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Author : David Loakes
Publisher :
ISBN 13 : 9788177361216
Total Pages : 161 pages
Book Rating : 4.3/5 (612 download)
Download or read book Modified Nucleosides Synthesis and Applications written by David Loakes and published by . This book was released on 2002 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Carina Stiller
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (138 download)
Download or read book Synthesis and Applications of Modified Nucleosides and RNA Nucleotides written by Carina Stiller and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Anant R. Kapdi
Publisher : Elsevier
ISBN 13 : 012811293X
Total Pages : 360 pages
Book Rating : 4.1/5 (281 download)
Download or read book Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides written by Anant R. Kapdi and published by Elsevier. This book was released on 2018-06-04 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides describes the procedures and protocols related to the modification of nucleosides, nucleotides and oligonucleotides via Pd-mediated cross-coupling processes. The book highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist this development. Users will find key synthetic protocols for these reactions in this latest volume in the Latest Trends in Palladium Chemistry series. As most of the research in the field of antiviral agents has centered on the use of modified nucleosides that have exhibited promising activity, this book provides an up-to-date reference for both professionals in industry and other interested parties. Provides synthetic routes for useful nucleoside molecules, information otherwise found only through time-consuming literature searches Covers metal-mediated and metal-catalyzed cross coupling processes of nucleosides and related compounds Includes Suzuki-Miyaura, Stille and Sonogashira reactions, as well as C-H bond functionalization Highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist
Author : Montserrat Shelbourne
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (868 download)
Download or read book Synthesis and Applications of Oligonucleotides Containing 2'-modified Nucleosides written by Montserrat Shelbourne and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Piet Herdewijn
Publisher : Springer Science & Business Media
ISBN 13 : 1592598234
Total Pages : 436 pages
Book Rating : 4.5/5 (925 download)
Download or read book Oligonucleotide Synthesis written by Piet Herdewijn and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of powerful new techniques for oligonucleotide synthesis and for the use of modified oligonucleotides in biotechnology. Among the protocol highlights are a novel two-step process that yields a high purity, less costly, DNA, the synthesis of phosphorothioates using new sulfur transfer agents, the synthesis of LNA, peptide conjugation methods to improve cellular delivery and cell-specific targeting, and triple helix formation. The applications include using molecular beacons to monitor the PCR amplification process, nuclease footprinting to study the sequence-selective binding of small molecules of DNA, nucleic acid libraries, and the use of small interference RNA (siRNA) as an inhibitor of gene expression.
Author : Kazuhiko Nakatani
Publisher : Springer
ISBN 13 : 3319271113
Total Pages : 280 pages
Book Rating : 4.3/5 (192 download)
Download or read book Modified Nucleic Acids written by Kazuhiko Nakatani and published by Springer. This book was released on 2016-04-04 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.
Author : Stefan Jurga
Publisher : Springer
ISBN 13 : 3319341758
Total Pages : 456 pages
Book Rating : 4.3/5 (193 download)
Download or read book Modified Nucleic Acids in Biology and Medicine written by Stefan Jurga and published by Springer. This book was released on 2016-07-29 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression. Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides. This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.
Author : Bruce Edward Watkins
Publisher :
ISBN 13 :
Total Pages : 196 pages
Book Rating : 4.:/5 (829 download)
Download or read book Synthesis of Modified Nucleosides and Oligonucleotides written by Bruce Edward Watkins and published by . This book was released on 1982 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Eric James Linnell
Publisher :
ISBN 13 :
Total Pages : 338 pages
Book Rating : 4.:/5 (192 download)
Download or read book Synthesis of Modified Nucleosides and Nucleotides written by Eric James Linnell and published by . This book was released on 1988 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jesús Fernández Lucas
Publisher : John Wiley & Sons
ISBN 13 : 3527343768
Total Pages : 348 pages
Book Rating : 4.5/5 (273 download)
Download or read book Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives written by Jesús Fernández Lucas and published by John Wiley & Sons. This book was released on 2019-04-29 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: A review of innovative tools for creative nucleic acid chemists that open the door to novel probes and therapeutic agents Nucleic acids continue to gain importance as novel diagnostic and therapeutic agents. With contributions from noted scientists and scholars, Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives is a practical reference that includes a wide range of approaches for the synthesis of designer nucleic acids and their derivatives. The book covers enzymatic (including chemo-enzymatic) methods, with a focus on the synthesis and incorporation of modified nucleosides. The authors also offer a review of innovative approaches for the non-enzymatic chemical synthesis of nucleic acids and their analogs and derivatives, highlighting especially challenging species. The book offers a concise review of the methods that prepare novel and heavily modified polynucleotides in sufficient amount and purity for most clinical and research applications. This important book: -Presents a timely and topical guide to the synthesis of designer nucleic acids and their derivatives -Addresses the growing market for nucleotide-derived pharmaceuticals used as anti-infectives and chemotherapeutic agents, as well as fungicides and other agrochemicals. -Covers novel methods and the most recent trends in the field -Contains contributions from an international panel of noted scientistics Written for biochemists, medicinal chemists, natural products chemists, organic chemists, and biotechnologists, Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives is a practice-oriented guide that reviews innovative methods for the enzymatic as well as non-enzymatic synthesis of nucleic acid species.
Author :
Publisher : Elsevier
ISBN 13 : 008085852X
Total Pages : 509 pages
Book Rating : 4.0/5 (88 download)
Download or read book Modified Nucleosides in Cancer and Normal Metabolism - Methods and Applications written by and published by Elsevier. This book was released on 1990-05-02 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modified Nucleosides in Cancer and Normal Metabolism - Methods and Applications
Author : Daniel Globisch
Publisher :
ISBN 13 : 9783869557359
Total Pages : 195 pages
Book Rating : 4.5/5 (573 download)
Download or read book Synthesis of Natural Modified Nucleosides and Their Mass Spectrometric Quantification in Cells and Tissue written by Daniel Globisch and published by . This book was released on 2011 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : G. Nass
Publisher : Springer Science & Business Media
ISBN 13 : 3642819478
Total Pages : 441 pages
Book Rating : 4.6/5 (428 download)
Download or read book Modified Nucleosides and Cancer written by G. Nass and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprises the lectures presented at the workshop Modified Nuc1eosides and Cancer held from 28 September to 2 October, 1981 in Freiburg, West Germany. The workshop was organized by Gisela Nass and sponsored by the Deutsche Forschungsgemeinschaft. The purpose of the workshop was to cover the varied analytical methods for quantitative and qualitative determination of modified nucleosides and their metabolism including bio synthesis, all in relation to the function of these compounds in the origin and growth of cancer cells. The potential signi ficance of measuring modified nucleosides in body fluids for tumor diagnosis in humans received particular attention. Various fields of research which have previously been segregat ed are thus unified in this volume. Emphasis was also placed on the fact that modified nucleosides are constituents of the genetic material, the desoxyribonucleic> acid, on the one hand, and of the transfer ribonucleic acids on the other hand, with the latter macromolecules participating not only in the translation of genetic information into protein, but also in many regulatory processes in all single- and multi-, cellular organisms including man.
Author : Sébastien Porcher
Publisher :
ISBN 13 :
Total Pages : 281 pages
Book Rating : 4.:/5 (428 download)
Download or read book Synthesis of Modified Nucleosides for the Incorporation Into TRNAs written by Sébastien Porcher and published by . This book was released on 2006 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lavinia Brennan
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (592 download)
Download or read book The Synthesis and Studies of 2'-C-modified Nucleosides written by Lavinia Brennan and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Pedro Merino
Publisher : John Wiley & Sons
ISBN 13 : 1118498100
Total Pages : 859 pages
Book Rating : 4.1/5 (184 download)
Download or read book Chemical Synthesis of Nucleoside Analogues written by Pedro Merino and published by John Wiley & Sons. This book was released on 2013-02-12 with total page 859 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compiles current tested and proven approaches to synthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including: Changes to the heterocyclic base Modification of substituents at the sugar ring Replacement of the furanose ring by a different carbo- or heterocyclic ring Introduction of conformational restrictions Synthesis of enantiomers Preparation of hydrolitically stable C-nucleosides Chemical Synthesis of Nucleoside Analogues covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds. Throughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field. Synthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With Chemical Synthesis of Nucleoside Analogues as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used as therapeutic drugs with fewer unwanted side effects.
Author : Shirshendu Kumar Deb
Publisher :
ISBN 13 :
Total Pages : 342 pages
Book Rating : 4.:/5 (622 download)
Download or read book Synthesis of 2'-amine Modified Nucleosides and Oligonucleotides to Study RNA Catalysis written by Shirshendu Kumar Deb and published by . This book was released on 2003 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
