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Author : Chin Hsiang Wu
Publisher :
ISBN 13 :
Total Pages : 254 pages
Book Rating : 4.:/5 (187 download)
Download or read book Multidimensional Solid-state NMR Spectroscopy of Peptides and Proteins written by Chin Hsiang Wu and published by . This book was released on 1994 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Frances Separovic
Publisher : Royal Society of Chemistry
ISBN 13 : 1849739102
Total Pages : 632 pages
Book Rating : 4.8/5 (497 download)
Download or read book Advances in Biological Solid-State NMR written by Frances Separovic and published by Royal Society of Chemistry. This book was released on 2014 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Biological NMR brings the reader up to date with chapters from international leaders of this growing field, covering the most recent developments in the methodology and applications of solid state NMR to studies of membrane interactions and molecular motions
Author : Hazime Saitô
Publisher : Springer Science & Business Media
ISBN 13 : 1402043031
Total Pages : 455 pages
Book Rating : 4.4/5 (2 download)
Download or read book Solid State NMR Spectroscopy for Biopolymers written by Hazime Saitô and published by Springer Science & Business Media. This book was released on 2006-08-05 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: ‘‘Biopolymers’’ are polymeric materials of biological origin, including globular, membrane, and fibrous proteins, polypeptides, nucleic acids, po- saccharides, lipids, etc. and their assembly, although preference to respe- ive subjects may be different among readers who are more interested in their biological significance or industrial and/or medical applications. Nevert- less, characterizing or revealing their secondary structure and dynamics may be an equally very important and useful issue for both kinds of readers. Special interest in revealing the 3D structure of globular proteins, nucleic acids, and peptides was aroused in relation to the currently active Structural Biology. X-ray crystallography and multidimensional solution NMR sp- troscopy have proved to be the standard and indispensable means for this purpose. There remain, however, several limitations to this end, if one intends to expand its scope further. This is because these approaches are not always straightforward to characterize fibrous or membrane proteins owing to extreme difficulty in crystallization in the former, and insufficient spectral resolution due to sparing solubility or increased effective molecular mass in the presence of surrounding lipid bilayers in the latter.
Author : S.R. Kiihne
Publisher : Springer Science & Business Media
ISBN 13 : 9780792371021
Total Pages : 256 pages
Book Rating : 4.3/5 (71 download)
Download or read book Perspectives on Solid State NMR in Biology written by S.R. Kiihne and published by Springer Science & Business Media. This book was released on 2001-07-31 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Solid state NMR is rapidly emerging as a universally applicable method for the characterization of ordered structures that cannot be studied with solution methods or diffraction techniques. This proceedings -; from a recent international workshop - captures an image of the latest developments and future directions for solid state NMR in biological research, particularly on membrane proteins. Detailed information on how hormones or drugs bind to their membrane receptor targets is needed, e.g. for rational drug design. Higher fields are bringing clear improvements, and the power of solid state NMR techniques for studying amorphous and membrane associated peptides, proteins and complexes is shown by examples of applications at ultra-high fields. Progress in protein expression, experimental design and data analysis are also presented by leaders in these research areas.
Author : Alessandro Mascioni
Publisher :
ISBN 13 :
Total Pages : 670 pages
Book Rating : 4.:/5 (319 download)
Download or read book Solution and Solid-state NMR of Membrane-bound Proteins and Peptides written by Alessandro Mascioni and published by . This book was released on 2003 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Clore
Publisher : CRC Press
ISBN 13 : 9780849377716
Total Pages : 328 pages
Book Rating : 4.3/5 (777 download)
Download or read book NMR of Proteins written by Clore and published by CRC Press. This book was released on 1993 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Determination of structures of larger proteins in solution by three- and four-dimensional heteronuclear magnetic resonance spectroscopy. Methodological advances in protein NMR. Determination of high-resolution NMR structures of proteins. Multidimensional NMR studies of immunosuppressant/immunophilin complexes. NMR studies of the structure and role of modules involved in protein-protein interactions. NMR structural studies of membrane proteins. Heteronuclear NMR studies of the molecular synamics of staphylococcal nuclease. Study of protein dynamics by NMR. The folding, stability and dynamics of T4 lysozyme: a perspective using nuclear magnetic resonance.
Author : Jerry C. C. Chan
Publisher : Springer Science & Business Media
ISBN 13 : 3642248020
Total Pages : 328 pages
Book Rating : 4.6/5 (422 download)
Download or read book Solid State NMR written by Jerry C. C. Chan and published by Springer Science & Business Media. This book was released on 2011-10-26 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dipolar Recoupling, by Niels Chr. Nielsen, Lasse A. Strassø and Anders B. Nielsen.- Solid-State NMR Techniques for the Structural Determination of Amyloid Fibrils, by Jerry C. C. Chan.- Solid-State 19F-NMR of Peptides in Native Membranes, by Katja Koch, Sergii Afonin, Marco Ieronimo, Marina Berditsch and Anne S. Ulrich.- Probing Quadrupolar Nuclei by Solid-State NMR Spectroscopy: Recent Advances, by Christian Fernandez and Marek Pruski.- Solid State NMR of Porous Materials Zeolites and Related Materials, by Hubert Koller and Mark Weiß.- Solid-State NMR of Inorganic Semiconductors, by James P. Yesinowski.-
Author : Philippe S. Nadaud
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (695 download)
Download or read book High-resolution Structural Studies of Paramagnetic Proteins by Multidimensional Solid-state Nuclear Magnetic Resonance Spectroscopy written by Philippe S. Nadaud and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Nuclear magnetic resonance (NMR) is one of the major spectroscopic techniques available for the characterization of molecular structure and conformational dynamics with atomic level detail. NMR relies on the intrinsic magnetic properties of certain nuclear isotopes, such as 1H, 13C, 15N, and 31P, which provide convenient, site-specific structural probes when placed inside a large external magnetic field. Recent developments in solid-state NMR (SSNMR) spectroscopy promise to enable detailed structural studies to be performed for important biological macromolecules, which are inherently insoluble but at the same time cannot be readily crystallized for analysis by X-ray diffraction. Prominent examples of systems of this type include large macromolecular complexes, membrane-bound peptides and proteins important in cell signaling, and fibrillar protein aggregates associated with the development of systemic and neurodegenerative human disorders, including Alzheimer's and Parkinson's diseases and type II diabetes.
Author : Oliver Zerbe
Publisher : John Wiley & Sons
ISBN 13 : 3527677836
Total Pages : 581 pages
Book Rating : 4.5/5 (276 download)
Download or read book Applied NMR Spectroscopy for Chemists and Life Scientists written by Oliver Zerbe and published by John Wiley & Sons. This book was released on 2013-11-26 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: From complex structure elucidation to biomolecular interactions - this applicationoriented textbook covers both theory and practice of modern NMR applications. Part one sets the stage with a general description of NMR introducing important parameters such as the chemical shift and scalar or dipolar couplings. Part two describes the theory behind NMR, providing a profound understanding of the involved spin physics, deliberately kept shorter than in other NMR textbooks, and without a rigorous mathematical treatment of all the physico-chemical computations. Part three discusses technical and practical aspects of how to use NMR. Important phenomena such as relaxation, exchange, or the nuclear Overhauser effects and the methods of modern NMR spectroscopy including multidimensional experiments, solid state NMR, and the measurement of molecular interactions are the subject of part four. The final part explains the use of NMR for the structure determination of selected classes of complex biomolecules, from steroids to peptides or proteins, nucleic acids, and carbohydrates. For chemists as well as users of NMR technology in the biological sciences.
Author : Bradley L. Nilsson
Publisher : Humana
ISBN 13 : 9781493978090
Total Pages : 0 pages
Book Rating : 4.9/5 (78 download)
Download or read book Peptide Self-Assembly written by Bradley L. Nilsson and published by Humana. This book was released on 2018-05-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details methods and protocols on b-sheet assemblies and collagen. Divided into three parts chapters focus on expanding use of solid-state NMR as a powerful method to enhance structural understanding of self-assembled peptide materials, methods for the design, synthesis, and application of self-assembled peptide materials, and structural and mechanistic analyses of pathological amyloid systems that provide novel ways to assess function of the various possible aggregates as well to determine how the structure of these materials correlates to function/dysfunction in the biological context. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Peptide Self-Assembly: Methods and Protocols aims to capture modern methods that span the breadth of the exciting and expanding field of peptide self-assembly.
Author : Frances Separovic
Publisher :
ISBN 13 : 9780750325325
Total Pages : 0 pages
Book Rating : 4.3/5 (253 download)
Download or read book Solid-state NMR written by Frances Separovic and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to describe the methodology and applications of solid-state NMR spectroscopy to studies of membrane proteins, membrane-active peptides and model biological membranes. As well as structural studies, this book contains coverage of membrane interactions and molecular motions. Advances in biological solid-state NMR are very pertinent with high-field developments seeing applications in biological membranes and whole cells. Experts who are leaders in the development and application of biological solid-state NMR are chapter contributors. Part of Biophysical Society-IOP series.
Author : N. Rama Krishna
Publisher : Springer Science & Business Media
ISBN 13 : 0306479362
Total Pages : 345 pages
Book Rating : 4.3/5 (64 download)
Download or read book Protein NMR for the Millennium written by N. Rama Krishna and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein NMR for the Millennium is the third volume in a special thematic series devoted to the latest developments in protein NMR under the Biological Magnetic Resonance umbrella. This book is divided into three major sections dealing with significant recent advances in the study of large proteins in solution and solid state, structure refinement, and screening of bioactive ligands. Key Features: TROSY, Segmental isotope labeling of proteins, Hydrogen bond scalar couplings, Structure refinement based on residual dipolar couplings, Written by the world's foremost experts who have provided broad leadership in advancing the protein NMR field.
Author : Lawrence Berliner
Publisher : Springer
ISBN 13 : 1489976213
Total Pages : 193 pages
Book Rating : 4.4/5 (899 download)
Download or read book Protein NMR written by Lawrence Berliner and published by Springer. This book was released on 2015-08-24 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers new techniques in protein NMR, from basic principles to state-of-the-art research. It covers a spectrum of topics ranging from a “toolbox” for how sequence-specific resonance assignments can be obtained using a suite of 2D and 3D NMR experiments and tips on how overlap problems can be overcome. Further topics include the novel applications of Overhauser dynamic nuclear polarization methods (DNP), assessing protein structure, and aspects of solid-state NMR of macroscopically aligned membrane proteins. This book is an ideal resource for students and researchers in the fields of biochemistry, chemistry, and pharmacology and NMR physics. Comprehensive and intuitively structured, this book examines protein NMR and new novel applications that include the latest technological advances. This book also has the features of: • A selection of various applications and cutting-edge advances, such as novel applications of Overhauser dynamic nuclear polarization methods (DNP) and a suite of 2D and 3D NMR experiments and tips on how overlap problems can be overcome • A pedagogical approach to the methodology • Engaging the reader and student with a clear, yet critical presentation of the applications
Author : Gordon S. Rule
Publisher : Springer Science & Business Media
ISBN 13 : 1402034997
Total Pages : 543 pages
Book Rating : 4.4/5 (2 download)
Download or read book Fundamentals of Protein NMR Spectroscopy written by Gordon S. Rule and published by Springer Science & Business Media. This book was released on 2005-10-28 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: NMR spectroscopy has proven to be a powerful technique to study the structure and dynamics of biological macromolecules. Fundamentals of Protein NMR Spectroscopy is a comprehensive textbook that guides the reader from a basic understanding of the phenomenological properties of magnetic resonance to the application and interpretation of modern multi-dimensional NMR experiments on 15N/13C-labeled proteins. Beginning with elementary quantum mechanics, a set of practical rules is presented and used to describe many commonly employed multi-dimensional, multi-nuclear NMR pulse sequences. A modular analysis of NMR pulse sequence building blocks also provides a basis for understanding and developing novel pulse programs. This text not only covers topics from chemical shift assignment to protein structure refinement, as well as the analysis of protein dynamics and chemical kinetics, but also provides a practical guide to many aspects of modern spectrometer hardware, sample preparation, experimental set-up, and data processing. End of chapter exercises are included to emphasize important concepts. Fundamentals of Protein NMR Spectroscopy not only offer students a systematic, in-depth, understanding of modern NMR spectroscopy and its application to biomolecular systems, but will also be a useful reference for the experienced investigator.
Author : John L. Markley
Publisher : Oxford University Press
ISBN 13 : 0195357426
Total Pages : 375 pages
Book Rating : 4.1/5 (953 download)
Download or read book Biological NMR Spectroscopy written by John L. Markley and published by Oxford University Press. This book was released on 1997-01-30 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a critical assessment of progress on the use of nuclear magnetic resonance spectroscopy to determine the structure of proteins, including brief reviews of the history of the field along with coverage of current clinical and in vivo applications. The book, in honor of Oleg Jardetsky, one of the pioneers of the field, is edited by two of the most highly respected investigators using NMR, and features contributions by most of the leading workers in the field. It will be valued as a landmark publication that presents the state-of-the-art perspectives regarding one of today's most important technologies.
Author : The Nuclear Magnetic Resonance Society of Japan
Publisher : Springer
ISBN 13 : 9811059667
Total Pages : 634 pages
Book Rating : 4.8/5 (11 download)
Download or read book Experimental Approaches of NMR Spectroscopy written by The Nuclear Magnetic Resonance Society of Japan and published by Springer. This book was released on 2017-11-23 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the advanced developments in methodology and applications of NMR spectroscopy to life science and materials science. Experts who are leaders in the development of new methods and applications of life and material sciences have contributed an exciting range of topics that cover recent advances in structural determination of biological and material molecules, dynamic aspects of biological and material molecules, and development of novel NMR techniques, including resolution and sensitivity enhancement. First, this book particularly emphasizes the experimental details for new researchers to use NMR spectroscopy and pick up the potentials of NMR spectroscopy. Second, the book is designed for those who are involved in either developing the technique or expanding the NMR application fields by applying them to specific samples. Third, the Nuclear Magnetic Resonance Society of Japan has organized this book not only for NMR members of Japan but also for readers worldwide who are interested in using NMR spectroscopy extensively.
Author : Zhe Qi
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (1 download)
Download or read book Peptide and Protein Supramolecular Assemblies Studied by Solid-state NMR Spectroscopy written by Zhe Qi and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The non-crystalline, nature of supramolecular assemblies makes it difficult to investigate their structures by traditional methods such as X-ray crystallography. On the other hand, solid-state nuclear magnetic resonance (NMR) spectroscopy, a fast-developing technique that mainly detects the local atomic environment, is suitable for this purpose. In this dissertation, we start with a brief introduction in Chapter 1, then focus on the application of solid-state NMR spectroscopy on a few peptide and protein supramolecular assemblies that have biological significance: amyloid fibrils formed by deletion mutants of human prion protein (huPrP) 23-144 in Chapter 2, peptide amphiphile (PA) palmitoyl-VVAAEE-NH2 nanofibers in Chapter 3, and nanofibrils and aggregates of several peptide-chromophore-peptide triblock compounds in Chapter 4. One- and two-dimensional high-resolution magic angle spinning (MAS) solid-state NMR spectroscopy was employed to fast access the conformation and dynamics of these assemblies. Inter-atomic distances were further measured by dipolar recoupling pulse sequences. Other methods, such as transmission electron microscopy (TEM) and atomic force microscopy (AFM) to characterize the morphology of the supramolecular assemblies, X-ray diffraction to measure the interlayer distance, as well as thioflavin T fluorescence assay to monitor the kinetic of amyloid fibril formation, were also largely involved in the dissertation. We have found the shortest fragment of huPrP23-144 that can be expressed at reasonable yield in E. coli and retain the wild-type like amyloid folding. For the PA and peptide-chromophore-peptide triblock compounds we studied, parallel, in-register ß-sheet structure largely exist even for one compound that only forms small, random aggregates. Polymorphism was observed to exist extensively in both PA and the p-conjugated peptides. DRAWS to measure the homo-nuclear distance and TEDOR to measure the hetero-nuclear distance were proven to be two useful experiments to study the stacking in the self- and co-assemblies. Our results can facilitate the understanding of huPrP23-144 amyloid structure and the mechanism of relevant prion diseases, as well as promote more rational design of peptide-based materials that have novel supramolecular structures.
