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Molecular Tinkering
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Book Synopsis Molecular Tinkering by : Ben Martynoga
Download or read book Molecular Tinkering written by Ben Martynoga and published by Troubador Publishing Ltd. This book was released on 2018-09-11 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reveals some of the thrilling developments that have transformed biology since the 1960s. Highlights the challenges ahead for biologists but suggests what they can learn from the past. Energetic, jargon-free writing that will appeal to a broad audience. During the 1960s Edinburgh became a hotbed for a forward-thinking group of biologists. This is the story of these innovators who saw that life’s big mysteries were best tackled by studying its molecular foundations. It introduces the eccentric thinkers, ingenious tinkerers and tenacious experimenters who broke down the cultural barriers between traditional scientific disciplines. They produced a series of transformative ideas and tools that wholly reoriented biology. Edinburgh scientists invented genetic engineering. They laid the foundations for DNA fingerprinting and the human genome project. They also cloned Dolly the sheep, purified the first gene and kick-started the now-influential fields of epigenetics and systems biology. Yet Edinburgh’s leading role in most of these world-changing stories have not been told before. Ben Martynoga intertwines science, biography and anecdote to describe the roots and lasting significance of key biological concepts. He describes the crucial micro-details, the blind alleys, botched experiments, and chance encounters to give a rare insight into the way science really progresses. Now, in the 21st century, biology is increasingly a ‘big science’ endeavour. A deeper understanding of biology could deliver not only new drugs and diagnostics, but also improved ways to feed, clothe and fuel us. But the world still awaits the long-promised fruits of biology’s molecular revolution. The successes of Edinburgh’s unsung molecular pioneers remind us why it is crucial to carve out space for small-scale, curiosity-led research.
Book Synopsis Evolutionary Tinkering in Gene Expression by : M. Grunberg-Manago
Download or read book Evolutionary Tinkering in Gene Expression written by M. Grunberg-Manago and published by Springer. This book was released on 2012-12-27 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Workshop on "Evolutionary Tinkering in Gene Expression" which was held at the end of August 1988. was planned to celebrate 20 successful Advanced Study Institutes (A. S. I.) in Molecular and Cell Biology. The first Institute was held in 1966 on the Island of Spetsai. after a N. A. T. O. suggestion and was entirely financed by N. A. T. O. The success was immediately so great that the Institute grew very rapidly and in the following years. N. A. T. O .• E. M. B. O. (since 1972) and F. E. B. S. (since 1981) co-sponsored it. Since the start of the AS!. the U. S. National Science Foundation has granted travel money for a limited number of American participants each year. In addition. the course was supported by minor industrial subsidies of varying amounts which enabled the organizers to improve some of the local facilities particularly with respect to the lecture hall. In particular. Boehringer Mannheim has contributed since 1966. Furthermore. the Greek Ministry of Science and Culture has provided support at least for a social event during each ASI.
Book Synopsis Chemical and Synthetic Biology Approaches to Understand Cellular Functions - Part C by :
Download or read book Chemical and Synthetic Biology Approaches to Understand Cellular Functions - Part C written by and published by Academic Press. This book was released on 2020-02-10 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical and Synthetic Biology Approaches to Understand Cellular Functions - Part C, Volume 633, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial. This release includes sections on Next generation probes for molecular imaging in cells, Competitive binding assay for biotin and biotin derivatives, based on avidin and biotin-4-fluorescein, Converting avidin to bind ligands other than biotin, especially steroids, Chemoenzymatic Labeling Strategy, Engineered Siderophores, Small molecules to inhibit bacterial population behavior, NMR tube bioreactor, Small molecule controlled RAS activation system, Small molecule regulated Cas9, the Design and application of synthetic receptors, and much more. - Contains the authority of authors who are leaders in their field - Provides a comprehensive source on new methods and research in enzymology
Book Synopsis Travaux scientifiques de François Jacob by : François Jacob
Download or read book Travaux scientifiques de François Jacob written by François Jacob and published by Odile Jacob. This book was released on 2002 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biology and Computation by : H. Gutfreund
Download or read book Biology and Computation written by H. Gutfreund and published by World Scientific. This book was released on 1994 with total page 880 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive review of the works in the rapidly evolving field of neural networks and brain studies. Its purpose is two-fold: to help physicists entering this field to get a broader view of the context of the domain, and to help scientists of other disciplines to reach a better understanding of the physicists' contributions within a context of perspectives they can relate to.Included in the volume are 68 carefully selected, high quality reprints to provide the volume with both breadth and depth. It is organized into 5 sections and 22 chapters, both the sections and chapters being preceded by introductory comments by the editors.
Book Synopsis Evolution From Molecules to Men by : D. S. Bendall
Download or read book Evolution From Molecules to Men written by D. S. Bendall and published by CUP Archive. This book was released on 1983 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Giving a broad view of biological evolution the topics discussed here range from the history of the development of evolutionary thought, through current problems in molecular evolution and the evolution of whole organisms, to evolution of behaviour, sociobiology and man's place in evolution.
Download or read book Living Earth written by R.E. Nisbet and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Life has shaped the Earth, and the Earth has moulded the history of life. That history, the co-evolution of our ancestors and their horne, has much to teach us about our place on the planet today. We are part of the fabric of the biosphere. As we change that fabric we would be wise to understand how our horne was built. Our planet is neither a hotel nor a colony. It is not a place which life briefly inhabits during a transient occupation. Instead, it is our horne, designed by the deeds of our ancestors and suited to our own needs. The history of life on Earth is held in the geological record, which is composed of the rocks, water and air that are available for study on the planet's surface. These rocks, the oceans and the atmosphere are not simply stores of information for the excitement of fossil hunters and geochemists, or resources to exploit without thought. Their cre ation and continued existence form an integral part of the development and management of the Earth as the horne of life.
Download or read book The Pangenome written by Hervé Tettelin and published by Springer Nature. This book was released on 2020-04-30 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.
Book Synopsis Supramolecular Synthons in Crystal Engineering of Pharmaceutical Properties by : Ashwini K. Nangia
Download or read book Supramolecular Synthons in Crystal Engineering of Pharmaceutical Properties written by Ashwini K. Nangia and published by CRC Press. This book was released on 2024-10-14 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive resource skillfully consolidates crystal engineering, the design of organic solids, and supramolecular synthons (i.e., structural hydrogen bond units) to achieve desired pharmaceutical properties, including solubility, dissolution, bioavailability, permeability, particle size, tableting, hydration, and mechanical strength. Covering 30 years of crystal engineering developments and pharmaceutical applications, this book will be a single and complete resource for supramolecular and structural chemists, the crystal engineering community, pharmaceutical scientists, and industrial researchers. Key Features Covers the fundamentals of crystal engineering and supramolecular synthons. Details the challenges of low solubility and low permeability facing oral drug formulations. Explains how heterosynthons provide a rational approach to address and implement solutions. Provides case studies from academic and industrial labs to walk the reader through the actual steps. Explores developments in the scale up and manufacture of crystal forms in pharmaceutical industry.
Book Synopsis The Plasma Proteins V5 by : Frank Putnam
Download or read book The Plasma Proteins V5 written by Frank Putnam and published by Elsevier. This book was released on 2012-12-02 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Plasma Proteins: Structure, Function, and Genetic Control, Second Edition, Volume V explores the contribution of molecular biology and gene cloning approaches to the advancement of plasma protein structure, function, and genomic organization studies. This volume is composed of five chapters and begins with a discussion on the DNA sequences and chromosomal location of plasma protein genes, specifically the cloning and sequencing of immunoglobulin genes. These topics are followed by a discussion on the advances in relation to discovered genetic variants present either as normal phenotypes or in dyslipoproteinemic states associated with cardiovascular disease. A chapter highlights the application of molecular biology techniques to the study of gene structure and the translational and maturation steps of every major plasma apolipoprotein. Another chapter emphasizes the unique features of protein structure and the conformational changes that characterize the assembly of macromolecular complexes in plasma and on cell surfaces. The concluding chapter provides a comprehensive review of the integration of molecular biology, physiology, and pathology of plasma proteins and their response in inflammation. This book will be of great value to molecular biologists, physiologists, pathologists, and clinicians.
Book Synopsis The Hope, Hype, and Reality of Genetic Engineering by : John C. Avise
Download or read book The Hope, Hype, and Reality of Genetic Engineering written by John C. Avise and published by Oxford University Press. This book was released on 2004-02-19 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: An introductory tour into the stranger-than-fiction world of genetic engineering, a scientific realm inhabited by eager researchers intent upon fashioning a prodigious medley of genetically modified (GM) organisms to serve human needs.
Book Synopsis Advanced Technologies for Managing Insect Pests by : Isaac Ishaaya
Download or read book Advanced Technologies for Managing Insect Pests written by Isaac Ishaaya and published by Springer Science & Business Media. This book was released on 2012-07-20 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Among the highlights of this book is the use of novel insecticides acting on a specific site in an insect group and are compatible with natural enemies and the environment. One of such approaches is based on disrupting the activity of biochemical sites acting on transcription factors such as the Helix-Loop-Helix (bHLH) family, anti juvenile hormone (AJH) agents that target JH biosynthetic enzymes, G-protein coupled receptors (GPCR) and bursicon as a target for insect control. Another one is the biotechnology or the genetic approach such as gene silencing (RNA interference) and Bt-crops. Other sections of the book are devoted to the plant’s natural products, optical manipulation and the use of nanotechnology for improving insect control methods.
Book Synopsis Evolution of the Protein Synthesis Machinery and Its Regulation by : Greco Hernández
Download or read book Evolution of the Protein Synthesis Machinery and Its Regulation written by Greco Hernández and published by Springer. This book was released on 2016-08-10 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: The “omics” era has given a new perspective to the findings on the origin and evolution of the process of translation. This book provides insight into the evolution of the translation process and machinery from a modern perspective. Written by leading experts in molecular biology, this text looks into the origins and evolution of the protein synthetic machinery.
Download or read book Chemical Biology written by Deniz Ekinci and published by BoD – Books on Demand. This book was released on 2012-02-17 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical biology utilizes chemical principles to modulate systems to either investigate the underlying biology or create new function. Over recent years, chemical biology has received particular attention of many scientists in the life sciences from botany to medicine. This book contains an overview focusing on the research area of protein purification, enzymology, vitamins, antioxidants, biotransformation, gene delivery, signaling, regulation and organization. Particular emphasis is devoted to both theoretical and experimental aspects. The textbook is written by international scientists with expertise in synthetic chemistry, protein biochemistry, enzymology, molecular biology, drug discovery and genetics many of which are active chemical, biochemical and biomedical research. The textbook is expected to enhance the knowledge of scientists in the complexities of chemical and biological approaches and stimulate both professionals and students to dedicate part of their future research in understanding relevant mechanisms and applications of chemical biology.
Download or read book Rhodopsin written by Valentin Gordeliy and published by Springer Nature. This book was released on 2022-07-20 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides readers with the latest information on the advances made in the field of rhodopsins. The chapters in this book cover topics such as new discoveries and developments; new ways to search for rhodopsins; methods to characterize the function and structure of rhodopsins on a molecular level; nano volume high throughput in meso crystallization, and fourth generation x-ray synchrotron sources. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Rhodopsin: Methods and Protocols is a valuable resource for any scientist and researcher interested in learning more about this developing field.
Book Synopsis Subterranean Rodents by : Sabine Begall
Download or read book Subterranean Rodents written by Sabine Begall and published by Springer Science & Business Media. This book was released on 2007-06-12 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Subterranean Rodents presents achievements from recent years of research on these rodents, divided into five sections: ecophysiology; sensory ecology; life histories, behavioural ecology and demography; environmental and economical impact; molecular ecology and evolution. It is a must for all researchers working in this field and will be of interest to zoologists, physiologists, morphologists, ecologists, and evolutionary biologists.
Book Synopsis Essentials of Biophysics by : P. Narayanan
Download or read book Essentials of Biophysics written by P. Narayanan and published by New Age International. This book was released on 2007 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt:
