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Modelisation De La Structure Tridimensionnelle De Macromolecules A Partir De Donnees Rmn
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Book Synopsis MODELISATION DE LA STRUCTURE TRIDIMENSIONNELLE DE MACROMOLECULES A PARTIR DE DONNEES RMN by : EDITH.. GINCEL
Download or read book MODELISATION DE LA STRUCTURE TRIDIMENSIONNELLE DE MACROMOLECULES A PARTIR DE DONNEES RMN written by EDITH.. GINCEL and published by . This book was released on 1993 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: L'INTERACTION DE MACROMOLECULES BIOLOGIQUES OU LA COMPLEXATION AVEC DES LIGANDS NECESSITE DES REARRANGEMENTS CONFORMATIONNELS ESSENTIELS A LEUR ACTIVITE BIOLOGIQUE. LA MODELISATION MOLECULAIRE PERMET DE DETERMINER LES STRUCTURES A PARTIR DE PARAMETRES EXPERIMENTAUX. MON TRAVAIL DE THESE A PORTE SUR L'ETUDE DE CES REARRANGEMENTS EN UTILISANT DES DONNEES DE RMN 2D. DEUX SYSTEMES ONT ETE ETUDIES: I) UN OLIGONUCLEOTIDE, L'OPERON LACTOSE COMPLEXE OU NON A SON REPRESSEUR. II) UNE PROTEINE DE BLE TRANSPORTANT DES LIPIDES, LA LTP (EN VUE D'ETUDIER LES DIFFERENCES STRUCTURALES OBTENUES AVEC CETTE MEME PROTEINE COMPLEXEE A UN PHOSPHOLIPIDE). POUR L'OPERON LACTOSE, NOUS DISPOSIONS DE CONTRAINTES RMN SUR L'OPERATEUR ISOLE ET COMPLEXE. UNE ETUDE EFFECTUEE EN UTILISANT LE LOGICIEL AMBER EN MECANIQUE ET DYNAMIQUE MOLECULAIRE NOUS A CONDUITS A DES RESULTATS DIFFICILES A EXPLOITER. SEULE LA MECANIQUE MOLECULAIRE EN COORDONNEES INTERNES (LOGICIEL JUMNA) PERMET DE S'AFFRANCHIR DES STRUCTURES INITIALES. LES MODIFICATIONS DE STRUCTURES ENTRE L'ADN ISOLE ET COMPLEXE SONT TRES LOCALISEES ET CONCERNENT LA STRUCTURE TRES FINE COMME PAR EXEMPLE UNE COURBURE DE LA DOUBLE HELICE. DANS LE CAS DE LA PROTEINE DE BLE, LA GENERATION DE STRUCTURES SE FAIT EN PLUSIEURS TEMPS. TOUT D'ABORD, LA GEOMETRIE DES DISTANCES EN UTILISANT LE LOGICIEL DSPACE PUIS UNE ETAPE DE RECUIT SIMULE A 1000K, ET ENFIN UNE ETAPE DE DYNAMIQUE MOLECULAIRE DE 100 PS A 300K EN UTILISANT LE LOGICIEL X-PLOR. C'EST LA PREMIERE STRUCTURE DE LTP ETABLIE. CETTE PROTEINE EST FORMEE DE QUATRE FRAGMENTS HELICOIDAUX ENROULES SELON UNE SPIRALE DROITE JUSQU'A UN FRAGMENT C-TERMINAL AYANT LA FORME D'UN SAXOPHONE
Book Synopsis TECHNIQUES DE MODELISATION MOLECULAIRE DEDIEES A L'ETUDE STRUCTURALE DE PEPTIDES ET PROTEINES EN SOLUTION, A PARTIR DE DONNEES DE RMN. APPLICATION A L'ETUDE DE LA COMPLEMENTATION D'UN MUTANT DE LA PHOSPHOGLYCERATE KINASE ET DU CHANGEMENT CONFORMATIONNEL PH-DEPENDANT DE L'ALPHA-COBRATOXINE by : Éric Leroy
Download or read book TECHNIQUES DE MODELISATION MOLECULAIRE DEDIEES A L'ETUDE STRUCTURALE DE PEPTIDES ET PROTEINES EN SOLUTION, A PARTIR DE DONNEES DE RMN. APPLICATION A L'ETUDE DE LA COMPLEMENTATION D'UN MUTANT DE LA PHOSPHOGLYCERATE KINASE ET DU CHANGEMENT CONFORMATIONNEL PH-DEPENDANT DE L'ALPHA-COBRATOXINE written by Éric Leroy and published by . This book was released on 1996 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: LES TECHNIQUES DE MODELISATION MOLECULAIRE PERMETTENT DE RECONSTRUIRE ET D'ETUDIER DES MODELES DE STRUCTURE 3D DE MOLECULES PROTEIQUES EN SOLUTION A PARTIR DE DONNEES DE RESONANCE MAGNETIQUE NUCLEAIRE. DES MODELES DE STRUCTURE 3D D'UN DODECAPEPTIDE DE SYNTHESE COMPLEMENTANT UN MUTANT DE LA PHOSPHOGLYCERATE KINASE ONT ETE RESOLUS A PARTIR DE DONNEES D'EFFET NUCLEAIRE OVERHAUSER TRANSFERE. CES MODELES CONFORTENT L'HYPOTHESE DE LA COMPLEMENTATION STRUCTURALE DU MUTANT. LA MODELISATION DU COMPLEXE SOLVATE MUTANT/PEPTIDE A FAIT APPARAITRE DES LIMITES DANS LA CAPACITE DES CHAMPS DE FORCE A TRAITER LES ERREURS CONFORMATIONNELLES LOCALES. L'ETABLISSEMENT DE MODELES DE STRUCTURE 3D DE L'ALPHA-COBRATOXINE A PH NEUTRE A PERMIS D'ETUDIER, A L'ECHELLE ATOMIQUE, LES DIFFERENCES CONFORMATIONNELLES PH-DEPENDANTES DE CETTE PROTEINE. LE CHANGEMENT CONFORMATIONNEL ENTRE LES DEUX ETATS STABLES DE LA MOLECULE A ALORS ETE MODELISE PAR LA METHODE DE SIMULATION DE DYNAMIQUE DIRIGEE. CETTE TECHNIQUE A PERMIS DE METTRE EN EVIDENCE LES DIFFERENTS RESIDUS IMPLIQUES DANS LA TRANSITION
Book Synopsis NOUVELLES METHODES POUR LA MODELISATION DE STRUCTURES TRIDIMENSIONNELLES DE MOLECULES EN SOLUTION EN RELATION AVEC LES DONNEES DE LA RMN 2D by : BERNARD.. STAWARZ
Download or read book NOUVELLES METHODES POUR LA MODELISATION DE STRUCTURES TRIDIMENSIONNELLES DE MOLECULES EN SOLUTION EN RELATION AVEC LES DONNEES DE LA RMN 2D written by BERNARD.. STAWARZ and published by . This book was released on 1990 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: LA RESONANCE MAGNETIQUE NUCLEAIRE (RMN) PERMET D'APPORTER UN GRAND D'INFORMATIONS SUR LA STRUCTURE MOLECULAIRE. LA RMN DU PROTON #1H PERMET D'ACCEDER AUX DISTANCES INTERPROTONS EN UTILISANT LES EFFETS OVERHAUSER OU NOE. CES NOE SONT UTILISES POUR MODELISER LES STRUCTURES MOLECULAIRES PAR MECANIQUE OU DYNAMIQUE MOLECULAIRE AVEC OU SANS CONTRAINTES. LES STRUCTURES OBTENUES SONT, EN GENERAL, RAFFINEES PAR DES METHODES DE CALCUL EN RETOUR QUI CONSISTENT A MINIMISER UNE FONCTION DU TYPE (A-A#0)#2 OU A#0 REPRESENTE LA VALEUR EXPERIMENTALE. CE TRAVAIL CONSISTE A DEVELOPPER UNE METHODE GLOBALE D'OPTIMISATION DE STRUCTURE UTILISANT DIRECTEMENT LES INTENSITES NOE. UN NOUVEAU POTENTIEL DE CONTRAINTE A ETE INTEGRE DANS UN PROGRAMME DE CALCUL APPELE MUNIC (MODELLING USING NOE INTENSITY CONSTRAINT) S'ARTICULANT AUTOUR DU LOGICIEL DE MODELISATION MOLECULAIRE GROMOS. CETTE NOUVELLE TECHNIQUE A ETE APPLIQUEE A L'ETUDE DE LA STRUCTURE TRIDIMENSIONNELLE DE LA STENDOMYCINE, LIPOPEPTIDE CYCLIQUE ANTIFONGIQUE. LES QUALITES DE CONVERGENCE DU POTENTIEL DE CONTRAINTE DEVELOPPE ONT ETE MONTREES. IL EST TOUT A FAIT ENVISAGEABLE DE CONDUIRE UNE SIMULATION DE DYNAMIQUE MOLECULAIRE AVEC CONTRAINTES D'INTENSITES NOE DANS LE BUT DE DECRIRE LA DYNAMIQUE INTERNE DES SYSTEMES BIOLOGIQUES
Book Synopsis Nouvelles techniques pour la reconstruction par RMN de la structure tridimensionnelle de molécules en solution by : Véronique Stoven
Download or read book Nouvelles techniques pour la reconstruction par RMN de la structure tridimensionnelle de molécules en solution written by Véronique Stoven and published by . This book was released on 1989 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: De nouvelles techniques de traitement des spectres de Résonance Magnétique Nucléaire à deux dimensions (RMN-2D) sont présentées, en vue d’aider à la reconstitution de la structure tridimensionnelle des molécules. L’expérience de NOESY-2D étant l’expérience clef dans la détermination des conformations, les problèmes posés par l’interprétation quantitative de l’Effet Nucléaire Overhauser (NOE), sont présentées en détail. Une méthode est proposée pour la détection et l’intégration automatique des pics dans les cartes de RMN-2D. Elle est utilisée dans la détermination de distances internucléaires à partir des cartes NOE, y compris en cas de présence de cohérences zéro-quanta. Les principes de la confrontation entre les données RMN, et celles de méthode de calculs théoriques de conformations, sont exposés. Un exemple d’application est donné par la détermination de la géométrie d’un oligo-nucléotide platiné. Cet exemple constitue un modèle dans l’étude de l’interaction entre l’ADN et une drogue antitumorale : le cisdiamine-dichloro-platine (II). Par ailleurs, l’auteur propose un algorithme de phasage automatique, et une méthode de déconvolution dans le cadre général de la reconstruction inverse des spectres par Maximum Entropie. Ces techniques devraient aider le spectroscopiste dans le traitement et l’interprétation de spectres complexes de macro-molécules.
Book Synopsis ETUDE PAR RMN 2D DE LA STRUCTURE TRIDIMENSIONNELLE EN SOLUTION AQUEUSE, DE PROTEINES DE TRANSFERT DE LIPIDES, ET DE LEURS INTERACTIONS AVEC LES LIPIDES by : MARIE-CHRISTINE.. PETIT
Download or read book ETUDE PAR RMN 2D DE LA STRUCTURE TRIDIMENSIONNELLE EN SOLUTION AQUEUSE, DE PROTEINES DE TRANSFERT DE LIPIDES, ET DE LEURS INTERACTIONS AVEC LES LIPIDES written by MARIE-CHRISTINE.. PETIT and published by . This book was released on 1994 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: LES PROTEINES DE TRANSFERT DE LIPIDES (NS-LTP) D'ORIGINE VEGETALE, FORMENT UNE FAMILLE DE PETITES PROTEINES (ENVIRON 9000 DALTONS), BASIQUES, QUI COMPRENNENT DANS LEURS SEQUENCES HUIT CYSTEINES ORGANISEES EN QUATRE PONTS DISULFURE. LE ROLE BIOLOGIQUE DE CES PROTEINES EST ENCORE MAL CONNU. IN VITRO, ELLES TRANSFERENT LES LIPIDES D'UNE MEMBRANE ARTIFICIELLE A UNE AUTRE. CE TRAVAIL PRESENTE LA DETERMINATION PAR RESONANCE MAGNETIQUE NUCLEAIRE (RMN), DE LA STRUCTURE TRIDIMENSIONNELLE EN SOLUTION DE LA NS-LTP EXTRAITE DU MAIS. DANS CE BUT DES EXPERIENCES DE RMN 2D DU TYPE TQF COSY ET COSY DQ, ONT ETE UTILISEES POUR RESOUDRE LES PROBLEMES D'ATTRIBUTION DES SPECTRES, INHERENTS A LA REPETITION DE CERTAINS ACIDES AMINES (SER, ALA, GLY). A PARTIR DES CONTRAINTES DEDUITES DES EXPERIENCES NOESY, LA STRUCTURE DE LA NS-LTP DE MAIS PU ETRE MODELISEE. IL S'AGIT D'UN ENROULEMENT DROIT DE QUATRE HELICES. AFIN D'APPREHENDER LES RELATIONS STRUCTURE/FONCTION DE CES PROTEINES, DES ETUDES ONT ETE ENTREPRISES SUR LES INTERACTIONS ENTRE LA NS-LTP DE MAIS ET DES PHOSPHOLIPIDES TELS QUE LA LYSOLAUROYL-PHOSPHATIDYLCHOLINE ET LA LYSO-PALMITOYL-PHOSPHATIDYLCHOLINE. POUR POUVOIR ETABLIR UNE COMPARAISON AVEC UNE PROTEINE DE LA MEME FAMILLE, DONT LA STRUCTURE A ETE RESOLUE AU LABORATOIRE, CES MEMES ETUDES ONT ETE REALISEES AVEC LA NS-LTP DE BLE. LES DONNEES DE LA RMN SUGGERENT UNE FIXATION DU LIPIDE A L'INTERIEUR DES POCHES HYDROPHOBES DES DEUX PROTEINES
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 1998 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis L'ARRIMAGE MOLECULAIRE SOUS CONTRAINTES RMN by : XAVIER.. MORELLI
Download or read book L'ARRIMAGE MOLECULAIRE SOUS CONTRAINTES RMN written by XAVIER.. MORELLI and published by . This book was released on 2000 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: LA PROTEIN DATA BANK POSSEDE PLUS DE 11000 STRUCTURES DONT SEULEMENT 4% SONT DES STRUCTURES DE COMPLEXES. DEUX METHODES MAJEURES PERMETTENT ACTUELLEMENT DE DETERMINER DE TELLES STRUCTURES. LA CRISTALLOGRAPHIE EST LIMITEE PAR L'ETAPE DE CO-CRISTALLISATION TANDIS QUE LA RESONANCE MAGNETIQUE NUCLEAIRE EST LIMITEE PAR LA MASSE MOLECULAIRE DES PROTEINES. L'ARRIMAGE MOLECULAIRE SOUS CONTRAINTES RMN PEUT ETRE UNE ALTERNATIVE A CES LIMITATIONS. L'EXEMPLE DU COMPLEXE CYTOCHROME C 5 5 3/FERREDOXINE ETANT PARFAITEMENT INTEGRE DANS L'APPROXIMATION DES CORPS RIGIDES (PEU DE CHANGEMENTS CONFORMATIONNELS ENTRE LA FORME LIBRE ET LA FORME COMPLEXEE), NOUS AVONS MARQUE LES DEUX MOLECULES A L'AZOTE 1 5N AFIN D'ENTREPRENDRE UNE ETUDE DE LA FORMATION DU COMPLEXE AVEC LE PARTENAIRE (NON MARQUE) PAR RMN HETERONUCLEAIRE. NOUS AVONS AINSI OBTENU LE SITE D'INTERACTION DE LA FERREDOXINE (NON MARQUEE) SUR LE CYTOCHROME (MARQUE) ET VICE-VERSA. LA DERNIERE ETAPE A CONCERNE L'ETUDE DE LA MODELISATION DE LA STRUCTURE TRIDIMENSIONNELLE PAR ARRIMAGE MOLECULAIRE SOUS CONTRAINTES RMN. NOUS AVONS INTEGRE UN NOUVEAU MODULE PERMETTANT D'INJECTER LES VALEURS DES DEPLACEMENTS CHIMIQUES OBTENUS PAR RMN HETERONUCLEAIRE, DANS LE LOGICIEL BIGGER. NOUS PROPOSONS ICI UN MODELE TRIDIMENSIONNEL CONCERNANT CE COMPLEXE D'OXYDOREDUCTION. CETTE APPROCHE OUVRE LA VOIE A TOUS LES AUTRES COMPLEXES REPONDANT AUX CONDITIONS D'APPROXIMATION DES CORPS RIGIDES. NOUS AVONS ENSUITE APPLIQUE CETTE STRATEGIE AU COMPLEXE HYDROGENASE / CYTOCHROME C 5 5 3 (COMPLEXE PHYSIOLOGIQUE DE 60 KDA) EN APPLIQUANT UNE NOUVELLE SEQUENCE D'IMPULSION DE RMN HETERONUCLEAIRE, LE TROSY, QUI PERMET DE REALISER L'ETUDE DE COMPLEXE A HAUT POIDS MOLECULAIRE PAR RMN EN DIMINUANT L'EFFET D'ELARGISSEMENT DE LA LARGEUR DE RAIE OBSERVEE. CETTE ETUDE A CONDUIT AU PREMIER MODELE STRUCTURAL DE CE COMPLEXE. LE CHEMIN DE TRANSFERT D'ELECTRON TROUVE IMPLIQUE LA CYSTEINE 10 DU CYTOCHROME ET LA CYSTEINE 38 DE L'HYDROGENASE. LA DISTANCE HEME/FES ETANT DE L'ORDRE DE 12A.
Book Synopsis Revue de l'Institut français du pétrole by : Institut français du pétrole
Download or read book Revue de l'Institut français du pétrole written by Institut français du pétrole and published by . This book was released on 1996 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Soil Analysis written by J. Gautheyrou and published by CRC Press. This book was released on 2001-01-01 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this book is to provide a better understanding of tools for soil analysis in order to use them more efficiently. It covers sampling problems as well as difficulties relating to actual analysis and quality control.
Book Synopsis Molecular System Bioenergetics by : Valdur Saks
Download or read book Molecular System Bioenergetics written by Valdur Saks and published by John Wiley & Sons. This book was released on 2008-01-08 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this first integrated view, practically each of the world's leading experts has contributed to this one and only authoritative resource on the topic. Bringing systems biology to cellular energetics, they address in detail such novel concepts as metabolite channeling and medical aspects of metabolic syndrome and cancer.
Book Synopsis Major Problems in Developmental Biology by : Michael Locke
Download or read book Major Problems in Developmental Biology written by Michael Locke and published by Elsevier. This book was released on 2012-12-02 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Major Problems in Developmental Biology contains the proceedings of the 25th Symposium of the Society for Developmental Biology, held in Haverford, Pennsylvania, in June 1966. The papers explore some of the major problems in developmental biology, particularly those relating to cell differentiation, movements, and death; patterning; and intercellular regulation in plants. Organized into 11 chapters, this book begins with an overview of the growth and development of developmental biology as a scientific discipline, with emphasis on the role of the Society for Developmental Biology, and in particular its symposia, in the emergence of the field. The book then discusses the intra- and extracellular factors impinging upon the nucleus and regulating cell differentiation. Some chapters focus on the dynamics of determination in cell systems of insects, morphogenetic movements of animal cells, and patterns at the cell and tissue levels. The reader is also introduced to the correlations between protein structure and function in relation to cell dynamics and differentiation, along with the physiological, biochemical, and molecular biological aspects of intercellular regulation in plants and the role of cell surface in carcinogenesis. The book concludes by suggesting directions for research into the ontogeny of behavior. This book is a valuable source of information for developmental biologists.
Book Synopsis Flexoelectricity in Liquid Crystals by : Agnes Buka
Download or read book Flexoelectricity in Liquid Crystals written by Agnes Buka and published by World Scientific. This book was released on 2013 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book intends to give a state-of-the-art overview of flexoelectricity, a linear physical coupling between mechanical (orientational) deformations and electric polarization, which is specific to systems with orientational order, such as liquid crystals. Chapters written by experts in the field shed light on theoretical as well as experimental aspects of research carried out since the discovery of flexoelectricity. Besides a common macroscopic (continuum) description the microscopic theory of flexoelectricity is also addressed. Electro-optic effects due to or modified by flexoelectricity as well as various (direct and indirect) measurement methods are discussed. Special emphasis is given to the role of flexoelectricity in pattern-forming instabilities. While the main focus of the book lies in flexoelectricity in nematic liquid crystals, peculiarities of other mesophases (bent-core systems, cholesterics, and smectics) are also reviewed. Flexoelectricity has relevance to biological (living) systems and can also offer possibilities for technical applications. The basics of these two interdisciplinary fields are also summarized.
Download or read book Sea Plants written by and published by Elsevier. This book was released on 2014-05-21 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. The series features several reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology. This thematic volume, number 71, features reviews on sea plants. Its chapters cover topics such as the role of algae in sustainability; the status of kelp exploitation and marine agronomy; potential applications for enzymatic recovery of metabolites from seaweeds; and many more. Publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences Features a wide range of reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology, and ecology Volume features reviews on sea plants
Book Synopsis Modern Surface Organometallic Chemistry by : Jean-Marie Basset
Download or read book Modern Surface Organometallic Chemistry written by Jean-Marie Basset and published by John Wiley & Sons. This book was released on 2009-07-10 with total page 725 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering everything from the basics to recent applications, this monograph represents an advanced overview of the field. Edited by internationally acclaimed experts respected throughout the community, the book is clearly divided into sections on fundamental and applied surface organometallic chemistry. Backed by numerous examples from the recent literature, this is a key reference for all chemists.
Book Synopsis Masters Theses in the Pure and Applied Sciences by : Wade H. Shafer
Download or read book Masters Theses in the Pure and Applied Sciences written by Wade H. Shafer and published by Springer. This book was released on 1976 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Masters Theses in the Pure and Applied Sciences was first conceived, published, and dis· seminated by the Center for Information and Numerical Data Analysis and Synthesis (CINDAS) *at Purdue University in 1957, starting its coverage of theses with the academic year 1955. Beginning with Volume 13, the printing and dissemination phases of the ac· tivity were transferred to University Microfilms/Xerox of Ann Arbor, Michigan, with the thought that such an arrangement would be more beneficial to the academic and general scientific and technical community. After five years of this joint undertaking we had concluded that it was in the interest of all concerned if the printing and distribution of the volume were handled by an international publishing house to assure improved service and broader dissemination. Hence, starting with Volume 18, Masters Theses in the Pure and Applied Sciences has been disseminated on a worldwide basis by Plenum Publishing Corporation of New York, and in the same year the coverage was broadened to include Canadian universities. All back issues can also be ordered from Plenum. We have reported in Volume 20 (thesis year 1975) a total of 10,374 theses titles from 28 Canadian and 239 United States universities. We are sure that this broader base for theses titles reported will greatly enhance the value of this important annual reference work. The organization of Volume 20 is identical to that of past years. It consists of theses titles arranged by discipline and by university within each discipline.
Book Synopsis Encapsulations by : Alexandru Grumezescu
Download or read book Encapsulations written by Alexandru Grumezescu and published by Academic Press. This book was released on 2016-05-27 with total page 926 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encapsulations, a volume in the Nanotechnology in the Agri-Food Industry series,presents key elements in establishing food quality through the improvement of food flavor and aroma. The major benefits of nanoencapsulation for food ingredients include improvement in bioavailability of flavor and aroma ingredients, improvement in solubility of poor water-soluble ingredients, higher ingredient retention during production process, higher activity levels of encapsulated ingredients, improved shelf life, and controlled release of flavor and aroma. This volume discusses main nanoencapsulation processes such as spray drying, melt injection, extrusion, coacervation, and emulsification. The materials used in nanoencapsulation include lipids, proteins, carbohydrates, cellulose, gums, and food grade polymers. Applications and benefits of nanoencapsulation such as controlled release, protections, and taste masking will be explained in detail. Includes the most up-to-date information on nanoencapsulation and nanocontainer-based delivery of antimicrobials Presents nanomaterials for innovation based on scientific advancements in the field Provides control release strategies to enhance bioactivity, including methods and techniques for research and innovation Provides useful tools to improve the delivery of bioactive molecules and living cells into foods
Book Synopsis Matricellular Receptors as Potential Targets in Anti-Cancer Therapeutic Strategies by : Hervé Emonard
Download or read book Matricellular Receptors as Potential Targets in Anti-Cancer Therapeutic Strategies written by Hervé Emonard and published by Frontiers Media SA. This book was released on 2016-11-22 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: The invasive character of a primary cancer is greatly dependent on numerous interactions between tumor cells and their extracellular surroundings. Matricellular receptors are defined as (cell-surface) receptors that bind extracellular matrix (ECM) structural proteins and soluble factors dynamically acting on ECM homeostasis. Matricellular receptors mediate numerous signalings from the extracellular environment to cell nucleus and drive main biological functions that are cell growth, survival and migration. Numerous data from the last decade evidence that matricellular receptors are biosensors that allow to a tumor cell answering to microenvironmental variations, and in this sense they are important contributors to tumor cell malignancy. Matricellular receptors represent thus valuable targets for the development of original anti-cancer strategies. Original reports, bibliographic reviews or hypotheses are welcome to improve the basic knowledge of matricellular receptor properties, their spatio-temporal regulation, the dynamic formation of complex receptors and the impact of such interactions on the invasive properties of tumor cells. Biological, biophysical and pharmacological, as well as in silico contributions will be appreciated.
