Mitochondrial Biology And Experimental Therapeutics

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Mitochondrial Biology and Experimental Therapeutics

Author : Paulo J. Oliveira
Publisher : Springer
ISBN 13 : 3319733443
Total Pages : 696 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Mitochondrial Biology and Experimental Therapeutics by : Paulo J. Oliveira

Download or read book Mitochondrial Biology and Experimental Therapeutics written by Paulo J. Oliveira and published by Springer. This book was released on 2018-03-21 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mitochondrial Dysfunction

Author : Lawrence H. Lash
Publisher : Elsevier
ISBN 13 : 1483218619
Total Pages : 527 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Mitochondrial Dysfunction by : Lawrence H. Lash

Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Mitochondrial Remodeling and Dynamic Inter-Organellar Contacts in Cardiovascular Physiopathology

Author : Giampaolo Morciano
Publisher : Frontiers Media SA
ISBN 13 : 2889669424
Total Pages : 182 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Mitochondrial Remodeling and Dynamic Inter-Organellar Contacts in Cardiovascular Physiopathology by : Giampaolo Morciano

Download or read book Mitochondrial Remodeling and Dynamic Inter-Organellar Contacts in Cardiovascular Physiopathology written by Giampaolo Morciano and published by Frontiers Media SA. This book was released on 2021-06-21 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mitochondrial Intoxication

Author : Marcos Roberto de Oliveira
Publisher : Elsevier
ISBN 13 : 0323884636
Total Pages : 800 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Mitochondrial Intoxication by : Marcos Roberto de Oliveira

Download or read book Mitochondrial Intoxication written by Marcos Roberto de Oliveira and published by Elsevier. This book was released on 2022-11-30 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrial Intoxication explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications and impact these have upon mitochondria and the diseases that can result from dysfunction and impairment in the human body. Furthermore, the book provides an overview of mitochondrial physiology and assesses the advances and challenges in testing mitochondrial toxicity. Case studies exploring mitochondrial intoxication in pregnancy and in the geriatric population are also included. This is a comprehensive reference on the main toxicants impacting mitochondria in the human body, and the consequences this can have for health and disease. - Features a wide range of toxicants and their effects on mitochondrial physiology - Covers molecular markers of mitochondrial intoxication - Includes case studies that illustrate the health impacts of toxicity upon mitochondria - Considers future directions regarding the study of mitochondrial intoxication

Multifunctional Nanocarriers

Author : Neelesh Kumar Mehra
Publisher : Elsevier
ISBN 13 : 0323852947
Total Pages : 604 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Multifunctional Nanocarriers by : Neelesh Kumar Mehra

Download or read book Multifunctional Nanocarriers written by Neelesh Kumar Mehra and published by Elsevier. This book was released on 2022-08-20 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional Nanocarriers provides information on the concept, theory and application of multifunctional nanocarriers. The book covers current research, beginning with product strategy, targeted drug delivery, and advanced drug delivery approaches, along with numerous multifunctional nanocarriers and their regulatory considerations for product development. The book covers targeting, receptor mediated targeting, and recent advancements using multifunctional nanocarriers and their regulatory aspects. This is an important reference source for materials scientists and engineers who want to learn more about how multifunctional nanocarriers are applied in a range of biomedical applications. - Explains the fundamentals, concepts, theory and application of multifunctional nanocarriers, with advanced content and applications for a range of biomedical applications - Covers production and manufacturing processes for multifunctional nanocarriers for biomedical applications - Assesses major challenges in applying multifunctional nanocarriers on an industrial scale

Modulation of Oxidative Stress in Heart Disease

Author : Sajal Chakraborti
Publisher : Springer Nature
ISBN 13 : 9811389462
Total Pages : 682 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Modulation of Oxidative Stress in Heart Disease by : Sajal Chakraborti

Download or read book Modulation of Oxidative Stress in Heart Disease written by Sajal Chakraborti and published by Springer Nature. This book was released on 2019-11-10 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the multifaceted roles of Reactive Oxygen Species (ROS) in modulating normal cellular and molecular mechanisms during the development of different types of heart disease. Each chapter in the book deals with the role that altered redox homeostasis plays in the pathophysiology of heart disease. In addition, the book explains how reactive oxidant species interact with their targets and provides novel strategies for attenuating oxidative stress-induced types of heart disease. The book not only covers ROS-induced response in heart disease at the cellular level, but also demonstrates that an imbalance of redox states has its roots in our genes, and explains the ways gene expression is regulated. In turn, it reviews potential sources of ROS, their pathological effects on the heart, and potential sites for therapeutic interventions.

Modern Trends in Structural and Solid Mechanics 3

Author : Noel Challamel
Publisher : John Wiley & Sons
ISBN 13 : 1119831814
Total Pages : 306 pages
Book Rating : 4.1/5 (198 download)

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Book Synopsis Modern Trends in Structural and Solid Mechanics 3 by : Noel Challamel

Download or read book Modern Trends in Structural and Solid Mechanics 3 written by Noel Challamel and published by John Wiley & Sons. This book was released on 2021-06-02 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprised of three separate volumes presents the recent developments and research discoveries in structural and solid mechanics; it is dedicated to Professor Isaac Elishakoff. This third volume is devoted to non-deterministic mechanics. Modern Trends in Structural and Solid Mechanics 3 has broad scope, covering topics such: design optimization under uncertainty, interval field approaches, convex analysis, quantum inspired topology optimization and stochastic dynamics. The book is illustrated by many applications in the field of aerospace engineering, mechanical engineering, civil engineering, biomedical engineering and automotive engineering. This book is intended for graduate students and researchers in the field of theoretical and applied mechanics.

Mitochondrial Biology

Author : Derek J. Chadwick
Publisher : John Wiley & Sons
ISBN 13 : 9780470725191
Total Pages : 254 pages
Book Rating : 4.7/5 (251 download)

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Book Synopsis Mitochondrial Biology by : Derek J. Chadwick

Download or read book Mitochondrial Biology written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2007-10-22 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the recent renaissance in mitochondrial biology and increasing recognition of their role in many diseases, this book provides a timely summary of the current state-of-the-art in mitochondrial research. The book opens with the regulation of mitochondrial replication and biogenesis and reviews the mechanisms and functional consequences of mitochondrial fission and fusion. Further chapters address mitochondria and oxidative stress and their roles in cell signalling and cell death. The book includes extensive, fascinating discussion of the biochemistry of mitochondrial cell signalling (especially involving calcium) and of oxidative stress. The nature of the proteins engaged in these processes, many only recently discovered, is covered in detail. Mitochondria have been strongly implicated in neurodegenerative diseases such as Parkinson’s, Huntington’s and amyotrophic lateral sclerosis. They are also affected in cancer, ageing and cardiovascular disease. The final section of the book reviews mitochondrial mutations and their consequences in ageing and other phenotypic manifestations. The authors discuss how mitochondrial proteins might constitute important therapeutic targets and describe initial attempts to develop compounds that can regulate their function.

Cancer as a Metabolic Disease

Author : Thomas Seyfried
Publisher : John Wiley & Sons
ISBN 13 : 1118310306
Total Pages : 482 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Cancer as a Metabolic Disease by : Thomas Seyfried

Download or read book Cancer as a Metabolic Disease written by Thomas Seyfried and published by John Wiley & Sons. This book was released on 2012-05-18 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.

Molecular Mechanisms of Action of Functional Foods and Nutraceuticals for Chronic Diseases

Author : Shima Abdollahi
Publisher : CRC Press
ISBN 13 : 1000850110
Total Pages : 421 pages
Book Rating : 4.0/5 (8 download)

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Book Synopsis Molecular Mechanisms of Action of Functional Foods and Nutraceuticals for Chronic Diseases by : Shima Abdollahi

Download or read book Molecular Mechanisms of Action of Functional Foods and Nutraceuticals for Chronic Diseases written by Shima Abdollahi and published by CRC Press. This book was released on 2023-04-19 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a global rise in the incidence of chronic illnesses, which may be partially attributed to the lengthening of the average human lifespan. Functional foods and nutraceuticals have a potential role to play in the development and maintenance of health. They can assist the body in its battle against inflammation and chronic illnesses. Molecular Mechanisms of Action of Functional Foods and Nutraceuticals for Chronic Diseases addresses the effects and mechanism of functional foods in relation to chronic diseases such as obesity, cardiovascular diseases, diabetes, cancer, etc. This volume, like the first volume Applications of Functional Foods and Nutraceuticals for Chronic Diseases, inspires new thought processes and a paradigm shift in research and development. Key Features: Discusses the molecular mechanism of action, the range of toxicities exerted by these food components for functional foods for addressing chronic conditions Enhances scientists and industrial personnel knowledge of functional foods and in the management of chronic diseases Presents research on the role of functional foods/nutraceuticals in preventing and treating chronic diseases through epigenetic modulation Explores various subjects such as epigenetics, immunological, metabolic, technological and neurodenerative aspects affected by functional foods in chronic diseases The world’s leading wellness centers for chronic diseases are using functional foods and nutraceuticals in their practice and discovering their useful applications, and this second of two volume set is another great reference for practitioners, scientists, and clinicians in the management of chronic diseases. Contributors hail from different geographical locations around the world and have many years of research and scholarly experience in functional foods, nutraceuticals, and biology.

Antibody Engineering

Author : Carl A. K. Borrebaeck
Publisher : Breakthroughs in Molecular Biology
ISBN 13 : 9780195091502
Total Pages : 410 pages
Book Rating : 4.0/5 (915 download)

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Book Synopsis Antibody Engineering by : Carl A. K. Borrebaeck

Download or read book Antibody Engineering written by Carl A. K. Borrebaeck and published by Breakthroughs in Molecular Biology. This book was released on 1995 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: In presenting a practical overview of the engineering of recombinant human or mouse monoclonal antibodies, the book incisively addresses essential topics such as antibody structure relevant to engineering, recombinatorial cDNA libraries, phage display, synthetic and humanized antibodies, engineering of affinity and biological effector functions, and plant, mammalian, and bacterial expression vectors and hosts. Antibody Engineering, Second Edition - written by leading experts and now thoroughly updated - is a unique resource for current information on the subject.

Senescence, Senotherapeutics and Mitochondria

Author :
Publisher : Elsevier
ISBN 13 : 0443188874
Total Pages : 480 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Senescence, Senotherapeutics and Mitochondria by :

Download or read book Senescence, Senotherapeutics and Mitochondria written by and published by Elsevier. This book was released on 2023-07-14 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Senescence, Senotherapeutics and Mitochondria, Volume 136 offers updates on this unique topics, with chapters covering Cellular Senescence in Aging: Molecular Basis, Implications and Therapeutic Interventions, Mitochondria-associated Cellular Senescence Mechanisms: Biochemical and Pharmacological Perspectives, Mitochondria in cell senescence: Friend or Foe?, The role of mitochondria and mitophagy in cell senescence, Small molecules targeting mitochondrial dysfunction for potential senotheraputics, Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction, Mitochondrial targeting peptides and probes, Mitochondria-derived peptides in healthy ageing and therapy of age-related diseases, and much more. Other sections cover Targeting of mitostasis-proteostasis axis by antioxidant polysaccharides in neurodegeneration, Phytotherapeutic targeting of the mitochondria in neurodegenerative disorders, Melatonin as mitochondria-targeted drugs, Coenzyme Q-related compounds to maintain healthy mitochondria during aging, Changing ROS, NAD and AMP: a path to longevity via mitochondrial therapeutics, and more. - Updates on how mitochondria are closely related to the survival of senescent cells using either mitochondria-targeted senolytic or redox modulator senomorphic strategies - Differentiates itself from other books with its multidisciplinary perspectives and multidimensional clinical approaches - Offers a novel perspective on both the basic and clinical sciences for a wide group of well-established academicians, students and researchers in medicinal chemistry, gerontology, geriatrics, oncology, pharmacology, pathology, bioinformatics, sports science and nutritional sciences

Biophysics and Nanotechnology of Ion Channels

Author : Mohammad Ashrafuzzaman
Publisher : CRC Press
ISBN 13 : 100045164X
Total Pages : 459 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Biophysics and Nanotechnology of Ion Channels by : Mohammad Ashrafuzzaman

Download or read book Biophysics and Nanotechnology of Ion Channels written by Mohammad Ashrafuzzaman and published by CRC Press. This book was released on 2021-09-20 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive review of the biophysics and nanotechnology of ion channels. It details the biological and physiological entities of ion channels in cells and addresses various physical perspectives of ion channel structures and functions. Naturally inbuilt and artificial applicable nanotechnologies of ion channels are modelled and explored. It discusses various methods that can be utilized toward understanding ion channel-based cellular diseases. Physical, biochemical, biomedical, and bioinformatics techniques are taken into consideration to enable the development of strategies to address therapeutic drug discovery and delivery. This book will be of interest to advanced undergraduate and graduate students in biophysics and related biomedical sciences in addition to researchers in the field and industry. Features: Provides a stimulating introduction to the structures and functions of ion channels of biological cell membranes and discusses the biophysics of ion channels in condensed matter state and physiological condition Addresses natural processes and nanotechnology opportunities for their purposeful manipulation Lays the groundwork for vitally important medical advances Mohammad Ashrafuzzaman, a biophysicist and condensed matter scientist, is passionate about investigating biological and biochemical processes utilizing the principles and techniques of physics. He is an associate professor at King Saud University’s Biochemistry Department of College of Science, Riyadh, Saudi Arabia, the co-founder of MDT Canada Inc., and the founder of Child Life Development Institute, Edmonton, Canada. He also authored Nanoscale Biophysics of the Cell and Membrane Biophysics.

Research Awards Index

Author :
Publisher :
ISBN 13 :
Total Pages : 1526 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Research Awards Index by :

Download or read book Research Awards Index written by and published by . This book was released on 1978 with total page 1526 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Research Grants Index

Author : National Institutes of Health (U.S.). Division of Research Grants
Publisher :
ISBN 13 :
Total Pages : 1328 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis Research Grants Index by : National Institutes of Health (U.S.). Division of Research Grants

Download or read book Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and published by . This book was released on 1971 with total page 1328 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mitochondrial Signaling in Health and Disease

Author : Sten Orrenius
Publisher : CRC Press
ISBN 13 : 1439880026
Total Pages : 530 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Mitochondrial Signaling in Health and Disease by : Sten Orrenius

Download or read book Mitochondrial Signaling in Health and Disease written by Sten Orrenius and published by CRC Press. This book was released on 2012-06-20 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis. With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include: Electron transport and energy production Mitochondrial biogenesis and dynamics Mitochondrial signaling Apoptosis and autophagy Pharmacology signaling Epigenetic signaling: mitochondrial methylation and acetylation reactions An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.