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Mrna Metabolism Post Transcriptional Gene Regulation
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Book Synopsis mRNA Metabolism & Post-Transcriptional Gene Regulation by : Joe B. Harford
Download or read book mRNA Metabolism & Post-Transcriptional Gene Regulation written by Joe B. Harford and published by John Wiley & Sons. This book was released on 1997-03-28 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: mRNA METABOLISM & POST-TRANSCRIPTIONAL GENE REGULATION Edited by Joe B. Harford and David R. Morris Gene expression is a process that begins with the transcription ofDNA to an RNA messenger (mRNA), which is then translated into aprotein. Historically, attention has been focused on the regulationof RNA synthesis (transcription); however, there is a growingrecognition of and appreciation for the importance of the manyregulatory mechanisms that take place after RNA synthesis has beencompleted. mRNA Metabolism and Post-Transcriptional Gene Regulation is thefirst comprehensive overview of the various modes of generegulation that exist post-transcriptionally. Collecting studies bysome of the top researchers in the field, this volume provides bothan up-to-date review of the complex "life" of an mRNA molecule andan introduction to current work on the diversity of mechanisms ofpost-transcriptional reactions. Topics covered include: * RNA structure * Mammalian RNA editing * RNA export from the nucleus * The fundamentals of translation initiation * Control of mRNA decay in plants * mRNA metabolism and cancer * Control of mRNA stability during herpes simplex virus infection * Regulation of mRNA expression in HIV-1 and other complexretroviruses * Nucleases * RNA localization A timely contribution to the understanding of genetic regulatorymechanisms, mRNA Metabolism and Post-Transcriptional GeneRegulation provides a basis from which potential therapeuticstrategies may be developed. This book will be of vital interest tocell and molecular biologists at all levels, from graduate studentsto senior investigators, clinical researchers, and professionals inthe pharmaceutical and biotechnology industries.
Book Synopsis Post-Transcriptional Gene Regulation by : Jeffrey Wilusz
Download or read book Post-Transcriptional Gene Regulation written by Jeffrey Wilusz and published by Springer Science & Business Media. This book was released on 2008 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Step-by-step instructions that ensure successful results.
Book Synopsis The mRNA Metabolism in Human Disease by : Luísa Romão
Download or read book The mRNA Metabolism in Human Disease written by Luísa Romão and published by Springer. This book was released on 2019-07-24 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: The eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate. The precursor mRNA is transcribed from DNA, processed by removal of introns and addition of the cap structure and the poly(A) tail. The mature mRNA is then exported to the cytoplasm where it is translated into protein and finally degraded. In this process, mRNA is associated with RNA-binding proteins forming ribonucleoprotein complexes, whose protein content evolves throughout the lifetime of the mRNA. While the complexity of eukaryotic gene expression allows the production of proteins to be controlled at many levels, it also makes the process vulnerable to errors. Although eukaryotic cells have evolved elaborate mRNA quality control mechanisms that ensure the fidelity of gene expression, some defects are not detected, thus affecting mRNA metabolism. This condition plays a fundamental role in the pathogenesis of several disease processes, such as neurodegeneration and oncogenesis. Besides, exciting recent data have shown that cellular RNAs can be modified post-transcriptionally via dynamic and reversible chemical modifications, the so-called epitranscriptome. These modifications can alter mRNA structure, being able to modulate different steps of the mRNA metabolism that can be associated with various human diseases, such as systemic lupus erythematosus and cancer. This book provides a collection of novel studies and hypotheses aimed to define the pathophysiological consequences of altered mRNA metabolism events in human cells, and is written for a wide spectrum of readers in the field of gene expression regulation. The last chapter highlights how the discovery of disease-causing defects (or modifications) in mRNA can provide a variety of therapeutic targets that can be used for the development of new RNA-based therapeutics. Hopefully, it may also contribute to inspire the drug-developing scientific community.
Book Synopsis A Time for Metabolism and Hormones by : Paolo Sassone-Corsi
Download or read book A Time for Metabolism and Hormones written by Paolo Sassone-Corsi and published by Springer. This book was released on 2016-04-04 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.
Book Synopsis Post-transcriptional Gene Regulation in Human Disease by : Buddhi Prakash Jain
Download or read book Post-transcriptional Gene Regulation in Human Disease written by Buddhi Prakash Jain and published by Academic Press. This book was released on 2022-08-12 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Post-transcriptional Gene Regulation in Human Disease, a new volume in the Translational Epigenetics book series, offers a thorough overview and discussion of post-transcriptional genetic control mechanisms and their roles across various pathologies and human developmental outcomes, along with regulatory mechanisms targeted for therapeutic approaches. The book is broadly divided in two parts: early chapters describe the basics of post-transcriptional gene regulation, associated epigenetic mechanisms, the role of RNA binding proteins, the evolution of post-transcriptional gene regulation, and methods to study these mechanisms. The second half of the book includes deeper discussion of post-transcriptional gene regulation across specific diseases and therapeutics targets. Various post-transcriptional events, including alternative splicing and polyadenylation, mRNA stability, and miRNAs and their involvement in the disease progression, are examined in detail. Includes full-color imagery illustrating key concepts and post-transcriptional disease processes, as well as descriptions of methods for studying post-transcriptional gene regulation Presents fundamental knowledge, molecular and biochemical mechanisms, and recent findings in concise and easily understandable formats Features a summary and conclusion at the end of each chapter
Book Synopsis Post‐Transcriptional Regulation by STAR Proteins by : Talila Volk
Download or read book Post‐Transcriptional Regulation by STAR Proteins written by Talila Volk and published by Springer Science & Business Media. This book was released on 2011-01-11 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the available information on the structure of the RNA binding STAR domain and provides insights into how these proteins discriminate between different RNA targets. It reviews what is known about STAR proteins and human disease.
Book Synopsis RNA Binding Proteins by : Kathryn Sandberg
Download or read book RNA Binding Proteins written by Kathryn Sandberg and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA binding proteins are an exciting area of research in gene regulation. A multitude of RNA-protein interactions are used to regulate gene expression including pre-mRNA splicing, polyadenylation, editing, transport, cytoplasmic targeting, translation and mRNA turnover. In addition to these post-transcriptional processes, RNA-protein interactions play a key role in transcription as illustrated by the life cycle of retroviruses. Unlike DNA, the structure of RNA is highly variable and conformationally flexible, thus creating a number of unique binding sites and the potential for complex regulation by RNA binding proteins. Although there is a wide range of topics included in this volume, general themes have been repeated, highlighting the overall integrative nature of RNA binding proteins. The chapters have been separated into three different sections: Translational Control; mRNA Metabolism; and Hormonal and Homeostatic Regulation. The chapters of this volume were written with the seasoned investigator and student in mind. Summaries of key concepts are reviewed within each chapter as well as guiding questions that can be used to stimulate class discussions. The Editors of this volume hope that this compendium educates, enthralls, and stimulates the readers to look to the future possibilities in this rapidly evolving field.
Book Synopsis Post-transcriptional Control of Gene Expression by : Orna Resnekov
Download or read book Post-transcriptional Control of Gene Expression written by Orna Resnekov and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many important cellular processes rely on posttranscriptional control of gene expression. This book describes the mechanisms of gene expression at this level that occur in the cytoplasm of prokaryotes and eukaryotes. Several introductory chapters discuss the general principles of translation and mRNA stability. The interactions of mature mRNA with the translational machinery, the components of mRNA degradation and antisense RNA are surveyed. Subsequent chapters discuss protein folding, transport, modification and degradation. The book is an invaluable source of information for both newcomers and those wishing an overview of the field.
Book Synopsis Post-Transcriptional Gene Regulation by N6-Methyladenosine and Selective RNA Binding Proteins by : Ian A. Roundtree
Download or read book Post-Transcriptional Gene Regulation by N6-Methyladenosine and Selective RNA Binding Proteins written by Ian A. Roundtree and published by . This book was released on 2017 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulation of genetic output is a complex biological phenomenon that allows cells with identical genetic material to enable diverse phenotypic outcomes. Epigenetics is the study of factors that change gene expression without perturbing the underlying genetic sequence. Mechanisms of epigenetics feature a multitude of chemical modifications to DNA as well as accompanying histone proteins, which tune the transcriptional output in a reversible manner. Recently, the concept of reversible RNA epigenetics has emerged as a mechanism to regulate gene expression post-transcriptionally. N6-methylasdenosein (m6A) is the most common internal modification in eukaryotic messenger RNA (mRNA). This RNA modification is recognized by m6A-selective RNA binding protein of the YTH family, which incorporate modified RNAs into canonical pathways for mRNA metabolism. In this work, we describe the function of the only nuclear YTH protein YTHDC1 in promoting the nuclear export of methylated mRNAs by interaction with the splicing and export adaptor protein SRSF3. We then turn to a biological example of rapid mRNA processing during progression through the cell cycle. We propose that m6A modifications serve roles in the dynamic regulation of the cellular transcriptome.
Book Synopsis Transcriptional and Post-transcriptional Regulation by : Ghedira Kais
Download or read book Transcriptional and Post-transcriptional Regulation written by Ghedira Kais and published by BoD – Books on Demand. This book was released on 2018-10-10 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the transcriptional and post-transcriptional gene regulations and presents a detailed portrait of many novel aspects related to highlighting the importance of key TFs in some vital biological processes, the role of certain TFs to control some infectious diseases, the role of non-coding RNAs in controlling mRNA expression, the involvement of these non-coding RNAs in diseases, and the interplay between TFs and microRNAs as key players for gene expression regulation giving a complete picture of how genes are regulated at the cellular level. The editor embarked upon this writing project entitled "Transcriptional and Post-transcriptional Regulation" to make pertinent contributions accessible to the scientific community. Hopefully, a large audience will enjoy reading and benefit from the chapters of this book.
Book Synopsis mRNA 3’ End Processing and Metabolism by :
Download or read book mRNA 3’ End Processing and Metabolism written by and published by Academic Press. This book was released on 2021-06-26 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: mRNA 3’ End Processing and Stability, Volume 655 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Updated release includes the latest information on mRNA 3' End Processing and Stability
Book Synopsis mRNA Translational Control as a Mechanism of Post-transcriptional Gene Regulation by : Daniel L. Kiss
Download or read book mRNA Translational Control as a Mechanism of Post-transcriptional Gene Regulation written by Daniel L. Kiss and published by Frontiers Media SA. This book was released on 2022-07-25 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Post-Transcriptional Gene Regulation by : Jane Wu
Download or read book Post-Transcriptional Gene Regulation written by Jane Wu and published by John Wiley & Sons. This book was released on 2013-04-24 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflecting the rapid progress in the field, the book presents the current understanding of molecular mechanisms of post-transcriptional gene regulation thereby focusing on RNA processing mechanisms in eucaryotic cells. With chapters on mechanisms as RNA splicing, RNA interference, MicroRNAs, RNA editing and others, the book also discusses the critical role of RNA processing for the pathogenesis of a wide range of human diseases. The interdisciplinary importance of the topic makes the title a useful resource for a wide reader group in science, clinics as well as pharmaceutical industry.
Book Synopsis Post-transcriptional Regulation of MRNA Metabolism During Differentiation of 3T3-L1 Cells by : Vesna Karschner
Download or read book Post-transcriptional Regulation of MRNA Metabolism During Differentiation of 3T3-L1 Cells written by Vesna Karschner and published by . This book was released on 2010 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our studies address early control points in the differentiation process that are necessary for expression as well as the maintenance of the adipocyte phenotype. We have focused on the post-transcriptional regulation of mRNA metabolism by the RNA binding protein HuR. Depending on the particular mRNA, HuR has been suggested to control polyadenylation, translocation to the cytosol, mRNA stability, and/or translational efficiency. Using the 3T3-L1 preadipocyte cell line, we have demonstrated a critical role for HuR in the differentiation process by use of siRNA mediated suppression which resulted in an inhibition of differentiation. We have identified several mRNAs that serve as HuR ligands early in the differentiation process, one of which is C/EBPβ, an important adipocyte transcription factor, whose expression is highly controlled and essential for proper acquisition of the adipocyte phenotype. Within minutes of induction of differentiation, HuR forms an mRNP complex with C/EBPβ mRNA in the nucleus followed by translocation to the cytoplasm. HuR remains associated with C/EBPβ mRNA suggesting a role in mRNA stability and translation efficiency. Our data suggest that formation of this complex in the nucleus serves as a regulator/attenuator of polyadenylation and that this interaction leads to a controlled metabolism of the C/EBPβ mRNA by determination of the quantity of message translocated to the cytosol and available for translation. Additionally, our data have directed us toward the Zfp206 mRNA as an important HuR ligand whose regulation is predicted to be responsible for maintenance of the differentiation potential of the cells and whose expression is terminated as the cells express PPARγ and establish the adipocyte phenotype. Our mechanistic analysis of these issues will identify novel control points in the initial stages of adipogenesis and thus fundamental to the pathological states of obesity and diabetes.
Book Synopsis mRNA Processing and Metabolism by : Daniel R. Schoenberg
Download or read book mRNA Processing and Metabolism written by Daniel R. Schoenberg and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells possess a wealth of posttranscriptional control mechanisms that impact on every conceivable aspect of the life of an mRNA. These processes are intimately intertwined in an almost baroque manner, where promoter context influences the recruitment of splicing factors, where the majority of pre-mRNAs undergo alternative splicing, and where proteins deposited during nuclear processing impact distal cytoplasmic processing, translation, and decay. If there is a unifying theme to mRNA Processing and Metabolism: Methods and Protocols, it is that mRNA processing and metabolism are integrated processes. Many of the techniques used to study mRNA have been described in a previous volume of this series (RNA–Protein Interaction Protocols, Susan Haynes, ed.) and specialized methods journals. In selecting topics for mRNA Processing and Metabolism: Methods and Protocols, I sought input on new and novel techniques and approaches that build on this foundation using technological advances in microscopy, whole genome sequencing, microarrays, mass spectrometry, fluorescent detection methodologies, and RNA interference. I have tried not to bias this book toward any single model organism, and approaches described in the various chapters use yeast, Drosophila, Xenopus, mice, plants, and cultured mammalian cells.
Book Synopsis Biology for AP ® Courses by : Julianne Zedalis
Download or read book Biology for AP ® Courses written by Julianne Zedalis and published by . This book was released on 2017-10-16 with total page 1923 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biology for AP® courses covers the scope and sequence requirements of a typical two-semester Advanced Placement® biology course. The text provides comprehensive coverage of foundational research and core biology concepts through an evolutionary lens. Biology for AP® Courses was designed to meet and exceed the requirements of the College Board’s AP® Biology framework while allowing significant flexibility for instructors. Each section of the book includes an introduction based on the AP® curriculum and includes rich features that engage students in scientific practice and AP® test preparation; it also highlights careers and research opportunities in biological sciences.
Book Synopsis Epitranscriptomics by : Stefan Jurga
Download or read book Epitranscriptomics written by Stefan Jurga and published by Springer Nature. This book was released on 2021-07-28 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews a novel and exciting field of cellular and molecular biology called epitranscriptomics, which focuses on changes in an organism’s cells resulting from the posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Exploring the mechanisms underlying RNA modifications and RBP function is an emerging area of biomedical research, taking the study of gene regulation a step beyond epigenetics. This book reveals that the RNA molecule is not just an information-carrying molecule with some secondary structures. Accordingly, how RNA is modified, regulated, packaged, and controlled is an important aspect. Leading experts address questions such as where the over 170 distinct posttranscriptional RNA modifications are located on the genome, what percentage of mRNAs and noncoding RNAs these modifications include, and how an RNA modification impacts a person’s biology. In closing, the book reviews the role of RNA modifications and RBPs in a variety of diseases and their pathogenesis. Addressing some of the most exciting challenges in epitranscriptomics, this book provides a valuable and engaging resource for researchers in academia and industry studying the phenomena of RNA modification.
