians, regulators and patients. New developments are presented to improve the choice and implementation of primary and sensitivity analyses for missing data. Many SAS code examples are included – the reader is given a toolbox for implementing analyses under a variety of assumptions.

Multiple Imputation of Missing Data in Practice

Author : Yulei He
Publisher : CRC Press
ISBN 13 : 1498722075
Total Pages : 495 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Multiple Imputation of Missing Data in Practice by : Yulei He

Download or read book Multiple Imputation of Missing Data in Practice written by Yulei He and published by CRC Press. This book was released on 2021-11-19 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple Imputation of Missing Data in Practice: Basic Theory and Analysis Strategies provides a comprehensive introduction to the multiple imputation approach to missing data problems that are often encountered in data analysis. Over the past 40 years or so, multiple imputation has gone through rapid development in both theories and applications. It is nowadays the most versatile, popular, and effective missing-data strategy that is used by researchers and practitioners across different fields. There is a strong need to better understand and learn about multiple imputation in the research and practical community. Accessible to a broad audience, this book explains statistical concepts of missing data problems and the associated terminology. It focuses on how to address missing data problems using multiple imputation. It describes the basic theory behind multiple imputation and many commonly-used models and methods. These ideas are illustrated by examples from a wide variety of missing data problems. Real data from studies with different designs and features (e.g., cross-sectional data, longitudinal data, complex surveys, survival data, studies subject to measurement error, etc.) are used to demonstrate the methods. In order for readers not only to know how to use the methods, but understand why multiple imputation works and how to choose appropriate methods, simulation studies are used to assess the performance of the multiple imputation methods. Example datasets and sample programming code are either included in the book or available at a github site (https://github.com/he-zhang-hsu/multiple_imputation_book). Key Features Provides an overview of statistical concepts that are useful for better understanding missing data problems and multiple imputation analysis Provides a detailed discussion on multiple imputation models and methods targeted to different types of missing data problems (e.g., univariate and multivariate missing data problems, missing data in survival analysis, longitudinal data, complex surveys, etc.) Explores measurement error problems with multiple imputation Discusses analysis strategies for multiple imputation diagnostics Discusses data production issues when the goal of multiple imputation is to release datasets for public use, as done by organizations that process and manage large-scale surveys with nonresponse problems For some examples, illustrative datasets and sample programming code from popular statistical packages (e.g., SAS, R, WinBUGS) are included in the book. For others, they are available at a github site (https://github.com/he-zhang-hsu/multiple_imputation_book)

The Prevention and Treatment of Missing Data in Clinical Trials

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030918651X
Total Pages : 163 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Prevention and Treatment of Missing Data in Clinical Trials by : National Research Council

Download or read book The Prevention and Treatment of Missing Data in Clinical Trials written by National Research Council and published by National Academies Press. This book was released on 2010-12-21 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.

Statistical Analysis with Missing Data

Author : Roderick J. A. Little
Publisher : John Wiley & Sons
ISBN 13 : 1118595696
Total Pages : 463 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis Statistical Analysis with Missing Data by : Roderick J. A. Little

Download or read book Statistical Analysis with Missing Data written by Roderick J. A. Little and published by John Wiley & Sons. This book was released on 2019-03-21 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: An up-to-date, comprehensive treatment of a classic text on missing data in statistics The topic of missing data has gained considerable attention in recent decades. This new edition by two acknowledged experts on the subject offers an up-to-date account of practical methodology for handling missing data problems. Blending theory and application, authors Roderick Little and Donald Rubin review historical approaches to the subject and describe simple methods for multivariate analysis with missing values. They then provide a coherent theory for analysis of problems based on likelihoods derived from statistical models for the data and the missing data mechanism, and then they apply the theory to a wide range of important missing data problems. Statistical Analysis with Missing Data, Third Edition starts by introducing readers to the subject and approaches toward solving it. It looks at the patterns and mechanisms that create the missing data, as well as a taxonomy of missing data. It then goes on to examine missing data in experiments, before discussing complete-case and available-case analysis, including weighting methods. The new edition expands its coverage to include recent work on topics such as nonresponse in sample surveys, causal inference, diagnostic methods, and sensitivity analysis, among a host of other topics. An updated “classic” written by renowned authorities on the subject Features over 150 exercises (including many new ones) Covers recent work on important methods like multiple imputation, robust alternatives to weighting, and Bayesian methods Revises previous topics based on past student feedback and class experience Contains an updated and expanded bibliography The authors were awarded The Karl Pearson Prize in 2017 by the International Statistical Institute, for a research contribution that has had profound influence on statistical theory, methodology or applications. Their work "has been no less than defining and transforming." (ISI) Statistical Analysis with Missing Data, Third Edition is an ideal textbook for upper undergraduate and/or beginning graduate level students of the subject. It is also an excellent source of information for applied statisticians and practitioners in government and industry.

Missing Data in Clinical Studies

Author : Geert Molenberghs
Publisher : John Wiley & Sons
ISBN 13 : 9780470510438
Total Pages : 526 pages
Book Rating : 4.5/5 (14 download)

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Book Synopsis Missing Data in Clinical Studies by : Geert Molenberghs

Download or read book Missing Data in Clinical Studies written by Geert Molenberghs and published by John Wiley & Sons. This book was released on 2007-04-04 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Missing Data in Clinical Studies provides a comprehensive account of the problems arising when data from clinical and related studies are incomplete, and presents the reader with approaches to effectively address them. The text provides a critique of conventional and simple methods before moving on to discuss more advanced approaches. The authors focus on practical and modeling concepts, providing an extensive set of case studies to illustrate the problems described. Provides a practical guide to the analysis of clinical trials and related studies with missing data. Examines the problems caused by missing data, enabling a complete understanding of how to overcome them. Presents conventional, simple methods to tackle these problems, before addressing more advanced approaches, including sensitivity analysis, and the MAR missingness mechanism. Illustrated throughout with real-life case studies and worked examples from clinical trials. Details the use and implementation of the necessary statistical software, primarily SAS. Missing Data in Clinical Studies has been developed through a series of courses and lectures. Its practical approach will appeal to applied statisticians and biomedical researchers, in particular those in the biopharmaceutical industry, medical and public health organisations. Graduate students of biostatistics will also find much of benefit.