Microrna Detection And Pathological Functions

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MicroRNA Detection and Pathological Functions

Author : Xueji Zhang
Publisher : Springer
ISBN 13 : 3662472937
Total Pages : 108 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis MicroRNA Detection and Pathological Functions by : Xueji Zhang

Download or read book MicroRNA Detection and Pathological Functions written by Xueji Zhang and published by Springer. This book was released on 2015-05-26 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes microRNA (miRNA) biology in a variety of pathological processes, emphasizing the significant potential applications of miRNA in diagnostics and prognostics, as well as novel drug targets. The conventional techniques used for miRNA detection including standard PCR, Northern blotting, microarray and clone methods are addressed. Recent emerging strategies in miRNA detection and quantification with superior flexibility and adaptability, such as novel molecular biological techniques and locked nucleic acid (LNA) modified probes, as well as nanotechnology-based approaches, are also included. The book also highlights the latest advances in clinical-related miRNA detection methods in living cells, circulating blood and tissue, such as in situ hybridization (ISH) and molecular imaging techniques, which are useful to elucidate the biogenesis and biological function of miRNAs in vivo. Finally, the respective advantages and drawbacks of various detection techniques in this fast-moving field are discussed, along with the challenges and promising new directions. This book offers a valuable resource for analytical chemists, biologists and physicians involved in miRNA research. Dr. Xueji Zhang and Dr. Haifeng Dong are Professors at the School of Chemistry & Biological Engineering, University of Science & Technology Beijing (USTB), China. Dr. Yaping Tian is a Professor at the Department of Clinical Biochemistry, Chinese PLA General Hospital and Military Medical School, China.

Circulating MicroRNAs

Author : Takahiro Ochiya
Publisher : Humana Press
ISBN 13 : 9781627034524
Total Pages : 0 pages
Book Rating : 4.0/5 (345 download)

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Book Synopsis Circulating MicroRNAs by : Takahiro Ochiya

Download or read book Circulating MicroRNAs written by Takahiro Ochiya and published by Humana Press. This book was released on 2013-05-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: microRNAs (miRNAs) are small non-coding RNAs that regulate various biological phenomena, such as development and homeostasis. The dysregulation of miRNA leads to disease progression, particularly of cancer. In Circulating MicroRNAs: Methods and Protocols, expert researchers in the field detail recent advances in the isolation, purification and analysis of circulating miRNAs from a variety of sources for research. The book is divided into three main topics. The first section involves the study of secretory miRNAs in cell-cell communication, and the second, the study of circulating miRNAs in body fluids. The last describes the novel techniques used to study circulating miRNAs. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Circulating MicroRNAs: Methods and Protocols seeks to aid scientists in dealing with the recent advances of RNAi technology from the bench to the bedside.

Nanotechnology-Enabled Sensors

Author : Kourosh Kalantar-zadeh
Publisher : Springer Science & Business Media
ISBN 13 : 0387680233
Total Pages : 502 pages
Book Rating : 4.3/5 (876 download)

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Book Synopsis Nanotechnology-Enabled Sensors by : Kourosh Kalantar-zadeh

Download or read book Nanotechnology-Enabled Sensors written by Kourosh Kalantar-zadeh and published by Springer Science & Business Media. This book was released on 2007-09-19 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology provides tools for creating functional materials, devices, and systems by controlling materials at the atomic and molecular scales and making use of novel properties and phenomena. Nanotechnology-enabled sensors find applications in several fields such as health and safety, medicine, process control and diagnostics. This book provides the reader with information on how nanotechnology enabled sensors are currently being used and how they will be used in the future in such diverse fields as communications, building and facilities, medicine, safety, and security, including both homeland defense and military operations.

MicroRNAs

Author : Krishnarao Appasani
Publisher : Cambridge University Press
ISBN 13 : 9780521118552
Total Pages : 580 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis MicroRNAs by : Krishnarao Appasani

Download or read book MicroRNAs written by Krishnarao Appasani and published by Cambridge University Press. This book was released on 2009-08-20 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNAs (miRNAs) are RNA molecules, conserved by evolution, that regulate gene expressions and their recent discovery is revolutionising both basic biomedical research and drug discovery. Expression levels of MiRNAs have been found to vary between tissues and with developmental stages and hence evaluation of the global expression of miRNAs potentially provides opportunities to identify regulatory points for many different biological processes. This wide-ranging reference work, written by leading experts from both academia and industry, will be an invaluable resource for all those wishing to use miRNA techniques in their own research, from graduate students, post-docs and researchers in academia to those working in R&D in biotechnology and pharmaceutical companies who need to understand this emerging technology. From the discovery of miRNAs and their functions to their detection and role in disease biology, this volume uniquely integrates the basic science with industry application towards drug validation, diagnostic and therapeutic development. Forewords by: Sidney Altman, Yale University, Winner of the Nobel Prize in Chemistry, 1989 and Victor R. Ambros, Dartmouth Medical School, Co-discoverer of MicroRNAs

Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues

Author : Haruo Sugi
Publisher : IntechOpen
ISBN 13 : 9789535106791
Total Pages : 0 pages
Book Rating : 4.1/5 (67 download)

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Book Synopsis Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues by : Haruo Sugi

Download or read book Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues written by Haruo Sugi and published by IntechOpen. This book was released on 2012-07-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains 17 short review articles classified into 3 parts. Part I consists of 7 articles dealing with basic aspects of contractile mechanism in skeletal and smooth muscle cells and also function of melanocytes having many properties common to those of smooth muscles. Part II and Part III contain articles dealing with pathological aspects of cardiac and smooth muscle cell functions, and dealing with factors influencing structure and function of cardiac and smooth muscle cells and tissues. The Editor believes that these articles are stimulating and informative for readers interested in basic, pathological and clinical aspects of muscle cells and tissues.

MicroRNA Signaling

Author : Dragos Cretoiu
Publisher : Frontiers Media SA
ISBN 13 : 2889662896
Total Pages : 260 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis MicroRNA Signaling by : Dragos Cretoiu

Download or read book MicroRNA Signaling written by Dragos Cretoiu and published by Frontiers Media SA. This book was released on 2020-12-29 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Regulatory microRNA

Author : Y-h. Taguchi
Publisher : MDPI
ISBN 13 : 3038977683
Total Pages : 348 pages
Book Rating : 4.0/5 (389 download)

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Book Synopsis Regulatory microRNA by : Y-h. Taguchi

Download or read book Regulatory microRNA written by Y-h. Taguchi and published by MDPI. This book was released on 2019-04-16 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes updated information about microRNA regulation, for example, in the fields of circular RNAs, multiomics analysis, biomarkers and oncogenes. The variety of topics included in this book reaffirms the extent to which microRNA regulation affects biological processes. Although microRNAs are not translated to proteins, their importance for biological processes is not less than proteins. An understanding of their roles in various biological processes is critical to understanding gene function in these biological processes. Although non-coding RNAs other than microRNAs have recently come under investigation, microRNA still remains the front runner as the subject of genetic and biological studies. In reading the collection of papers, readers can grasp the most updated information regarding microRNA regulation, which will continue to be an important topic in genetics and biology.

Gene Therapy

Author : Chunsheng Kang
Publisher : BoD – Books on Demand
ISBN 13 : 9533076178
Total Pages : 370 pages
Book Rating : 4.5/5 (33 download)

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Book Synopsis Gene Therapy by : Chunsheng Kang

Download or read book Gene Therapy written by Chunsheng Kang and published by BoD – Books on Demand. This book was released on 2011-06-22 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to cover key aspects of existing problems in the field of development and future perspectives in gene therapy. Contributions consist of basic and translational research, as well as clinical experiences, and they outline functional mechanisms, predictive approaches, patient-related studies and upcoming challenges in this stimulating but also controversial field of gene therapy research. This source will make our doctors become comfortable with the common problems of gene therapy and inspire others to delve a bit more deeply into a topic of interest.

RNA Delivery Function for Anticancer Therapeutics

Author : Loutfy H. Madkour
Publisher : CRC Press
ISBN 13 : 1000532232
Total Pages : 424 pages
Book Rating : 4.0/5 (5 download)

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Book Synopsis RNA Delivery Function for Anticancer Therapeutics by : Loutfy H. Madkour

Download or read book RNA Delivery Function for Anticancer Therapeutics written by Loutfy H. Madkour and published by CRC Press. This book was released on 2022-01-25 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, systemic circulation, and cellular barriers for the clinical translation of RNAi cancer therapeutics, and with partial content for discussing the safety concerns. It then focuses on imaging-guided delivery of RNAi therapeutics in preclinical development, including the basic principles of different imaging modalities, and their advantages and limitations for biological imaging. With growing number of RNAi therapeutics entering the clinic, various imaging methods will play an important role in facilitating the translation of RNAi cancer therapeutics from bench to bedside. RNAi technique has become a powerful tool for basic research to selectively knock down gene expression in vitro and in vivo. Our scientific and industrial communities have started to develop RNAi therapeutics as the next class of drugs for treating a variety of genetic disorders, such as cancer and other diseases that are particularly hard to address with current treatment strategies. Key Features Provides insight into the current advances and hurdles of RNAi therapeutics. Accelerates RNAi, miRNAs, and siRNA drug development for cancer therapy from bench to bedside. Addresses various modifications and novel delivery strategies for miRNAs, piRNAs and siRNA delivery in anticancer therapeutics. Explores the need for the interaction of hematologists,cell biologists, immunologists, and material scientists in the development of novel cancer therapies. Describes the current status of clinical trials related to miRNA and siRNA-based cancer therapy Presents remaining issues that need to be overcome to establish successful therapies.

The Liver

Author : Irwin M. Arias
Publisher : John Wiley & Sons
ISBN 13 : 1119436834
Total Pages : 3296 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis The Liver by : Irwin M. Arias

Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-01-22 with total page 3296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.

The origin, function and diagnostic potential of extracellular microRNA in human body fluids

Author : Andrey Turchinovich
Publisher : Frontiers E-books
ISBN 13 : 2889192423
Total Pages : 115 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis The origin, function and diagnostic potential of extracellular microRNA in human body fluids by : Andrey Turchinovich

Download or read book The origin, function and diagnostic potential of extracellular microRNA in human body fluids written by Andrey Turchinovich and published by Frontiers E-books. This book was released on 2014-07-28 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: Short non-coding RNA molecules, microRNAs (miRNAs), post-transcriptionally regulate gene expression in living cells. In recent years, miRNAs have been found in a wide spectrum of mammalian body fluids including blood plasma, saliva, urine, milk, seminal plasma, tears and amniotic fluid as extracellular circulating nuclease-resistant entities. The changes in miRNA spectra observed in certain fluids correlated with various pathological conditions suggesting that extracellular miRNAs can serve as informative biomarkers for certain diseases including cancer. However, the mechanism of generation and a biological role of extracellular miRNAs remain unclear. The current theories regarding extracellular miRNA origin and function suggest that these miRNAs can be either non-specific ‘by-products’ of cellular activity and cell death or specifically released cell-cell signaling messengers. The goal of this Research Topic is to bring together up-to-date knowledge about the extracellular miRNA and its role in disease diagnostics and, possibly, inter-cellular communication.

Omics Approaches in Breast Cancer

Author : Debmalya Barh
Publisher : Springer
ISBN 13 : 8132208439
Total Pages : 559 pages
Book Rating : 4.1/5 (322 download)

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Book Synopsis Omics Approaches in Breast Cancer by : Debmalya Barh

Download or read book Omics Approaches in Breast Cancer written by Debmalya Barh and published by Springer. This book was released on 2014-10-13 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer is the most common cancer in females that accounts for highest cancer specific deaths worldwide. In the last few decades research has proven that breast cancer can be treated if diagnosed at early stages and proper therapeutic strategy is adopted. Omics-based recent approaches have unveiled the molecular mechanism behind the breast tumorigenesis and aid in identification of next-generation molecular markers for early diagnosis, prognosis and even the effective targeted therapy. Significant development has taken place in the field of omics in breast cancer in the last decade. The most promising omics approaches and their outcomes in breast cancer have been presented in this book for the first time. The book covers omics technologies and budding fields such as breast cancer miRNA, lipidomics, epigenomics, proteomics, nutrigenomics, stem cell, pharmacogenomics and personalized medicine and many more along with conventional topics such as breast cancer management etc. It is a research-based reference book useful for clinician-scientists, researchers, geneticists and health care industries involved in various aspects of breast cancer. The book will also be useful for students of biomedicine, pathology and pharmacy.

Novel roles of non-coding brain RNAs in health and disease

Author : Hermona Soreq
Publisher : Frontiers E-books
ISBN 13 : 2889193098
Total Pages : 214 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Novel roles of non-coding brain RNAs in health and disease by : Hermona Soreq

Download or read book Novel roles of non-coding brain RNAs in health and disease written by Hermona Soreq and published by Frontiers E-books. This book was released on 2014-10-23 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-coding RNAs (ncRNAs), and in particular microRNAs are rapidly becoming the focus of research interest in numerous basic and translational fields, including brain research; and their importance for many aspects in brain functioning merits special discussion. The wide-scope, multi-targeted and highly efficient manner of ncRNA regulatory activities draws attention to this topic by many, but the available research and analysis tools and experimental protocols are still at their infancy, and calls for special discussion given their importance for many aspects in brain functioning. This eBook is correspondingly focused on the search for, identification and exploration of those non-coding RNAs whose activities modulate the multi-leveled functions of the eukaryotic brain. The different articles strive to cover novel approaches for identifying and establishing ncRNA-target relationships, provide state of the art reports of the affected neurotransmission pathways, describe inherited and acquired changes in ncRNA functioning and cover the use of ncRNA mimics and blockade tools for interference with their functions in health and disease of the brain. Non-coding RNAs are here to stay, and this exciting eBook provides a glimpse into their impact on our brain’s functioning at the physiology, cell biology, behavior and immune levels.

Mesenchymal Stem Cell Derived Exosomes

Author : Yaoliang Tang
Publisher : Academic Press
ISBN 13 : 0128004975
Total Pages : 287 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Mesenchymal Stem Cell Derived Exosomes by : Yaoliang Tang

Download or read book Mesenchymal Stem Cell Derived Exosomes written by Yaoliang Tang and published by Academic Press. This book was released on 2015-09-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. - Introduces the MSC-exosome mediated cell-cell communication - Covers the major functional benefits in current MSC-derived exosome studies - Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies

Multidisciplinary Research in Arts, Science & Commerce (Volume-9)

Author : Chief Editor- Biplab Auddya, Editor- Dr. B.S. Rajitha, Dr. Anita Konwar, Dr. P. C. Gangurde, Ms. Prachee V Waray, Dr. Sameena Kausar, Vidwan Manjesh M
Publisher : The Hill Publication
ISBN 13 : 8197785139
Total Pages : 38 pages
Book Rating : 4.1/5 (977 download)

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Book Synopsis Multidisciplinary Research in Arts, Science & Commerce (Volume-9) by : Chief Editor- Biplab Auddya, Editor- Dr. B.S. Rajitha, Dr. Anita Konwar, Dr. P. C. Gangurde, Ms. Prachee V Waray, Dr. Sameena Kausar, Vidwan Manjesh M

Download or read book Multidisciplinary Research in Arts, Science & Commerce (Volume-9) written by Chief Editor- Biplab Auddya, Editor- Dr. B.S. Rajitha, Dr. Anita Konwar, Dr. P. C. Gangurde, Ms. Prachee V Waray, Dr. Sameena Kausar, Vidwan Manjesh M and published by The Hill Publication. This book was released on 2024-10-17 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Physical exercise for age-related neuromusculoskeletal disorders

Author : Xue-Qiang Wang
Publisher : Frontiers Media SA
ISBN 13 : 2832511880
Total Pages : 502 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Physical exercise for age-related neuromusculoskeletal disorders by : Xue-Qiang Wang

Download or read book Physical exercise for age-related neuromusculoskeletal disorders written by Xue-Qiang Wang and published by Frontiers Media SA. This book was released on 2023-01-19 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Comprehensive Toxicology

Author :
Publisher : Elsevier
ISBN 13 : 0081006128
Total Pages : 8639 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Comprehensive Toxicology by :

Download or read book Comprehensive Toxicology written by and published by Elsevier. This book was released on 2017-12-01 with total page 8639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts