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Download or read book Molecular Basis of Cell Adhesion Mechanics written by and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Martin E. Hemler
Publisher : Springer Science & Business Media
ISBN 13 : 1461528305
Total Pages : 292 pages
Book Rating : 4.4/5 (615 download)
Download or read book Cell Adhesion Molecules written by Martin E. Hemler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fourth Annual Pezcoller Symposium entitled Adhesion Molecules: Cellular Recognition Mechanisms was held in Rovereto, Italy, June 24-26, 1992 and was focussed on the detailed mechanisms whereby cells utilize certain integral membrane proteins to perceive their surrounding environment and interact with it. With timely presentations and stimulating discussions this Symposium addressed the genetics and biochemistry of adhesion molecules, the regulation of their functions and their role in cancer and the immune system. Emphasis was given to adhesion proteins in the integrin family because of the widespread distribution of this group of molecules and its important role in essentially all eukaryotic biological systems. The regulation of integrin genes and their expression are discussed in detail, as are specific aspects of the genetics of fibronectin. The molecular basis for the regulation of certain integrins, the function of these proteins in determining cell adhesion, and the consequences of this adhesion for the function of the cells involved are discussed. The role of certain integrins in stimulating signal transduction, the essential involvement of integrins in conditioning the function of T and NK cells function, the heterogeneity of integrins and its biological consequences, and the role of cell adhesion molecules in tumor cells invasion and metastases are all extensively analyzed. New information was presented on the role of CD44 and splice variants in normal differentiation and tumor progression.
Author : Michael A. Horton
Publisher :
ISBN 13 :
Total Pages : 272 pages
Book Rating : 4.3/5 (91 download)
Download or read book Molecular Biology of Cell Adhesion Molecules written by Michael A. Horton and published by . This book was released on 1996-12-16 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This series is designed to bridge the gap between pure research in the biomedical sciences and its practical application in clinical medicine. The objective is to promote the understanding of the molecular basis of human physiology and disease, and new techniques for diagnosis and treatment. Primarily intended for graduate students of medicine, the books will also be of use to molecular biologists, biochemists, physiologists, pharmacologists and biotechnologists, as well as medical practitioners and technicians who seek to update their knowledge. There has been an explosion of interest in adhesion molecules in recent years and this has led to a greater understanding of cell behaviour in physiological and pathological situations. What has become increasingly clear is that data from enquiry-based research are eminently suited to be translated into applied clinical research. This timely and informative book introduces the topic of cell adhesion to the non-specialist and signifies areas where continuing research may yield results of clinical benefit. It will appeal to a wide audience including clinicians and postgraduate researchers in immunology and molecular biology and those involved in rheumatology, dermatology, gastroenterology, cardiology and haematology.
Author : Pierre Bongrand
Publisher : CRC Press
ISBN 13 : 135108402X
Total Pages : 283 pages
Book Rating : 4.3/5 (51 download)
Download or read book Physical Basis of Cell-Cell Adhesion written by Pierre Bongrand and published by CRC Press. This book was released on 2018-02-01 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Present book is aimed at providing a readable account of physical methods and results required to measure cell adhesion and interpret experimental data. Since on the one hand readability seemed a major quality for a book, and on the other hand, the problems posed referred to a wide range of domains of physics, chemistry, and biology, completeness had to sacrificed. Indeed, a whole book would not suffice to quote the relevant literature (and many more authors would be required to have read it). Hence, only a limited number of topics were selected for reliability of methods, availability of enough experimental results to illustrate basic conception or potential use in the future. These were discussed in three sections.
Author : Marie Mildred Roberson
Publisher :
ISBN 13 :
Total Pages : 162 pages
Book Rating : 4.:/5 (14 download)
Download or read book Molecular Basis of Cell-cell Adhesion in Amphibian Embryos written by Marie Mildred Roberson and published by . This book was released on 1979 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Van C. Mow
Publisher : Springer Science & Business Media
ISBN 13 : 1461384257
Total Pages : 571 pages
Book Rating : 4.4/5 (613 download)
Download or read book Cell Mechanics and Cellular Engineering written by Van C. Mow and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell mechanics and cellular engineering may be defined as the application of principles and methods of engineering and life sciences toward fundamental understanding of structure-function relationships in normal and pathological cells and the development of biological substitutes to restore cellular functions. This definition is derived from one developed for tissue engineering at a 1988 NSF workshop. The reader of this volume will see the definition being applied and stretched to study cell and tissue structure-function relationships. The best way to define a field is really to let the investigators describe their areas of study. Perhaps cell mechanics could be compartmentalized by remembering how some of the earliest thinkers wrote about the effects of mechanics on growth. As early as 1638, Galileo hypothesized that gravity and of living mechanical forces place limits on the growth and architecture organisms. It seems only fitting that Robert Hooke, who gave us Hooke's law of elasticity, also gave us the word "cell" in his 1665 text, Micrographid, to designate these elementary entities of life. Julius Wolffs 1899 treatise on the function and form of the trabecular architecture provided an incisive example of the relationship between the structure of the body and the mechanical load it bears. In 1917, D' Arcy Thompson's On Growth and Form revolutionized the analysis of biological processes by introducing cogent physical explanations of the relationships between the structure and function of cells and organisms.
Author : Roland Kaunas
Publisher : CRC Press
ISBN 13 : 1466553812
Total Pages : 380 pages
Book Rating : 4.4/5 (665 download)
Download or read book Cell and Matrix Mechanics written by Roland Kaunas and published by CRC Press. This book was released on 2014-10-23 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explores a Range of Multiscale Biomechanics/Mechanobiology Concepts Cell and Matrix Mechanics presents cutting-edge research at the molecular, cellular, and tissue levels in the field of cell mechanics. This book involves key experts in the field, and covers crucial areas of cell and tissue mechanics, with an emphasis on the roles of mechanical forces in cell–matrix interactions. Providing material in each chapter that builds on the previous chapters, it effectively integrates length scales and contains, for each length scale, key experimental observations and corresponding quantitative theoretical models. Summarizes the Three Hierarchical Levels of Cell Mechanics The book contains 14 chapters and is organized into three sections. The first section focuses on the molecular level, the second section details mechanics at the cellular level, and the third section explores cellular mechanics at the tissue level. The authors offer a thorough description of the roles of mechanical forces in cell and tissue biology, and include specific examples. They incorporate descriptions of associated theoretical models, and provide the data and modeling framework needed for a multi-scale analysis. In addition, they highlight the pioneering studies in cell–matrix mechanics by Albert K. Harris. The topics covered include: The passive and active mechanical properties of cytoskeletal polymers and associated motor proteins along with the behavior of polymer networks The mechanical properties of the cell membrane, with an emphasis on membrane protein activation caused by membrane forces The hierarchical organization of collagen fibrils, revealing that a delicate balance exists between specific and nonspecific interactions to result in a structure with semicrystalline order as well as loose associations The roles of matrix mechanical properties on cell adhesion and function along with different mechanical mechanisms of cell–cell interactions The effects of mechanical loading on cell cytoskeletal remodeling, summarizing various modeling approaches that explain possible mechanisms regulating the alignment of actin stress fibers in response to stretching The mechanical testing of cell-populated collagen matrices, along with theory relating the passive and active mechanical properties of the engineered tissues Cell migration behavior in 3-D matrices and in collective cell motility The role of mechanics in cartilage development The roles of both cellular and external forces on tissue morphogenesis The roles of mechanical forces on tumor growth and cancer metastasis Cell and Matrix Mechanics succinctly and systematically explains the roles of mechanical forces in cell–matrix biology. Practitioners and researchers in engineering and physics, as well as graduate students in biomedical engineering and mechanical engineering related to mechanobiology, can benefit from this work.
Author : Jürgen Bereiter-Hahn
Publisher : Springer Science & Business Media
ISBN 13 : 3642728634
Total Pages : 304 pages
Book Rating : 4.6/5 (427 download)
Download or read book Cytomechanics written by Jürgen Bereiter-Hahn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic information determines the composition of molecules comprising cytoskeletal elements, membranes and receptors. The supramolecular arrangement of these components represents a self-assembly process controlled by physicochemical and mechanical interactions. This general hypothesis demarcates the aim of studying cellular mechanics. Description and evaluation of mechanical properties of cells and their organelles, as well as of the forces exerted by them, is the scope of this book on Cytomechanics. Emphasis is laid on the role of mechanical properties in the generation of shape and cytoplasmic motion, and on the basic principles and components determining mechanical properties.
Author : Yu-Li Wang
Publisher : Academic Press
ISBN 13 : 0080548709
Total Pages : 629 pages
Book Rating : 4.0/5 (85 download)
Download or read book Cell Mechanics written by Yu-Li Wang and published by Academic Press. This book was released on 2007-07-05 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell mechanics is the field of study that looks at how cells detect, modify, and respond to the physical properties of the cell environment. Cells communicate with each other through chemical and physical signals which are involved in a range of process from embryogenesis and wound healing to pathological conditions such as cancerous invasion. Similar principles are also likely to be critical for success in regenerative medicine. Cell mechanics is thus central to understanding these principles. As cell mechanics draws from the fields of biology, chemistry, physics, engineering, and mathematics, this book aims not only to provide a collection of research methods, but also to develop a common language among scientists who share the interest in cell mechanics but enter the field with diverse backgrounds. To this end all of the contributing authors have sought to explain in plain language the nature of the biological problems, the rationale for the approaches, in addition to the methods themselves. In addition, to balance practical utility against conceptual advances, Cell Mechanics has intentionally included both chapters that provide detailed recipes and those that emphasize basic principles. Presents a distinctive emphasis on matrix mechanics and their interplay with cell functions Includes highly significant topics relevant to basic and translational research, as well as tissue engineering Emphasizes mechanical input and output of cells
Author : Yifat Levy
Publisher :
ISBN 13 :
Total Pages : 130 pages
Book Rating : 4.:/5 (884 download)
Download or read book The Molecular Basis for Modulation of Cell Adhesion and Cell Growth Induced by Galectin-8 written by Yifat Levy and published by . This book was released on 2002 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Basis of Cellular Adhesion written by and published by . This book was released on 1990 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Claudia Tanja Mierke
Publisher : Springer Nature
ISBN 13 : 3030585328
Total Pages : 919 pages
Book Rating : 4.0/5 (35 download)
Download or read book Cellular Mechanics and Biophysics written by Claudia Tanja Mierke and published by Springer Nature. This book was released on 2020-10-30 with total page 919 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the mechanical properties of cells, discussing the basic concepts and processes in the fields of immunology, biology, and biochemistry. It introduces and explains state-of-the-art biophysical methods and examines the role of mechanical properties in the cell/protein interaction with the connective tissue microenvironment. The book presents a unique perspective on cellular mechanics and biophysics by combining the mechanical, biological, physical, biochemical, medical, and immunological views, highlighting the importance of the mechanical properties of cells and biophysical measurement methods. The book guides readers through the complex and growing field of cellular mechanics and biophysics, connecting and discussing research findings from different fields such as biology, cell biology, immunology, physics, and medicine. Featuring suggestions for further reading throughout and addressing a wide selection of biophysical topics, this book is an indispensable guide for graduate and advanced undergraduate students in the fields of cellular mechanics and biophysics.
Author : Henrik Flyvbjerg
Publisher : Springer Science & Business Media
ISBN 13 : 3540457011
Total Pages : 591 pages
Book Rating : 4.5/5 (44 download)
Download or read book Physics of Bio-Molecules and Cells written by Henrik Flyvbjerg and published by Springer Science & Business Media. This book was released on 2003-07-01 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aimed at those working to enter this rapidly developing field, this volume on biological physics is written in a pedagogical style by leading scientists giving explanations that take their starting point where any physicist can follow and end at the frontier of research in biological physics. These lectures describe the state-of-the-art physics of biomolecules and cells. In biological systems ranging from single biomolecules to entire cells and larger biological systems, it focuses on aspects that require concepts and methods from physics for their analysis and understanding, such as the mechanics of motor proteins; how the genetic code is physically read and managed; the machinery of protein--DNA interactions; force spectroscopy of biomolecules' velopes, cytoskeletons, and cytoplasms; polymerization forces; listeria propulsion; cell motility; lab-on-a-chip nanotechnology for single-molecule analysis of biomolecules; bioinformatics; and coding and computational strategies of the brain.
Author : Hengameh Shams
Publisher :
ISBN 13 :
Total Pages : 167 pages
Book Rating : 4.:/5 (957 download)
Download or read book Molecular Mechanisms of Mechanosensitivity in Focal Adhesions written by Hengameh Shams and published by . This book was released on 2016 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physical environment guides tissue regeneration and morphology in both health and disease. In the past three decades, several experiments illustrated that mechanical cues are captured and transduced to biochemical signals in the cellular level (mechanotransduction) mediated by cell adhesion. Cells adhere to their microenvironment through large protein assemblies known as focal adhesions that directly couple intra- and extra-cellular matrices and play a critical role in many vital cell functions including proliferation, differentiation and cell fate. It is inherently difficult to investigate the molecular basis of focal adhesion formation and growth using current experimental methodologies due to the fine time- and length-scales of protein-protein interactions. Here, I used molecular dynamics simulations to investigate the underlying molecular mechanisms of focal adhesion formation and maturation with atomic resolution. Integrins are key focal adhesion receptors that reside on the cell membrane and mediate bi-directional signaling between cell cytoskeleton and ECM. Focal adhesions are a mixture of integrin-associated protein complexes known as integrin modules that forms the basic adhesion units. Integrin module formation is initiated by talin binding to the integrin tail, which is shown to be sufficient for integrin activation. A few other focal adhesion proteins can also directly engage with integrin's cytoplasmic tail and link it to the actin cytoskeleton. It is not yet clear how simultaneous (cooperative) versus sequential (competitive) binding of focal adhesion proteins to integrin with respect to talin result in different functionalities of integrin modules. In the first part of this study, competitive versus cooperative integrin binding between two important focal adhesion proteins -filamin and [alpha]-actinin- with talin were studied. The purpose of this aim was to gain insight on integrin module formation that eventually determines its functional properties. Maturation of focal adhesions follows an increase in local forces. A well-established hypothesis on force transmission across focal adhesion complexes is the presence of mechanosensitive elements that change their conformations in response to force. In the second part of this study, we investigated and argued force-induced conformational changes of two important focal adhesion proteins -vinculin and [alpha]-actinin- in order to shed light on their role in transmission of forces across focal adhesions leading to adhesion maturation and growth. In conclusion, this study unravels the structural basis of mechanosensitivity of key focal adhesions. Furthermore, important molecular interactions that give rise to mechanosensitivite characteristics of focal adhesions were studies. Important impacts of the current study include but are not limited to the following: 1) our results was used to complement previous experimental studies and also construct new hypotheses for future experiments; 2) Understanding regulatory mechanisms of focal adhesions is critical for developing novel therapeutics for many diseases involving cell adhesion including cancer as it enhances target recognition and the accuracy of drug delivery systems. 3) In addition, performing extensive simulations on protein complexes will contribute to improving the accuracy of various aspects of computational methods including empirical force fields that is indicative of our understanding of fundamental physical and chemical principles governing protein-protein interactions. 4) And most importantly, this work provides a fundamental insight into the relation between structure and function of mechanosensitive proteins in focal adhesions.
Author : Takaaki Matsui
Publisher : Frontiers Media SA
ISBN 13 : 2889456943
Total Pages : 122 pages
Book Rating : 4.8/5 (894 download)
Download or read book Cell Adhesion and Migration in the Development of Multicellular Organisms written by Takaaki Matsui and published by Frontiers Media SA. This book was released on 2019-01-24 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: During development, cells are generated at specific locations within the embryo and then migrate into their destinations. At their destinations, they assemble together through cell adhesions, eventually leading to the formation of tissues and organs. In some cases, orchestration of cell adhesion and migration produces the global movement of cell groups, called collective cell migration, which is also required for the development of basic tissue structures such as spheres, clusters, and vesicles in the morphogenetic processes of development. Therefore, individual regulation and orchestration of cell adhesion and migration are quite important for appropriate tissue/organ formation during development. However, how cell adhesion and migration are regulated, and orchestrated during development? How cell adhesion and migration affects tissue formation during development? To answer these questions, we assembled several review and research articles in this eBook. By assembling these articles, we could explore the presence of core regulatory mechanisms and deepen the current understanding of cell adhesion and migration during the development of multicellular organisms.
Author : Eric Wong
Publisher : Axolotl Academic Publishing
ISBN 13 : 0985226110
Total Pages : 283 pages
Book Rating : 4.9/5 (852 download)
Download or read book Cells: Molecules and Mechanisms written by Eric Wong and published by Axolotl Academic Publishing. This book was released on 2009 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Yet another cell and molecular biology book? At the very least, you would think that if I was going to write a textbook, I should write one in an area that really needs one instead of a subject that already has multiple excellent and definitive books. So, why write this book, then? First, it's a course that I have enjoyed teaching for many years, so I am very familiar with what a student really needs to take away from this class within the time constraints of a semester. Second, because it is a course that many students take, there is a greater opportunity to make an impact on more students' pocketbooks than if I were to start off writing a book for a highly specialized upper- level course. And finally, it was fun to research and write, and can be revised easily for inclusion as part of our next textbook, High School Biology."--Open Textbook Library.
