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Molecular Genetic Studies Of Hypertension And Associated Disorders In Humans And Of Gene Expression In Hypertensive Rats
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Book Synopsis Molecular Genetic Studies of Hypertension and Associated Disorders in Humans and of Gene Expression in Hypertensive Rats by : Ruby Ching-Yu Lin
Download or read book Molecular Genetic Studies of Hypertension and Associated Disorders in Humans and of Gene Expression in Hypertensive Rats written by Ruby Ching-Yu Lin and published by . This book was released on 2002 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Genetics and Pathophysiology of Essential Hypertension by : Madhu Khullar
Download or read book Genetics and Pathophysiology of Essential Hypertension written by Madhu Khullar and published by BoD – Books on Demand. This book was released on 2012-03-09 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, authored by renowned researchers in the field of Hypertension Research, details the state of the art knowledge in genetics, genomics and pathophysiology of Essential hypertension, specifically the genetic determinants of hypertension and role of gene variants in response to anti-hypertensive therapy. Two chapters describe mitochondrial mutations in Essential hypertension and in hypertension associated Left ventricular hypertrophy, one chapter reviews in detail the global gene expression in hypertension, and an up to date treatise on pathophysiology of resistant hypertension is detailed in another chapter. Other topics included in the book are end organ damage, baroreceptor sensitivity and role of music therapy in essential hypertension.
Book Synopsis Genetic, Immune and Molecular Predisposition to Hypertension by : P. M. Frossard
Download or read book Genetic, Immune and Molecular Predisposition to Hypertension written by P. M. Frossard and published by VSP. This book was released on 1999-01-01 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Genetics of Hypertension by : Anna F. Dominiczak
Download or read book Genetics of Hypertension written by Anna F. Dominiczak and published by Elsevier Health Sciences. This book was released on 2007-01-01 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Classic and modern tools of genetics have been applied to hypertension research for some 20 years. This volume in the Handbook of Hypertension series aims to go beyond a simple summary of discoveries and provides a critical commentary on many controversial issues. It will be particularly useful for clinician scientists at all stages of their careers, graduate students and post-doctoral scientists as well as all those interested in cardiovascular medicine and research throughout the entire spectrum from bench to bedside. As in every relatively young area of research, the initial excitement over the early positive observations has not always been confirmed by subsequent larger studies with greater statistical power. Issues related to current recommendations on design of studies and their analysis are therefore included. Pharmacogenetics and pharmacogenomics have been the subjects of many debates in recent years and are of particular importance in hypertension as life-long treatments, frequently with multiple drugs are given to millions of people world-wide. A critical appraisal of this controversial topic is provided. Several chapters on experimental genetics of hypertension with a special focus on physiological genomics are also included.
Download or read book Hypertension written by Jérôme P. Fennell and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of new and essential molecular techniques for cardiovascular research. These readily reproducible methods range widely from producing congenic, consomic, transgenic, and knockout models of hypertension to the gene transfer of specific genetic material using nonviral (polymers, liposomes, and antisense agents) and adenoviral vectors. Additional techniques described include single nucleotide polymorphism (SNP) genotyping, RNA interference, microarray analysis, pharmacogenetics, and pharmacogenomics for the genetic dissection of hypertension, as well as a practical method for deriving cardiomyocytes from embryonic stem cells that would serve as replacement cells for those damaged by hypertension or heart attack. The book offers both novice and experienced hypertension researchers an indispensable collection of readily reproducible techniques for successful research, work that has already dramatically improved the outlook for hypertensive patients, and promises much future success.
Book Synopsis Genetics of Hypertension by : Xi Cheng
Download or read book Genetics of Hypertension written by Xi Cheng and published by Biota Publishing. This book was released on 2015-08-01 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hypertension, or elevated blood pressure, is a major risk factor for various cardiovascular, renal diseases, and stroke. The form of hypertension with no identifiable cause is referred to as Essential Hypertension. Familial studies indicate that Essential Hypertension is heritable and, thereby, classical genetic approaches have been applied on both human and other mammalian models of hypertension to map the locations of the allelic variants within quantitative trait loci for blood pressure. The post genome era has further elevated this area of research into large-scale genome-wide association studies of hypertension in humans. Collectively, these studies have resulted in the prioritization and cataloging of several genomic regions containing allelic variants as candidates linked or associated with essential hypertension. Further, they are providing evidence to suggest that the inheritance of hypertension is rather complex, encompassing multiple variants both within protein-coding and non-coding annotations, each of which may act independently or interactively with other genes and/or environmental factors to differentially regulate blood pressure. This book provides an overview of the various methods employed to study the genetics of hypertension and discuss the progress and prospects of this area of research that may contribute towards individualized clinical management of hypertension in the future.
Book Synopsis Experimental and Genetic Models of Hypertension by : Wybren de Jong
Download or read book Experimental and Genetic Models of Hypertension written by Wybren de Jong and published by . This book was released on 1994 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardbound. This volume is a worthy successor to volume 4 by virtue of its focus on the recent conceptual revolution in fundamental hypertension research. Without neglecting the heritage of earlier achievements, it highlights such brilliant breakthroughs in molecular genetics as the creation of transgenic animals as a source of a new pathogenesis of hypertension.A core of (patho)physiological mechanisms operative in experimental hypertension is provided, including several which act to maintain a normotensive state. The volume provides background and technical information on the use of different models of hypertension in a variety of animal species. A wealth of new information regarding the several different complications observed in genetic and other models of hypertension, as well as new animal models dedicated to these aspects, are also presented. Furthermore, new chapters addressing genotyping and the use of transgenics in hypertension are included.
Book Synopsis Molecular Genetics of Hypertension by :
Download or read book Molecular Genetics of Hypertension written by and published by Academic Press. This book was released on 1999-10-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a rapidly expanding research area, with most current publications existing as journal articles, or as single chapters in larger volumes. This will be one of the first books to bring all this information together into a comprehensive review volume, aimed at both researchers and clinicians. Hypertension is a condition in humans which is characterized by persistently high arterial blood pressure (over 140/90 mm Hg). Affected individuals are at risk from heart disease, stroke and kidney failure. This important disease affects a huge number of people worldwide, and therefore the study of the disease is of vital clinical importance. Hypertension is a genetically determined disease, with many other contributing factors. Research has expanded rapidly in this area, particularly over the last decade, and there are continuing advances in our understanding of the disease.
Book Synopsis Development of the Hypertensive Phenotype by : David A. Blizard
Download or read book Development of the Hypertensive Phenotype written by David A. Blizard and published by Elsevier Science & Technology. This book was released on 1999 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardbound. The present volume of the Handbook of Hypertension draws together knowledge on the endogenous (genetic) and exogenous (environmental) components contributing to the pathogenesis of essential hypertension. In the field of hypertension research, the importance of adopting a genetic approach to its phenomenology was recognized at an early stage. There was early debate concerning the nature of the genetic architecture underlying population variability in blood-pressure but today its polygenic nature is generally accepted and is reflected in the design and orientation of human investigations as well as in the heterogeneity of mechanisms that have been unearthed by exploration with diverse animal genetic models. Concurrently, epidemiological studies have emphasized the contribution of a variety of environmental factors in the etiology of hypertension. In particular, the contribution of dietary factors, smoking and lifestyle to the develop
Book Synopsis Role of Genomics in the Management of Hypertension by : Paolo Mulatero
Download or read book Role of Genomics in the Management of Hypertension written by Paolo Mulatero and published by MDPI. This book was released on 2021-01-21 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arterial hypertension affects about 1 billion people worldwide and it is the strongest modifiable risk factor for cardiovascular disease and related disability. Since the initial discovery of rare monogenic disorders with large effects, the role of genomics has evolved into large genome-wide association studies detecting common variants with a modest effect size. Similarly, pharmacogenomics has emerged as a new tool for understanding variability in drug response, to maximize efficacy and reduce toxicity. This book presents the most recent advances in the field of genetics and genomics of arterial hypertension and their potential impact on clinical management. The book is a useful tool for clinicians but also to the research community and those who want to be updated in the field.
Book Synopsis Cellular and Molecular Mechanisms in Hypertension by : Robert H. Cox
Download or read book Cellular and Molecular Mechanisms in Hypertension written by Robert H. Cox and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hypertension is recognized to be one of the major risk factors for the development of peripheral vascular disease. The last decade has witnessed several major advances in therapy for hypertension, including the development of angiotensin-converting enzyme inhibitors and calcium channel blockers. These compounds have greatly improved the ability to control blood pressure and to reduce the impact of this risk factor on morbidity and mortality. In spite of these advances, cardiovascular disease remains a major health problem in most modern industrialized countries with related deaths exceeding those from all other causes combined. In contrast to these advances in therapy, our understanding of the basic mechanisms responsible for the pathogenesis of hypertension remains incomplete. Recent studies have produced new insights into the nature of the regulation of muscle contraction in both heart and blood vessels as well as the changes in muscle function that occur in hypertension. However, the effects of antihypertensive therapy, both in terms of restoring normal function and in producing reversal of hypertension-associated changes, has not been as thoroughly studied, especially in the vasculature. Studies in the heart suggest that the efficacy of different therapeutic agents in restoring normal function and reversing hypertensive changes vary substantially with the mechanism of action of the therapeutic agent. It has also been recently determined that some therapeutic agents produce adverse effects on plasma lipid profiles, which could lead to the secondary acceleration of the atherosclerotic process, while at the same time normalizing blood pressure.
Book Synopsis Genetics and Pathophysiology of Essential Hypertension by : Madhu Khullar
Download or read book Genetics and Pathophysiology of Essential Hypertension written by Madhu Khullar and published by . This book was released on 2012 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, authored by renowned researchers in the field of Hypertension Research, details the state of the art knowledge in genetics, genomics and pathophysiology of Essential hypertension, specifically the genetic determinants of hypertension and role of gene variants in response to anti-hypertensive therapy. Two chapters describe mitochondrial mutations in Essential hypertension and in hypertension associated Left ventricular hypertrophy, one chapter reviews in detail the global gene expression in hypertension, and an up to date treatise on pathophysiology of resistant hypertension is detailed in another chapter. Other topics included in the book are end organ damage, baroreceptor sensitivity and role of music therapy in essential hypertension.
Book Synopsis Human Polygenic Diseases by : Dragani
Download or read book Human Polygenic Diseases written by Dragani and published by CRC Press. This book was released on 1998-07-01 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Human Polygenic Diseases - Animal Models" deals with the emerging role of complex genetic factors in the pathogenesis of common diseases. These diseases include hypertension, diabetes, obesity, and cancer, and cause a large fraction of morbidity and death. Complex genetic factors are difficult to study in humans, and this book will give the reader a concise view of the major experimental models of polygenic inheritance of predisposition to diseases. It emphasizes the use of models as tools for understanding the basis of the complex genetics of human diseases. This timely publication can be used as both a reference tool and as a textbook for specialized university courses. It should be of interest to those involved in basic research in animal genetics, molecular genetics, human genetics, and medicine.
Book Synopsis Cellular and Molecular Biology of the Renin-Angiotensin System by : Mohan K. Raizada
Download or read book Cellular and Molecular Biology of the Renin-Angiotensin System written by Mohan K. Raizada and published by CRC Press. This book was released on 2017-12-08 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: SECTION VI: RENIN-ANGIOTENSIN AND HUMAN HYPERTENSION -- Chapter 20 Derangements in Renin-Angiotensin Regulation in the Pathogenesis of Hypertension -- Chapter 21 Genes of the Renin-Angiotensin System and the Genetics of Human Hypertension -- Index
Book Synopsis From Molecule to Men by : M. Zehender
Download or read book From Molecule to Men written by M. Zehender and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: From molecule to man: Medical research has indeed taken this direction, and major improvements of our understanding of the pathophysiology and epidemiology of disease have been achieved. The molecular basis of the congenital cardiovascular disorders has been extended from relatively few congenital malformations into everyday illnesses such as diabetes mellitus, hyperlipoproteinaemea, and arterial hypertension. The monogenic and, more difficult, polygenic basis for a vast majority of cardiovascular disorders are being defined more precisely from year to year. This book gives an overview of what has been achieved so far and defines the current position.
Book Synopsis Evidence for a Genetic Mechanism of the Chromogranin A and Phenylethanolamine-N-methyltransferase Genes in the Pathogenesis of Hypertension in the Spontaneously Hypertensive Rat by : Ryan Scott Friese
Download or read book Evidence for a Genetic Mechanism of the Chromogranin A and Phenylethanolamine-N-methyltransferase Genes in the Pathogenesis of Hypertension in the Spontaneously Hypertensive Rat written by Ryan Scott Friese and published by . This book was released on 2007 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dissection of the genetic basis of human essential hypertension is greatly hindered by the inherent complexity of the disorder. Indeed, susceptibility genes are estimated to contribute ∼20-30% to development of essential hypertension, and gene actions are confounded by environmental variables, such as diet and exercise, and the diverse heterozygosity of the human population. In contrast, identification of susceptibility genes in the Spontaneously Hypertensive Rat (SHR) model of human essential hypertension is greatly enhanced by the purely genetic basis of hypertension in the SHR and the ability to strictly control the environment. The large gap in physiology between the immediate action of susceptibility genes and the ultimate development of hypertension, however, looms large, even in the SHR. The objective of the dissertation, therefore, is to identify polymorphisms within candidate genes for hypertension in the SHR that manifest as intermediate phenotypes for the ultimate hypertensive disease state. Differential expression of adrenal mRNA is proposed as a novel intermediate phenotype for hypertension in the SHR. Initially, a comparison of adrenal gene expression between the SHR rat and BPH mouse, two independent models of human essential hypertension, was performed to uncover common genetic mechanisms of hypertension across mammalian species. A diverse set of differentially expressed genes and biochemical systems within and between the SHR and BPH strains was identified, reinforcing the complexity of the disease. Next, candidate genes for hypertension in the SHR were identified using a method to integrate adrenal gene expression data with blood pressure QTL data. Seven candidate genes were identified and resequenced. Polymorphisms discovered in the promoter and/or 3'-untranslated region of the chromogranin A (Chga) and phenylethanolamine-N-methyltransferase (Pnmt ) genes were hypothesized to contribute to differential expression of Chga (1.73-fold overexpressed) and Pnmt (0.67-fold underexpressed) adrenal mRNA in the SHR. Finally, luciferase assays were used to demonstrate that promoter polymorphisms are likely to contribute to the adrenal differential mRNA expression of Chga and Pnmt in vivo. The crucial role of Chga and Pnmt in the biosynthesis and exocytosis of catecholamines makes them strong candidate genes for hypertension in the SHR. More importantly, the association of Chga and Pnmt with human essential hypertension makes them potential therapeutic targets as well.
Book Synopsis Experimental and Genetic Models of Hypertension by : W. De Jong
Download or read book Experimental and Genetic Models of Hypertension written by W. De Jong and published by Elsevier. This book was released on 2013-06-02 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental and Genetic Models of Hypertension
