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Modified Nucleosides
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Book Synopsis Modified Nucleosides by : Piet Herdewijn
Download or read book Modified Nucleosides written by Piet Herdewijn and published by John Wiley & Sons. This book was released on 2008-09-08 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by one of the main driving forces behind the field's momentous rise in recent years, this one-stop reference is the first comprehensive resource to integrate recent advances. The first part addresses biochemical aspects and applications, the second and third parts are devoted to compounds with therapeutic potential, with the third part focusing on newly introduced anticancer nucleoside drugs. Essential reading for every scientist working in this area.
Book Synopsis Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides by : Anant R. Kapdi
Download or read book Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides written by Anant R. Kapdi and published by Elsevier. This book was released on 2018-06-04 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides describes the procedures and protocols related to the modification of nucleosides, nucleotides and oligonucleotides via Pd-mediated cross-coupling processes. The book highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist this development. Users will find key synthetic protocols for these reactions in this latest volume in the Latest Trends in Palladium Chemistry series. As most of the research in the field of antiviral agents has centered on the use of modified nucleosides that have exhibited promising activity, this book provides an up-to-date reference for both professionals in industry and other interested parties. Provides synthetic routes for useful nucleoside molecules, information otherwise found only through time-consuming literature searches Covers metal-mediated and metal-catalyzed cross coupling processes of nucleosides and related compounds Includes Suzuki-Miyaura, Stille and Sonogashira reactions, as well as C-H bond functionalization Highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist
Book Synopsis Modified Nucleosides and Cancer by : G. Nass
Download or read book Modified Nucleosides and Cancer written by G. Nass and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprises the lectures presented at the workshop Modified Nuc1eosides and Cancer held from 28 September to 2 October, 1981 in Freiburg, West Germany. The workshop was organized by Gisela Nass and sponsored by the Deutsche Forschungsgemeinschaft. The purpose of the workshop was to cover the varied analytical methods for quantitative and qualitative determination of modified nucleosides and their metabolism including bio synthesis, all in relation to the function of these compounds in the origin and growth of cancer cells. The potential signi ficance of measuring modified nucleosides in body fluids for tumor diagnosis in humans received particular attention. Various fields of research which have previously been segregat ed are thus unified in this volume. Emphasis was also placed on the fact that modified nucleosides are constituents of the genetic material, the desoxyribonucleic> acid, on the one hand, and of the transfer ribonucleic acids on the other hand, with the latter macromolecules participating not only in the translation of genetic information into protein, but also in many regulatory processes in all single- and multi-, cellular organisms including man.
Book Synopsis Modified Nucleic Acids in Biology and Medicine by : Stefan Jurga
Download or read book Modified Nucleic Acids in Biology and Medicine written by Stefan Jurga and published by Springer. This book was released on 2016-07-29 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression. Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides. This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.
Book Synopsis The Modified Nucleosides in Nucleic Acids by : Ross Hume Hall
Download or read book The Modified Nucleosides in Nucleic Acids written by Ross Hume Hall and published by New York : Columbia University Press. This book was released on 1971-01-01 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modified Nucleosides in Cancer and Normal Metabolism - Methods and Applications by :
Download or read book Modified Nucleosides in Cancer and Normal Metabolism - Methods and Applications written by and published by Elsevier. This book was released on 1990-05-02 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modified Nucleosides in Cancer and Normal Metabolism - Methods and Applications
Download or read book RNA Vaccines written by Thomas Kramps and published by Humana. This book was released on 2024-06-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition volume expands on the previous edition with discussions of the latest technology and advancements in the development of RNA vaccines and proposed solutions on how to tackle currently unmet medical needs. The chapters in this book are organized into four parts and cover topics such as replication and non-replicating RNA vectors, formulation and delivery of RNA vaccines, and clinical and nonclinical development of RNA vaccines. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and comprehensive, RNA Vaccines: Methods and Protocols, Second Edition is a valuable resource for any researcher interested in learning more about this important and developing field.
Book Synopsis Analytical Methods for Major and Modified Nucleosides - HPLC, GC, MS, NMR, UV and FT-IR by :
Download or read book Analytical Methods for Major and Modified Nucleosides - HPLC, GC, MS, NMR, UV and FT-IR written by and published by Elsevier. This book was released on 1989-12-13 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analytical Methods for Major and Modified Nucleosides - HPLC, GC, MS, NMR, UV and FT-IR
Book Synopsis Modified Nucleic Acids by : Kazuhiko Nakatani
Download or read book Modified Nucleic Acids written by Kazuhiko Nakatani and published by Springer. This book was released on 2016-04-04 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.
Book Synopsis Modified Nucleosides as DNA-sugar Centered Radical Precursors by : Antonio Manetto
Download or read book Modified Nucleosides as DNA-sugar Centered Radical Precursors written by Antonio Manetto and published by Cuvillier Verlag. This book was released on 2008 with total page 31 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chemical Synthesis of Nucleoside Analogues by : Pedro Merino
Download or read book Chemical Synthesis of Nucleoside Analogues written by Pedro Merino and published by John Wiley & Sons. This book was released on 2013-02-12 with total page 859 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compiles current tested and proven approaches to synthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including: Changes to the heterocyclic base Modification of substituents at the sugar ring Replacement of the furanose ring by a different carbo- or heterocyclic ring Introduction of conformational restrictions Synthesis of enantiomers Preparation of hydrolitically stable C-nucleosides Chemical Synthesis of Nucleoside Analogues covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds. Throughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field. Synthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With Chemical Synthesis of Nucleoside Analogues as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used as therapeutic drugs with fewer unwanted side effects.
Book Synopsis Modified Nucleosides Synthesis and Applications by : David Loakes
Download or read book Modified Nucleosides Synthesis and Applications written by David Loakes and published by . This book was released on 2002 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mass Spectrometry of Nucleosides and Nucleic Acids by : Joseph H. Banoub
Download or read book Mass Spectrometry of Nucleosides and Nucleic Acids written by Joseph H. Banoub and published by CRC Press. This book was released on 2009-12-21 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assembling the work of an international panel of researchers, Mass Spectrometry of Nucleosides and Nucleic Acids summarizes and reviews the latest developments in the field and provides a window on the next generation of analysis. Beginning with an overview of recent developments, the book highlights the most popular ionization methods and illustra
Book Synopsis Synthesis of natural modified nucleosides and their mass spectrometric quantification in cells and tissue by : Daniel Globisch
Download or read book Synthesis of natural modified nucleosides and their mass spectrometric quantification in cells and tissue written by Daniel Globisch and published by Cuvillier Verlag. This book was released on 2011-05-13 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book RNA Modification written by and published by Elsevier. This book was released on 2007-09-13 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: The presence of modified nucleotides in cellular RNAs has been known for decades and over 100 distinct RNA modifications have been characterized to date. While the exact role of many of these modifications is still unclear, many are highly conserved across evolution and most contribute to the overall fitness of the organism. In recent years, new methods and bioinformatics approaches have been developed for the dissection of modification pathways and functions. These methods intersect a number of related fields, ranging from RNA processing to comparative genomics and systems biology. In addition, many of the techniques described in this volume have broad applicability, particularly in regards to the isolation, characterization, and reconstitution of ribonucleoprotein complexes, expanding the experimental repertoire available to all RNA researchers.
Book Synopsis Chromatography and Modification of Nucleosides: Analytical methods for major and modified nucleosides, HPLC, GC, MS, NMR, UV, and FT-IR by : Charles W. Gehrke
Download or read book Chromatography and Modification of Nucleosides: Analytical methods for major and modified nucleosides, HPLC, GC, MS, NMR, UV, and FT-IR written by Charles W. Gehrke and published by Elsevier Publishing Company. This book was released on 1990 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatography and Modification of Nucleosides is a four-volume work which provides state-of-the-art chromatography and analytical methods for use in a wide spectrum of nucleic acid modification research. The focus of Part A, is the presentation of advanced methods for modification research on tRNAs, mRNAs, mtRNAs, rRNAs and DNAs. HPLC-UV, GC-MS, NMR, FT-IR and affinity chromatography approaches to nucleic acid modification studies are presented, as are nucleoside, oligonucleotide and nucleic acid isolation techniques. Part B has as its central theme the modified nucleosides of tRNA and the current analytical means for studying tRNA modifications. Modified nucleoside synthesis, function, structural conformation, biological regulation, and occurrence of modification in a wide range of tRNAs are presented, as is a chapter on DNA modification and a chapter on solid phase immunoassay for determining a particular modification. Part C provides the reader with a comprehensive treatment of modified nucleosides as biochemical signals of neoplasia and normal metabolism.The final volume, Part D, will present structural characterization of unknown nucleosides as well as extensive biochemical, chemical and physical properties of RNA and DNA nucleosides, as a database for researchers in the field. Chromatographic methodology will be described for analysis of total modification of tRNAs and DNAs. The chapters are written by leading scientists in their respective fields and present an up-to-date review on the roles of modified nucleosides in nucleic acids which will be extremely useful for workers in chromatography, molecular biology, genetics, biochemistry, biotechnology and the pharmaceutical industry.
Book Synopsis DNA and RNA Modification Enzymes by : Henri Grosjean
Download or read book DNA and RNA Modification Enzymes written by Henri Grosjean and published by CRC Press. This book was released on 2009-06-11 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a timely and comprehensive description of the many facets of DNA and RNA modification-editing processes and to some extent repair mechanisms. Each chapter offers fundamental principles as well as up to date information on recent advances in the field (up to end 2008). They ended by a short ‘conclusion and future prospect’ section and an exhaustive list of 35 to up to 257 references (in average 87). Contributors are geneticists, structural enzymologists and molecular biologists working at the forefront of this exciting, fast-moving and diverse field of researches. This book will be a major interest to PhD students and University teachers alike. It will also serve as an invaluable reference tool for new researchers in the field, as well as for specialists of RNA modification enzymes generally not well informed about what is going on in similar processes acting on DNA and vice-versa for specialists of the DNA modification-editing and repair processes usually not much acquainted with what is going on in the RNA maturation field. The book is subdivided into 41 chapters (740 pages). The common links between them are mainly the enzymatic aspects of the different modification-editing and repair machineries: structural, mechanistic, functional and evolutionary aspects. It starts with two general and historical overview of the discovery of modified nucleosides in DNA and RNA and corresponding modification-editing enzymes. Then follows eleven chapters on DNA modification and editing (mechanistic and functional aspects). Two additional chapters cover problems related to DNA/RNA repair and base editing by C-to-U deaminases, followed by three chapters on RNA editing by C-to-U and A-to-I type of deamination. Discussions about interplay between DNA and RNA modifications and the emergence of DNA are covered in two independent chapters, followed by twenty chapters on different but complementary aspects of RNA modification enzymes and their cellular implications. The last chapter concerns the description of the present state-of-the art for incorporating modified nucleosides by in vitro chemical synthesis. At the end of the book, six appendicies give useful details on modified nucleosides, modification-editing enzymes and nucleosides analogs. This information is usually difficult to obtain from current scientific literature.
