Molecular Mechanisms That Underpin Antigen Receptor Recombination

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Molecular Biology of B Cells

Author : Tasuku Honjo
Publisher : Academic Press
ISBN 13 : 9780123979339
Total Pages : 0 pages
Book Rating : 4.9/5 (793 download)

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Book Synopsis Molecular Biology of B Cells by : Tasuku Honjo

Download or read book Molecular Biology of B Cells written by Tasuku Honjo and published by Academic Press. This book was released on 2014-12-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics.

Molecular Mechanisms that Orchestrate the Assembly of Antigen Receptor Loci

Author :
Publisher : Academic Press
ISBN 13 : 0128033304
Total Pages : 476 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Molecular Mechanisms that Orchestrate the Assembly of Antigen Receptor Loci by :

Download or read book Molecular Mechanisms that Orchestrate the Assembly of Antigen Receptor Loci written by and published by Academic Press. This book was released on 2015-11-16 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Mechanisms That Orchestrate the Assembly of Antigen Receptor Loci, the latest volume in the Advances in Immunology series focuses on the generation of an effective immune response to invading pathogens As B and T lymphocytes are characterized by the expression of antigen receptors that specifically recognize determinants expressed on pathogens, this volume discusses how antigen receptors are synthesized in B and T lymphocytes. - Focuses on the generation of an effective immune response to invading pathogens - Contains contributions from leading authorities - Informs and updates on all the latest developments in the field of immunology

Encyclopedia of Medical Immunology

Author : Ian R. Mackay
Publisher :
ISBN 13 : 9781461492092
Total Pages : pages
Book Rating : 4.4/5 (92 download)

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Book Synopsis Encyclopedia of Medical Immunology by : Ian R. Mackay

Download or read book Encyclopedia of Medical Immunology written by Ian R. Mackay and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering a broad appeal to microbiologists, immunologists, and infectious disease specialists, this four volume encyclopedia covers all autoimmune, tropical, and infectious diseases. Emphasis will also be placed on genetics, physiology, metabolism, pathogenesis and applied microbiology. Under the leadership of some of the most world renowned names in the field, the encyclopedia will bring together an outstanding collection of contributions by top scientists in a variety of fields. Volumes 1-3: Diseases will be divided by the 11 main sections of the body, namely Integumentary, Skeletal, Respiratory, Digestive, Urinary, and Reproductive. For some of the autoimmune disease, more then one system will be involved but the delineation serves to broadly break down the diseases into systems. Volume 4 will cover the vaccines for said diseases and future prospects will be offered by leaders in industry and academia. Volume 4 will also be broken down into all the body systems, as in the other two volumes. For each vaccine, for each disease, and in each system the following will be included: • A list of the vaccines currently available along with a list of the companies that manufacture them • Molecular Immunology of the Vaccine • Type of Immunity involved in protection • Mode of Vaccination for each vaccine; repeated boosters and length of immunological memory • Commercial production of vaccines • Storage of vaccines • Standardization and Control of Vaccines • WHO programs and World-Wide Disease Eradication Programs based upon Vaccines.

Chromatin Structure and Dynamics

Author : J. Zlatanova
Publisher : Gulf Professional Publishing
ISBN 13 : 9780444515940
Total Pages : 546 pages
Book Rating : 4.5/5 (159 download)

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Book Synopsis Chromatin Structure and Dynamics by : J. Zlatanova

Download or read book Chromatin Structure and Dynamics written by J. Zlatanova and published by Gulf Professional Publishing. This book was released on 2004 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological processes that replicate, preserve and use the genetic information encoded in DNA must operate in the context of chromatin, a highly organized complex of DNA and proteins. These proteins do not merely package the DNA in the tiny volume of the nucleus, but impart the structure the ability to change according to the requirements of the specific process the DNA is involved in. Moreover, chromatin structure is used by the cell to control the activity of DNA. In this volume the basics of chromatin structure and dynamics are presented by established experts in the field.

DNA Replication, Recombination, and Repair

Author : Fumio Hanaoka
Publisher : Springer
ISBN 13 : 443155873X
Total Pages : 548 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis DNA Replication, Recombination, and Repair by : Fumio Hanaoka

Download or read book DNA Replication, Recombination, and Repair written by Fumio Hanaoka and published by Springer. This book was released on 2016-01-22 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R research fields have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other important processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation, and so on. This book comprises 7 parts and 21 chapters: Part 1 (Chapters 1–3), DNA Replication; Part 2 (Chapters 4–6), DNA Recombination; Part 3 (Chapters 7–9), DNA Repair; Part 4 (Chapters 10–13), Genome Instability and Mutagenesis; Part 5 (Chapters 14–15), Chromosome Dynamics and Functions; Part 6 (Chapters 16–18), Cell Cycle and Checkpoints; Part 7 (Chapters 19–21), Interplay with Transcription and Epigenetic Regulation. This volume should attract the great interest of graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only the core 3Rs, but also the various related fields (chromosome, cell cycle, transcription, epigenetics, and similar areas). Additionally, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields will find this book valuable.

How Tobacco Smoke Causes Disease

Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

DNA Damage, DNA Repair and Disease

Author : Miral Dizdaroglu
Publisher : Royal Society of Chemistry
ISBN 13 : 1839162562
Total Pages : 509 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis DNA Damage, DNA Repair and Disease by : Miral Dizdaroglu

Download or read book DNA Damage, DNA Repair and Disease written by Miral Dizdaroglu and published by Royal Society of Chemistry. This book was released on 2020-11-11 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the interdisciplinary area of DNA damage and DNA repair, and their relevance to disease pathology. Edited by recognised leaders in the field, this two-volume set is an appealing resource to a variety of readers including chemists, chemical biologists, geneticists, cancer researchers and drug discovery scientists.

Polymers

Author : Herbert Morawetz
Publisher : Courier Corporation
ISBN 13 : 9780486495132
Total Pages : 328 pages
Book Rating : 4.4/5 (951 download)

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Book Synopsis Polymers by : Herbert Morawetz

Download or read book Polymers written by Herbert Morawetz and published by Courier Corporation. This book was released on 2002-01-01 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: The finest history of the subject describes early concepts of molecular structure; molecular weight; colloids; addition polymerization; natural polymers; beginning of polymer-based industries; the work of Staudinger, Mark, Carothers, and other pioneers in defining the macromolecule; plus more recent advances in polymerization. 1985 edition.

Essential Immunology for Surgeons

Author : Oleg Eremin
Publisher : Oxford University Press, USA
ISBN 13 : 019958687X
Total Pages : 547 pages
Book Rating : 4.1/5 (995 download)

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Book Synopsis Essential Immunology for Surgeons by : Oleg Eremin

Download or read book Essential Immunology for Surgeons written by Oleg Eremin and published by Oxford University Press, USA. This book was released on 2011-04-28 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing the necessary foundation for a critical understanding of this rapidly expanding area of biological science that underpins and explains the modern concepts of a wide range of diseases and conditions, this book gives a concise, readable, and up-to-date account of immunology in general and its translation into key areas of clinical practice.

PI3K signalling

Author : Klaus Okkenhaug
Publisher : Frontiers Media SA
ISBN 13 : 2889194191
Total Pages : 140 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis PI3K signalling by : Klaus Okkenhaug

Download or read book PI3K signalling written by Klaus Okkenhaug and published by Frontiers Media SA. This book was released on 2015-03-05 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells. Considerable progress in understanding the role of this pathway in cells of the immune system has been made in recent years, starting with analysis of various PI3K and Pten knockout mice and subsequently mTOR and Foxo knockout mice. Together, these experiments have revealed how PI3Ks control B cell and T cell development, T helper cell differentiation, regulatory T cell development and function, B cell and T cell trafficking, immunoglobulin class switching and much, much more. The PI3Kd inhibitor idelalisib has recently been approved for the treatment of B cell lymphoma. Clinical trials of other PI3K inhibitors in autoimmune and inflammatory diseases are also in progress. This is an opportune time to consider a Research Topic considering when what we have learned about the PI3K signalling module in lymphocyte biology and how this is making an impact on clinical immunology and haematology.

Molecular Epidemiology

Author : Paul A. Schulte
Publisher : Academic Press
ISBN 13 : 0323138578
Total Pages : 609 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Molecular Epidemiology by : Paul A. Schulte

Download or read book Molecular Epidemiology written by Paul A. Schulte and published by Academic Press. This book was released on 2012-12-02 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.

Environmental Epigenetics

Author : L. Joseph Su
Publisher : Springer
ISBN 13 : 1447166787
Total Pages : 327 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Environmental Epigenetics by : L. Joseph Su

Download or read book Environmental Epigenetics written by L. Joseph Su and published by Springer. This book was released on 2015-05-18 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Lectures on the comparative pathology of inflammation delivered at the Pasteur Institute in 1891

Author : Elie Metchnikoff
Publisher : Рипол Классик
ISBN 13 : 5877128566
Total Pages : 287 pages
Book Rating : 4.8/5 (771 download)

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Book Synopsis Lectures on the comparative pathology of inflammation delivered at the Pasteur Institute in 1891 by : Elie Metchnikoff

Download or read book Lectures on the comparative pathology of inflammation delivered at the Pasteur Institute in 1891 written by Elie Metchnikoff and published by Рипол Классик. This book was released on 1893 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chromosome Translocation

Author : Yu Zhang
Publisher : Springer
ISBN 13 : 9811305935
Total Pages : 171 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Chromosome Translocation by : Yu Zhang

Download or read book Chromosome Translocation written by Yu Zhang and published by Springer. This book was released on 2018-06-28 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses various aspects of mechanisms and methodologies of chromosome translocations, ranging from a historical and clinical overview of chromosome translocations to the rapid development of the next-generation sequencing technologies, which has dramatically increased our understanding of the spectrum of chromosome translocations in human diseases. The book also introduces the mechanistic studies on chromosome deletions and their implications in cancer, and discusses the mechanisms of regulating chromothripsis, a unique complex type of chromosome translocation. It is a valuable resource for students and researchers alike, providing insights into chromosome translocations and, potentially, other genomic aberrations involved in understanding and curing human diseases.

Essential Immunology

Author : Ivan Maurice Roitt
Publisher :
ISBN 13 :
Total Pages : 244 pages
Book Rating : 4.:/5 (42 download)

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Book Synopsis Essential Immunology by : Ivan Maurice Roitt

Download or read book Essential Immunology written by Ivan Maurice Roitt and published by . This book was released on 1971 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Paul's Fundamental Immunology

Author : Martin Flajnik
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1975142527
Total Pages : 3597 pages
Book Rating : 4.9/5 (751 download)

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Book Synopsis Paul's Fundamental Immunology by : Martin Flajnik

Download or read book Paul's Fundamental Immunology written by Martin Flajnik and published by Lippincott Williams & Wilkins. This book was released on 2022-07-19 with total page 3597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Selected as a Doody's Core Title for 2022! Defining the field of immunology for 40 years, Paul’s Fundamental Immunology continues to provide detailed, authoritative, up-to-date information that uniquely bridges the gap between basic immunology and the disease process. The fully revised 8th edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015, and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland. It’s an ideal reference and gold standard text for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role.

Molecular Mechanism of Crucifer’s Host-Resistance

Author : Govind Singh Saharan
Publisher : Springer Nature
ISBN 13 : 9811619743
Total Pages : 809 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Molecular Mechanism of Crucifer’s Host-Resistance by : Govind Singh Saharan

Download or read book Molecular Mechanism of Crucifer’s Host-Resistance written by Govind Singh Saharan and published by Springer Nature. This book was released on 2022-01-03 with total page 809 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is a comprehensive compilation of applied knowledge for developing resistant varieties to all the major biotrophs, hemibiotrophs and necrotrophs pathogens of crucifers through the use of latest biotechnological approaches. The book includes, multi-component resistance, incorporation of non-host resistance gene, function of particular gene in resistance, expression of age related resistance, enhanced gene resistance, sources of alternative gene which enhance disease resistance, through the use of latest biotechnical approaches like proteomics, omics, transcriptomics and metabolomics. The book also explores the molecular basis of disease resistance, its biometabolomics activities in response to infection and interaction by the various biotrophs, hemibiotrophs and necrotrophs pathogens. The identification of R genes and its incorporation into agronomically superior varieties through use of molecular mechanisms is also explained. This compilation is immensely useful to the researchers especially Brassica breeders, teachers, extension specialists, students, industrialists, farmers, and all others who are interested to grow healthy, and profitable cruciferous crops all over the world.