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Author : Liat Shimoni
Publisher :
ISBN 13 :
Total Pages : 123 pages
Book Rating : 4.:/5 (187 download)
Download or read book Molecular Recognition in Selected Biological Systems written by Liat Shimoni and published by . This book was released on 1998 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michel Delaage
Publisher : Wiley-VCH
ISBN 13 :
Total Pages : 304 pages
Book Rating : 4.3/5 (91 download)
Download or read book Molecular Recognition Mechanisms written by Michel Delaage and published by Wiley-VCH. This book was released on 1991 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Margaret Mary Harding
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (223 download)
Download or read book Molecular Recognition in Chemical and Biological Systems written by Margaret Mary Harding and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : F. S. Dukhovich
Publisher : Nova Publishers
ISBN 13 : 9781594546761
Total Pages : 230 pages
Book Rating : 4.5/5 (467 download)
Download or read book Pharmacological Aspects of Molecular Recognition written by F. S. Dukhovich and published by Nova Publishers. This book was released on 2005 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the monograph, recognition of the receptors by drugs is described as a complex phenomenon that has not been yet entirely understood. The description of molecular structure information necessary to achieve specific receptors without getting lost among huge amounts of non-specific acceptors is present. Various examples of receptor' binding features for narcotic analgetics, neuroleptics, tranquilisators, ligands of acetylcholine receptors are also included. The three stages of drug interaction with acceptors are considered, namely, distant stage, stage of orientation of the molecule on the acceptor, stage of molecule fixation. Kinetics and thermodynamics of these stages as well as factors preventing drug binding to non-specific acceptors are described. Some considerations concerning methods of changing activity and selectivity of drugs are given. Literature information needed for analysis of molecular mechanisms of interactions between drugs and receptors is present.
Author : Zeno Simon
Publisher : CRC Press
ISBN 13 : 9780849353987
Total Pages : 356 pages
Book Rating : 4.3/5 (539 download)
Download or read book Specific Interaction and Biological Recognition Processes written by Zeno Simon and published by CRC Press. This book was released on 1993-06-16 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Specific Interaction and Biological Recognition Processes is devoted to two major aspects of biological processes: specificity in biological recognition and the recognition processes themselves. Topics covered in specificity include the theoretical basis for specificity in biological recognition; the thermodynamic and chemical equilibrium background; and consideration of the relationship between size of combining sites and specificity. The use of semi-emperical potentials for calculating interaction energies and the potential of quantum chemistry methods for calculating receptor-effector affinities are also discussed. The various recognition processes described include DNA replication, transcription, translation, enzymatic reactions, transmembrane transport processes, mechanisms of action of hormones and other chemical messengers, and self-nonself recognition in immunology. Specific Interaction and Biological Recognition Processes will be a useful reference for molecular biologists, biochemists, enzymologists, immunologists oncologists, pharmaceutical researchers, and others interested in the topic.
Author : Derek J. Chadwick
Publisher : John Wiley & Sons
ISBN 13 : 0470514094
Total Pages : 288 pages
Book Rating : 4.4/5 (75 download)
Download or read book Host-Guest Molecular Interactions written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Composed of contributions from experts in the chemical and biological sciences, it explores host-guest molecular interactions leading to the formation of molecular assemblies containing two or more species. Exciting applications are emerging in this field and it is expected that improved understanding of the interactions in synthetic host molecule complexes will lead to a better understanding of the more complex biological systems. Topics include biomimetic chemistry, preorganization, self-assembly, template-directed synthesis, antibiotic binding to peptides and DNA, interactions between proteins and other molecules.
Author : Pedro Cintas
Publisher : Springer
ISBN 13 : 3642376266
Total Pages : 318 pages
Book Rating : 4.6/5 (423 download)
Download or read book Biochirality written by Pedro Cintas and published by Springer. This book was released on 2014-07-08 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early History of the Recognition of Molecular Biochirality, by Joseph Gal, Pedro Cintas Synthesis and Chirality of Amino Acids Under Interstellar Conditions, by Chaitanya Giri, Fred Goesmann, Cornelia Meinert, Amanda C. Evans, Uwe J. Meierhenrich Chemical and Physical Models for the Emergence of Biological Homochirality, by son E. Hein, Dragos Gherase, Donna G. Blackmond Biomolecules at Interfaces: Chiral, Naturally, by Arántzazu González-Campo and David B. Amabilino Stochastic Mirror Symmetry Breaking: Theoretical Models and Simulation of Experiments, by Celia Blanco, David Hochberg Self-Assembly of Dendritic Dipeptides as a Model of Chiral Selection in Primitive Biological Systems, by Brad M. Rosen, Cécile Roche, Virgil Percec Chirality and Protein Biosynthesis, by Sindrila Dutta Banik, Nilashis Nandi
Author : Ian S. Dunn
Publisher : John Wiley & Sons
ISBN 13 : 0470551445
Total Pages : 480 pages
Book Rating : 4.4/5 (75 download)
Download or read book Searching for Molecular Solutions written by Ian S. Dunn and published by John Wiley & Sons. This book was released on 2010-01-05 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive look at empirical approaches to molecular discovery, their relationships with rational design, and the future of both Empirical methods of discovery, along with serendipitous and rational design approaches, have played an important role in human history. Searching for Molecular Solutions compares empirical discovery strategies for biologically useful molecules with serendipitous discovery and rational design, while also considering the strengths and limitations of empirical pathways to molecular discovery. Logically arranged, this text examines the different modes of molecular discovery, empha-sizing the historical and ongoing importance of empirical strategies. Along with a broad overview of the subject matter, Searching for Molecular Solutions explores: The differing modes of molecular discovery Biological precedents for evolutionary approaches Directed evolutionary methods and related areas Enzyme evolution and design Functional nucleic acid discovery Antibodies and other recognition molecules General aspects of molecular recognition Small molecule discovery approaches Rational molecular design The interplay between empirical and rational strategies and their ongoing roles in the future of molecular discovery Searching for Molecular Solutions covers several major areas of modern research, development, and practical applications of molecular sciences. This text offers empirical-rational principles of broad relevance to scientists, professionals, and students interested in general aspects of molecular discovery, as well as the thought processes behind experimental approaches.
Author : Gandhi Radis-Baptista
Publisher : BoD – Books on Demand
ISBN 13 : 9535111515
Total Pages : 548 pages
Book Rating : 4.5/5 (351 download)
Download or read book An Integrated View of the Molecular Recognition and Toxinology written by Gandhi Radis-Baptista and published by BoD – Books on Demand. This book was released on 2013-07-01 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Toxinology has been consolidated as a scientific area focused on the intertwined description of several aspects of animal toxins. In an inquiring biotechnological world, animal toxins appear as an invaluable source for the discovery of therapeutic polypeptides. Animal toxins rely on specific chemical interactions with their partner molecule to exert their biological actions. The comprehension of how molecules interact and recognize their target is essential for the rational exploration of bioactive polypeptides as therapeutics. Investigation on the mechanism of molecular interaction and recognition offers a window of opportunity for the pharmaceutical industry and clinical medicine. Thus, this book brings examples of two interconnected themes - molecular recognition and toxinology concerning to the integration between analytical procedures and biomedical applications.
Author : Vincent Rotello
Publisher : John Wiley & Sons
ISBN 13 : 0470384042
Total Pages : 492 pages
Book Rating : 4.4/5 (73 download)
Download or read book Molecular Recognition and Polymers written by Vincent Rotello and published by John Wiley & Sons. This book was released on 2008-09-15 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: State-of-the-art techniques for tapping the vast potential of polymers The use of specific non-covalent interactions to control polymer structure and properties is a rapidly emerging field with applications in diverse disciplines. Molecular Recognition and Polymers covers the fundamental aspects and applications of molecular recognition—in the creation of novel polymeric materials for use in drug delivery, sensors, tissue engineering, molecular imprinting, and other areas. This reference begins by explaining the fundamentals of supramolecular polymers; it progresses to cover polymer formation and self-assembly with a wide variety of examples, and then includes discussions of biomolecular recognition using polymers. With chapters contributed by the foremost experts in their fields, this resource: Provides an integrated resource for supramolecular chemistry, polymer science, and interfacial science Covers advanced, state-of-the-art techniques used in the design and characterization of non-covalent interactions in polymers Illustrates how to tailor the properties of polymeric materials for various applications Stand-alone chapters address specific applications independently for easy reference. This is a premier resource for graduate students and researchers in polymer chemistry, supramolecular chemistry, materials science, and physical organic chemistry.
Author : CIBA Foundation Symposium
Publisher : Wiley
ISBN 13 : 9780471929581
Total Pages : 296 pages
Book Rating : 4.9/5 (295 download)
Download or read book Host-Guest Molecular Interactions written by CIBA Foundation Symposium and published by Wiley. This book was released on 1991-05-30 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Composed of contributions from experts in the chemical and biological sciences, it explores host-guest molecular interactions leading to the formation of molecular assemblies containing two or more species. Exciting applications are emerging in this field and it is expected that improved understanding of the interactions in synthetic host molecule complexes will lead to a better understanding of the more complex biological systems. Topics include biomimetic chemistry, preorganization, self-assembly, template-directed synthesis, antibiotic binding to peptides and DNA, interactions between proteins and other molecules.
Author : Dr. A.Abdul Jameel
Publisher : Vandana Publications
ISBN 13 : 819328433X
Total Pages : 208 pages
Book Rating : 4.1/5 (932 download)
Download or read book Selected Topics in Chemistry written by Dr. A.Abdul Jameel and published by Vandana Publications. This book was released on with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: While searching the syllabi for the spectral aspects of Inorganic compounds and metal complexes, we come across some important chapters in chemistry in almost all Universities in India and abroad. Laser Raman spectroscopy, Supramolecular chemistry, Nanochemistry and Sonochemistry are found either as separate papers or as chapters in a paper in B.Sc., M.Sc. and M.Phil. syllabi. So we thought of including these chapters along with the inorganic aspects of spectroscopy like Nuclear Quadrupole spectroscopy, ORD and CD of Inorganic compounds, Mass spectra of inorganic compounds and Photoelectron spectroscopy. The limited knowledge of Laser chemistry and Raman spectroscopy leads to the less understanding of Laser Raman spectroscopy. Hence chapters on Laser chemistry and Fundamentals of Raman spectroscopy are included in this book. These chapters were once considered as specialization in chemistry but due to advancement in chemistry, they find place in the regular curriculum. The book is written in a simple language with more advanced and latest informations. Diagrams and tables are given for the better understanding of the subject matter. The book provides a comprehensive and indepth coverage of the subject. There is a shortage of suitable text books for these chapters and this book may fill the gap and will mostly be useful to all the B.Sc. and M.Sc. students and M.Phil. Scholars globally. This book is an outcome of very long teaching and research experience of the authors in the field of Inorganic chemistry. Apart from the subject study, this book may also be used for writing the competitive examinations like UGC–NET, Civil Services Examination and so on. This book is also useful for the interdisciplinary students studying physics and biological sciences.
Author :
Publisher : Elsevier
ISBN 13 : 0080497063
Total Pages : 664 pages
Book Rating : 4.0/5 (84 download)
Download or read book Recognition of Carbohydrates in Biological Systems, Part B: Specific Applications written by and published by Elsevier. This book was released on 2003-11-06 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognition of carbohydrates in biological systems has been gaining more and more attention in recent years. Although methodology for studying recognition has been developing, there is no volume that covers the wide area of methodology of carbohydrate recognition. This volume, Recognition of Carbohydrates in Biological Systems, Part B: Specific Applications, and its companion, Volume 362, present state-of-the-art methodologies, as well as the most recent biological observations in this area. Covers carbohydrate-binding proteins Discusses glycoproteins and glycolipids Polysaccharides, enzymes and cells are also covered
Author : Anna Kataki Anastasakou
Publisher :
ISBN 13 :
Total Pages : 452 pages
Book Rating : 4.:/5 (129 download)
Download or read book Molecular Recognition Tools for Chemistry in Living Systems written by Anna Kataki Anastasakou and published by . This book was released on 2021 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: The introduction of unnatural functionality in biological systems, coupled with detection using bioorthogonal chemical reactions, revolutionized the field of chemical biology by enabling the investigation of biological processes in live cells and simple organisms. However, the translation to complex organisms has led to less-than-optimal results with high background noise due to cross reactivity with activated reagents. This dissertation investigates the utilization of non-covalent chemistry and bioorthogonal host-guest pairs to obtain more efficient labeling of living systems. Complexation between a host and guest is diffusion-limited, hence can be efficient in dilute environments. The cucurbit[n]uril scaffold has been utilized to determine the minimum binding affinity required for efficient bioorthogonal complexation and investigate how guest size and charge affects the introduction of guests as unnatural metabolites. Carboranes, a cucurbit[7]uril guest class that can be removed "on demand" from the host cavity, were found compatible with metabolic glycoengineering and were successfully incorporated on the cell surface. The cucurbit[7]uril-carborane system serves as the first example of bioorthogonal complexation of a metabolically-incorporated guest and answers fundamental questions required for the further development of bioorthogonal host-guest pairs. Finally, work in expanding the properties of unnatural functionality that can be tolerated by biological systems led to the development of fluorescent guest molecules that could be used independently or in conjunction with molecular recognition tools to investigate living systems.Chapter One is a review on the expansion of chemical reporters beyond bioorthogonal chemistry by metabolic incorporation of alternative moieties with novel functions. These chemical reporters expand on our ability to study and manipulate biological processes with non-invasive methods. Chapters Two details the synthetic methodologies for functionalized cucurbit[7]urils. The two main synthetic approaches to obtaining mono-functionalized cucurbit[7]urils were investigated and cucurbit[7]uril-payload conjugates were synthesized that were used in the remaining work on bioorthogonal complexation described in this dissertation. Chapter Three describes the discovery of carboranes as cucurbit[7]uril guests and their derivatization to increase their binding affinity and aqueous solubility. Ortho-carborane is presented as an stimuli-responsive guest that allows recycling cucurbit[7]uril-solid support constructs through multiple payload isolation rounds in cell lysate. Chapter Four introduces bioorthogonal complexation, namely the labeling of cell-surfaces using host-guest chemistry. A variety of cucurbit[7]uril guests were labeled with a cucurbit[7]- uril-fluorescein conjugate to determine the minimum binding affinity required for bioorthogonal complexation. Metabolic incorporation of a cucurbit[7]uril guest is also presented as a sialic acid derivative on the cell surface that can be similarly labeled with cucurbit[7]uril-fluorophore conjugates. Chapters Five explores the functionality of cucurbit[7]uril guests that can be tolerated by the sialic acid biosynthetic pathway along with in vitro and in vivo methods to analyze and determine successful metabolic incorporation. Chapters Six outlines the development of fluorescent guest molecules that can serve as independent fluorophores or in conjuction with bioorthogonal complexation. The mechanism of luminescence is investigated and preliminary in cellulo data is presented that point towards potential applications.
Author : Binghe Wang
Publisher : John Wiley & Sons
ISBN 13 : 1118019571
Total Pages : 830 pages
Book Rating : 4.1/5 (18 download)
Download or read book Chemosensors written by Binghe Wang and published by John Wiley & Sons. This book was released on 2011-08-24 with total page 830 pages. Available in PDF, EPUB and Kindle. Book excerpt: A thorough, accessible, and general overview of chemosensors Providing a comprehensive overview of chemosensors organic molecules designed to bind and sense small molecules or metal ions and their applications, Chemosensors: Principles, Strategies, and Applications is an accessible one-stop resource for analysts, clinicians, and graduate students studying advanced chemistry and chemosensing. Chemosensors function on a molecular level, generating a signal upon binding. The book reviews their synthesis, design, and applications for detecting biological and organic molecules as well as metal ions. The text highlights applications in drug discovery and catalyses that have not been well covered elsewhere. Covering such topics as molecular recognition, detection methods, design strategies, and important biological issues, the book is broken into four sections that examine intermolecular interactions, strategies in sensor design, detection methods, and case studies in metal, saccharide, and amino acid sensing. An indispensable source of information for chemical and biomedical experts using sensors, Chemosensors includes case studies to make the material both accessible and understandable to chemists of all backgrounds.
Author : Raz Jelinek
Publisher : John Wiley & Sons
ISBN 13 : 3527627022
Total Pages : 368 pages
Book Rating : 4.5/5 (276 download)
Download or read book Cellular and Biomolecular Recognition written by Raz Jelinek and published by John Wiley & Sons. This book was released on 2009-07-10 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: With its exploration of the scientific and technological characteristics of systems exploiting molecular recognition between synthetic materials, such as polymers and nanoparticles, and biological entities, this is a truly multidisciplinary book bridging chemistry, life sciences, pharmacology and medicine. The authors introduce innovative biomimetic chemical assemblies which constitute platforms for recruitment of cellular components or biological molecules, while also focusing on physical, chemical, and biological aspects of biomolecular recognition. The diverse applications covered include biosensors, cell adhesion, synthetic receptors, cell patterning, bioactive nanoparticles, and drug design.
Author : A.D. Buckingham
Publisher : Springer Science & Business Media
ISBN 13 : 9401121680
Total Pages : 213 pages
Book Rating : 4.4/5 (11 download)
Download or read book Principles of Molecular Recognition written by A.D. Buckingham and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: The importance of molecular recognition in chemistry and biology is reflected in a recent upsurge in relevant research, promoted in particular by high-profile initiatives in this area in Europe, the USA and Japan. Although molecular recognition is necessarily microscopic in origin, its consequences are de facto macroscopic. Accordingly, a text that starts with intermolecular interactions between simple molecules and builds to a discussion of molecular recognition involving larger scale systems is timely. This book was planned with such a development in mind. The book begins with an elementary but rigorous account of the various types of forces between molecules. Chapter 2 is concerned with the hydrogen bond between pairs of simple molecules in the gas phase, with particular reference to the preferred relative orientation of the pair and the ease with which this can be distorted. This microscopic view continues in chapter 3 wherein the nature of interactions between solute molecules and solvents or between two or more solutes is examined from the experimental standpoint, with various types of spectroscopy providing the probe of the nature of the interactions. Molecular recognition is central to the catalysis of chemical reactions, especially when bonds are to be broken and formed under the severe con straint that a specific configuration is to result, as in the production of enan tiotopically pure compounds. This important topic is considered in chapter 4.
