Gene Drives on the Horizon

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Author :
Publisher : National Academies Press
ISBN 13 : 0309437873
Total Pages : 231 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Gene Drives on the Horizon by : National Academies of Sciences, Engineering, and Medicine

Download or read book Gene Drives on the Horizon written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-08-28 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.

Genetic Control of Malaria and Dengue

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Publisher : Academic Press
ISBN 13 : 0128004053
Total Pages : 487 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Genetic Control of Malaria and Dengue by : Zach N. Adelman

Download or read book Genetic Control of Malaria and Dengue written by Zach N. Adelman and published by Academic Press. This book was released on 2015-10-15 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Control of Malaria and Dengue focuses on the knowledge, technology, regulation and ethics of using genetically modified mosquitoes to interrupt the transmission of important vector-borne diseases including Malaria. It contains coverage of the current state of knowledge of vector-borne diseases and how they are currently controlled; vaccine, drug and insecticide development; various strategies for altering the genome of mosquitoes in beneficial ways; and the regulatory, ethical and social environment concerning these strategies. For more than five decades, the prospect of using genetically-modified mosquitoes to control vector-borne disease transmission has been a purely hypothetical scenario. We simply did not have the technology or basic knowledge to be able to do it. With the explosion of field trials and potential interventions in development, Genetic Control of Malaria and Dengue provides a comprehensive overview of research in genetics, microbiology, virology, and ecology involved in the development and implementation of genetic modification programs for virus and disease control. This book is meant to provide a practical guide to researchers, regulators and the general public about how this technology actually works, how it can be improved, and what is still unknown. - Includes coverage of vectorial capacity, critical to understanding vector-borne disease transmission - Provides a summary of the concepts of both population suppression and population replacement - Contains pivotal coverage of ethical and ecological ramifications of genetics-based control strategies

Mosquito Gene Drives and the Malaria Eradication Agenda

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Author :
Publisher : CRC Press
ISBN 13 : 1000626008
Total Pages : 277 pages
Book Rating : 4.0/5 (6 download)

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Book Synopsis Mosquito Gene Drives and the Malaria Eradication Agenda by : Rebeca Carballar-Lejarazú

Download or read book Mosquito Gene Drives and the Malaria Eradication Agenda written by Rebeca Carballar-Lejarazú and published by CRC Press. This book was released on 2023-02-24 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is one of most serious infectious diseases today and has afflicted humankind for thousands of years. A significant number of people still die from this mosquito-borne disease, despite the use of various malaria prevention and control methods over hundreds of years and more than a century of coordinated global control efforts using modern tools, together with research into and development of new strategies for prevention, diagnosis, and disease treatment. Genetic approaches that focus on the vector mosquitoes to prevent malaria parasite transmission have been considered for many decades. Genetic control strategies received a significant boost with the successful development of gene drive systems, genetic methods for rapidly spreading beneficial genes and phenotypes through mosquito populations. This book reviews some concepts of gene drive systems and describes pioneering applications to control mosquito populations and prevent parasite transmission.

Disease Control Priorities, Third Edition (Volume 6)

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Publisher : World Bank Publications
ISBN 13 : 1464805253
Total Pages : 1027 pages
Book Rating : 4.4/5 (648 download)

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Book Synopsis Disease Control Priorities, Third Edition (Volume 6) by : King K. Holmes

Download or read book Disease Control Priorities, Third Edition (Volume 6) written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

Cancer Cell Lines Part 1

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Publisher : Springer Science & Business Media
ISBN 13 : 0306468727
Total Pages : 295 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis Cancer Cell Lines Part 1 by : John Masters

Download or read book Cancer Cell Lines Part 1 written by John Masters and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuous cell lines derived from human cancers are the most widely used resource in laboratory-based cancer research. The first 3 volumes of this series on Human Cell Culture are devoted to these cancer cell lines. The chapters in these first 3 volumes have a common aim. Their purpose is to address 3 questions of fundamental importance to the relevance of human cancer cell lines as model systems of each type of cancer: 1. Do the cell lines available accurately represent the clinical presentation? 2. Do the cell lines accurately represent the histopathology of the original tumors? 3. Do the cell lines accurately represent the molecular genetics of this type of cancer? The cancer cell lines available are derived, in most cases, from the more aggressive and advanced cancers. There are few cell lines derived from low grade organ-confined cancers. This gap can be filled with conditionally immortalized human cancer cell lines. We do not know why the success rate for establishing cell lines is so low for some types of cancer and so high for others. The histopathology of the tumor of origin and the extent to which the derived cell line retains the differentiated features of that tumor are critical. The concept that a single cell line derived from a tumor at a particular site is representative of tumors at that site is naïve and misleading.

Genetically Modified Mosquitoes for Malaria Control

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Publisher : CRC Press
ISBN 13 :
Total Pages : 198 pages
Book Rating : 4.0/5 (918 download)

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Book Synopsis Genetically Modified Mosquitoes for Malaria Control by : Christophe Boete

Download or read book Genetically Modified Mosquitoes for Malaria Control written by Christophe Boete and published by CRC Press. This book was released on 2006-07-15 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the epidemiological and evolutionary consequences of the use of genetically modified (GM) mosquitoes as well as research orientations and ethical issues concerning the use of GM mosquitoes. It also includes discussion on transgenic mosquitoes for malaria control.

Towards Malaria Elimination

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Publisher : BoD – Books on Demand
ISBN 13 : 1789235502
Total Pages : 454 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Towards Malaria Elimination by : Sylvie Manguin

Download or read book Towards Malaria Elimination written by Sylvie Manguin and published by BoD – Books on Demand. This book was released on 2018-07-18 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Towards Malaria Elimination - A Leap Forward was started to mark the occasion for renewed commitment to end malaria transmission for good (the WHO's call for "Malaria Free World" by 2030). This book is dedicated for the benefit of researchers, scientists, program and policy managers, students and anyone interested in malaria and other mosquito-borne diseases with the goal of sharing recent information on success stories, innovative control approaches and challenges in different regions of the world. Some main issues that emerged included multidrug-resistant malaria and pandemic risk, vaccines, cross-border malaria, asymptomatic parasite reservoir, the threat of Plasmodium vivax and Plasmodium knowlesi, insecticide resistance in Anopheles vectors and outdoor malaria transmission. This book is one little step forward to bring together in 17 chapters the experiences of malaria-expert researchers from five continents to present updated information on disease epidemiology and control at the national/regional level, highlighting the constraints, challenges, accomplishments and prospects of malaria elimination.

Malaria Control During Mass Population Movements and Natural Disasters

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Publisher : National Academies Press
ISBN 13 : 0309086159
Total Pages : 181 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Malaria Control During Mass Population Movements and Natural Disasters by : Program on Forced Migration and Health at the Mailman School of Public Health of Columbia University

Download or read book Malaria Control During Mass Population Movements and Natural Disasters written by Program on Forced Migration and Health at the Mailman School of Public Health of Columbia University and published by National Academies Press. This book was released on 2003-01-16 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: Admittedly, the world and the nature of forced migration have changed a great deal over the last two decades. The relevance of data accumulated during that time period can now be called into question. The roundtable and the Program on Forced Migration at the Mailman School of Public Health of Columbia University have commissioned a series of epidemiological reviews on priority public health problems for forced migrants that will update the state of knowledge. Malaria Control During Mass Population Movements and Natural Disasters- the first in the series, provides a basic overview of the state of knowledge of epidemiology of malaria and public health interventions and practices for controlling the disease in situations involving forced migration and conflict.

Genes in Conflict

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Publisher : Harvard University Press
ISBN 13 : 9780674017139
Total Pages : 650 pages
Book Rating : 4.0/5 (171 download)

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Book Synopsis Genes in Conflict by : Austin Burt

Download or read book Genes in Conflict written by Austin Burt and published by Harvard University Press. This book was released on 2006 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: In evolution, most genes survive and spread within populations because they increase the ability of their hosts (or their close relatives) to survive and reproduce. But some genes spread in spite of being harmful to the host organism—by distorting their own transmission to the next generation, or by changing how the host behaves toward relatives. As a consequence, different genes in a single organism can have diametrically opposed interests and adaptations.Covering all species from yeast to humans, Genes in Conflict is the first book to tell the story of selfish genetic elements, those continually appearing stretches of DNA that act narrowly to advance their own replication at the expense of the larger organism. As Austin Burt and Robert Trivers show, these selfish genes are a universal feature of life with pervasive effects, including numerous counter-adaptations. Their spread has created a whole world of socio-genetic interactions within individuals, usually completely hidden from sight.Genes in Conflict introduces the subject of selfish genetic elements in all its aspects, from molecular and genetic to behavioral and evolutionary. Burt and Trivers give us access for the first time to a crucial area of research—now developing at an explosive rate—that is cohering as a unitary whole, with its own logic and interconnected questions, a subject certain to be of enduring importance to our understanding of genetics and evolution.

The Handy Bug Answer Book

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Publisher :
ISBN 13 : 9781578590490
Total Pages : 308 pages
Book Rating : 4.5/5 (94 download)

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Book Synopsis The Handy Bug Answer Book by : Gilbert Waldbauer

Download or read book The Handy Bug Answer Book written by Gilbert Waldbauer and published by . This book was released on 1998 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Answers questions about bugs and insects, including insect anatomy, growth, reproduction, care of offspring, insect behavior, social insects, predators, beneficial insects, insect pests, and pest control

Pictorial Keys for the Identification of Mosquitoes (Diptera: Culicidae) Associated with Dengue Virus Transmission

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Publisher :
ISBN 13 : 9781877354465
Total Pages : 60 pages
Book Rating : 4.3/5 (544 download)

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Book Synopsis Pictorial Keys for the Identification of Mosquitoes (Diptera: Culicidae) Associated with Dengue Virus Transmission by : L. M. Rueda

Download or read book Pictorial Keys for the Identification of Mosquitoes (Diptera: Culicidae) Associated with Dengue Virus Transmission written by L. M. Rueda and published by . This book was released on 2004-01-01 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biodiversity and Health in the Face of Climate Change

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Publisher : Springer
ISBN 13 : 3030023184
Total Pages : 494 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Biodiversity and Health in the Face of Climate Change by : Melissa R. Marselle

Download or read book Biodiversity and Health in the Face of Climate Change written by Melissa R. Marselle and published by Springer. This book was released on 2019-06-11 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book identifies and discusses biodiversity’s contribution to physical, mental and spiritual health and wellbeing. Furthermore, the book identifies the implications of this relationship for nature conservation, public health, landscape architecture and urban planning – and considers the opportunities of nature-based solutions for climate change adaptation. This transdisciplinary book will attract a wide audience interested in biodiversity, ecology, resource management, public health, psychology, urban planning, and landscape architecture. The emphasis is on multiple human health benefits from biodiversity - in particular with respect to the increasing challenge of climate change. This makes the book unique to other books that focus either on biodiversity and physical health or natural environments and mental wellbeing. The book is written as a definitive ‘go-to’ book for those who are new to the field of biodiversity and health.

GMOs

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Publisher : Springer Nature
ISBN 13 : 303053183X
Total Pages : 667 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis GMOs by : Anurag Chaurasia

Download or read book GMOs written by Anurag Chaurasia and published by Springer Nature. This book was released on 2020-11-30 with total page 667 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers a broad spectrum of topics related to GMOs and allied new gene-based technologies, biodiversity, and ecosystem processes, bringing together the contributions of researchers and regulators from around the world. The aim is to offer a clear view of the benefits and effects of genetically modified crops, insects, and other animals on the soil microbiome and ecological processes. Contributors examine issues related to the development of risk assessment procedures and regulations designed to maximize benefits while minimizing risks. Beyond the scientific challenges of GMOs, the book explores the broad and contentious terrain of ethical considerations. The contributors discuss such questions as the unintended, possibly unforeseen, consequences of releasing GMOs into ecosystems, and the likelihood that the full effects of GMOs could take years, even decades, of close monitoring to become evident. The importance of developing a precautionary approach is stressed. The final chapter describes the critical issues of governance and regulation of new and emerging gene-based technologies, as nations grapple with the consequences of adopting the Cartagena Protocol on Biosafety (CPB). The volume includes an extensive Annex which outlines legal perspectives on the state of GMO governance around the world, with more than 20 examples from nations in Africa, South and Central America, Asia, Australasia, and Europe.

Under a White Sky

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Publisher : Crown
ISBN 13 : 0593136292
Total Pages : 273 pages
Book Rating : 4.5/5 (931 download)

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Book Synopsis Under a White Sky by : Elizabeth Kolbert

Download or read book Under a White Sky written by Elizabeth Kolbert and published by Crown. This book was released on 2021-02-09 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: NATIONAL BESTSELLER • The Pulitzer Prize–winning author of The Sixth Extinction returns to humanity’s transformative impact on the environment, now asking: After doing so much damage, can we change nature, this time to save it? RECOMMENDED BY PRESIDENT OBAMA AND BILL GATES • SHORTLISTED FOR THE WAINWRIGHT PRIZE FOR WRITING • ONE OF THE TEN BEST BOOKS OF THE YEAR: The Washington Post • ONE OF THE BEST BOOKS OF THE YEAR: Time, Esquire, Smithsonian Magazine, Vulture, Publishers Weekly, Kirkus Reviews, Library Journal • “Beautifully and insistently, Kolbert shows us that it is time to think radically about the ways we manage the environment.”—Helen Macdonald, The New York Times That man should have dominion “over all the earth, and over every creeping thing that creepeth upon the earth” is a prophecy that has hardened into fact. So pervasive are human impacts on the planet that it’s said we live in a new geological epoch: the Anthropocene. In Under a White Sky, Elizabeth Kolbert takes a hard look at the new world we are creating. Along the way, she meets biologists who are trying to preserve the world’s rarest fish, which lives in a single tiny pool in the middle of the Mojave; engineers who are turning carbon emissions to stone in Iceland; Australian researchers who are trying to develop a “super coral” that can survive on a hotter globe; and physicists who are contemplating shooting tiny diamonds into the stratosphere to cool the earth. One way to look at human civilization, says Kolbert, is as a ten-thousand-year exercise in defying nature. In The Sixth Extinction, she explored the ways in which our capacity for destruction has reshaped the natural world. Now she examines how the very sorts of interventions that have imperiled our planet are increasingly seen as the only hope for its salvation. By turns inspiring, terrifying, and darkly comic, Under a White Sky is an utterly original examination of the challenges we face.

Perspectives on Innovation

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Publisher : Cambridge University Press
ISBN 13 : 0521685613
Total Pages : 465 pages
Book Rating : 4.5/5 (216 download)

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Book Synopsis Perspectives on Innovation by : Franco Malerba

Download or read book Perspectives on Innovation written by Franco Malerba and published by Cambridge University Press. This book was released on 2007-03-29 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Case studies, empirical models, appreciative analyses and formal theories abound.

The Life You Can Save

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Publisher : Random House Trade Paperbacks
ISBN 13 : 0812981561
Total Pages : 242 pages
Book Rating : 4.8/5 (129 download)

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Book Synopsis The Life You Can Save by : Peter Singer

Download or read book The Life You Can Save written by Peter Singer and published by Random House Trade Paperbacks. This book was released on 2010 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Argues that for the first time in history we're in a position to end extreme poverty throughout the world, both because of our unprecedented wealth and advances in technology, therefore we can no longer consider ourselves good people unless we give more to the poor. Reprint.

Saving Lives, Buying Time

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Publisher : National Academies Press
ISBN 13 : 0309165938
Total Pages : 384 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Saving Lives, Buying Time by : Institute of Medicine

Download or read book Saving Lives, Buying Time written by Institute of Medicine and published by National Academies Press. This book was released on 2004-09-09 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.