Molecular Biology of Neurodegenerative Diseases: Visions for the Future

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Author :
Publisher : Academic Press
ISBN 13 : 0128178752
Total Pages : 410 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Molecular Biology of Neurodegenerative Diseases: Visions for the Future by :

Download or read book Molecular Biology of Neurodegenerative Diseases: Visions for the Future written by and published by Academic Press. This book was released on 2019-11-05 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of Neurodegenerative Diseases: Visions for the Future, Volume 168 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Alzheimer's disease, Prion-like propagation of alpha-synuclein, What - if anything - can we learn about neurodegenerative diseases from yeast?, Mitochondrial rejuvenation and replacement as a novel strategy for treatment of age-related neurodegenerative diseases, Propagation and removal of cerebral amyloid angiopathy, and much more. - Includes comprehensive coverage of molecular biology - Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided - Contains contributions from renowned experts in the field

Molecular Biology of Neurodegenerative Diseases: Visions for the Future - Part B

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Author :
Publisher : Academic Press
ISBN 13 : 0128241446
Total Pages : 222 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Molecular Biology of Neurodegenerative Diseases: Visions for the Future - Part B by :

Download or read book Molecular Biology of Neurodegenerative Diseases: Visions for the Future - Part B written by and published by Academic Press. This book was released on 2021-01-14 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of Neurodegenerative Diseases: Visions for the Future, Part B, Volume 177 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Alzheimer's disease, Prion-like propagation of alpha-synuclein, What - if anything - can we learn about neurodegenerative diseases from yeast?, Mitochondrial rejuvenation and replacement as a novel strategy for treatment of age-related neurodegenerative diseases, and more. - Includes comprehensive coverage of molecular biology - Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided - Contains contributions from renowned experts in the field

Alzheimer’s Disease Research

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Publisher : Springer Nature
ISBN 13 : 3031315707
Total Pages : 661 pages
Book Rating : 4.0/5 (313 download)

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Book Synopsis Alzheimer’s Disease Research by : Christian Behl

Download or read book Alzheimer’s Disease Research written by Christian Behl and published by Springer Nature. This book was released on 2023-08-14 with total page 661 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the key phases and central findings of Alzheimer’s Disease research since the introduction of the label ‘Alzheimer’s Disease’ in 1910. The author, Christian Behl, puts dementia research in the context of the respective zeitgeist and summarizes the paths that have led to the currently available Alzheimer’s drugs. As the reader is taken through the major developments in Alzheimer's Disease research, particularly over the past thirty years, Behl poses critical questions: Why are the exact causes of Alzheimer's Disease still in the dark, despite all the immense, worldwide research efforts in academia as well as in the pharmaceutical industry? Why has the majority of an entire research field kept focusing on a single hypothesis that establishes the deposition of the amyloid beta peptide in the brain as the key trigger of Alzheimer's pathology, even though this concept has still not been convincingly proven in the clinics? Are there other hypotheses that might explain the pathogenesis of this complex brain disease, and if so, why were these perspectives not adequately followed? In this book, Behl tries to answer these questions. Starting with the historical background, the author illustrates the long and arduous research journey, its numerous setbacks, and the many alternative explanations for the disease, which have started gaining increasing attention and acceptance in the Alzheimer’s research community only more recently. With his deep dive into the history and progression of this research, including the most recent developments, Behl explains why he believes that it is high time to promote a paradigm shift in Alzheimer’s Disease research. The book is written for all researchers in the fields of neurobiology and neurodegeneration, as well as other biomedical fields, who would like to gain a broad and beyond the surface insight into (the key developments of) one of the most promoted research fields of our time. With its extensive literature references and over 100 illustrations, the book is also attractive for students and interested lay persons. Elaborating on all the different aspects and research approaches of this research field, the author aims to convince the reader that the underlying causes of Alzheimer’s Disease may be much more complex than previously thought and that this must be considered for future research directions. While he hopes that the Alzheimer’s research community is finally ready to shed its ‘amyloid-straitjacket’ that has hampered progress for too long, he is also convinced that a much-needed paradigm shift can guide future Alzheimer’s Disease research and provide a new and broader perspective on this age-dependent brain disease.

Recent Advances in Parkinson's Disease

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Author :
Publisher : Elsevier
ISBN 13 : 0444642609
Total Pages : 578 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Recent Advances in Parkinson's Disease by :

Download or read book Recent Advances in Parkinson's Disease written by and published by Elsevier. This book was released on 2020-04-02 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Advances in Parkinson ́s Disease Research, Volume 252, represents a follow-up on two previous volumes presented in the Progress in Brain Research series, Volumes 193 and 193, both published in 2010. It contains a collection of overview articles written by leading researchers in Parkinson's, discussing the most important advances made in basic, translational and clinical research. Topics of note in this new release include What can we learn from iPS cell models of PD, What can we learn from animal models of PD?, Molecular basis of selective neuronal vulnerability in PD, Role of innate and adaptive immunity in Parkinson ́s disease, and much more.

Neurodegenerative Diseases

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Publisher : Springer Science & Business Media
ISBN 13 : 1461406536
Total Pages : 421 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Neurodegenerative Diseases by : Shamim I. Ahmad

Download or read book Neurodegenerative Diseases written by Shamim I. Ahmad and published by Springer Science & Business Media. This book was released on 2012-03-12 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.

Amino Acids, Electrochemical Reactions, Sensory Interactions, and Molecular Biology

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Author :
Publisher : SolveForce
ISBN 13 :
Total Pages : 350 pages
Book Rating : 4./5 ( download)

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Book Synopsis Amino Acids, Electrochemical Reactions, Sensory Interactions, and Molecular Biology by : Ron Legarski

Download or read book Amino Acids, Electrochemical Reactions, Sensory Interactions, and Molecular Biology written by Ron Legarski and published by SolveForce. This book was released on 2024-09-09 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Amino Acids, Electrochemical Reactions, Sensory Interactions, and Molecular Biology: Exploring Life’s Building Blocks" offers a comprehensive journey into the foundational elements of life, examining the intricate relationships between amino acids, electrochemical processes, and sensory systems. Written by Ron Legarski, this book explores how the molecular structures that make up our bodies interact with environmental factors to shape our health, perception, and biological functions. This detailed work provides a clear analysis of how amino acids serve as the building blocks of proteins, how electrochemical reactions power cellular functions, and how these processes are vital for sensory systems like vision, hearing, taste, and touch. By diving into the molecular biology behind these essential functions, Legarski explains the fundamental mechanisms that allow us to interact with the world around us. The book also delves into how environmental influences—such as toxins, pollutants, and climate factors—affect molecular and sensory systems, impacting everything from our neurological health to our immune responses. Through its exploration of gene expression, cellular communication, and electrochemical balance, this book connects the molecular basis of life to larger themes of human interaction and environmental adaptation. Accessible to both scientific and general audiences, "Amino Acids, Electrochemical Reactions, Sensory Interactions, and Molecular Biology" offers a valuable resource for students, researchers, and health professionals looking to deepen their understanding of molecular biology and its practical applications. Through clear explanations and expert insights, Ron Legarski sheds light on the unseen processes that drive life itself, from the micro to the macro level. This work serves as a crucial guide for understanding how the body’s internal molecular world interacts with external conditions, presenting a detailed exploration of life’s building blocks and how they influence everything from cellular function to sensory perception.

Advances in Blood Transfusion Research and Application: 2012 Edition

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Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464991618
Total Pages : 800 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Advances in Blood Transfusion Research and Application: 2012 Edition by :

Download or read book Advances in Blood Transfusion Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Blood Transfusion Research and Application / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Blood Transfusion. The editors have built Advances in Blood Transfusion Research and Application / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Blood Transfusion in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Blood Transfusion Research and Application / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Molecular Biology of Aging

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Author :
Publisher : Academic Press
ISBN 13 : 0128115335
Total Pages : 394 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Molecular Biology of Aging by :

Download or read book Molecular Biology of Aging written by and published by Academic Press. This book was released on 2017-02-18 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of Aging, the latest volume in the Progress in Molecular Biology and Translational Science series, focuses on placental development and disease. - Contains contributions from leading authorities on the topic - Publishes cutting-edge reviews in molecular biology

Frontotemporal Dementias

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Publisher : Springer Nature
ISBN 13 : 3030511405
Total Pages : 320 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Frontotemporal Dementias by : Bernardino Ghetti

Download or read book Frontotemporal Dementias written by Bernardino Ghetti and published by Springer Nature. This book was released on 2021-01-12 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Under the name of Frontotemporal Dementias (FTD) numerous hereditary and sporadic disorders are listed. FTD may take away speech and language, social skills and ethical judgement, wishes and will, empathy and emotions; it may also impair motor functions. FTD may affect men and women in midlife or during old age leading to the demolition of the uniqueness of the human mind. In the last decade of the 20th century and in the first two decades of the 21st century, progress in the understanding of clinical, neuropathological, biochemical, and genetic aspects of FTD has accelerated. The novel awareness about FTD has directed young generations of researchers toward the study of this complex group of disorders. This Volume has been formulated with the participation of some of the leading scientists who have contributed to the development of knowledge in the clinical and basic science arenas. It captures the current central elements that are relevant to an up-to-date understanding of causes and pathogenesis of multiple forms of FTD. The volume is an opus that represents a distillation of the work of many scientists and addresses the current directions in the study of one of the most complex groups of diseases. In view of its structure, the book could also be used as a textbook, that offers both a broad and deep analysis of major areas in FTD. This book, planned by the International Society for Frontotemporal Dementias, is distinctive as it opens a window to a wide landscape about the biology of FTD. Thus, the book represents a moment of reflection on the present state of our knowledge of FTD and a collective vision toward scientific progress. The authors of each chapter share their knowledge and vision aimed at reducing the suffering which is caused by FTD.

Regulatory RNAs in the Nervous System, 2nd Edition

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889456579
Total Pages : 346 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Regulatory RNAs in the Nervous System, 2nd Edition by : Tommaso Pizzorusso

Download or read book Regulatory RNAs in the Nervous System, 2nd Edition written by Tommaso Pizzorusso and published by Frontiers Media SA. This book was released on 2018-11-13 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Until about a decade ago, the non-coding part of the genome was considered without function. RNA sequencing studies have shown, however, that a considerable part of the non-coding genome is transcribed and that these non-coding RNAs (nc-RNAs) can regulate gene expression. Almost on weekly basis, new findings reveal the regulatory role of nc-RNAs exert in many biological processes. Overall, these studies are making increasingly clear that, both in model organisms and in humans, complexity is not a function of the number of protein-coding genes, but results from the possibility of using combinations of genetic programs and controlling their spatial and temporal regulation during development, senescence and in disease by regulatory RNAs. This has generated a novel picture of gene regulatory networks where regulatory nc-RNAs represent novel layers of regulation. Particularly well-characterized is the role of microRNAs (miRNAs), small nc-RNAs, that bind to mRNAs and regulate gene expression after transcritpion. This message is particularly clear in the nervous system, where miRNAs have been involved in regulating cellular pathways controlling fundamental functions during development, synaptic plasticity and in neurodegenerative disease. It has also been shown that neuronal miRNAs are tightly regulated by electrical activity at the level of transcription, biogenesis, stability and specifically targeted to dendrites and synapses. Deregulation of expression of miRNAs is proposed not only as potential disease biomarker, but it has been implicated directly in the pathogenesis of complex neurodegenerative disease. This so-called RNA revolution also lead to the exploitation of RNA interference and the development of related tools as potential treatment of a vast array of CNS disease that could benefit from regulation of disease-associated genes. In spite of these advancements, the relatively young age of this field together with the inherent high molecular complexity of RNA regulation of biological processes have somewhat hindered its communication to the whole of the neuroscience community. This Research Topic aims at improving this aspect by putting around the same virtual table scientists covering aspects ranging from basic molecular mechanisms of regulatory RNAs in the nervous system to the analysis of the role of specific regulatory RNAs in neurobiological processes of development, plasticity and aging. Furthermore, we included papers analyzing the role of regulatory RNAs in disease models from neuromuscular to higher cognitive functions, and more technically oriented papers dealing with new methodologies to study regulatory RNA biology and its translational potential.

Multiple Sclerosis

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Publisher : National Academies Press
ISBN 13 : 0309072859
Total Pages : 457 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Multiple Sclerosis by : Institute of Medicine

Download or read book Multiple Sclerosis written by Institute of Medicine and published by National Academies Press. This book was released on 2001-08-10 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.

Molecular Epidemiology

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Publisher : Academic Press
ISBN 13 : 0323138578
Total Pages : 609 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Molecular Epidemiology by : Paul A. Schulte

Download or read book Molecular Epidemiology written by Paul A. Schulte and published by Academic Press. This book was released on 2012-12-02 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.

Organelle and Molecular Targeting

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Author :
Publisher : CRC Press
ISBN 13 : 1000505936
Total Pages : 511 pages
Book Rating : 4.0/5 (5 download)

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Book Synopsis Organelle and Molecular Targeting by : Lara Scheherazade Milane

Download or read book Organelle and Molecular Targeting written by Lara Scheherazade Milane and published by CRC Press. This book was released on 2021-12-27 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: We have surpassed the omics era and are truly in the Age of Molecular Therapeutics. The fast-paced development of SARS-CoV-2 vaccines, such as the mRNA vaccines encoding the viral spike protein, demonstrated the need for and capability of molecular therapy and nanotechnology-based solutions for drug delivery. In record speed, the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community, allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enable the delivery of the fragile, degradation-sensitive nucleic acid payloads. Molecular-based therapeutics and nanotechnology solutions continue to drive the scientific and medical response to the COVID-19 pandemic as new mRNA, DNA, and protein-based vaccines are developed and approved and the emergency use approved vaccines are rapidly manufactured and distributed throughout the globe. The need for molecular therapies and drug delivery solutions is clear, and as these therapies progress and become more specialized there will be important advancements in organelle targeting. For example, using organelle targeting to direct lipid nanoparticles with mRNA payloads to the endoplasmic reticulum would increase the efficacy of mRNA vaccines, reducing the required dose and therefore the biomanufacturing demand. Likewise, improving the delivery of DNA therapeutics to the nucleus would improve efficacy. Organelles and molecules have always been drug targets, but until recently we have not had the tools or capability to design and develop such highly specific therapeutics. Organelle targeting has far-reaching implications. For example, mitochondria are central to both energy production and intrinsic apoptosis. Effectively targeting and manipulating mitochondria has therapeutic applications for diseases such as myopathies, cancer, neurodegeneration, progerias, diabetes, and the natural aging process. The SARS-CoV-2 vaccines that exploit the endoplasmic reticulum (for mRNA vaccines) and the nucleic translational process (DNA vaccines) attest to the need for organelle and molecular therapeutics. This book covers the status, demand, and future of organelle- and molecularly targeted therapeutics that are critical to the advancement of modern medicine. Organelle and molecular targeting is the drug design and drug delivery approach of today and the future; understanding this approach is essential for students, scientists, and clinicians contributing to modern medicine.

The Neurobiology of Aging and Alzheimer Disease in Down Syndrome

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Author :
Publisher : Academic Press
ISBN 13 : 0128188464
Total Pages : 354 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis The Neurobiology of Aging and Alzheimer Disease in Down Syndrome by : Elizabeth Head

Download or read book The Neurobiology of Aging and Alzheimer Disease in Down Syndrome written by Elizabeth Head and published by Academic Press. This book was released on 2021-08-31 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena. - Discusses the complexities involved with aging and Alzheimer's disease in Down syndrome - Summarizes the neurobiology of aging that requires management in adults with DS and leads to healthier aging and better quality of life into old age - Serves as learning tool to orient researchers to the key challenges and offers insights to help establish critical areas of need for further research

Neuronal Cell Death

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Author :
Publisher : Humana Press
ISBN 13 : 9781493921515
Total Pages : 0 pages
Book Rating : 4.9/5 (215 download)

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Book Synopsis Neuronal Cell Death by : Laura Lossi

Download or read book Neuronal Cell Death written by Laura Lossi and published by Humana Press. This book was released on 2014-11-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume represents a valuable and readily reproducible collection of established and emerging techniques for neuronal cell death research. Conveniently divided into four parts, sections cover a series of techniques for the molecular, structural, functional and genomic characterization of dying neurons, a number of protocols that are of primary interest in neuropathology and in experimental neuropathology, a series of gene engineering techniques to obtain and manipulate neuronal stem cells and progenitors, to prepare HSV-1 vectors for the gene therapy, and to CNS transplantation of bone marrow stem cells, and finally, some very interesting protocols for the study of cell death in non-mammalian models. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Neuronal Cell Death: Methods and Protocols seeks to serve a large audience of scientists that are currently active in the field or are willing to enter such an exciting and still expanding area of neurobiology.

Scientific Report

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Publisher :
ISBN 13 :
Total Pages : 372 pages
Book Rating : 4.3/5 (555 download)

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Book Synopsis Scientific Report by : Scripps Research Institute

Download or read book Scientific Report written by Scripps Research Institute and published by . This book was released on 2004 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Contemporary Topics about Phosphorus in Biology and Materials

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Author :
Publisher : BoD – Books on Demand
ISBN 13 : 1789850398
Total Pages : 216 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Contemporary Topics about Phosphorus in Biology and Materials by : David Churchill

Download or read book Contemporary Topics about Phosphorus in Biology and Materials written by David Churchill and published by BoD – Books on Demand. This book was released on 2020-09-09 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses a diverse set of topics regarding phosphorus chemistry, namely phosphates and closely related chemical systems. Divided into two sections, chapters cover such topics as phosphate dynamics and phosphates in biomaterials. This volume is a useful reference for scholars and researchers and will inspire readers to make future discoveries in the field.