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Microsomes Drug Oxidations And Chemical Carcinogenesis V1
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Book Synopsis Microsomes, Drug Oxidations and Chemical Carcinogenesis V1 by : Minor Coon
Download or read book Microsomes, Drug Oxidations and Chemical Carcinogenesis V1 written by Minor Coon and published by Elsevier. This book was released on 2012-12-02 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microsomes, Drug Oxidations, and Chemical Carcinogenesis, Volume I, documents the proceedings of the 4th International Symposium on Microsomes and Drug Oxidations held in Ann Arbor, July 1979. The symposium reviewed progress in the understanding of scientific and biomedical problems from a biochemical, biophysical, pharmacological, and toxicological perspective. The book contains 117 contributions made by researchers at the symposium, which are organized into three sections. The papers in Section I focus on the chemical and physical characteristics of cytochrome P-450. Section II examines the mechanisms of action of cytochrome P-450 and related enzymes. The studies in Section III deal with the influence of membrane structure and protein synthesis on electron transfer components. This book seeks to aid future progress in understanding the complexities of metabolic transformations by these versatile enzyme systems that act on physiologically important lipids as well as on a wide array of foreign substances, including drugs, anesthetics, industrial chemicals, food additives, pesticides, carcinogens, and nonnutrient dietary chemicals.
Book Synopsis Microsomes, Drug Oxidations and Chemical Carcinogenesis V2 by : Minor Coon
Download or read book Microsomes, Drug Oxidations and Chemical Carcinogenesis V2 written by Minor Coon and published by Elsevier. This book was released on 2012-12-02 with total page 655 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microsomes, Drug Oxidations, and Chemical Carcinogenesis, Volume II, documents the proceedings of the 4th International Symposium on Microsomes and Drug Oxidations held in Ann Arbor, July 1979. The symposium reviewed progress in the understanding of scientific and biomedical problems from a biochemical, biophysical, pharmacological, and toxicological perspective. Volume I contained 117 contributions made by researchers at the symposium, which were organized into three sections (Sections I-III). This second volume contains 122 contributions, divided into four sections (Sections IV-VII). The papers on Section IV examine the metabolic fate of oxygenated compounds. Section V provides studies on microsomal enzymes and lipid metabolism. Section VI includes papers on microsomal enzymes and toxicity of foreign compounds. Section VII covers microsomal enzymes and chemical mutagenesis and carcinogenesis. This book seeks to aid future progress in understanding the complexities of metabolic transformations by these versatile enzyme systems that act on physiologically important lipids as well as on a wide array of foreign substances, including drugs, anesthetics, industrial chemicals, food additives, pesticides, carcinogens, and nonnutrient dietary chemicals.
Book Synopsis Microsomes, Drug Oxidations, and Chemical Carcinogenesis by : Minor Jesser Coon
Download or read book Microsomes, Drug Oxidations, and Chemical Carcinogenesis written by Minor Jesser Coon and published by . This book was released on 1980 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Microsomes, Drug Oxidations and Drug Toxicology by : Ryo Sato
Download or read book Microsomes, Drug Oxidations and Drug Toxicology written by Ryo Sato and published by John Wiley & Sons. This book was released on 1982 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the Fifth International Symposium on Microsomes and Drug Oxidations held in Tokyo, July 1981. Researchers from a wide range of disciplines discuss recent developments in the field. Emphasizes the characterization and mechanisms of action of cytochrome P-450 and related enzymes; microsomal metabolism of endogenous substrates; regulation of microsomal metabolism; and metabolic activation and drug toxicity.
Book Synopsis Biological Oxidation Systems V1 by : C.C. Reddy
Download or read book Biological Oxidation Systems V1 written by C.C. Reddy and published by Elsevier. This book was released on 2012-12-02 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological Oxidation Systems, Volume I is a collection of papers presented at the 1989 Bangalore Symposium on Oxygen Systems. This symposium covers various research studies on the essential roles, and the dangers of dioxygen reactions in biology. This volume is organized into five parts encompassing 32 chapters, and starts with an overview of the biological oxidation mechanisms involving oxygen and reduced oxygen derivatives. Parts I and II deal with the catalytic role of cytochrome P-450 and oxidase and oxygenase containing a flavin or pteridine enzymes in several biological oxidation reactions. These parts examine the biochemical aspects, reaction kinetics, and reaction mechanisms of such reactions. Parts III and IV describe first the structure function and properties of copper-containing oxidases and oxygenases. These parts also discuss the role of nonheme iron-containing and other oxygenases in the indole metabolism. Part V focuses on the role of peroxidase enzymes in cell protection and metabolism. This book will prove useful to biologists, enzyme scientists, and researchers.
Book Synopsis Current Catalog by : National Library of Medicine (U.S.)
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1979 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1988 with total page 1328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biochemistry written by David E. Metzler and published by Elsevier. This book was released on 2003-05-04 with total page 1063 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemistry: The Chemical Reactions of Living Cells is a well-integrated, up-to-date reference for basic chemistry and underlying biological phenomena. Biochemistry is a comprehensive account of the chemical basis of life, describing the amazingly complex structures of the compounds that make up cells, the forces that hold them together, and the chemical reactions that allow for recognition, signaling, and movement. This book contains information on the human body, its genome, and the action of muscles, eyes, and the brain. * Thousands of literature references provide introduction to current research as well as historical background * Contains twice the number of chapters of the first edition * Each chapter contains boxes of information on topics of general interest
Book Synopsis Circadian Pharmacokinetics by : Baojian Wu
Download or read book Circadian Pharmacokinetics written by Baojian Wu and published by Springer Nature. This book was released on 2020-10-28 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.
Book Synopsis Handbook of Anticancer Drugs from Marine Origin by : Se-Kwon Kim
Download or read book Handbook of Anticancer Drugs from Marine Origin written by Se-Kwon Kim and published by Springer. This book was released on 2014-11-27 with total page 801 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely desk reference focuses on marine-derived bioactive substances which have biological, medical and industrial applications. The medicinal value of these marine natural products are assessed and discussed. Their function as a new and important resource in novel, anticancer drug discovery research is also presented in international contributions from several research groups. For example, the potential role of Spongistatin, Apratoxin A, Eribulin mesylate, phlorotannins, fucoidan, as anticancer agents is explained. The mechanism of action of bioactive compounds present in marine algae, bacteria, fungus, sponges, seaweeds and other marine animals and plants are illustrated via several mechanisms. In addition, this handbook lists various compounds that are active candidates in chemoprevention and their target actions. The handbook also places into context the demand for anticancer nutraceuticals and their use as potential anti-cancer pharmaceuticals and medicines. This study of advanced and future types of natural compounds from marine sources is written to facilitate the understanding of Biotechnology and its application to marine natural product drug discovery research.
Book Synopsis Metabolism of Drugs and Other Xenobiotics by : Pavel Anzenbacher
Download or read book Metabolism of Drugs and Other Xenobiotics written by Pavel Anzenbacher and published by John Wiley & Sons. This book was released on 2012-05-29 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.
Book Synopsis Tolerable upper intake levels for vitamins and minerals by : European Commission. Scientific Committee on Food
Download or read book Tolerable upper intake levels for vitamins and minerals written by European Commission. Scientific Committee on Food and published by . This book was released on 2006 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Optimizing the "Drug-Like" Properties of Leads in Drug Discovery by : Ronald Borchardt
Download or read book Optimizing the "Drug-Like" Properties of Leads in Drug Discovery written by Ronald Borchardt and published by Springer. This book was released on 2006-09-25 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book arises from a workshop organized by the American Association of Pharmaceutical Scientists entitled "Optimizing the Drug-Like Properties of Leads in Drug Discovery," which took place in Parsippany, NJ in September 2004. The workshop focused on the optimization of the drug-like properties of leads in drug discovery. The volume outlines strategies and methodologies designed to guide pharmaceutical and biotechnology companies through the drug discovery and development process.
Book Synopsis Cancer Therapeutics by : Beverly A. Teicher
Download or read book Cancer Therapeutics written by Beverly A. Teicher and published by Springer Science & Business Media. This book was released on 1996-12-03 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer drug discovery has been and continues to be a process of ingenuity, serendip ity, and dogged determination. In an effort to develop and discover better therapies against cancer, investigators all over the world have increased our knowledge of cell biology, biochemistry, and molecular biology. The goal has been to define therapeuti cally exploitable differences between normal and malignant cells. The result has been an increased understanding of cellular and whole-organism biology and an increased respect for the flexibility and resiliency ofbiologically systems. Thus, as some new therapeutic targets have been defined and new therapeutic strategies have been attempted, so have some new biological hurdles resulting from tumor evasion of the intended therapeutic attack been discovered. Historically, anticancer drugs have originated from all available chemical sources. Synthetic molecules from the chemical industry, especially dyestuffs and warfare agents, and natural products from plants, microbes, and fungi have all been potential sources of pharmaceuticals, including anticancer agents. There is no shortage of molecules; the challenge has been and continues to be methods of identifying molecules that have the potential to be therapeutically important in human malignant disease. "Screening" remains the most important and most controversial method in cancer drug discovery. In vitro screens have generally focused on cytotoxicity and have identified several highly cytotoxic molecules. Other endpoints available in vitro are inhibition of proliferation, 3 inhibition of [ H]thymidine incorporation into DNA and various viability assays, based most frequently on dye exclusion or metabolism.
Book Synopsis Nicotine Psychopharmacology by : Jack E. Henningfield
Download or read book Nicotine Psychopharmacology written by Jack E. Henningfield and published by Springer Science & Business Media. This book was released on 2009-02-01 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fact that tobacco ingestion can affect how people feel and think has been known for millennia, placing the plant among those used spiritually, honori?cally, and habitually (Corti 1931; Wilbert 1987). However, the conclusion that nicotine - counted for many of these psychopharmacological effects did not emerge until the nineteenth century (Langley 1905). This was elegantly described by Lewin in 1931 as follows: “The decisive factor in the effects of tobacco, desired or undesired, is nicotine. . . ”(Lewin 1998). The use of nicotine as a pharmacological probe to und- stand physiological functioning at the dawn of the twentieth century was a landmark in the birth of modern neuropharmacology (Limbird 2004; Halliwell 2007), and led the pioneering researcher John Langley to conclude that there must exist some “- ceptive substance” to explain the diverse actions of various substances, including nicotine, when applied to muscle tissue (Langley 1905). Research on tobacco and nicotine progressed throughout the twentieth century, but much of this was from a general pharmacological and toxicological rather than a psychopharmacological perspective (Larson et al. 1961). There was some attention to the effects related to addiction, such as euphoria (Johnston 1941), tolerance (Lewin 1931), and withdrawal (Finnegan et al. 1945), but outside of research supported by the tobacco industry, addiction and psychopharmacology were not major foci for research (Slade et al. 1995; Hurt and Robertson 1998; Henning?eld et al. 2006; Henning?eld and Hartel 1999; Larson et al. 1961).
Book Synopsis Potential Industrial Carcinogens and Mutagens by : L. Fishbein
Download or read book Potential Industrial Carcinogens and Mutagens written by L. Fishbein and published by Elsevier. This book was released on 2011-08-30 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Potential Industrial Carcinogens and Mutagens
Book Synopsis Genetic Glass Ceilings by : Jonathan Gressel
Download or read book Genetic Glass Ceilings written by Jonathan Gressel and published by JHU Press. This book was released on 2020-03-03 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the world’s population rises to an expected ten billion in the next few generations, the challenges of feeding humanity and maintaining an ecological balance will dramatically increase. Today we rely on just four crops for 80 percent of all consumed calories: wheat, rice, corn, and soybeans. Indeed, reliance on these four crops may also mean we are one global plant disease outbreak away from major famine. In this revolutionary and controversial book, Jonathan Gressel argues that alternative plant crops lack the genetic diversity necessary for wider domestication and that even the Big Four have reached a “genetic glass ceiling”: no matter how much they are bred, there is simply not enough genetic diversity available to significantly improve their agricultural value. Gressel points the way through the glass ceiling by advocating transgenics—a technique where genes from one species are transferred to another. He maintains that with simple safeguards the technique is a safe solution to the genetic glass ceiling conundrum. Analyzing alternative crops—including palm oil, papaya, buckwheat, tef, and sorghum—Gressel demonstrates how gene manipulation could enhance their potential for widespread domestication and reduce our dependency on the Big Four. He also describes a number of ecological benefits that could be derived with the aid of transgenics. A compelling synthesis of ideas from agronomy, medicine, breeding, physiology, population genetics, molecular biology, and biotechnology, Genetic Glass Ceilings presents transgenics as an inevitable and desperately necessary approach to securing and diversifying the world's food supply.
