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Author : Lee-Chuan Kao
Publisher :
ISBN 13 :
Total Pages : 306 pages
Book Rating : 4.:/5 (796 download)
Download or read book Molecular Events in Human Placental Trophoblast Differentiation written by Lee-Chuan Kao and published by . This book was released on 1991 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Arthur Tremain Hertig
Publisher :
ISBN 13 :
Total Pages : 384 pages
Book Rating : 4.3/5 (91 download)
Download or read book Human Trophoblast written by Arthur Tremain Hertig and published by . This book was released on 1968 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michael J. Soares
Publisher : Springer Science & Business Media
ISBN 13 : 1592599834
Total Pages : 472 pages
Book Rating : 4.5/5 (925 download)
Download or read book Placenta and Trophoblast written by Michael J. Soares and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of cutting-edge laboratory techniques for the study of trophoblast and placental biology. The techniques presented range from experimental animal models, to animal and human placental organ and cell culture systems, to morphological, biochemical, and molecular strategies for assessing trophoblast/placental growth, differentiation and function. Volume 1 provides readily reproducible protocols for studying embryo-uterine implantation, trophoblast cell development, and the organization and molecular characterization of the placenta. Highlights include strategies for the isolation and culture of trophoblast cells from primates, ruminants, and rodents, and precise guidance to the molecular and cellular analysis of the placental phenotype. A companion second volume concentrates on methods for investigating placental function.
Author : C. Redman
Publisher : Wiley-Blackwell
ISBN 13 : 9780632027217
Total Pages : 608 pages
Book Rating : 4.0/5 (272 download)
Download or read book The Human Placenta written by C. Redman and published by Wiley-Blackwell. This book was released on 1993-01-18 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: The placenta is fascinating and complex. Basically foreign to the maternal body, it can be thought of as an organ transplanted onto the mother's host tissue. As such it embodies all the principles of tissue acceptance and rejection. Many of the risks of pregnancy and labor have now been eliminated and the placenta is likely to be at the root of many of the dangers to the unborn child that remain. A breakdown of the relationship between the placenta and the maternal tissue may turn out to be the cause of the majority of early lost pregnancies.
Author : Nima Soleymanlou
Publisher :
ISBN 13 : 9780494159323
Total Pages : 544 pages
Book Rating : 4.1/5 (593 download)
Download or read book Human Trophoblast Cell Death in Pathological and Physiological Models of Hypoxia written by Nima Soleymanlou and published by . This book was released on 2006 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second chapter shows that increased trophoblast cell death in preeclampsia is due to expression of Mtd-P, a novel pro-apoptotic splice variant of Matador (Mtd), a cell death inducing Bcl-2 family member. Mtd-P expression, resulting from exon II-skipping, increases under conditions of placental hypoxia/oxidative stress and is responsible for inducing apoptotic-mediated trophoblast cell death. Preeclampsia is a leading cause of maternal and fetal morbidity and death. This placental disease is characterized by reduced uteroplacental oxygenation; an event potentially responsible for increased trophoblast cell death. This pathologic insult is believed to contribute to the molecular events leading to the clinical manifestations of this disease. Hence, it is of paramount importance to study the impact of oxygenation on placental gene expression and to understand the regulation of molecules governing cell death pathways in placental pathology. Using high-throughput functional genomics, the first chapter of this dissertation demonstrates that global gene expression profiles obtained from in vitro and in vivo models of human placental hypoxia have a striking similarity to the profile of placental tissues obtained from preeclamptic pregnancies. These results represent the first molecular proof that global gene expression changes in preeclamptic pregnancies are due to placental hypoxia and that these events can successfully be mimicked in vitro and in vivo. The third chapter reports that aberrant placental oxygenation compromises the anti-apoptotic function of Mcl-1, the only interacting partner of Mtd. Notably, hypoxia-reoxygenation in vitro results in caspase-3-mediated Mcl-1 cleavage and induction of pro apoptotic Mcl-1 isoform expression, events that are only observed in severe early-onset preeclamptic placentae. Finally, studies in chapter four reveal that the pro-apoptotic function of Mtd-P cannot be antagonized by the anti-apoptotic Mcl-1L molecule. This lack of inhibition allows Mtd-P to cause trophoblast cell death and impair trophoblast cell fusion. The present body of work demonstrates that reduced oxygenation impacts global placental gene expression in preeclampsia and likely results in an imbalance in the Mtd-Mcl1 apoptotic rheostat, hence causing increased trophoblast cell death and impaired differentiation. As such, these molecular events may be important contributors leading to the pathogenesis of preeclampsia.
Author : Yuping Wang
Publisher : Biota Publishing
ISBN 13 : 1615047514
Total Pages : 126 pages
Book Rating : 4.6/5 (15 download)
Download or read book Vascular Biology of the Placenta written by Yuping Wang and published by Biota Publishing. This book was released on 2017-06-23 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: The placenta is an organ that connects the developing fetus to the uterine wall, thereby allowing nutrient uptake, waste elimination, and gas exchange via the mother's blood supply. Proper vascular development in the placenta is fundamental to ensuring a healthy fetus and successful pregnancy. This book provides an up-to-date summary and synthesis of knowledge regarding placental vascular biology and discusses the relevance of this vascular bed to the functions of the human placenta.
Author : Raymond W. Redline
Publisher : Cambridge University Press
ISBN 13 : 1316632539
Total Pages : 367 pages
Book Rating : 4.3/5 (166 download)
Download or read book Placental and Gestational Pathology with Online Resource written by Raymond W. Redline and published by Cambridge University Press. This book was released on 2018-08-23 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to identifying disease processes in the placenta affecting pregnancy outcome, with current diagnostic criteria and clinical consequences.
Author : Robert Pijnenborg
Publisher : Cambridge University Press
ISBN 13 : 1139488686
Total Pages : 325 pages
Book Rating : 4.1/5 (394 download)
Download or read book Placental Bed Disorders written by Robert Pijnenborg and published by Cambridge University Press. This book was released on 2010-06-03 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now recognized that defective placentation in the human is a cause of many pregnancy complications, such as spontaneous abortion, preterm labor and delivery, pre-eclampsia, intrauterine growth restriction, fetal death and abruptio placenta. These clinical disorders can often have long-term consequences into adulthood, causing cardiovascular disease, obesity and diabetes for the newborn as well as an increased risk of premature death in the mother. This is the first book to be entirely focused on the placental bed, bringing together the results of basic and clinical research in cell biology, immunology, endocrinology, pathology, genetics and imaging to consolidate in a single, informative source for investigators and clinicians. Its core aim is to explore new approaches and improve current clinical practice. This is essential reading for clinicians in obstetric, cardiovascular and reproductive medicine.
Author : Robert N. Taylor
Publisher : Elsevier
ISBN 13 : 0124079458
Total Pages : 500 pages
Book Rating : 4.1/5 (24 download)
Download or read book Chesley's Hypertensive Disorders in Pregnancy written by Robert N. Taylor and published by Elsevier. This book was released on 2014-08-28 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chesley’s Hypertensive Disorders in Pregnancy continues its tradition as one of the beacons to guide the field of preeclampsia research, recognized for its uniqueness and utility. Hypertensive disorders remain one the major causes of maternal and fetal morbidity and death. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this the hypertensive disorders remain marginally studied and management is often controversial. The fourth edition of Chesley’s Hypertensive Disorders in Pregnancy focuses on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. Differing from other texts devoted to preeclampsia, it covers the whole gamut of high blood pressure, and not just preeclampsia. Features new chapters focusing on recent discoveries in areas such as fetal programming, genomics/proteomics, and angiogenesis Includes extensive updates to chapters on epidemiology, etiological considerations, pathophysiology, prediction, prevention, and management Discusses the emerging roles of metabolic syndrome and obesity and the increasing incidence of preeclampsia Each section overseen by one of the editors; each chapter co-authored by one of the editors, ensuring coherence throughout book
Author : Stanley R. Glasser
Publisher : CRC Press
ISBN 13 : 0203219031
Total Pages : 1079 pages
Book Rating : 4.2/5 (32 download)
Download or read book The Endometrium written by Stanley R. Glasser and published by CRC Press. This book was released on 2002-05-16 with total page 1079 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Endometrium is devoted to a comprehensive multi-disciplinary account of the uterine endometrium. This book is the first to define the regulatory biological interrelationships between epithelial and stromal cell phenotypes, endothelial cells, extracellular matrix and immunobiological elements. It highlights their relevance to clinical conditions
Author : Peter Rugg-Gunn
Publisher : Humana
ISBN 13 : 9781071619070
Total Pages : 288 pages
Book Rating : 4.6/5 (19 download)
Download or read book Human Naïve Pluripotent Stem Cells written by Peter Rugg-Gunn and published by Humana. This book was released on 2021-12-07 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides readers with a comprehensive collection of methods to guide them on how to generate, characterize, and use naïve human pluripotent stem cells (hPSCs). The chapters in this book cover topics such as three predominant routes to generate naïve hPSC lines; methods to differentiate naïve hPSCs into specialized cell types; and techniques to characterize naïve hPSCs using key molecular landmarks that benchmark and quality control the cell lines. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Human Naïve Pluripotent Stem Cells: Methods and Protocols is a valuable resource for novice and expert researchers who are looking to learn more or expand their research in this developing field.
Author : Graham J. Burton
Publisher : Cambridge University Press
ISBN 13 : 1139494228
Total Pages : 267 pages
Book Rating : 4.1/5 (394 download)
Download or read book The Placenta and Human Developmental Programming written by Graham J. Burton and published by Cambridge University Press. This book was released on 2010-12-16 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developmental programming is a rapidly advancing discipline of great importance to basic scientists and health professionals alike. This text integrates, for the first time, contributions from world experts to explore the role of the placenta in developmental programming. The book considers the materno-fetal supply line, and how perturbations of placental development impact on its functional capacity. Chapters examine ways in which environmental, immunological and vascular insults regulate expression of conventional and imprinted genes, along with their impact on placental shape and size, transport, metabolism and endocrine function. Research in animal models is integrated with human clinical and epidemiological data, and questions for future research are identified. Transcripts of discussions between the authors allow readers to engage with controversial issues. Essential reading for researchers in placental biology and developmental programming, as well as specialists and trainees in the wider field of reproductive medicine.
Author : Alison Fiander
Publisher : Cambridge University Press
ISBN 13 : 1107667135
Total Pages : 557 pages
Book Rating : 4.1/5 (76 download)
Download or read book MRCOG Part One written by Alison Fiander and published by Cambridge University Press. This book was released on 2016-10-13 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fully updated and illustrated handbook providing comprehensive coverage of all curriculum areas covered by the MRCOG Part 1 examination.
Author : Sue Pavord
Publisher : Cambridge University Press
ISBN 13 : 1108548377
Total Pages : 362 pages
Book Rating : 4.1/5 (85 download)
Download or read book The Obstetric Hematology Manual written by Sue Pavord and published by Cambridge University Press. This book was released on 2018-02-08 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understand the rapidly growing complexities of obstetric hematology and high-risk pregnancy management, with experts in the field. Now in its second edition, this comprehensive and essential guide focuses on providing the best support for patients and clinical staff, to prevent serious complications in pregnancy and the post-partum period for both mother and baby. Wide-ranging and detailed, the guide offers discussions on basic principles of best care, through to tackling lesser-known hematological conditions, such as cytopenias and hemoglobinopathies. Updated with color illustrations, cutting-edge research, accurate blood film reproductions, and practical case studies, the revised edition places invaluable advice into everyday context. This unique resource is essential reading for trainees and practitioners in obstetrics, anesthesia, and hematology, as well as midwives, nurses, and laboratory staff. Clarifying difficult procedures for disease prevention, the guide ensures safety when the stakes are high. Reflecting current evidence-based guidelines, the updated volume is key to improving pregnancy outcomes worldwide.
Author : Arlene Chiu
Publisher : Springer Science & Business Media
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.3/5 (91 download)
Download or read book Human Embryonic Stem Cells written by Arlene Chiu and published by Springer Science & Business Media. This book was released on 2003-08 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: A discussion of all the key issues in the use of human pluripotent stem cells for treating degenerative diseases or for replacing tissues lost from trauma. On the practical side, the topics range from the problems of deriving human embryonic stem cells and driving their differentiation along specific lineages, regulating their development into mature cells, and bringing stem cell therapy to clinical trials. Regulatory issues are addressed in discussions of the ethical debate surrounding the derivation of human embryonic stem cells and the current policies governing their use in the United States and abroad, including the rules and conditions regulating federal funding and questions of intellectual property.
Author : Matthew H. Kaufman
Publisher : Academic Press
ISBN 13 : 0080573371
Total Pages : 306 pages
Book Rating : 4.0/5 (85 download)
Download or read book The Anatomical Basis of Mouse Development written by Matthew H. Kaufman and published by Academic Press. This book was released on 1999-03-10 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an essential anatomical resource for developmental biologists who need to know about any aspect of mouse developmental anatomy, as well as for geneticists using the mouse embryo as a model. The book is a companion to Kaufman's The Atlas of Mouse Development, and details the developmental anatomy of the early embryo, the transitional tissues, and all the major organ systems. It also provides extensive comparisons with human developmental anatomy, both normal and abnormal. The book has extensive reference indexes detailing developmental stage criteria. The Anatomical Basis of Mouse Development will be a key reference work for anyone who needs to understand developmental anatomy in normal and mutant mice. Complements Kaufman's The Atlas of Mouse Development Gives anatomical descriptions from oogenesis to birth, at a level of detail that goes beyond that found in most literature Provides detailed explanations for geneticists and molecular biologists with limited anatomical background to help them understand the emergence of all the major structures in the mouse embryo Contains comprehensive indexes detailing the appearance of over 1000 organs, tissues, and their components at different stages of mouse embryogenesis Includes comparisons with normal and abnormal human development Contains over 100 clear line diagrams showing mouse developmental anatomy as well as lineage relationships for the major organ systems
Author : Ronald A. Asherson
Publisher : CRC Press
ISBN 13 : 1351085573
Total Pages : 357 pages
Book Rating : 4.3/5 (51 download)
Download or read book The Antiphospholipid Syndrome written by Ronald A. Asherson and published by CRC Press. This book was released on 2018-05-04 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost researchers in the field, this book gathers together in a single source the many important clinical associations of antiphospholipid antibodies. Antibody-related clotting mechanisms and their relationship to conditions such as recurrent strokes, chorea, multi infarct dementias, a variety of spinal syndromes, Addison's Disease, recurrent miscarriages, and many more are discussed in depth. The importance of these antibodies in 'Primary,' 'Secondary,' and 'Catastrophic' Antiphospholipid Syndrome is highlighted. Each chapter is devoted to a specific internal system and the clinical effects this syndrome has on that system. This authoritative book is an essential addition to medical libraries as well as an invaluable reference for general physicians, internists, rheumatologists, neurologists, cardiologists, nephrologists, endocrinologists, gastroenterologists, pulmonologists, dermatologists, and obstetricians.
