Molecular Imaging With Reporter Genes

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Molecular Imaging with Reporter Genes

Author : Sanjiv Sam Gambhir
Publisher : Cambridge University Press
ISBN 13 : 1139489526
Total Pages : pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Molecular Imaging with Reporter Genes by : Sanjiv Sam Gambhir

Download or read book Molecular Imaging with Reporter Genes written by Sanjiv Sam Gambhir and published by Cambridge University Press. This book was released on 2010-05-31 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Reporter genes have been used for several decades to study regulation of gene expression in vivo. However, it was little more than a decade ago that a new class of reporter genes was developed for imaging molecular events within living subjects. By following the interactions of protein molecules, researchers can resolve the complex chemical pathways that living cells utilise. This book focuses on this group of imaging reporter genes, starting with detailed descriptions of all reporter genes from different imaging modalities, including optical, MRI, and radionuclide-based imaging. Key scientists in the field explain how to enhance reporter gene imaging utility through instrumentation and the various applications of this technology. This is the first comprehensive book on all aspects of reporter gene imaging, detailing what is known in the field and future goals for research. Investigators in biomedical sciences, physicians, and the biotechnology and pharmaceutical industries will benefit from topics covered.

Molecular Imaging with Reporter Genes

Author : Sanjiv Sam Gambhir
Publisher :
ISBN 13 : 9780511729898
Total Pages : 337 pages
Book Rating : 4.7/5 (298 download)

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Book Synopsis Molecular Imaging with Reporter Genes by : Sanjiv Sam Gambhir

Download or read book Molecular Imaging with Reporter Genes written by Sanjiv Sam Gambhir and published by . This book was released on 2014-05-14 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focuses on the imaging of reporter genes in living subjects, a technology that was developed only ten years ago.

Reporter Gene Imaging

Author : Purnima Dubey
Publisher : Humana
ISBN 13 : 9781493993062
Total Pages : 221 pages
Book Rating : 4.9/5 (93 download)

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Book Synopsis Reporter Gene Imaging by : Purnima Dubey

Download or read book Reporter Gene Imaging written by Purnima Dubey and published by Humana. This book was released on 2019-06-16 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an introduction for the scientist who is new to the field of molecular imaging, as well as detailed methods for experts in other areas of molecular imaging. Chapters detail the advantages and limitations of combining fluorescent, bioluminescent and radioisotopic, creating dual modality imaging reporter gene construct, bioluminescent imaging, and bioluminescent or fluorescent imaging. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Reporter Gene Imaging : Methods and Protocols aims to ensure successful results in the further study of this vital field.

Reporter Genes

Author : Donald S. Anson
Publisher : Springer Science & Business Media
ISBN 13 : 158829739X
Total Pages : 165 pages
Book Rating : 4.5/5 (882 download)

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Book Synopsis Reporter Genes by : Donald S. Anson

Download or read book Reporter Genes written by Donald S. Anson and published by Springer Science & Business Media. This book was released on 2007-09-13 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reporter genes have played, and continue to play, a vital role in many areas of biological research by providing a ready means for qualitative and quantitative assessment of the activity of genes and location of gene products in different environments. In Reporter Genes: A Practical Guide, renowned researchers describe practical protocols for experimentation with the most useful reporter genes for mammalian systems that are available, concentrating on those marker genes that are currently most commonly used. Among the topics covered in this volume are methodologies for staining and visualization of ß-galactosidase in embryos and tissues, immunohistochemical detection of ß-galactosidase, detection of reporter gene expression in murine airways, and three dimensional analysis of molecular signals with episcopic imaging techniques. Also covered in this groundbreaking text are fluorescent proteins, detection of GFP during nervous system development, fluorescent protein reporter systems for single cell measurements, and non-invasive imaging of molecular events. Comprehensive and illuminating, Reporter Genes: A Practical Guide will be an oft-used reference for geneticists, molecular engineers, and molecular biologists.

Molecular Imaging: Basic Principles And Applications In Biomedical Research (3rd Edition)

Author : Markus Rudin
Publisher : World Scientific
ISBN 13 : 1786346869
Total Pages : 801 pages
Book Rating : 4.7/5 (863 download)

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Book Synopsis Molecular Imaging: Basic Principles And Applications In Biomedical Research (3rd Edition) by : Markus Rudin

Download or read book Molecular Imaging: Basic Principles And Applications In Biomedical Research (3rd Edition) written by Markus Rudin and published by World Scientific. This book was released on 2020-04-04 with total page 801 pages. Available in PDF, EPUB and Kindle. Book excerpt: The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full biological context. Due to the high specificity of the molecular readouts the approach bears a high potential for diagnostics. It is fair to say that molecular imaging has become an indispensable tool for biomedical research and drug discovery and development today.This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities, and the design of targeted probes are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events in the living organism. Topics covered include the studies of the biodistribution of reporter probes and drugs, visualization of the expression of biomolecules such as receptors and enzymes, and how imaging can be used for analyzing consequences of the interaction of a ligand or a drug with its molecular target by visualizing signal transduction, or assessing the metabolic, physiological, or structural response of the organism studied.The third edition has been extended considerably. This holds for the chapter on imaging modalities, which now includes sections on intravital microscopy and mass spectrometric imaging. All chapters have been updated and a new chapter on the challenges of translating molecular imaging solutions for clinical use has been added.

Reporter Gene Assays

Author : Robert Damoiseaux
Publisher :
ISBN 13 : 9781493977246
Total Pages : 234 pages
Book Rating : 4.9/5 (772 download)

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Book Synopsis Reporter Gene Assays by : Robert Damoiseaux

Download or read book Reporter Gene Assays written by Robert Damoiseaux and published by . This book was released on 2018 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Imaging

Author : Brian D. Ross
Publisher : Academic Press
ISBN 13 : 0128163879
Total Pages : 1872 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Molecular Imaging by : Brian D. Ross

Download or read book Molecular Imaging written by Brian D. Ross and published by Academic Press. This book was released on 2021-08-03 with total page 1872 pages. Available in PDF, EPUB and Kindle. Book excerpt: The detection and measurement of the dynamic regulation and interactions of cells and proteins within the living cell are critical to the understanding of cellular biology and pathophysiology. The multidisciplinary field of molecular imaging of living subjects continues to expand with dramatic advances in chemistry, molecular biology, therapeutics, engineering, medical physics and biomedical applications. Molecular Imaging: Principles and Practice, Volumes 1 and 2, Second Edition provides the first point of entry for physicians, scientists, and practitioners. This authoritative reference book provides a comprehensible overview along with in-depth presentation of molecular imaging concepts, technologies and applications making it the foremost source for both established and new investigators, collaborators, students and anyone interested in this exciting and important field. The most authoritative and comprehensive resource available in the molecular-imaging field, written by over 170 of the leading scientists from around the world who have evaluated and summarized the most important methods, principles, technologies and data Concepts illustrated with over 600 color figures and molecular-imaging examples Chapters/topics include, artificial intelligence and machine learning, use of online social media, virtual and augmented reality, optogenetics, FDA regulatory process of imaging agents and devices, emerging instrumentation, MR elastography, MR fingerprinting, operational radiation safety, multiscale imaging and uses in drug development This edition is packed with innovative science, including theranostics, light sheet fluorescence microscopy, (LSFM), mass spectrometry imaging, combining in vitro and in vivo diagnostics, Raman imaging, along with molecular and functional imaging applications Valuable applications of molecular imaging in pediatrics, oncology, autoimmune, cardiovascular and CNS diseases are also presented This resource helps integrate diverse multidisciplinary concepts associated with molecular imaging to provide readers with an improved understanding of current and future applications

Molecular Diagnostics: Promises and Possibilities

Author : Mousumi Debnath
Publisher : Springer Science & Business Media
ISBN 13 : 9048132614
Total Pages : 527 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Molecular Diagnostics: Promises and Possibilities by : Mousumi Debnath

Download or read book Molecular Diagnostics: Promises and Possibilities written by Mousumi Debnath and published by Springer Science & Business Media. This book was released on 2010-01-29 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: A rapid development in diverse areas of molecular biology and genetic engineering resulted in emergence of variety of tools. These tools are not only applicable to basic researches being carried out world over, but also exploited for precise detection of abnormal conditions in plants, animals and human body. Although a basic researcher is well versed with few techniques used by him/her in the laboratory, they may not be well acquainted with methodologies, which can be used to work out some of their own research problems. The picture is more blurred when the molecular diagnostic tools are to be used by physicians, scientists and technicians working in diagnostic laboratories in hospitals, industry and academic institutions. Since many of them are not trained in basics of these methods, they come across several gray areas in understanding of these tools. The accurate application of molecular diagnostic tools demands in depth understanding of the methodology for precise detection of the abnormal condition of living body. To meet the requirements of a good book on molecular diagnostics of students, physicians, scientists working in agricultural, veterinary, medical and pharmaceutical sciences, it needs to expose the reader lucidly to: Give basic science behind commonly used tools in diagnostics Expose the readers to detailed applications of these tools and Make them aware the availability of such diagnostic tools The book will attract additional audience of pathologists, medical microbiologists, pharmaceutical sciences, agricultural scientists and veterinary doctors if the following topics are incorporated at appropriate places in Unit II or separately as a part of Unit-III in the book. Molecular diagnosis of diseases in agricultural crops Molecular diagnosis of veterinary diseases. Molecular epidemiology, which helps to differentiate various epidemic strains and sources of disease outbreaks. Even in different units of the same hospital, the infections could be by different strains of the same species and the information becomes valuable for infection control strategies. Drug resistance is a growing problem for bacterial, fungal and parasitic microbes and the molecular biology tools can help to detect the drug resistance genes without the cultivation and in vitro sensitivity testing. Molecular diagnostics offers faster help in the selection of the proper antibiotic for the treatment of tuberculosis, which is a major problem of the in the developing world. The conventional culture and drug sensitivity testing of tuberculosis bacilli is laborious and time consuming, whereas molecular diagnosis offers rapid drug resistant gene detection even from direct clinical samples. The same approach for HIV, malaria and many more diseases needs to be considered. Molecular diagnostics in the detection of diseases during foetal life is an upcoming area in the foetal medicine in case of genetic abnormalities and infectious like TORCH complex etc. The book will be equally useful to students, scientists and professionals working in the field of molecular diagnostics.

Molecular Imaging

Author : Hossein Jadvar
Publisher : Cambridge University Press
ISBN 13 : 1107621283
Total Pages : 93 pages
Book Rating : 4.1/5 (76 download)

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Book Synopsis Molecular Imaging by : Hossein Jadvar

Download or read book Molecular Imaging written by Hossein Jadvar and published by Cambridge University Press. This book was released on 2017-11-16 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: Trace the history, and advances in the field of molecular imaging, with this guide to the visual world of disease.

Molecular Imaging

Author : Ralph Weissleder
Publisher : PMPH-USA
ISBN 13 : 9781607950059
Total Pages : 1384 pages
Book Rating : 4.9/5 (5 download)

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Book Synopsis Molecular Imaging by : Ralph Weissleder

Download or read book Molecular Imaging written by Ralph Weissleder and published by PMPH-USA. This book was released on 2010 with total page 1384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of molecular imaging of living subjects have evolved considerably and have seen spectacular advances in chemistry, engineering and biomedical applications. This textbook was designed to fill the need for an authoritative source for this multi-disciplinary field. We have been fortunate to recruit over 80 leading authors contributing 75 individual chapters. Given the multidisciplinary nature of the field, the book is broken into six different sections: "Molecular Imaging technologies", "Chemistry", "Molecular Imaging in Cell and Molecular Biology", "Applications of Molecular Imaging", "Molecular Imaging in Drug Evaluation" with the final section comprised of chapters on computation, bioinformatics and modeling. The organization of this large amount of information is logical and strives to avoid redundancies among chapters. It encourages the use of figures to illustrate concepts and to provide numerous molecular imaging examples.

Make Life Visible

Author : Yoshiaki Toyama
Publisher : Springer Nature
ISBN 13 : 9811379084
Total Pages : 292 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Make Life Visible by : Yoshiaki Toyama

Download or read book Make Life Visible written by Yoshiaki Toyama and published by Springer Nature. This book was released on 2019-10-02 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.

Small Animal Imaging

Author : Fabian Kiessling
Publisher : Springer
ISBN 13 : 3319422022
Total Pages : 875 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Small Animal Imaging by : Fabian Kiessling

Download or read book Small Animal Imaging written by Fabian Kiessling and published by Springer. This book was released on 2017-05-22 with total page 875 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.

Bioimaging

Author : Shoogo Ueno
Publisher : CRC Press
ISBN 13 : 0429536569
Total Pages : 273 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis Bioimaging by : Shoogo Ueno

Download or read book Bioimaging written by Shoogo Ueno and published by CRC Press. This book was released on 2020-05-26 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioimaging: Imaging by Light and Electromagnetics in Medicine and Biology explores new horizons in biomedical imaging and sensing technologies, from the molecular level to the human brain. It explores the most up-to-date information on new medical imaging techniques, such as the detection and imaging of cancer and brain diseases. This book also provides new tools for brain research and cognitive neurosciences based on new imaging techniques. Edited by Professor Shoogo Ueno, who has been leading the field of biomedical imaging for 40 years, it is an ideal reference book for graduate and undergraduate students and researchers in medicine and medical physics who are looking for an authoritative treatise on this expanding discipline of imaging and sensing in medicine and biology. Features: Provides step-by-step explanations of biochemical and physical principles in biomedical imaging Covers state-of-the art equipment and cutting-edge methodologies used in biomedical imaging Serves a broad spectrum of readers due to the interdisciplinary topic and approach Shoogo Ueno, Ph.D, is a professor emeritus of the University of Tokyo, Tokyo, Japan. His research interests include biomedical imaging and bioelectromagnetics, particularly in brain mapping and neuroimaging, transcranial magnetic stimulation (TMS), and magnetic resonance imaging (MRI). He was the President of the Bioelectromagnetics Society, BEMS (2003-2004) and the Chairman of the Commission K on Electromagnetics in Biology and Medicine of the International Union of Radio Science, URSI (2000-2003). He was named the IEEE Magnetics Society Distinguished Lecturer during 2010 and received the d’Arsonval Medal from the Bioelectromagnetics Society in 2010.

Encyclopedia of Cancer

Author : Manfred Schwab
Publisher : Springer Science & Business Media
ISBN 13 : 3540368477
Total Pages : 3307 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Encyclopedia of Cancer by : Manfred Schwab

Download or read book Encyclopedia of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2008-09-23 with total page 3307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.

Molecular Imaging

Author : Alexei Bogdanov
Publisher : Springer Science & Business Media
ISBN 13 : 9783540210214
Total Pages : 278 pages
Book Rating : 4.2/5 (12 download)

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Book Synopsis Molecular Imaging by : Alexei Bogdanov

Download or read book Molecular Imaging written by Alexei Bogdanov and published by Springer Science & Business Media. This book was released on 2004-10-07 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: The continuous progress in the understanding of molecular processes of disease formation and progression attributes an increasing importance to biomedical molecular imaging methods. The purpose of this workshop was to discuss and overview multiple applications and emerging technologies in the area of diagnostic imaging including its fundamental capabilities in preclinical research, the opportunities for medical care, and the options involving therapeutic concepts. The book provides the reader with state-of-the-art information on the different aspects of diagnostic imaging, illuminating new developments in molecular biology, imaging agents and molecular probe design, and therapeutic techniques.

Introduction to Medical Imaging

Author : Nadine Barrie Smith
Publisher : Cambridge University Press
ISBN 13 : 1139492047
Total Pages : pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Introduction to Medical Imaging by : Nadine Barrie Smith

Download or read book Introduction to Medical Imaging written by Nadine Barrie Smith and published by Cambridge University Press. This book was released on 2010-11-18 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering the basics of X-rays, CT, PET, nuclear medicine, ultrasound, and MRI, this textbook provides senior undergraduate and beginning graduate students with a broad introduction to medical imaging. Over 130 end-of-chapter exercises are included, in addition to solved example problems, which enable students to master the theory as well as providing them with the tools needed to solve more difficult problems. The basic theory, instrumentation and state-of-the-art techniques and applications are covered, bringing students immediately up-to-date with recent developments, such as combined computed tomography/positron emission tomography, multi-slice CT, four-dimensional ultrasound, and parallel imaging MR technology. Clinical examples provide practical applications of physics and engineering knowledge to medicine. Finally, helpful references to specialised texts, recent review articles, and relevant scientific journals are provided at the end of each chapter, making this an ideal textbook for a one-semester course in medical imaging.

Reporter Genes

Author : Don Anson
Publisher : Humana Press
ISBN 13 : 9781588297396
Total Pages : 158 pages
Book Rating : 4.2/5 (973 download)

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Book Synopsis Reporter Genes by : Don Anson

Download or read book Reporter Genes written by Don Anson and published by Humana Press. This book was released on 2007-09-13 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reporter genes have played, and continue to play, a vital role in many areas of biological research by providing a ready means for qualitative and quantitative assessment of the activity of genes and location of gene products in different environments. This book describes practical protocols for experimentation with the most useful reporter genes for mammalian systems that are available.