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Multi Analyte Biosensing
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Book Synopsis Biosensors – Recent Advances and Future Challenges by : Paolo Bollella
Download or read book Biosensors – Recent Advances and Future Challenges written by Paolo Bollella and published by MDPI. This book was released on 2021-01-27 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present book is devoted to all aspects of biosensing in a very broad definition, including, but not limited to, biomolecular composition used in biosensors (e.g., biocatalytic enzymes, DNAzymes, abiotic nanospecies with biocatalytic features, bioreceptors, DNA/RNA, aptasensors, etc.), physical signal transduction mechanisms (e.g., electrochemical, optical, magnetic, etc.), engineering of different biosensing platforms, operation of biosensors in vitro and in vivo (implantable or wearable devices), self-powered biosensors, etc. The biosensors can be represented with analogue devices measuring concentrations of analytes and binary devices operating in the YES/NO format, possibly with logical processing of input signals. Furthermore, the book is aimed at attracting young scientists and introducing them to the field, while providing newcomers with an enormous collection of literature references.
Book Synopsis Electrochemical, Multi-analyte Biosensor Array for Neurotransmitter Detection by : Anita Karegar
Download or read book Electrochemical, Multi-analyte Biosensor Array for Neurotransmitter Detection written by Anita Karegar and published by . This book was released on 2007 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Multi-analyte Biosensing by : Matthew John Schmid
Download or read book Multi-analyte Biosensing written by Matthew John Schmid and published by . This book was released on 2005 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genome sequencing programs have identified hundreds of thousands of genetic and proteomic targets for which there are presently no ascribed functions. The challenge for researchers now is to characterize them, as well as identify and characterize their natural variants. Historically, this has meant studying each individual target separately. However, due to the recent development of multi-analyte microarray devices, these characterizations can be performed in a combinatorial manner in which a single experiment provides information on thousands of targets at a time. In the past decade, microarray technology has settled in on two major designs. The first entails spotting individual receptor types onto a functionalized glass substrate. This is a simple and inexpensive process; however, due to the limited resolution of the mechanical devices used to do the spotting, the densities of these arrays are relatively low. Moreover, receptor preparation requires substantial time and effort. The second variety of microarray uses photolithographic techniques adapted from the semi-conductor industry to chemically synthesize the receptor elements in situ on the sensing surface. Because lithographic patterning is spatially very precise, these arrays achieve very high densities, with as many as one million features per square centimeter. Although these arrays obviate the necessity for laborious "off chip" probe preparation, they are expensive to produce and are limited to two types of receptors (oligonucleotides and peptides). This dissertation presents the development work performed on a hydrogel-based biosensor platform which provides a high density and low cost alternative to the two aforementioned designs. The array features are fabricated lithographically from a liquid pre-polymer doped with biologically active sensing elements at sizes as small as 50[micrometer]. Each of the feature types is uniquely shaped, which enables the features to be mass-produced in batches, pooled together and then assembled into randomly ordered arrays using highly-parallelized self-assembly techniques. The three-dimensional hydrogel features accommodate a wide variety of sensing elements, such as enzymes, antibodies and cells, which cannot be deployed using the traditional designs. This dissertation presents methods developed to integrate cellular and oligonucleotide sensing elements into the hydrogel features which preserve their biological activity and optimize the sensor's performance.
Book Synopsis Electrochemical Biosensors by : Ali A. Ensafi
Download or read book Electrochemical Biosensors written by Ali A. Ensafi and published by Elsevier. This book was released on 2019-07-25 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electrochemical Biosensors summarizes fundamentals and trends in electrochemical biosensing. It introduces readers to the principles of transducing biological information to measurable electrical signals to identify and quantify organic and inorganic substances in samples. The complexity of devices related to biological matrices makes this challenging, but this measurement and analysis are critically valuable in biotechnology and medicine. Electrochemical biosensors combine the sensitivity of electroanalytical methods with the inherent bioselectivity of the biological component. Some of these sensor devices have reached the commercial stage and are routinely used in clinical, environmental, industrial and agricultural applications. Describes several electrochemical methods used as detection techniques with biosensors Discusses different modifiers, including nanomaterials, for preparing suitable pathways for immobilizing biomaterials at the sensor Explains various types of signal monitoring, along with several recognition systems, including antibodies/antigens, DNA-based biosensors, aptamers (protein-based), and more
Book Synopsis Electrochemical Biosensors by : Serge Cosnier
Download or read book Electrochemical Biosensors written by Serge Cosnier and published by CRC Press. This book was released on 2015-01-26 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since four decades, rapid detection and monitoring in clinical and food diagnostics and in environmental and biodefense have paved the way for the elaboration of electrochemical biosensors. Thanks to their adaptability, ease of use in relatively complex samples, and their portability, electrochemical biosensors now are one of the mainstays of analy
Book Synopsis Multi-Analyte Acoustic Biosensing Platform by : Konstantinos Mitsakakis
Download or read book Multi-Analyte Acoustic Biosensing Platform written by Konstantinos Mitsakakis and published by LAP Lambert Academic Publishing. This book was released on 2012-03 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: The early, rapid, and reliable diagnosis of a pathological condition is of critical importance for the subsequent treatment of a patient. Molecular diagnostic methods using biomarkers are increasingly advancing due to their non-invasive nature and are greatly benefited by the implementation of microsystems, as minute amounts of sample can be analyzed in a quick, cost-effective and highly sensitive way. Still a challenging feature is multiplexity in analysis: diseases like tumor, cardiovascular, Alzheimer s, are related to not only one but several biomarkers which should all be addressed in a test in order to assess reliably the patient s condition. This work describes an acoustic wave microsystem integrating microfluidics to compartmentalize its surface into discrete domains and achieve multiplicity. The development steps are described from concept to design, fabrication, evaluation, and proof-of-principle through detection of four protein cardiac markers. The sensitivity and reproducibility of the sensing domains, as well as the highly selective capture of the desired biomarkers are very promising for the development of the system into an integrated lab-on-chip diagnostic platform.
Book Synopsis A Hand-Held Evanescent Wave Multianalyte Biosensor with Fully Disposable Components by :
Download or read book A Hand-Held Evanescent Wave Multianalyte Biosensor with Fully Disposable Components written by and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phase 1's primary objective was a handheld, multi-analyte, wet-chemistry instrument design that could measure a wide range of chemicals, proteins, viruses, bacteria and biological fragments at concentrations ranging to below one part per billion. This was to be accomplished through an integration of state-of-the-art digital and analog circuitry with novel miniaturized fluid handling technologies, optics, and highly specific antibody-based assay techniques. Successful implementation of a dot-style immunoassay strategy was demonstrated on a prototype molded polystyrene optical element. Experimental tests strongly substantiated the design strategy. A 5-channel electro-optic module was constructed that produced signal levels well within the measurement ability of state-of-the-art PIN photodiode technology, and experimental binding curves for model assays were remarkably smooth, lacking in noise, and exhibited no optical cross-talk between channels.
Book Synopsis Handbook of Biosensors and Biosensor Kinetics by : Ajit Sadana
Download or read book Handbook of Biosensors and Biosensor Kinetics written by Ajit Sadana and published by Elsevier. This book was released on 2010-08-26 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biosensors are essential to an ever-expanding range of applications, including healthcare; drug design; detection of biological, chemical, and toxic agents; environmental monitoring; biotechnology; aviation; physics; oceanography; and the protection of civilian and engineering infrastructures. This book, like the previous five books on biosensors by this author (and one by the co-author), addresses the neglected areas of analyte-receptor binding and dissociation kinetics occurring on biosensor surfaces. Topics are covered in a comprehensive fashion, with homogeneous presentation for the benefit of the reader. The contributors address the economic aspects of biosensors and incorporate coverage of biosensor fabrication and nanobiosensors, among other topics. The comments, comparison, and discussion presented provides a better perspective of where the field of biosensors is heading. Serves as a comprehensive resource on biosensor analysis Examines timely topics such as biosensor fabrication and nanobiosensors Covers economic aspects and medical applications (e.g., the role of analytes in controlling diabetes)
Book Synopsis Biomedical Applications of Graphene and 2D Nanomaterials by : Md Nurunnabi
Download or read book Biomedical Applications of Graphene and 2D Nanomaterials written by Md Nurunnabi and published by Elsevier. This book was released on 2019-03-31 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical Applications of Graphene and 2D Nanomaterials provides a much-needed reference on the biomedical applications of 2D nanomaterials, as well as theoretical knowledge on their structure, physicochemical properties and biomedical applications. Chapters are dedicated to growth areas, such as size and shape-dependent chemical and physical properties and applications, such as in diagnostic and therapeutic products. The book also discusses the concept, development and preclinical studies of 2D nanomaterials-based biomedical tools, such as biosensors, artificial organs and photomedicine. Case studies and reports form the core of the book, making it an ideal resource on potential applications in biomedical science and engineering. This timely resource for scientists and engineers in this rapidly advancing field features contributions from over 30 leaders who address advanced methods and strategies for controlling the physical-chemical properties of 2D nanomaterials, along with expert opinions on a range of 2D nanomaterials that have therapeutic and diagnostic applications. Presents advanced methods and strategies for controlling the physical-chemical properties of 2D nanomaterials Provides state-of-the-art biomedical applications for 2D nanomaterials, including graphene and boron nitride Includes key information from a broad selection of subject areas for researchers in both materials, engineering and medicine
Book Synopsis Aggregation-Induced Emission (AIE) by : Jianwei Xu
Download or read book Aggregation-Induced Emission (AIE) written by Jianwei Xu and published by Elsevier. This book was released on 2022-04-17 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aggregation-Induced Emission (AIE): A Practical Guide introduces readers to the topic, guiding them through fundamental concepts and the latest advances in applications. The book covers concepts, principles and working mechanisms of AIE in AIE-active luminogens, with different classes of AIE luminogens reviewed, including polymers, three-dimensional frameworks (MOFs and COFs) and supramolecular gels. Special focus is given to the structure-property relationship, structural design strategies, targeted properties and application performance. The book provides readers with a deep understanding, not only on the fundamental principles of AIE, but more importantly, on how AIE luminogens and AIE properties can be incorporated in material development. Provides the fundamental principles, design and synthesis strategies of aggregation induced emission materials Reviews the most relevant applications in materials design for stimuli-responsive materials, biomedical applications, chemo-sensing and optoelectronics Emphasizes structural design and its connection to aggregation induced emission properties, also exploring the structure-property relationship
Book Synopsis Engineering the Bioelectronic Interface by : Jason J. Davis
Download or read book Engineering the Bioelectronic Interface written by Jason J. Davis and published by Royal Society of Chemistry. This book was released on 2009 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interfacing of man-made electronics with redox proteins and enzymes not only tells us a great deal about the levels of sophistication active in biology, but also paves the way to using it in derived sensory devices. Some of these have already had a profound impact on both clinical diagnostics and the quality of life enjoyed by those unfortunate enough to live with disease. Though much remains to be learnt about controlling and optimising these interfacial interactions, their potential uses are, if anything, growing. Written by leaders in the field, this is the only book to focus on the generation of biosensing interfaces with analyses and control at the molecular level. Some of these are enzyme based, others associated with the generation of surfaces for protein-protein recognition. Summaries of state-of-the-art investigations into the interfacing of structurally complex molecular species with electrode surfaces are included along with their design, analysis and potential application. Studies into the "wiring" of biomolecules to man-made surfaces through the use of delocalised "molecular wires" or carbon nanotubes are detailed as are the application of surface chemical and genetic engineering methods to the construction of robust, orientated biomolecular monolayers.
Book Synopsis Nanobiosensors by : Alexandru Grumezescu
Download or read book Nanobiosensors written by Alexandru Grumezescu and published by Academic Press. This book was released on 2016-09-28 with total page 928 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanobiosensors: Nanotechnology in the Agri-Food Industry, Volume 8, provides the latest information on the increasing demand for robust, rapid, inexpensive, and safe alternative technologies that monitor, test, and detect harmful or potentially dangerous foods. Due to their high sensitivity and selectivity, nanobiosensors have attracted attention for their use in monitoring not only biological contaminants in food, but also potential chemical and physical hazards. This book offers a broad overview regarding the current progress made in the field of nanosensors, including cutting-edge technological progress and the impact of these devices on the food industry. Special attention is given to the detection of microbial contaminants and harmful metabolotes, such as toxins and hormones, which have a great impact on both humans and animal health and feed. Includes the most up-to-date information on nanoparticles based biosensors and quantum dots for biological detection Provides application methods and techniques for research analysis for bacteriological detection and food testing Presents studies using analytical tools to improve food safety and quality analysis
Book Synopsis Biosensing for the 21st Century by : Fred Lisdat
Download or read book Biosensing for the 21st Century written by Fred Lisdat and published by Springer. This book was released on 2007-11-20 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts
Book Synopsis Novel Approaches in Biosensors and Rapid Diagnostic Assays by : Zvi Liron
Download or read book Novel Approaches in Biosensors and Rapid Diagnostic Assays written by Zvi Liron and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the medical, food, and environmental fields there is a continuous demand for inexpensive and sensitive analytical devices that are reliable, rapid, capable of high-throughput screening, and have low cost per test unit. Small and portable biosensor devices are designed to fulfill most of these requirements, and can be used in laboratory and on-site field testing. This volume discusses major issues in optical, acoustic and electrochemical-based biosensors, biochips, sensing recognition elements, and biosensors for medical and environmental applications. The papers presented at the conference represent basic and applied research studies in the fields of diagnostic assays and biosensor development. Novel technologies, such as arrays of sensors using high-density fiber optics to sense labeled or unlabeled oligonucleotides, and patterned arrays of recognition elements, demonstrated the capability of biosensors to analyze multiple analytes.
Book Synopsis Label-Free Biosensing by : Michael J. Schöning
Download or read book Label-Free Biosensing written by Michael J. Schöning and published by Springer. This book was released on 2018-07-20 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes the state-of-the-art technologies, key advances and future trends in the field of label-free biosensing. It provides detailed insights into the different types of solid-state, label-free biosensors, their underlying transducer principles, advanced materials utilized, device-fabrication techniques and various applications. The book offers graduate students, academic researchers, and industry professionals a comprehensive source of information on all facets of label-free biosensing and the future trends in this flourishing field. Highlights of the subjects covered include label-free biosensing with: · semiconductor field-effect devices such as nanomaterial-modified capacitive electrolyte-insulator-semiconductor structures, silicon nanowire transistors, III-nitride semiconductor devices and light-addressable potentiometric sensors · impedimetric biosensors using planar and 3D electrodes · nanocavity and solid-state nanopore devices · carbon nanotube and graphene/graphene oxide biosensors · electrochemical biosensors using molecularly imprinted polymers · biomimetic sensors based on acoustic signal transduction · enzyme logic systems and digital biosensors based on the biocomputing concept · heat-transfer as a novel transducer principle · ultrasensitive surface plasmon resonance biosensors · magnetic biosensors and magnetic imaging devices
Book Synopsis Development and Evaluation of a Multianalyte Optical Fiber Imaging Biosensor Platform Using Contact-based Microdispensing Technology by : Rosa Margarita Alvis
Download or read book Development and Evaluation of a Multianalyte Optical Fiber Imaging Biosensor Platform Using Contact-based Microdispensing Technology written by Rosa Margarita Alvis and published by . This book was released on 2006 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Adsorption Processes for Water Treatment by : Samuel D. Faust
Download or read book Adsorption Processes for Water Treatment written by Samuel D. Faust and published by Elsevier. This book was released on 2013-10-22 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adsorption Processes for Water Treatment discusses the application of adsorption in water purification. The book is comprised of 10 chapters that detail the carbon and resin adsorptive processes for potable water treatment. The text first covers the elements of surface chemistry and then proceeds to discussing adsorption models. Chapter 3 tackles the kinetics of adsorption, while Chapter 4 deals with batch systems and fixed fluid beds. Next, the book talks about the physical and chemical properties of carbon. The next two chapters discuss the adsorption of organic compounds and the removal of inorganic compounds, respectively. The eighth chapter presents operational, pilot plant, and case studies. Chapter 9 discusses the biological activated carbon treatment of drinking water, and Chapter 10 covers the adsorption of macroreticular resins. The book will be of great use to both researchers and professionals involved in the research and development of water treatment process.
