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Author : Michael Thomas Baynham
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (595 download)
Download or read book Microcolumn Separations Coupled to Mass Spectrometry written by Michael Thomas Baynham and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michael Thomas Baynham
Publisher :
ISBN 13 :
Total Pages : 500 pages
Book Rating : 4.:/5 (125 download)
Download or read book Microcolumn Separations Coupled to Mass Spectroscopy written by Michael Thomas Baynham and published by . This book was released on 2000 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (86 download)
Download or read book Novel Micro-separation Techniques and Their Couplings to Mass Spectrometry for the Analysis of Complex Peptides and Proteins written by and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass spectrometry (MS)-based technology has evolved as a powerful tool for the analysis of a wide array of biomolecules. However, its application to complex peptidomics and proteomics samples, for example neuropeptides, has proven to be challenging due to their extreme chemical complexities and low abundances in biological tissue samples. This PhD dissertation is focused on addressing some of these challenges by developing novel micro-separation tools and coupling them with MS to achieve enhanced MS sensitivity and increased peptide and protein coverage with lower sample consumption and reduced experimental time. Both chromatography-based and electrophoresis-based separations as well as their couplings to MS have been explored in this work, including monolithic material-based chromatography, improved capillary electrophoresis (CE) separation and novel coupling of separations to mass spectrometric imaging. N-acryloxysuccinimide-based monolithic column has been fabricated with specific antibodies immobilized onto the column to enable the extraction of targeted neuropeptide family from biological matrices. Alternatively, enzymes were immobilized onto the column for highly efficient on-column enzymatic digestion for proteomics studies. A methacrylate-based monolithic column with C12 functional groups was developed and coupled to both electrospray ionization (ESI) MS and matrix-assisted laser desorption/ionization (MALDI) MS for reversed-phase liquid chromatography (RPLC). For capillary electrophoresis, two improved capillary isoelectric focusing (CIEF) systems have been developed, including membrane-assisted CIEF and immobilized pH-gradient CIEF to obtain reduced sample loss and enhanced MS signal for neuropeptide analysis. An improved sheathless pressure-assisted CE (PACE) system was also developed for coupling to MALDI MS. For novel separation-MS imaging coupling, three generations of interfaces have been designed to couple CE, LC and multi-dimensional separations to MS imaging (MSI) for quantitative analysis of complex peptides. Collectively, this work results in development of the new generation of micro-separation and sample preparation tools and their coupling to various mass spectrometric ionization and detection modes for sensitive and rapid analysis of complex peptides and proteins. The technological innovations have significantly expanded the toolbox for peptidomics/proteomics analysis and will enable more in-depth investigations on peptide function and regulation.
Author : M.V. Novotny
Publisher : Elsevier
ISBN 13 : 0080858333
Total Pages : 349 pages
Book Rating : 4.0/5 (88 download)
Download or read book Microcolumn Separations written by M.V. Novotny and published by Elsevier. This book was released on 2011-09-22 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by two of the pioneers of microcolumn chromatography and written by recognized experts in the field, this book summarizes advances in microcolumn liquid chromatography, capillary supercritical fluid chromatography and microelectrophoresis. Its unique combination of expert knowledge from leading laboratories in the USA, Japan and Switzerland, results in a particularly in-depth and comprehensive coverage of the various aspects of microcolumn separation methods.
Author : Stephen C. Beale
Publisher :
ISBN 13 :
Total Pages : 548 pages
Book Rating : 4.3/5 ( download)
Download or read book Detection Aspects of Microcolumn Liquid Chromatography written by Stephen C. Beale and published by . This book was released on 1989 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Matthew Earl Monroe
Publisher :
ISBN 13 :
Total Pages : 556 pages
Book Rating : 4.:/5 (517 download)
Download or read book Development of Instrumentation and Applications for Microcolumn Liquid Chromatography Coupled to Time-of-flight Mass Spectrometry written by Matthew Earl Monroe and published by . This book was released on 2002 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Milos Krejci
Publisher : CRC Press
ISBN 13 : 1000104761
Total Pages : 217 pages
Book Rating : 4.0/5 (1 download)
Download or read book Trace Analysis with Microcolumn Liquid Chromatography written by Milos Krejci and published by CRC Press. This book was released on 2020-07-24 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a detailed description of technical elements of a microbore column liquid chromatograph suitable for use in trace analysis. It presents examples of analyses, especially from the spheres of biochemistry, pharmacology, and environmental analytical chemistry.
Author : Barry L. Karger
Publisher : Elsevier
ISBN 13 : 9780121821715
Total Pages : 664 pages
Book Rating : 4.8/5 (217 download)
Download or read book High Resolution Separation and Analysis of Biological Macromolecules written by Barry L. Karger and published by Elsevier. This book was released on 1996 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 260 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Key Features * Liquid chromatography * Electrophoresis * Mass spectrometry.
Author : R. Andrew Shalliker
Publisher : CRC Press
ISBN 13 : 084939077X
Total Pages : 311 pages
Book Rating : 4.8/5 (493 download)
Download or read book Hyphenated and Alternative Methods of Detection in Chromatography written by R. Andrew Shalliker and published by CRC Press. This book was released on 2011-12-14 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Widely employed for separating and detecting chemicals in solution, separation techniques are most often applied in tandem, subsequently referred to as hyphenated methods. Hyphenated and Alternative Methods of Detection in Chromatography details the development and application of mass spectral detection techniques coupled with gas phase and liquid phase chromatographies. With contributions from experts in a variety of fields, as evidenced by the range of topics, the book describes the advantages and disadvantages of various separation techniques and addresses methods for cutting-edge applications such as proteomics research. Specifically, this book covers: The development of the LC-NMR and its application in chromatographic science, particularly in relation to the analysis of natural and environmental samples and in the study of reaction monitoring, biosynthetic analysis, and structural elucidation The application of LC-ICP in biological samples for the speciation of organoarsenic and organoselenium compounds; metal complexes in microorganisms, plants, and foods of plant origin; human body fluids and tissues; and in the detection of chemical warfare agents Electrochemical detection in liquid chromatography, system optimization, and applications in the analysis of flavonoids The use of chemiluminescence for microcolumn and capillary methods of separation The process of employing multidimensional separation methods as a means of identifying components in complex samples A detailed reference for those starting out in the field, this book also suits those who are more experienced yet require assistance in new directions. It is an ideal reference for senior undergraduate and postgraduate students wishing to supplement their learning experience. Containing over 800 references, this book is an excellent source of information within the field of hyphenated methods of chromatographic analysis.
Author : Janusz Pawliszyn
Publisher : Elsevier
ISBN 13 : 0123914493
Total Pages : 497 pages
Book Rating : 4.1/5 (239 download)
Download or read book Handbook of Solid Phase Microextraction written by Janusz Pawliszyn and published by Elsevier. This book was released on 2011-12-01 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: The relatively new technique of solid phase microextraction (SPME) is an important tool to prepare samples both in the lab and on-site. SPME is a "green" technology because it eliminates organic solvents from analytical laboratory and can be used in environmental, food and fragrance, and forensic and drug analysis. This handbook offers a thorough background of the theory and practical implementation of SPME. SPME protocols are presented outlining each stage of the method and providing useful tips and potential pitfalls. In addition, devices and fiber coatings, automated SPME systems, SPME method development, and In Vivo applications are discussed. This handbook is essential for its discussion of the latest SPME developments as well as its in depth information on the history, theory, and practical application of the method. - Practical application of Solid Phase Microextraction methods including detailed steps - Provides history of extraction methods to better understand the process - Suitable for all levels, from beginning student to experienced practitioner
Author : Kevin Jooß
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (112 download)
Download or read book Development and Application of Two-dimensional Separation Systems Coupled to Mass Spectrometry Incorporating Capillary Electrophoresis written by Kevin Jooß and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Shrimati A. Balram
Publisher :
ISBN 13 :
Total Pages : 276 pages
Book Rating : 4.:/5 (15 download)
Download or read book Multidimensional Chromatography Interfaced with Inductively Coupled Plasma Mass Spectrometry for Separation of Zinc Metalloproteins written by Shrimati A. Balram and published by . This book was released on 2007 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Academic Press
ISBN 13 : 9780121821715
Total Pages : 622 pages
Book Rating : 4.8/5 (217 download)
Download or read book High Resolution Separation and Analysis of Biological Macromolecules, Part A: Fundamentals written by and published by Academic Press. This book was released on 1996-07-08 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 260 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Liquid chromatography Electrophoresis Mass spectrometry
Author : Gregory J. Opiteck
Publisher :
ISBN 13 :
Total Pages : 532 pages
Book Rating : 4.:/5 (46 download)
Download or read book Two Dimensional Separations Coupled to Mass Spectrometry for the Micropreparative Isolation, Identification, and Characterization of Proteins written by Gregory J. Opiteck and published by . This book was released on 1998 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lesley E Smart
Publisher : Royal Society of Chemistry
ISBN 13 : 184755783X
Total Pages : 122 pages
Book Rating : 4.8/5 (475 download)
Download or read book Separation, Purification and Identification written by Lesley E Smart and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book looks at the common techniques used to prepare, purify and identify chemicals. Topics including distillation, recrystallisation, chromatography, elemental analysis, atomic absorption spectroscopy and mass spectrometry are discussed, and are illustrated on video on the accompanying CD-ROMs. Infrared and nuclear magnetic resonance spectroscopy are covered entirely through multi-media, with animations and virtual experiments. The reader is provided with examples for interpretation, and can draw in the structures using the software provided. There is also a set of interactive self-assessment questions. In all, the multi-media software suite comprises more than twelve hours of material. Separation, Purification and Identification concludes with a Case Study on Forensic Science, in which illustrations of criminal cases where spectroscopic techniques provided evidence are given. The Molecular World series provides an integrated introduction to all branches of chemistry for both students wishing to specialise and those wishing to gain a broad understanding of chemistry and its relevance to the everyday world and to other areas of science. The books, with their Case Studies and accompanying multi-media interactive CD-ROMs, will also provide valuable resource material for teachers and lecturers. (The CD-ROMs are designed for use on a PC running Windows 95, 98, ME or 2000.)
Author : Ana Valéria Colnaghi Simionato
Publisher : Springer Nature
ISBN 13 : 3030772527
Total Pages : 277 pages
Book Rating : 4.0/5 (37 download)
Download or read book Separation Techniques Applied to Omics Sciences written by Ana Valéria Colnaghi Simionato and published by Springer Nature. This book was released on 2021-10-09 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers liquid chromatography, gas chromatography and capillary electrophoresis, the three main separation techniques lately available, applied to key omic sciences, such as genomics, proteomics, metabolomics and foodomics. The fundamentals of each technique are not covered herein. Instead, the recent advances in such techniques are presented focusing on the application to omics analyses and unique aspects in each case. This volume intends to offer wide ranging options available to researchers on omics sciences, and how to integrate them in order to achieve the comprehension of a biological system as a whole. Omic sciences have been of ultimate importance to comprehend the complex biochemical reactions and related events that occurs upon a biological system. The classical central dogma of molecular biology, which states that genetic information flows unidirectionally from DNA to RNA and then to proteins, has been gradually replaced by the systems biology approach. This book presents a multidisciplinary approach that explains the biological system as a whole, where the entire organism is influenced by a variety of internal events as well as by the environment, showing that each level of the biological information flux may influence the previous or the subsequent one.
Author : Colin F. Poole
Publisher : Elsevier
ISBN 13 : 0128096144
Total Pages : 628 pages
Book Rating : 4.1/5 (28 download)
Download or read book Capillary Electromigration Separation Methods written by Colin F. Poole and published by Elsevier. This book was released on 2018-04-13 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: Capillary Electromigration Separation Methods is a thorough, encompassing reference that not only defines the concept of contemporary practice, but also demonstrates its implementation in laboratory science. Chapters are authored by recognized experts in the field, ensuring that the content reflects the latest developments in research. Thorough, comprehensive coverage makes this the ideal reference for project planning, and extensive selected referencing facilitates identification of key information. The book defines the concept of contemporary practice in capillary electromigration separation methods, also discussing its applications in small mass ions, stereoisomers, and proteins. - Edited and authored by world-leading capillary electrophoresis experts - Presents comprehensive coverage on the subject - Includes extensive referencing that facilitates the identification of key research developments - Provides more than 50 figures and tables that aid in the retention of key concepts
