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Author :
Publisher :
ISBN 13 : 9789402806281
Total Pages : 139 pages
Book Rating : 4.8/5 (62 download)
Download or read book Multi-scale Investigation of Protein-protein Interactions written by and published by . This book was released on 2017 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nurcan Tunçbağ
Publisher :
ISBN 13 :
Total Pages : 258 pages
Book Rating : 4.:/5 (13 download)
Download or read book Multi-scale Analysis and Prediction of Protein-protein Interactions written by Nurcan Tunçbağ and published by . This book was released on 2010 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jeong-Mo Choi
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (995 download)
Download or read book Multi-Scale Theoretical Investigations of Protein Interactions and Evolution written by Jeong-Mo Choi and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Evolution of biological systems requires players of multiple layers, from atoms and molecules to organisms and populations. Expression of a gene is operated by molecular machineries for transcription, translation, regulation, and maintenance, which work in concert to produce certain macroscopic and observable phenotypes. And when these phenotypes are exposed to selective pressures, more fit phenotypes (with their genes, molecular machineries, and interaction networks) survive in the population. While the relationship of a gene to its cellular consequences is not fully elucidated, it is known that molecular interactions are one of the key factors that determine the relationship.
Author : Andrzej Kolinski
Publisher : Springer Science & Business Media
ISBN 13 : 144196889X
Total Pages : 360 pages
Book Rating : 4.4/5 (419 download)
Download or read book Multiscale Approaches to Protein Modeling written by Andrzej Kolinski and published by Springer Science & Business Media. This book was released on 2010-10-13 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book gives a comprehensive review of the most advanced multiscale methods for protein structure prediction, computational studies of protein dynamics, folding mechanisms and macromolecular interactions. It approaches span a wide range of the levels of coarse-grained representations, various sampling techniques and variety of applications to biomedical and biophysical problems. This book is intended to be used as a reference book for those who are just beginning their adventure with biomacromolecular modeling but also as a valuable source of detailed information for those who are already experts in the field of biomacromolecular modeling and in related areas of computational biology or biophysics.
Author : Thomas Gaudelet
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (125 download)
Download or read book Integration of Multi-scale Protein Interactions for Biomedical Data Analysis written by Thomas Gaudelet and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Luis Pera Fernandes
Publisher :
ISBN 13 :
Total Pages : 334 pages
Book Rating : 4.:/5 (757 download)
Download or read book Multiscale Analysis of Protein Interaction Networks written by Luis Pera Fernandes and published by . This book was released on 2010 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: High-throughput proteomics has allowed for the drafting of large protein-interaction networks and systems biology devotes a large effort to the statistical analysis of these. But rather than just a 'dot' connected in a network, each protein is a complex and dynamic three-dimensional object with sophisticated bio-chemical properties. To capture the complexity of these networks I have followed a multiscale approach by performing analysis of networks at different levels: a) a microscopic level where I analysed structural properties of interacting proteins; b) a medium-scale level in which I focused on system specific sub-networks; c) a macroscopic level where I performed a large-scale statistical and topological characterisation of protein-protein interaction networks (PPINs). For the microscopic analysis I focused on a special class of proteins: hub proteins which, contrary to most proteins in a network, can be involved in a large number of interactions. To date, it is not clear which properties facilitate hub's promiscuity; therefore, I have investigated a number of structural properties that may differentiate hubs from non-hubs and studied how these relate to single and multi-interface hub's classification. While PPINs portray a global picture of protein's connectivity, a medium-scale detailed analysis of a particular cellular function may benefit from accurately selected sub-networks of knowledge (SNK). Such SNKs contain high confidence interactions and multiple sources of information for its nodes (proteins) such as tissue specific expression data, gene expression data, domain profiles and structural data. SNK analysis provides the basis for the identification of fundamental components and pathways that can be carefully selected to focus experimental research and for helping the design of new experiments.
Author : Stefan T. Bromley
Publisher : Elsevier
ISBN 13 : 9780081022320
Total Pages : 0 pages
Book Rating : 4.0/5 (223 download)
Download or read book Computational Modelling of Nanoparticles written by Stefan T. Bromley and published by Elsevier. This book was released on 2018-09-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Modelling of Nanoparticles highlights recent advances in the power and versatility of computational modelling, experimental techniques, and how new progress has opened the door to a more detailed and comprehensive understanding of the world of nanomaterials. Nanoparticles, having dimensions of 100 nanometers or less, are increasingly being used in applications in medicine, materials and manufacturing, and energy. Spanning the smallest sub-nanometer nanoclusters to nanocrystals with diameters of 10s of nanometers, this book provides a state-of-the-art overview on how computational modelling can provide, often otherwise unobtainable, insights into nanoparticulate structure and properties. This comprehensive, single resource is ideal for researchers who want to start/improve their nanoparticle modelling efforts, learn what can be (and what cannot) achieved with computational modelling, and understand more clearly the value and details of computational modelling efforts in their area of research.
Author : Valentina Tozzini
Publisher : Frontiers Media SA
ISBN 13 : 2889661091
Total Pages : 235 pages
Book Rating : 4.8/5 (896 download)
Download or read book Multiscale Modeling From Macromolecules to Cell: Opportunities and Challenges of Biomolecular Simulations written by Valentina Tozzini and published by Frontiers Media SA. This book was released on 2020-10-27 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author : Bartlomiej Tywoniuk
Publisher :
ISBN 13 :
Total Pages : 170 pages
Book Rating : 4.:/5 (129 download)
Download or read book Multiscale Theoretical and Computational Methods for Modelling Proteins and Protein-protein Interactions written by Bartlomiej Tywoniuk and published by . This book was released on 2019 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Aidong Zhang
Publisher : Cambridge University Press
ISBN 13 : 1139479032
Total Pages : 283 pages
Book Rating : 4.1/5 (394 download)
Download or read book Protein Interaction Networks written by Aidong Zhang and published by Cambridge University Press. This book was released on 2009-04-06 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: The analysis of protein-protein interactions is fundamental to the understanding of cellular organization, processes, and functions. Proteins seldom act as single isolated species; rather, proteins involved in the same cellular processes often interact with each other. Functions of uncharacterized proteins can be predicted through comparison with the interactions of similar known proteins. Recent large-scale investigations of protein-protein interactions using such techniques as two-hybrid systems, mass spectrometry, and protein microarrays have enriched the available protein interaction data and facilitated the construction of integrated protein-protein interaction networks. The resulting large volume of protein-protein interaction data has posed a challenge to experimental investigation. This book provides a comprehensive understanding of the computational methods available for the analysis of protein-protein interaction networks. It offers an in-depth survey of a range of approaches, including statistical, topological, data-mining, and ontology-based methods. The author discusses the fundamental principles underlying each of these approaches and their respective benefits and drawbacks, and she offers suggestions for future research.
Author : Weibo Cai
Publisher : BoD – Books on Demand
ISBN 13 : 9535103970
Total Pages : 488 pages
Book Rating : 4.5/5 (351 download)
Download or read book Protein-Protein Interactions written by Weibo Cai and published by BoD – Books on Demand. This book was released on 2012-03-30 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others.
Author : Mary Griffin Krone
Publisher : ProQuest
ISBN 13 : 9780549363255
Total Pages : 280 pages
Book Rating : 4.3/5 (632 download)
Download or read book Investigating the Molecular Basis of Protein Aggregation and Alzheimer's Disease with Multi-scale Computer Simulations written by Mary Griffin Krone and published by ProQuest. This book was released on 2007 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of disorders are associated with the deposition of a variety insoluble protein aggregates. A great deal of evidence has led to the hypothesis that there exists a commonality between the aggregation processes of this diverse body of proteins and peptides. Understanding the universally applicable factors which influence the formation and stability of protein aggregates will provide a better understanding of the diseases to which they lead. To this end, we study several intrinsic and environmental factors which influence protein aggregation, including the role of water, the amount of frustration inherent in the individual proteins, confinement, and protein-surface interactions.
Author : Krishnanand N. Kaipa
Publisher : Springer
ISBN 13 : 3319515950
Total Pages : 265 pages
Book Rating : 4.3/5 (195 download)
Download or read book Glowworm Swarm Optimization written by Krishnanand N. Kaipa and published by Springer. This book was released on 2017-01-10 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive account of the glowworm swarm optimization (GSO) algorithm, including details of the underlying ideas, theoretical foundations, algorithm development, various applications, and MATLAB programs for the basic GSO algorithm. It also discusses several research problems at different levels of sophistication that can be attempted by interested researchers. The generality of the GSO algorithm is evident in its application to diverse problems ranging from optimization to robotics. Examples include computation of multiple optima, annual crop planning, cooperative exploration, distributed search, multiple source localization, contaminant boundary mapping, wireless sensor networks, clustering, knapsack, numerical integration, solving fixed point equations, solving systems of nonlinear equations, and engineering design optimization. The book is a valuable resource for researchers as well as graduate and undergraduate students in the area of swarm intelligence and computational intelligence and working on these topics.
Author : Asif Ladiwala
Publisher :
ISBN 13 : 9780542106781
Total Pages : 380 pages
Book Rating : 4.1/5 (67 download)
Download or read book A Multiscale Investigation of Protein Affinity and Displacer Efficacy in Chromatographic Systems Using Quantitative Structure-property Relationship Modeling written by Asif Ladiwala and published by . This book was released on 2005 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Thomas S. Deisboeck
Publisher : CRC Press
ISBN 13 : 1439814422
Total Pages : 492 pages
Book Rating : 4.4/5 (398 download)
Download or read book Multiscale Cancer Modeling written by Thomas S. Deisboeck and published by CRC Press. This book was released on 2010-12-08 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is a complex disease process that spans multiple scales in space and time. Driven by cutting-edge mathematical and computational techniques, in silico biology provides powerful tools to investigate the mechanistic relationships of genes, cells, and tissues. It enables the creation of experimentally testable hypotheses, the integration of dat
Author : Pandjassarame Kangueane
Publisher : Springer
ISBN 13 : 9811073473
Total Pages : 216 pages
Book Rating : 4.8/5 (11 download)
Download or read book Protein-Protein and Domain-Domain Interactions written by Pandjassarame Kangueane and published by Springer. This book was released on 2018-02-16 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the importance and significance of the molecular (physical and chemical) and evolutionary (gene fusion) principles of protein-protein and domain-domain interactions towards the understanding of cell division, disease mechanism and target definition in drug discovery. It describes the complex issues associated with this phenomenon using cutting edge advancement in Bioinformatics and Bioinformation Discovery. The chapters provide current information pertaining to the types of protein-protein complexes (homodimers, heterodimers, multimer complexes) in context with various specific and sensitive biological functions. The significance of such complex formation in human biology in the light of molecular evolution is also highlighted using several examples. The chapters also describe recent advancements on the molecular principles of protein-protein interaction with reference to evolution towards target identification in drug discovery. Finally, the book also elucidates a comprehensive yet a representative description of a large number of challenges associated with the molecular interaction of proteins.
Author : Peter Schuck
Publisher : Springer Science & Business Media
ISBN 13 : 0387359664
Total Pages : 537 pages
Book Rating : 4.3/5 (873 download)
Download or read book Protein Interactions written by Peter Schuck and published by Springer Science & Business Media. This book was released on 2007-03-20 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume successfully and clearly examines how biophysical approaches can be used to study complex systems of reversibly interacting proteins. It deals with the methodology behind the research and shows how to synergistically incorporate several methodologies for use. Each chapter treats and introduces the reader to different biological systems, includes a brief summary of the physical principles, and mentions practical requirements.
