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Molecular Counting Analysis Of Infectious Disease
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Book Synopsis Molecular Counting Analysis of Infectious Disease by : Richard Lance Martin
Download or read book Molecular Counting Analysis of Infectious Disease written by Richard Lance Martin and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases have a profound impact on humankind, influencing the course of wars and the fate of nations. The case for applying next-generation sequencing (NGS) in clinical microbiology is becoming increasingly clear. A flood of recent studies have shown how this powerful technology can address pressing modern problems in infectious diseases, including resistance, rare infections, and outbreaks. In this thesis, we show that molecular counting of pathogen-derived cell-free DNA is a new diagnostic paradigm for infectious disease. We built a pipeline for counting pathogen-derived cell-free molecules in human plasma and a web appli- cation for browsing the resulting data. We applied these tools to thousands of clin- ical samples collected from hundreds of patients at Stanford hospital. We further processed thousands of clinical test records in order to show that this method can be broadly applied for non-invasive monitoring of viral, bacterial, and fungal infec- tions in deep tissues. Finally, we show that unbiased pathogen monitoring using this technique can track infections that escape hypothesis-centric clinical testing. As well as demonstrating this new diagnostic application of NGS, we show how NGS technology can be used to understand infectious disease mechanism. We de- veloped a pipeline for counting of sequencing reads derived from RNA-protein in- teractions in vivo. We show that this method (CLIP-seq) can be applied to viruses that have infected human cells and use it to reveal novel interactions between the Hepatitis-C virus (HCV) genome and human protein PCBP2. We also applied this method to HERV-K, an endogenous retrovirus. We showed that human embryo development occurs in the presence of retroviral products, which may protect the embryo from exogenous infection and help regulate early development. We highlight three separate ways to validate results from mechanistic CLIP-seq experiments, including comparative analysis, replicate matching, and functional studies. We also developed a multiplexed RNA-protein interaction assay that is compatible with the scale of CLIP-seq experiments and exceeds the throughput of common biochemical assays. We applied this technology to a model RNA-protein interaction (histone stem-loop and stem loop binding protein), recapitulating two decades of biochemistry and revealing novel features of the interaction. In summary, we built computational tools that apply molecular counting to in- fectious disease diagnostics and mechanism. For validation of these results, we developed a novel microfluidic tool for high-throughput biophysical measurements.
Book Synopsis Molecular Tools and Infectious Disease Epidemiology by : Betsy Foxman
Download or read book Molecular Tools and Infectious Disease Epidemiology written by Betsy Foxman and published by Academic Press. This book was released on 2010-12-28 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Tools and Infectious Disease Epidemiology examines the opportunities and methodologic challenges in the application of modern molecular genetic and biologic techniques to infectious disease epidemiology. The application of these techniques dramatically improves the measurement of disease and putative risk factors, increasing our ability to detect and track outbreaks, identify risk factors and detect new infectious agents. However, integration of these techniques into epidemiologic studies also poses new challenges in the design, conduct, and analysis. This book presents the key points of consideration when integrating molecular biology and epidemiology; discusses how using molecular tools in epidemiologic research affects program design and conduct; considers the ethical concerns that arise in molecular epidemiologic studies; and provides a context for understanding and interpreting scientific literature as a foundation for subsequent practical experience in the laboratory and in the field. The book is recommended for graduate and advanced undergraduate students studying infectious disease epidemiology and molecular epidemiology; and for the epidemiologist wishing to integrate molecular techniques into his or her studies. Presents the key points of consideration when integrating molecular biology and epidemiology Discusses how using molecular tools in epidemiologic research affects program design and conduct Considers the ethical concerns that arise in molecular epidemiologic studies Provides a context for understanding and interpreting scientific literature as a foundation for subsequent practical experience in the laboratory and in the field
Book Synopsis Epidemiologic Methods for the Study of Infectious Diseases by : James C. Thomas
Download or read book Epidemiologic Methods for the Study of Infectious Diseases written by James C. Thomas and published by Oxford University Press. This book was released on 2001-03-22 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive text on the methodological issues in epidemiologic research on infectious diseases. It will be an invaluable resource both to students of epidemiology and to established researchers. The authors address such questions as: What needs to be considered when enrolling participants in a study of sexually transmitted diseases? What are common sources of measurement error in population-based studies of respiratory infections? What are some sources of existing data for epidemiologic studies of infectious diseases? Answers to these and many other related questions can be found in this well-organized, comprehensive and authoritative volume - the first to thoroughly address the methodologic issues in conducting epidimiologic research on infectious diseases. The book will be an ideal complement to texts on general epidemiology and infectious disease. An introductory section will make it accessible to a wide variety of disciplines by providing an overview of topics that are foundational to understanding infectious disease epidemiology, such as the immunology of infections, the biology of infectious diseases, and concepts of causation, transmission, and dynamics. The rest of the book is structured around sections on data sources and measurement; methods by transmission type; outbreak investigation and evaluation research; and special topics such as HIV/AIDS research, infections in the elderly, and research collaborations in developing countries.
Book Synopsis Molecular Epidemiology of Infectious Diseases by : Lee W. Riley
Download or read book Molecular Epidemiology of Infectious Diseases written by Lee W. Riley and published by . This book was released on 2004 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed as both a textbook and a reference, this book outlines the principles, methods, and application of this new discipline of public health. Techniques used in the field of molecular biology have been recognized as critical tools in solving infectious disease problems. This introductory volume, distinguishing molecular epidemiology from taxonomy and phylogeny, will familiarize epidemiologists with molecular biology and molecular biologists with epidemiology, and presents vocabulary and concepts of both fields to infectious disease clinicians.
Book Synopsis Molecular diagnostics for infectious diseases: Novel approaches, clinical applications and future challenges by : Xiaogang Xu
Download or read book Molecular diagnostics for infectious diseases: Novel approaches, clinical applications and future challenges written by Xiaogang Xu and published by Frontiers Media SA. This book was released on 2023-03-31 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Diagnosis of Infectious Diseases by : Jochen Decker
Download or read book Molecular Diagnosis of Infectious Diseases written by Jochen Decker and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Populations of the western world are now healthier and enjoying higher life expectancy than ever. They are beginning to benefit from an array of costly new therapies made possible through recent rapid advances in medical science and technology, and their demands on modern medicine are rising. Meanwhile, healthcare systems are struggling with their outdated legacy models of the m- th 20 century and are experiencing ever-increasing financial pressure from g- ernments and health insurance organizations. The equation is no longer in balance, and this predicament is forcing societies to explore new approaches to managing healthcare in the future. Since the first edition of Molecular Diagnosis of Infectious Diseases was published, we have witnessed the sequencing of the (almost) complete human genome and a shift in medical research from an emphasis on genetics to the advancement and useful application of proteomics. Bioinformatics has become the key tool for managing and analyzing the upsurge of data, and faster and more effective test methods and technologies have opened up new prospects for ind- try and academia. The tools of modern genomics and proteomics are now being utilized to specifically guide the discovery of drugs for the prevention, diagnosis, and treatment of human disease. They may also help us to find a way out of the current healthcare calamity.
Book Synopsis Handbook of Infectious Disease Data Analysis by : Leonhard Held
Download or read book Handbook of Infectious Disease Data Analysis written by Leonhard Held and published by CRC Press. This book was released on 2019-11-07 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen an explosion in new kinds of data on infectious diseases, including data on social contacts, whole genome sequences of pathogens, biomarkers for susceptibility to infection, serological panel data, and surveillance data. The Handbook of Infectious Disease Data Analysis provides an overview of many key statistical methods that have been developed in response to such new data streams and the associated ability to address key scientific and epidemiological questions. A unique feature of the Handbook is the wide range of topics covered. Key features Contributors include many leading researchers in the field Divided into four main sections: Basic concepts, Analysis of Outbreak Data, Analysis of Seroprevalence Data, Analysis of Surveillance Data Numerous case studies and examples throughout Provides both introductory material and key reference material
Book Synopsis Molecular Diagnostics of Infectious Diseases by : Harald H. Kessler
Download or read book Molecular Diagnostics of Infectious Diseases written by Harald H. Kessler and published by Walter de Gruyter. This book was released on 2010-05-27 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a unique way, the laboratory professionalist's knowledge about the molecular diagnostics of infectious diseases is connected with the clinician's practical experience. The increasing prevalence of infectious diseases makes correct diagnosis, ordering the right tests, quality control and correct interpretation of the results even more important. The possible pathogens are discussed in the second part according to the specific symptoms or to where the infection is located in the body. For clinicians and laboratory professionalists Up-to-date diagnostics of all infectious diseases Molecular diagnostics, diseases, choice of methods Specific pathogens in alphabetic order Tables and flow charts
Book Synopsis Mathematical Analysis of Infectious Diseases by : Praveen Agarwal
Download or read book Mathematical Analysis of Infectious Diseases written by Praveen Agarwal and published by Academic Press. This book was released on 2022-06-01 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical Analysis of Infectious Diseases updates on the mathematical and epidemiological analysis of infectious diseases. Epidemic mathematical modeling and analysis is important, not only to understand disease progression, but also to provide predictions about the evolution of disease. One of the main focuses of the book is the transmission dynamics of the infectious diseases like COVID-19 and the intervention strategies. It also discusses optimal control strategies like vaccination and plasma transfusion and their potential effectiveness on infections using compartmental and mathematical models in epidemiology like SI, SIR, SICA, and SEIR. The book also covers topics like: biodynamic hypothesis and its application for the mathematical modeling of biological growth and the analysis of infectious diseases, mathematical modeling and analysis of diagnosis rate effects and prediction of viruses, data-driven graphical analysis of epidemic trends, dynamic simulation and scenario analysis of the spread of diseases, and the systematic review of the mathematical modeling of infectious disease like coronaviruses. Offers analytical and numerical techniques for virus models Discusses mathematical modeling and its applications in treating infectious diseases or analyzing their spreading rates Covers the application of differential equations for analyzing disease problems Examines probability distribution and bio-mathematical applications
Book Synopsis Cases in Medical Microbiology and Infectious Diseases by : Peter H. Gilligan
Download or read book Cases in Medical Microbiology and Infectious Diseases written by Peter H. Gilligan and published by John Wiley & Sons. This book was released on 2020-08-06 with total page 605 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cases in Medical Microbiology and Infectious Diseases challenges students to develop a working knowledge of the variety of microorganisms that cause infections in humans. This valuable, interactive text will help them better understand the clinical importance of the basic science concepts presented in medical microbiology or infectious disease courses. The cases are presented as "unknowns" and represent actual case presentations of patients the authors have encountered. Each case is accompanied by several questions to test knowledge in four broad areas including the organism's characteristics and laboratory diagnosis; pathogenesis and clinical characteristics of the infection; epidemiology; and prevention and, in some cases, drug resistance and treatment. This new fourth edition includes: an entirely new section, "Advanced Cases," which includes newly recognized disease agents as well as highly complex cases where the interaction of the immune system and human pathogens can be more closely examined a revised "Primer on the Laboratory Diagnosis of Infectious Diseases" section that reflects the increasing importance of molecular-based assays Forty-two new cases that explore the myriad advances in the study of infectious disease in the past decade Thirty-two updated cases that reflect the current state of the art as it relates to the organism causing the infection This textbook also include specific tools to assist students in solving the cases, including a table of normal values, glossary of medical terms, and figures illustrating microscopic organism morphology, laboratory tests, and clinical symptoms. Cases in Medical Microbiology and Infectious Diseases is a proven resource for preparing for Part I of the National Board of Medical Examiners Exam and an excellent reference for infectious disease rotations.
Book Synopsis Bacteriology Methods for the Study of Infectious Diseases by : Rowena Jenkins
Download or read book Bacteriology Methods for the Study of Infectious Diseases written by Rowena Jenkins and published by Academic Press. This book was released on 2019-07-23 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bacteriology Methods for the Study of Infectious Diseases provides knowledge, understanding and experience of contemporary, robust methodologies for studies into the pathogenicity and virulence of human/animal bacterial pathogens. This book presents contemporary, yet widely utilized methodologies, for the study of pathogenicity and virulence in bacterial pathogens of human and/or animal origin. Protocols are clearly outlined, with lists of required equipment and reagents, alongside underpinning theory. This text will provide undergraduate and postgraduate students with practical guidance for dissertation projects with protocols for individual project ideas that can be developed further, hence a starting point for additional literature searches is also provided. Helps users research dissertations and interdisciplinary research projects Presents a valuable resource that enables researchers from diverse backgrounds to undertake research within the field of infectious diseases Summarizes protocols that give a fundamental start to research, but are highly adaptable or can be built upon and integrated into other methodologies Provides knowledge, understanding and experience of contemporary, robust methodologies for studies into the pathogenicity and virulence of human/animal bacterial pathogens
Book Synopsis Molecular Methods for Microbial Identification and Typing by : K.J. Towner
Download or read book Molecular Methods for Microbial Identification and Typing written by K.J. Towner and published by Springer Science & Business Media. This book was released on 2013-03-07 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: The accurate identification and typing of microbes is essential for workers active in all fields of microbiology. Many examples of modern molecular methods have been concealed in scientific and medical literature but this introductory text considers the possible applications of such methods and compares their advantages and disadvantages.
Book Synopsis Disease Control Priorities, Third Edition (Volume 6) by : King K. Holmes
Download or read book Disease Control Priorities, Third Edition (Volume 6) written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Book Synopsis Human Cytomegalovirus by : Thomas E. Shenk
Download or read book Human Cytomegalovirus written by Thomas E. Shenk and published by Springer Science & Business Media. This book was released on 2008-05-09 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume has gathered some of the experts in the field to review aspects of our understanding of CMV and to offer perspectives of the current problems associated with CMV. The editors and authors hope that the chapters will lead to a better understanding of the virus that will assist in the development of new and unique antivirals, a protective vaccine, and a full understanding of CMV's involvement in human disease.
Book Synopsis Analysis of Infectious Disease Problems (Covid-19) and Their Global Impact by : Praveen Agarwal
Download or read book Analysis of Infectious Disease Problems (Covid-19) and Their Global Impact written by Praveen Agarwal and published by Springer. This book was released on 2022-10-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume is a collection of selected research articles discussing the analysis of infectious diseases by using mathematical modelling in recent times. Divided into two parts, the book gives a general and country-wise analysis of Covid-19. Analytical and numerical techniques for virus models are presented along with the application of mathematical modelling in the analysis of their spreading rates and treatments. The book also includes applications of fractional differential equations as well as ordinary, partial and integrodifferential equations with optimization methods. Probability distribution and their bio-mathematical applications have also been studied. This book is a valuable resource for researchers, scholars, biomathematicians and medical experts.
Book Synopsis New Frontiers of Molecular Epidemiology of Infectious Diseases by : Serge Morand
Download or read book New Frontiers of Molecular Epidemiology of Infectious Diseases written by Serge Morand and published by Springer. This book was released on 2011-09-10 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular epidemiology has recently broaden its focuses due to the development of molecular tools but also by incorporating advances of other fields such as mathematical epidemiology, molecular ecology, population genetics and evolution. Facing new risks of emerging and re-emerging infectious diseases that are threats for humans and their livestock, the objectives of molecular epidemiology include: - the development of molecular tools, genotyping and gene expression - the incorporation of concepts and results of population genetics of infectious diseases - the integration of recent advances in theoretical epidemiology and evolutionary ecology of diseases - a better understanding of transmission for the development of risk factors analyses. This book will demonstrate how the latest developments in molecular tools and in epidemiology can be integrated with studies of host-pathogen interactions. Besides a strong theoretical component, there will also be an emphasis on applications in the fields of epidemiology, public health, veterinary medicine, and health ecology. Students and researchers in the fields of epidemiology, animal and human health, evolutionary ecology, parasitology are the main potential readers of the book, as well as a broader audience from veterinary medicine and conservation.
Author :N.G. (La Trobe University) Becker Publisher :Chapman & Hall/CRC Monographs on Statistics and Applied Probability ISBN 13 :9780367451073 Total Pages :234 pages Book Rating :4.4/5 (51 download)
Book Synopsis Analysis of Infectious Disease Data by : N.G. (La Trobe University) Becker
Download or read book Analysis of Infectious Disease Data written by N.G. (La Trobe University) Becker and published by Chapman & Hall/CRC Monographs on Statistics and Applied Probability. This book was released on 2019-12-03 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book gives an up-to-date account of various approaches availablefor the analysis of infectious disease data. Most of the methods havebeen developed only recently, and for those based on particularlymodern mathematics, details of the computation are carefullyillustrated. Interpretation is discussed at some length and the emphasisthroughout is on making statistical inferences about epidemiologicallyimportant parameters.Niels G. Becker is Reader in Statistics at La Trobe University, Australia
