Molecular and Evolutionary Genetics of the Segregation Distorter System of Meiotic Drive in Drosophila Melanogaster

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ISBN 13 :
Total Pages : 272 pages
Book Rating : 4.:/5 (86 download)

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Book Synopsis Molecular and Evolutionary Genetics of the Segregation Distorter System of Meiotic Drive in Drosophila Melanogaster by : Michael F. Palopoli

Download or read book Molecular and Evolutionary Genetics of the Segregation Distorter System of Meiotic Drive in Drosophila Melanogaster written by Michael F. Palopoli and published by . This book was released on 1995 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Evolutionary Genetics of Recombination and Segregation in Drosophila

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Publisher :
ISBN 13 :
Total Pages : 123 pages
Book Rating : 4.:/5 (112 download)

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Book Synopsis The Evolutionary Genetics of Recombination and Segregation in Drosophila by : Cara L.. Brand

Download or read book The Evolutionary Genetics of Recombination and Segregation in Drosophila written by Cara L.. Brand and published by . This book was released on 2018 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: "During meiosis, sexually reproducing eukaryotes exchange genetic material via recombination and segregate homologous chromosomes into gametes. Surprisingly, some genes involved in meiotic recombination and chromosomal segregation experience frequent evolutionary turnover. Growing evidence suggests selfish genetic elements? DNA entities that promote their own transmission at the expense of other genes in the genome? are a significant evolutionary force driving rapid molecular evolution at genes involved in an otherwise conserved biological process. The research in this dissertation integrates classical, molecular, and population genetics to study the evolution of recombination rates and biased chromosomal segregation in Drosophila. First, in Chapters 2-4, I focus on the evolution of recombination rates in Drosophila. In Chapter 2, I perform an evolutionary screen to identify a meiosis gene with a history of recurrent positive selection that might contribute to differences in the rate of crossing over between two closely related Drosophila species. I then use a transgenic approach to show this gene, mei-217/mei-218, mediates the species differences in the rate and patterning of crossing over. In Chapter 3, I use further transgenic analyses to functionally dissect mei-217/mei-218 to determine which gene regions control the species differences in crossing over. In Chapter 4, I explore the long-term molecular evolution of mei-217/mei-218 and find evidence for frequent positive selection during the phylogenetic history of Drosophila. I find that mei-217/mei-218 wildtype alleles of two additional Drosophila species have also functionally diverged in their control of crossing over. I speculate that recurrent bouts of adaptive functional evolution at mei-217/-218 might reflect a history of coevolution with selfish genetic elements. Next, in Chapter 5, I turn to the evolution of a meiotic drive system, Segregation Distorter, that causes biased segregation in Drosophila melanogaster. I use molecular and population genetic tools to investigate the age, geographic origins, and population dynamics of Segregation Distorter chromosomes. I find that despite its stable frequency, Segregation Distorter chromosomes experience frequent selective sweeps and replacement events."--Pages xi-xii.

Cytological and Genetic Observations of Meiotic Drive in Drosophila Melanogaster

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ISBN 13 :
Total Pages : 150 pages
Book Rating : 4.3/5 (129 download)

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Book Synopsis Cytological and Genetic Observations of Meiotic Drive in Drosophila Melanogaster by : Mary Fae Rengo

Download or read book Cytological and Genetic Observations of Meiotic Drive in Drosophila Melanogaster written by Mary Fae Rengo and published by . This book was released on 1969 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Gene Drives on the Horizon

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Publisher : National Academies Press
ISBN 13 : 0309437873
Total Pages : 231 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Gene Drives on the Horizon by : National Academies of Sciences, Engineering, and Medicine

Download or read book Gene Drives on the Horizon written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-08-28 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.

Meiotic Drive and Rapid Genome Evolution in Drosophila

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ISBN 13 :
Total Pages : 212 pages
Book Rating : 4.:/5 (133 download)

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Book Synopsis Meiotic Drive and Rapid Genome Evolution in Drosophila by : Ching-Ho Chang (Biologist)

Download or read book Meiotic Drive and Rapid Genome Evolution in Drosophila written by Ching-Ho Chang (Biologist) and published by . This book was released on 2020 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Genes in a genome do not always play as an orchestra. Selfish meiotic drivers play by their own rules and can spread in populations - either killing other sperm during male meiosis or segregating preferentially into eggs during female meiosis to bias their transmission. Meiotic drivers generally arise in heterochromatic regions, which are also enriched for structural variations, e.g., inversions and translocations. Meiotic drivers frequently segregate with these structural variations, which may offer short-term advantages with long-term consequences. My dissertation shows how meiotic drivers shape genome evolution by enabling new structural variations to overcome their own deleterious effects and persist in populations. I first assessed the impact of inversions and complex epistasis between genetic modifiers on known male driving chromosomes, Segregation Distorter (SD), in D. melanogaster. By surveying the driving effect of a marked SD chromosome in 90 inbred lines from a population from North Carolina (DGRP), we determined that multiple genetic modifiers affect the driving ability of SD chromosomes and suppressors are widespread (74%) on X and autosomes. I found that a North American X-linked suppressor has distinct effects on SD chromosomes that are from the same population, but bear different inversions. This suggests that SDs might acquire genetic modifiers through chromosomal inversions to escape suppressors. To ask how meiotic drive shape the structural divergence, I investigated rapid genomic rearrangements on previously unassembled Y chromosomes and centromeric regions among species that diverged just 0.2-2 MYA by combining long-read sequencing and cytological mapping. I discovered two new Y-linked gene families, which amplified more than 40 times on the Y chromosome, and two new centromeric repeats expanded in the D. simulans clade. Intriguingly, similar Y-linked gene families cause male meiotic drive, and expansions of centromeric repeats cause female meiotic drive in other systems. My sequence analyses revealed that potential drivers could arise with massive genomic rearrangements. Together, my results provide evidence of links between rapid genomic rearrangements and the evolution of meiotic drive"--Pages xi-xii

Genes in Conflict

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Publisher : Harvard University Press
ISBN 13 : 0674029119
Total Pages : 613 pages
Book Rating : 4.6/5 (74 download)

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Book Synopsis Genes in Conflict by : Austin BURT

Download or read book Genes in Conflict written by Austin BURT and published by Harvard University Press. This book was released on 2009-06-30 with total page 613 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering all species from yeast to humans, this is the first book to tell the story of selfish genetic elements that act narrowly to advance their own replication at the expense of the larger organism.

Encyclopedia of Evolutionary Biology

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Publisher : Academic Press
ISBN 13 : 0128004266
Total Pages : 2138 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Encyclopedia of Evolutionary Biology by :

Download or read book Encyclopedia of Evolutionary Biology written by and published by Academic Press. This book was released on 2016-04-14 with total page 2138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Evolutionary Biology, Four Volume Set is the definitive go-to reference in the field of evolutionary biology. It provides a fully comprehensive review of the field in an easy to search structure. Under the collective leadership of fifteen distinguished section editors, it is comprised of articles written by leading experts in the field, providing a full review of the current status of each topic. The articles are up-to-date and fully illustrated with in-text references that allow readers to easily access primary literature. While all entries are authoritative and valuable to those with advanced understanding of evolutionary biology, they are also intended to be accessible to both advanced undergraduate and graduate students. Broad topics include the history of evolutionary biology, population genetics, quantitative genetics; speciation, life history evolution, evolution of sex and mating systems, evolutionary biogeography, evolutionary developmental biology, molecular and genome evolution, coevolution, phylogenetic methods, microbial evolution, diversification of plants and fungi, diversification of animals, and applied evolution. Presents fully comprehensive content, allowing easy access to fundamental information and links to primary research Contains concise articles by leading experts in the field that ensures current coverage of each topic Provides ancillary learning tools like tables, illustrations, and multimedia features to assist with the comprehension process

Encyclopedia of Genetics

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Publisher :
ISBN 13 : 9780122270826
Total Pages : 620 pages
Book Rating : 4.2/5 (78 download)

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Book Synopsis Encyclopedia of Genetics by : Sydney Brenner

Download or read book Encyclopedia of Genetics written by Sydney Brenner and published by . This book was released on 2002 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genetic Control of Malaria and Dengue

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Publisher : Academic Press
ISBN 13 : 0128004053
Total Pages : 487 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Genetic Control of Malaria and Dengue by : Zach N. Adelman

Download or read book Genetic Control of Malaria and Dengue written by Zach N. Adelman and published by Academic Press. This book was released on 2015-10-15 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Control of Malaria and Dengue focuses on the knowledge, technology, regulation and ethics of using genetically modified mosquitoes to interrupt the transmission of important vector-borne diseases including Malaria. It contains coverage of the current state of knowledge of vector-borne diseases and how they are currently controlled; vaccine, drug and insecticide development; various strategies for altering the genome of mosquitoes in beneficial ways; and the regulatory, ethical and social environment concerning these strategies. For more than five decades, the prospect of using genetically-modified mosquitoes to control vector-borne disease transmission has been a purely hypothetical scenario. We simply did not have the technology or basic knowledge to be able to do it. With the explosion of field trials and potential interventions in development, Genetic Control of Malaria and Dengue provides a comprehensive overview of research in genetics, microbiology, virology, and ecology involved in the development and implementation of genetic modification programs for virus and disease control. This book is meant to provide a practical guide to researchers, regulators and the general public about how this technology actually works, how it can be improved, and what is still unknown. Includes coverage of vectorial capacity, critical to understanding vector-borne disease transmission Provides a summary of the concepts of both population suppression and population replacement Contains pivotal coverage of ethical and ecological ramifications of genetics-based control strategies

Genetics of Speciation

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ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Genetics of Speciation by : David L. Jameson

Download or read book Genetics of Speciation written by David L. Jameson and published by . This book was released on 1977 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nature of populations, races, subspecies, and species. Genetic basis of isolation. Origin of isolation - theoretical. Origin of isolation - experimental. The nature of the speciation process.

The Major Transitions in Evolution

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Publisher : Oxford University Press
ISBN 13 : 019850294X
Total Pages : 361 pages
Book Rating : 4.1/5 (985 download)

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Book Synopsis The Major Transitions in Evolution by : John Maynard Smith

Download or read book The Major Transitions in Evolution written by John Maynard Smith and published by Oxford University Press. This book was released on 1997-10-30 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: During evolution there have been several major changes in the way genetic information is organized and transmitted from one generation to the next. These transitions include the origin of life itself, the first eukaryotic cells, reproduction by sexual means, the appearance of multicellular plants and animals, the emergence of cooperation and of animal societies. This is the first book to discuss all these major transitions and their implications for our understanding of evolution.Clearly written and illustrated with many original diagrams, this book will be welcomed by students and researchers in the fields of evolutionary biology, ecology, and genetics.

Sperm Biology

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Publisher : Academic Press
ISBN 13 : 0080919871
Total Pages : 683 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Sperm Biology by : Scott S. Pitnick

Download or read book Sperm Biology written by Scott S. Pitnick and published by Academic Press. This book was released on 2008-11-21 with total page 683 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sperm Biology represents the first analysis of the evolutionary significance of sperm phenotypes and derived sperm traits and the possible selection pressures responsible for sperm-egg coevolution. An understanding of sperm evolution is fast developing and promises to shed light on many topics from basic reproductive biology to the evolutionary process itself as well as the sperm proteome, the sperm genome and the quantitative genetics of sperm. The Editors have identified 15 topics of current interest and biological significance to cover all aspects of this bizarre, fascinating and important subject. It comprises the most comprehensive and up-to-date review of the evolution of sperm and pointers for future research, written by experts in both sperm biology and evolutionary biology. The combination of evolution and sperm is a potent mix, and this is the definitive account. The first review survey of this emerging field Written by experts from a broad array of disciplines from the physiological and biomedical to the ecological and evolutionary Sheds light on the intricacies of reproduction and the coevolution of sperm, egg and reproductive behavior

Encyclopedia of Reproduction

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Publisher : Academic Press
ISBN 13 : 0128151455
Total Pages : 3905 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Encyclopedia of Reproduction by :

Download or read book Encyclopedia of Reproduction written by and published by Academic Press. This book was released on 2018-06-29 with total page 3905 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Reproduction, Second Edition, Six Volume Set comprehensively reviews biology and abnormalities, also covering the most common diseases in humans, such as prostate and breast cancer, as well as normal developmental biology, including embryogenesis, gestation, birth and puberty. Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers, from advanced undergraduate students, to research professionals. Chapters also explore the latest advances in cloning, stem cells, endocrinology, clinical reproductive medicine and genomics. As reproductive health is a fundamental component of an individual’s overall health status and a central determinant of quality of life, this book provides the most extensive and authoritative reference within the field. Provides a one-stop shop for information on reproduction that is not available elsewhere Includes extensive coverage of the full range of topics, from basic, to clinical considerations, including evolutionary advances in molecular, cellular, developmental and clinical sciences Includes multimedia and interactive teaching tools, such as downloadable PowerPoint slides, video content and interactive elements, such as the Virtual Microscope

Systematics and the Origin of Species

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Publisher : National Academies Press
ISBN 13 : 0309165105
Total Pages : 382 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Systematics and the Origin of Species by : National Academy of Sciences

Download or read book Systematics and the Origin of Species written by National Academy of Sciences and published by National Academies Press. This book was released on 2005-09-28 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: In December 2004, the National Academy of Sciences sponsored a colloquium on "Systematics and the Origin of Species" to celebrate Ernst Mayr's 100th anniversary and to explore current knowledge concerning the origin of species. In 1942, Ernst Mayr, one of the twentieth century's greatest scientists, published Systematics and the Origin of Species, a seminal book of the modern theory of evolution, where he advanced the significance of population variation in the understanding of evolutionary process and the origin of new species. Mayr formulated the transition from Linnaeus's static species concept to the dynamic species concept of the modern theory of evolution and emphasized the species as a community of populations, the role of reproductive isolation, and the ecological interactions between species. In addition to a preceding essay by Edward O. Wilson, this book includes the 16 papers presented by distinguished evolutionists at the colloquium. The papers are organized into sections covering the origins of species barriers, the processes of species divergence, the nature of species, the meaning of "species," and genomic approaches for understanding diversity and speciation.

Insect Molecular Genetics

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Publisher : Elsevier
ISBN 13 : 1483293718
Total Pages : 569 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Insect Molecular Genetics by : Marjorie A. Hoy

Download or read book Insect Molecular Genetics written by Marjorie A. Hoy and published by Elsevier. This book was released on 2013-10-22 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed as an introduction to new molecular genetic techniques, Insect Molecular Genetics also provides literature, terminology, and additional sources of information to students, researchers, and professional entomologists. Although most molecular genetics studies have employed Drosophila, this book applies the same techniques to other insects, including pest insects of economic importance. As a text, as a reference, as a primer, and as a review of a vast and growing literature, Insect Molecular Genetics is a valuable addition to the libraries of entomologists, geneticists, and molecular biologists. Features offered by this unique reference source: Detailed illustrations Suggested readings at the end of each chapter Glossary of molecular genetic terms

In the Light of Evolution

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ISBN 13 :
Total Pages : 388 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis In the Light of Evolution by : National Academy of Sciences

Download or read book In the Light of Evolution written by National Academy of Sciences and published by . This book was released on 2007 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Arthur M. Sackler Colloquia of the National Academy of Sciences address scientific topics of broad and current interest, cutting across the boundaries of traditional disciplines. Each year, four or five such colloquia are scheduled, typically two days in length and international in scope. Colloquia are organized by a member of the Academy, often with the assistance of an organizing committee, and feature presentations by leading scientists in the field and discussions with a hundred or more researchers with an interest in the topic. Colloquia presentations are recorded and posted on the National Academy of Sciences Sackler colloquia website and published on CD-ROM. These Colloquia are made possible by a generous gift from Mrs. Jill Sackler, in memory of her husband, Arthur M. Sackler.

The Genetic Gods

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Publisher : Harvard University Press
ISBN 13 : 0674020359
Total Pages : 289 pages
Book Rating : 4.6/5 (74 download)

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Book Synopsis The Genetic Gods by : John C. Avise

Download or read book The Genetic Gods written by John C. Avise and published by Harvard University Press. This book was released on 2009-06-30 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: They mastermind our lives, shaping our features, our health, and our behavior, even in the sacrosanct realms of love and sex, religion, aging, and death. Yet we are the ones who house, perpetuate, and give the promise of immortality to these biological agents, our genetic gods. The link between genes and gods is hardly arbitrary, as the distinguished evolutionary geneticist John Avise reveals in this compelling book. In clear, straightforward terms, Avise reviews recent discoveries in molecular biology, evolutionary genetics, and human genetic engineering, and discusses the relevance of these findings to issues of ultimate concern traditionally reserved for mythology, theology, and religious faith. The book explains how the genetic gods figure in our development--not just our metabolism and physiology, but even our emotional disposition, personality, ethical leanings, and, indeed, religiosity. Yet genes are physical rather than metaphysical entities. Having arisen via an amoral evolutionary process--natural selection--genes have no consciousness, no sentient code of conduct, no reflective concern about the consequences of their actions. It is Avise's contention that current genetic knowledge can inform our attempts to answer typically religious questions--about origins, fate, and meaning. The Genetic Gods challenges us to make the necessary connection between what we know, what we believe, and what we embody. Table of Contents: Preface Prologue 1. The Doctrines of Biological Science 2. Geneses 3. Genetic Maladies 4. Genetic Beneficence 5. Strategies of the Genes 6. Genetic Sovereignty 7. New Lords of Our Genes? 8. Meaning Epilogue Notes Glossary Index Reviews of this book: Our genes, [Avise] says, are responsible not only for how we got here and exist day to day, but also for the core of our being--our personalities and morals. It is our genetic make-up that allows for and formulates our religious belief systems, he argues. Avise does not eschew spirituality but seeks a more informed, less confrontational approach between science and the pulpit. --Science News Reviews of this book: For the general scientific reader, the book is an excellent distillation of a broad and increasingly important field, a course of causation that cannot be ignored. From advising expectant parents to getting innocent people off death row, genetics increasingly dominates our lives. The sections on genetics are expertly written, particularly for those readers without in-depth knowledge. The author explains slowly and carefully just how genetics operates, using multiple metaphors. His genetic discourse proceeds in a neighborly fashion, as one might tell stories while sitting in a rocking chair at a country store. He seems to be invigorated by genes and just can't wait to tell about them. --David W. Hodo, Journal of the American Medical Association Reviews of this book: As a whole, this book is quite informative and stimulating, and sections of it are beautifully written. Indeed, Professor Avise has a real gift for prose and scientific expositions, and I would suspect that he must be a formidable lecturer...At its core, [The Genetic Gods] is a survey, and a very nice one at that, of evolutionary genetics, the field of the author's major research interests. There is a strong sociobiological cast to the arguments, and the work and ideas of E. O. Wilson figure prominently. The presentation of evolutionary genetics is imbedded in a more general discussion of modern human and molecular genetics...However, this book is, most of all, a philosophical treatise that attempts, admittedly with the bias of a biologist, to examine the intersection of the fundamental premises of evolution and religion. Professor Avise has given us plenty to think about in this book [and]...it was a real pleasure to wrestle with the ideas he was presenting. I would suggest that other readers give it a try. --Charles J. Epstein, Trends in Genetics Reviews of this book: [Avise's] account of the role genes play in shaping the human condition is wholly involving, paying particular attention to issues of reproduction, aging and death. In addition to presenting ample biological information in a form accessible to the nonspecialist, Avise does a superb job of discussing many of the ethical implications that have arisen from our growing knowledge of human genetics. Just a few of the topics covered are genetic engineering, the patenting of life, genetic screening, abortion, human cloning, gene therapy and insurance-related controversies. --Publishers Weekly Reviews of this book: Avise explains thoroughly how evolution operates on a genetic level. His goal is to show that humans can look to this information as a way to answer fundamental questions of life instead of looking to traditional religious beliefs...Avise includes some very interesting discussions of ethical concerns related to genetic issues. --Eric D. Albright, Library Journal This is a splendid account of a subject that affects us all: the breathtaking increase in understanding of human genetics and the insight it provides into human evolution. John Avise speaks with authority of molecular evolutionary genetics and with affecting compassion of what it might mean. --Douglas J. Futuyma, State University of New York at Stony Brook The Genetic Gods is many things. It is a wonderful introduction to modern molecular biology, by a man who knows his subject backwards. It is a stimulating account of the ways in which genetics impinges on human nature--our thinking and our behavior. It is a remarkably level-headed and sympathetic account of the implications of our new findings for traditional and not-so-traditional issues in philosophy and religion. In an age of genetic counseling, cloning, construction of new life forms, the book is worth its weight in gold for this alone. But most of all, it is a huge amount of fun to read--you want to applaud or argue with the author on nigh every page. Highly recommended! --Michael Ruse, University of Guelph The Genetic Gods makes a valuable contribution to the on-going task of sorting out the implications of evolutionary biology and genetics for human self-understanding. Avise addresses, with authority and grace, the most consequential intellectual issues of our time. A challenging and insightful book. --Loyal Rue, Harvard University A wonderfully informative and engaging book. Avise offers a lucid, accessible primer on our genes, angelic and demonic, and examines religious and ethical issues, all too human, now confronted by genetic science. He makes a compelling case that anyone seeking to 'Know Thyself' should study the DNA molecular scriptures, our most ancient and universal legacy. --Dudley Herschbach, Harvard University, Nobel Laureate in Chemistry